A Hutchinson, R Pais, AN Edginton, B Pilon, JM MacDonald, ME MacDonald, T Lewis, M Offringa, BT Kalish
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引用次数: 0
摘要
导言：尽管目前的治疗标准不尽人意，但缺氧缺血性脑病（HIE）婴儿神经发育受损的风险很高。因此需要辅助治疗来促进大脑修复。抗糖尿病药物二甲双胍最近被认为是一种神经修复剂，但迄今为止尚未用于婴儿。在此，我们介绍了一项临床试验，旨在证明二甲双胍用于改善 HIE 婴儿神经发育结局的安全性和可行性。
A Safety and Feasibility Trial Protocol of Metformin in Infants after Perinatal Brain Injury
Introduction Infants with hypoxic-ischemic encephalopathy (HIE) are at high risk for neurodevelopmental impairment, despite current standards of care. Adjunctive treatments to promote brain repair are needed. The antidiabetic drug metformin has recently been recognized as a neurorestorative agent, but, to date, has not been used in infants. Herein, we describe a clinical trial with the aim of demonstrating the safety and feasibility of metformin use to improve neurodevelopmental outcomes in infants with HIE.
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