Journal of Pediatric Endocrinology & Metabolism最新文献_第8页

The effect of gonadotropin-releasing hormone analog treatment on the endocrine system in central precocious puberty patients: a meta-analysis. 促性腺激素释放激素类似物治疗对中枢性性早熟患者内分泌系统的影响：一项荟萃分析。

IF 1.4 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2024-01-19 Print Date: 2024-03-25 DOI: 10.1515/jpem-2023-0480

Na Guo, Fei Zhou, Xiaolan Jiang, Linlin Yang, Huijuan Ma

{"title":"The effect of gonadotropin-releasing hormone analog treatment on the endocrine system in central precocious puberty patients: a meta-analysis.","authors":"Na Guo, Fei Zhou, Xiaolan Jiang, Linlin Yang, Huijuan Ma","doi":"10.1515/jpem-2023-0480","DOIUrl":"10.1515/jpem-2023-0480","url":null,"abstract":"Objectives: Gonadotropin-releasing hormone (GnRHa) is the first choice for the treatment of patients with central precocious puberty (CPP). However, the effects of GnRHa on the endocrine system of CPP patients, including insulin sensitivity, lipid level, thyroid function, bone mineral density (BMD), and testosterone (T) level, are currently contradictory. Therefore, the long-term safety of GnRHa therapy remains controversial.Content: A systematic literature search was performed using PubMed, Embase, Cochrane Library, and CNKI databases. The changes in HOMA-IR, TG, LDL-C, HDL-C, TSH, FT3, FT4, T, and BMD in CPP patients before and after GnRHa treatment were compared by meta-analysis. As the heterogeneity between studies, we estimated standard deviation mean differences (SMDs) and 95 % confidence intervals (CIs) using a random-effects model. Egger's test was used to assess publication bias.Summary: A total of 22 studies were included in our meta-analysis. Compared with before GnRHa treatment, there were no statistically significant differences in endocrine indicators including HOMA-IR, TG, LDL-C, HDL-C, TSH, FT4, FT3, T, and BMD of CPP patients treated with GnRHa.Outlook: Treatment with GnRHa for central precocious puberty will not increase the adverse effect on the endocrine system.","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":" ","pages":"197-208"},"PeriodicalIF":1.4,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with neonatal hyperinsulinemic hypoglycemia, a case-control study. 新生儿高胰岛素血症低血糖的相关因素，一项病例对照研究。

IF 1.4 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2024-01-19 Print Date: 2024-03-25 DOI: 10.1515/jpem-2023-0526

Thanaporn Rattanasakol, Ratchada Kitsommart

{"title":"Factors associated with neonatal hyperinsulinemic hypoglycemia, a case-control study.","authors":"Thanaporn Rattanasakol, Ratchada Kitsommart","doi":"10.1515/jpem-2023-0526","DOIUrl":"10.1515/jpem-2023-0526","url":null,"abstract":"Objectives: We aimed to identify perinatal risk factors associated with hyperinsulinemic hypoglycemia in neonates. Secondary objectives included an examination of clinical and biochemical characteristics at the time of diagnosis and an exploration of the duration of diazoxide therapy.Methods: A case-control study was conducted, involving individual chart reviews of inborn infants diagnosed with hyperinsulinemic hypoglycemia (the HH group) between 2014 and 2021. These cases were paired with controls (the non-HH group) belonging to the same gestational age (GA) strata who did not exhibit HH or only had transient postnatal hypoglycemia.Results: A total of 52 infants with HH were matched with corresponding controls. The mean GA in the HH group was 34.4 ± 3.1 weeks. Notably, the HH group exhibited lower mean minimum plasma glucose (PG) levels and required higher glucose infusion rates in comparison to the non-HH group (26.5 ± 15.6 vs. 49.1 ± 37.7 mg/dL and 12.9 ± 3.8 vs. 5.7 ± 2.1 mg/kg/min, respectively; p<0.001 for both). After adjusting for potential confounding factors, only two variables, fetal growth restriction (FGR) and neonatal sepsis, demonstrated significant associations with HH (adjusted odds ratio [95 % confidence interval]: 8.1 [2.1-31.0], p=0.002 and 6.3 [1.9-21.4], p=0.003, respectively). The median duration of diazoxide therapy for the HH group was 4 months.Conclusions: FGR and neonatal sepsis emerged as notable risk factors for HH. These infants exhibited lower PG levels and necessitated higher glucose infusion rates compared to their non-HH counterparts. Importantly, a substantial proportion of the HH group received diazoxide therapy, with a median treatment duration of 4 months.","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":" ","pages":"243-249"},"PeriodicalIF":1.4,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin for "hearts that had lost hope" - on the first pediatric patients and the 1923 Nobel Prize in Physiology or Medicine. 为 "失去希望的心脏 "注射胰岛素--首例儿科患者和 1923 年诺贝尔生理学或医学奖。

IF 1.4 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2024-01-12 Print Date: 2024-03-25 DOI: 10.1515/jpem-2023-0560

Iuliana Popescu

引用次数: 0

Artificial intelligence in paediatric endocrinology: conflict or cooperation. 儿科内分泌学中的人工智能：冲突还是合作。

IF 1.4 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2024-01-08 Print Date: 2024-03-25 DOI: 10.1515/jpem-2023-0554

Paul Dimitri, Martin O Savage

{"title":"Artificial intelligence in paediatric endocrinology: conflict or cooperation.","authors":"Paul Dimitri, Martin O Savage","doi":"10.1515/jpem-2023-0554","DOIUrl":"10.1515/jpem-2023-0554","url":null,"abstract":"Artificial intelligence (AI) in medicine is transforming healthcare by automating system tasks, assisting in diagnostics, predicting patient outcomes and personalising patient care, founded on the ability to analyse vast datasets. In paediatric endocrinology, AI has been developed for diabetes, for insulin dose adjustment, detection of hypoglycaemia and retinopathy screening; bone age assessment and thyroid nodule screening; the identification of growth disorders; the diagnosis of precocious puberty; and the use of facial recognition algorithms in conditions such as Cushing syndrome, acromegaly, congenital adrenal hyperplasia and Turner syndrome. AI can also predict those most at risk from childhood obesity by stratifying future interventions to modify lifestyle. AI will facilitate personalised healthcare by integrating data from 'omics' analysis, lifestyle tracking, medical history, laboratory and imaging, therapy response and treatment adherence from multiple sources. As data acquisition and processing becomes fundamental, data privacy and protecting children's health data is crucial. Minimising algorithmic bias generated by AI analysis for rare conditions seen in paediatric endocrinology is an important determinant of AI validity in clinical practice. AI cannot create the patient-doctor relationship or assess the wider holistic determinants of care. Children have individual needs and vulnerabilities and are considered in the context of family relationships and dynamics. Importantly, whilst AI provides value through augmenting efficiency and accuracy, it must not be used to replace clinical skills.","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":" ","pages":"209-221"},"PeriodicalIF":1.4,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139111322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes and experiences of adults with congenital hypogonadism can inform improvements in the management of delayed puberty. 成人先天性性腺功能减退症的结局和经验可以改善青春期延迟的管理。

IF 1.4 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-24 Print Date: 2024-01-29 DOI: 10.1515/jpem-2023-0407

Sasha R Howard, Richard Quinton

引用次数: 0

Very elevated serum copeptin concentrations occur in a subset of healthy children in the minutes after phlebotomy. 血copeptin浓度升高发生在一小部分健康儿童在放血后的几分钟内。

IF 1.3 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-23 Print Date: 2024-01-29 DOI: 10.1515/jpem-2023-0390

Shruti Sastry, Christine A March, Michael J McPhaul, Luigi R Garibaldi

{"title":"Very elevated serum copeptin concentrations occur in a subset of healthy children in the minutes after phlebotomy.","authors":"Shruti Sastry, Christine A March, Michael J McPhaul, Luigi R Garibaldi","doi":"10.1515/jpem-2023-0390","DOIUrl":"10.1515/jpem-2023-0390","url":null,"abstract":"Objectives: Although AVP and its surrogate, copeptin, are mainly regulated by osmotic and volume stimuli, their secretion is also elicited by stress and growth hormone (GH) stimulating agents. The aim of this report is to describe unusual patterns of copeptin response in a subset of children undergoing GH stimulation tests (GH-ST).Methods: We conducted a secondary analysis of a cohort of 93 healthy short children with no polydipsia, polyuria or fluid/electrolyte abnormalities, undergoing GH-ST with intravenous arginine, insulin, oral clonidine, or L-Dopa/carbidopa in various combinations. Serum copeptin concentrations were measured 1-3 min after phlebotomy (0 min) and at 60, 90, 120 min during GH-ST.Results: In 85 subjects (normal response group, NRG) serum copeptin concentrations increased from a 0 min median of 9 pmol/L (IQR 6, 11.5) (all values ≤21) to a median peak between 60 and 120 min of 22 (IQR15, 38) pmol/L, which varied depending on the stimulating agent. Conversely, in the eight outliers, copeptin concentrations decreased gradually from a median of 154 (IQR 61, 439) pmol/L (all ≥40 pmol/L) to values as low as 14 % of the basal value, by 120 min. Test-associated anxiety was described in 17 subjects in the NRG (20 %) and five of the outliers (63 %).Conclusions: A distinctive pattern of very elevated serum copeptin concentrations occurred in 9 % of children undergoing GH-ST, similar to reports in previous pediatric studies. Etiology may include pain or stress of phlebotomy. This phenomenon should be recognized for proper interpretation of copeptin values in children.","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":" ","pages":"8-14"},"PeriodicalIF":1.3,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Features of liver injury in 138 Chinese patients with NICCD. 138例NICCD患者肝损伤特点分析。

IF 1.4 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-10 Print Date: 2023-12-15 DOI: 10.1515/jpem-2023-0026

MinYan Jiang, MinZhi Peng, ZhiKun Lu, YongXian Shao, ZongCai Liu, XiuZhen Li, YunTing Lin, Li Liu, Wen Zhang, YanNa Cai

{"title":"Features of liver injury in 138 Chinese patients with NICCD.","authors":"MinYan Jiang, MinZhi Peng, ZhiKun Lu, YongXian Shao, ZongCai Liu, XiuZhen Li, YunTing Lin, Li Liu, Wen Zhang, YanNa Cai","doi":"10.1515/jpem-2023-0026","DOIUrl":"10.1515/jpem-2023-0026","url":null,"abstract":"Objectives: To find biochemical and molecular markers can assist in identifying serious liver damage of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) patients.Methods: 138 patients under 13 days to 1.1 year old diagnosed of NICCD in our center from 2004 to 2020. Base on the abnormal liver laboratory tests, we divided 138 patients into three groups: acute liver failure (ALF), liver dysfunction, and non-liver dysfunction groups, then compared their clinical, biochemical and, molecular data.Results: 96 % of 138 patients had high levels of citrulline and high ratio of threonine to serine, which is the distinctive feature of plasma amino acid profile for NICCD. A total of 18.1 % of 138 patients had evidence of ALF who presented the most severity hepatic damage, 51.5 % had liver dysfunction, and the remaining 30.4 % presented mild clinical symptoms (non-liver dysfunction). In ALF group, the levels of citrulline, tyrosine, TBIL, ALP, and γ-GT was significantly elevated, and the level of ALB and Fisher ratio was pronounced low. Homozygous mutations of 1,638_1660dup, IVS6+5G.A, or IVS16ins3kb in SLC25A13 gene were only found in ALF and liver dysfunction groups. Supportive treatment including medium-chain triglyceride supplemented diet and fresh frozen plasma could be life-saving and might reverse ALF.Conclusions: High level of citrulline, tyrosine, TBIL, ALP, γ-GT, and ammonia, low level of albumin, and low Fisher ratio were predictors to suggest severe liver damage in NICCD patients who may go on to develop fatal metabolic disorder. Early identification and proper therapy is particularly important for these patients.","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":" ","pages":"1154-1160"},"PeriodicalIF":1.4,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Carbamezapine and Valproic Acid on Bone Mineral Density, IGF-I and IGFBP-3. 卡巴米氮平和丙戊酸对骨矿密度、IGF-I 和 IGFBP-3 的影响

IF 1.3 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190411

Sefer Kumandas, Esad Koklu, Hakan Gümüs, Selmin Koklu, Selim Kurtoglu, Musa Karakukcu, Mehmet Keskin

引用次数: 0

The Growing Child with Thalassaemia. 地中海贫血症儿童的成长。

IF 1.3 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190403

Nicos Skordis

引用次数: 0

Congenital Combined Pituitary Hormone Deficiency Attributable to a Novel PROP1 Mutation (467insT). 一种新的PROP1突变引起的先天性联合垂体激素缺乏症（467insT）。

IF 1.4 4区医学

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190406

O Nose, K Tatsumi, Y Nakano, N Amino

引用次数: 0