arXiv - QuanBio - Cell Behavior最新文献_第3页

Embedding-based Multimodal Learning on Pan-Squamous Cell Carcinomas for Improved Survival Outcomes 基于嵌入式多模态学习的泛鳞状细胞癌改善生存结果

arXiv - QuanBio - Cell Behavior Pub Date : 2024-06-11 DOI: arxiv-2406.08521

Asim Waqas, Aakash Tripathi, Paul Stewart, Mia Naeini, Ghulam Rasool

引用次数: 0

How cells stay together; a mechanism for maintenance of a robust cluster explored by local and nonlocal continuum models 细胞如何保持在一起；局部和非局部连续模型探索的稳健集群维持机制

arXiv - QuanBio - Cell Behavior Pub Date : 2024-06-05 DOI: arxiv-2406.02846

Andreas Buttenschön, Shona Sinclair, Leah Edelstein-Keshet

引用次数: 0

Lichen-Mediated Self-Growing Construc8on Materials for Habitat Outfitting on Mars 用于火星人居装备的地衣自生长建筑材料

arXiv - QuanBio - Cell Behavior Pub Date : 2024-06-04 DOI: arxiv-2406.02522

Nisha Rokaya, Erin C. Carr, Richard A. Wilson, Congrui Jin

引用次数: 0

The development of drug resistance in metastatic tumours under chemotherapy: an evolutionary perspective 化疗下转移性肿瘤耐药性的产生：进化的视角

arXiv - QuanBio - Cell Behavior Pub Date : 2024-05-30 DOI: arxiv-2405.20203

Federica Padovano, Luis Almeida, Chiara Villa

引用次数: 0

Immune cells interactions in the tumor microenvironment 肿瘤微环境中免疫细胞的相互作用

arXiv - QuanBio - Cell Behavior Pub Date : 2024-05-28 DOI: arxiv-2405.18452

Mobina Tousian, Christian Solis Calero, Julio Cesar Perez Sansalvador

引用次数: 0

Active gel model for one-dimensional cell migration coupling actin flow and adhesion dynamics 连接肌动蛋白流动和粘附动力学的一维细胞迁移活性凝胶模型

arXiv - QuanBio - Cell Behavior Pub Date : 2024-05-27 DOI: arxiv-2405.16870

Valentin WössnerHeidelberg University, Oliver M. DrozdowskiHeidelberg University, Falko ZiebertHeidelberg University, Ulrich S. SchwarzHeidelberg University

{"title":"Active gel model for one-dimensional cell migration coupling actin flow and adhesion dynamics","authors":"Valentin WössnerHeidelberg University, Oliver M. DrozdowskiHeidelberg University, Falko ZiebertHeidelberg University, Ulrich S. SchwarzHeidelberg University","doi":"arxiv-2405.16870","DOIUrl":"https://doi.org/arxiv-2405.16870","url":null,"abstract":"Migration of animal cells is based on the interplay between actin\u0000polymerization at the front, adhesion along the cell-substrate interface, and\u0000actomyosin contractility at the back. Active gel theory has been used before to\u0000demonstrate that actomyosin contractility is sufficient for polarization and\u0000self-sustained cell migration in the absence of external cues, but did not\u0000consider the dynamics of adhesion. Likewise, migration models based on the\u0000mechanosensitive dynamics of adhesion receptors usually do not include the\u0000global dynamics of intracellular flow. Here we show that both aspects can be\u0000combined in a minimal active gel model for one-dimensional cell migration with\u0000dynamic adhesion. This model demonstrates that load sharing between the\u0000adhesion receptors leads to symmetry breaking, with stronger adhesion at the\u0000front, and that bistability of migration arises for intermediate adhesiveness.\u0000Local variations in adhesiveness are sufficient to switch between sessile and\u0000motile states, in qualitative agreement with experiments.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141170504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell migration: Beyond Brownian motion 细胞迁移：超越布朗运动

arXiv - QuanBio - Cell Behavior Pub Date : 2024-05-27 DOI: arxiv-2405.17578

Rainer Klages

引用次数: 0

Emergent behaviour and phase transitions in spatially distributed multi-cellular metabolic networks 空间分布式多细胞代谢网络中的新兴行为和相变

arXiv - QuanBio - Cell Behavior Pub Date : 2024-05-22 DOI: arxiv-2405.13424

K. Narayanankutty, J. A. Pereiro-Morejon, A. Ferrero, V. Onesto, S. Forciniti, L. L. del Mercato, R. Mulet, A. De Martino, D. S. Tourigny, D. De Martino

{"title":"Emergent behaviour and phase transitions in spatially distributed multi-cellular metabolic networks","authors":"K. Narayanankutty, J. A. Pereiro-Morejon, A. Ferrero, V. Onesto, S. Forciniti, L. L. del Mercato, R. Mulet, A. De Martino, D. S. Tourigny, D. De Martino","doi":"arxiv-2405.13424","DOIUrl":"https://doi.org/arxiv-2405.13424","url":null,"abstract":"Overflow metabolism is a ubiquitous phenomenon whereby cells in aerobic\u0000conditions excrete byproducts of glycolysis, such as lactate or acetate, into\u0000the medium in a seemingly wasteful and polluting fashion. Whilst overflow may\u0000confer microbes a fitness advantage by allowing them to overcome a finite\u0000oxidative capacity, its occurrence in higher organisms is harder to assess.\u0000Important insight was however obtained in recent experiments conducted at\u0000single-cell resolution, which revealed that accumulation of overflow products\u0000in tumor cell cultures known as the Warburg effect arises from imbalances in\u0000the dynamic and heterogeneous inter-cellular exchange network through which\u0000cells collectively regulate the microenvironment. Here we provide a\u0000quantitative characterization of this scenario by integrating metabolic network\u0000modeling with diffusion constraints, statistical physics theory and single-cell\u0000experimental flux data. On the theoretical side, we clarify how\u0000diffusion-limited exchanges shape the space of viable metabolic states of a\u0000multi-cellular system. Specifically, a phase transition from a balanced network\u0000of exchanges to an unbalanced overflow regime occurs as the mean cellular\u0000glucose and oxygen uptakes vary while single-cell metabolic phenotypes are\u0000highly heterogeneous around this transition. We then show that time-resolved\u0000data from human tumor-stroma cell co-cultures consistently map to this\u0000crossover region, supporting the idea that environmental deterioration reflects\u0000a failure of coordination among recurrently interacting cells. In summary, our\u0000findings suggest that, rather than deriving from multiple independent\u0000cell-autonomous processes, environmental control is an emergent feature of\u0000multi-cellular systems.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141145951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Run-and-tumble particle with saturating rates 具有饱和速率的运行和翻滚粒子

arXiv - QuanBio - Cell Behavior Pub Date : 2024-05-22 DOI: arxiv-2405.13521

Kavita Jain, Sakuntala Chatterjee

{"title":"Run-and-tumble particle with saturating rates","authors":"Kavita Jain, Sakuntala Chatterjee","doi":"arxiv-2405.13521","DOIUrl":"https://doi.org/arxiv-2405.13521","url":null,"abstract":"We consider a run-and-tumble particle whose speed and tumbling rate are\u0000space-dependent on an infinite line. Unlike most of the previous work on such\u0000models, here we make the physical assumption that at large distances, these\u0000rates saturate to a constant. For our choice of rate functions, we show that a\u0000stationary state exists, and the exact steady state distribution decays\u0000exponentially or faster and can be unimodal or bimodal. The effect of\u0000boundedness of rates is seen in the mean-squared displacement of the particle\u0000that displays qualitative features different from those observed in the\u0000previous studies where it approaches the stationary state value monotonically\u0000in time; in contrast, here we find that if the initial position of the particle\u0000is sufficiently far from the origin, the variance in its position either varies\u0000nonmonotonically or plateaus before reaching the stationary state. These\u0000results are captured quantitatively by the exact solution of the Green's\u0000function when the particle has uniform speed but the tumbling rates change as a\u0000step-function in space; the insights provided by this limiting case are found\u0000to be consistent with the numerical results for the general model.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141146026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular dynamics of host-parasitoid interactions: Insights from the encapsulation process in a partially resistant host 寄主与寄生虫相互作用的细胞动力学：从部分抗性寄主的封装过程中获得的启示

arXiv - QuanBio - Cell Behavior Pub Date : 2024-05-13 DOI: arxiv-2405.07771

Samuel GornardEGCE, Florence Mougel, Isabelle Germon, Véronique Borday-Birraux, Pascaline Venon, Salimata Drabo, Laure Marie-Paule Kaiser-Arnauld

{"title":"Cellular dynamics of host-parasitoid interactions: Insights from the encapsulation process in a partially resistant host","authors":"Samuel GornardEGCE, Florence Mougel, Isabelle Germon, Véronique Borday-Birraux, Pascaline Venon, Salimata Drabo, Laure Marie-Paule Kaiser-Arnauld","doi":"arxiv-2405.07771","DOIUrl":"https://doi.org/arxiv-2405.07771","url":null,"abstract":"Cotesia typhae is an eastern African endoparasitoid braconid wasp that\u0000targets the larval stage of the lepidopteran stem borer, Sesamia nonagrioides,\u0000a maize crop pest in Europe. The French host population is partially resistant\u0000to the Makindu strain of the wasp, allowing its development in only 40% of the\u0000cases. Resistant larvae can encapsulate the parasitoid and survive the\u0000infection. This interaction provides a very interesting frame for investigating\u0000the impact of parasitism on host cellular resistance. We characterized the\u0000parasitoid ovolarval development in a permissive host and studied the\u0000encapsulation process in a resistant host by dissection and histological\u0000sectioning compared to that of inert chromatography beads. We measured the\u0000total hemocyte count in parasitized and bead-injected larvae over time to\u0000monitor the magnitude of the immune reaction. Our results show that parasitism\u0000of resistant hosts delayed encapsulation but did not affect immune abilities\u0000towards inert beads. Moreover, while bead injection increased total hemocyte\u0000count, it remained constant in resistant and permissive larvae. We conclude\u0000that while Cotesia spp virulence factors are known to impair the host immune\u0000system, our results suggest that passive evasion could also occur.","PeriodicalId":501321,"journal":{"name":"arXiv - QuanBio - Cell Behavior","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140928708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0