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Very elevated serum copeptin concentrations occur in a subset of healthy children in the minutes after phlebotomy. 血copeptin浓度升高发生在一小部分健康儿童在放血后的几分钟内。
IF 1.3 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-23 Print Date: 2024-01-29 DOI: 10.1515/jpem-2023-0390
Shruti Sastry, Christine A March, Michael J McPhaul, Luigi R Garibaldi
{"title":"Very elevated serum copeptin concentrations occur in a subset of healthy children in the minutes after phlebotomy.","authors":"Shruti Sastry, Christine A March, Michael J McPhaul, Luigi R Garibaldi","doi":"10.1515/jpem-2023-0390","DOIUrl":"10.1515/jpem-2023-0390","url":null,"abstract":"<p><strong>Objectives: </strong>Although AVP and its surrogate, copeptin, are mainly regulated by osmotic and volume stimuli, their secretion is also elicited by stress and growth hormone (GH) stimulating agents. The aim of this report is to describe unusual patterns of copeptin response in a subset of children undergoing GH stimulation tests (GH-ST).</p><p><strong>Methods: </strong>We conducted a secondary analysis of a cohort of 93 healthy short children with no polydipsia, polyuria or fluid/electrolyte abnormalities, undergoing GH-ST with intravenous arginine, insulin, oral clonidine, or L-Dopa/carbidopa in various combinations. Serum copeptin concentrations were measured 1-3 min after phlebotomy (0 min) and at 60, 90, 120 min during GH-ST.</p><p><strong>Results: </strong>In 85 subjects (normal response group, NRG) serum copeptin concentrations increased from a 0 min median of 9 pmol/L (IQR 6, 11.5) (all values ≤21) to a median peak between 60 and 120 min of 22 (IQR15, 38) pmol/L, which varied depending on the stimulating agent. Conversely, in the eight outliers, copeptin concentrations decreased gradually from a median of 154 (IQR 61, 439) pmol/L (all ≥40 pmol/L) to values as low as 14 % of the basal value, by 120 min. Test-associated anxiety was described in 17 subjects in the NRG (20 %) and five of the outliers (63 %).</p><p><strong>Conclusions: </strong>A distinctive pattern of very elevated serum copeptin concentrations occurred in 9 % of children undergoing GH-ST, similar to reports in previous pediatric studies. Etiology may include pain or stress of phlebotomy. This phenomenon should be recognized for proper interpretation of copeptin values in children.</p>","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":" ","pages":"8-14"},"PeriodicalIF":1.3,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of liver injury in 138 Chinese patients with NICCD. 138例NICCD患者肝损伤特点分析。
IF 1.4 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-10 Print Date: 2023-12-15 DOI: 10.1515/jpem-2023-0026
MinYan Jiang, MinZhi Peng, ZhiKun Lu, YongXian Shao, ZongCai Liu, XiuZhen Li, YunTing Lin, Li Liu, Wen Zhang, YanNa Cai
{"title":"Features of liver injury in 138 Chinese patients with NICCD.","authors":"MinYan Jiang, MinZhi Peng, ZhiKun Lu, YongXian Shao, ZongCai Liu, XiuZhen Li, YunTing Lin, Li Liu, Wen Zhang, YanNa Cai","doi":"10.1515/jpem-2023-0026","DOIUrl":"10.1515/jpem-2023-0026","url":null,"abstract":"<p><strong>Objectives: </strong>To find biochemical and molecular markers can assist in identifying serious liver damage of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) patients.</p><p><strong>Methods: </strong>138 patients under 13 days to 1.1 year old diagnosed of NICCD in our center from 2004 to 2020. Base on the abnormal liver laboratory tests, we divided 138 patients into three groups: acute liver failure (ALF), liver dysfunction, and non-liver dysfunction groups, then compared their clinical, biochemical and, molecular data.</p><p><strong>Results: </strong>96 % of 138 patients had high levels of citrulline and high ratio of threonine to serine, which is the distinctive feature of plasma amino acid profile for NICCD. A total of 18.1 % of 138 patients had evidence of ALF who presented the most severity hepatic damage, 51.5 % had liver dysfunction, and the remaining 30.4 % presented mild clinical symptoms (non-liver dysfunction). In ALF group, the levels of citrulline, tyrosine, TBIL, ALP, and γ-GT was significantly elevated, and the level of ALB and Fisher ratio was pronounced low. Homozygous mutations of 1,638_1660dup, IVS6+5G.A, or IVS16ins3kb in <i>SLC25A13</i> gene were only found in ALF and liver dysfunction groups. Supportive treatment including medium-chain triglyceride supplemented diet and fresh frozen plasma could be life-saving and might reverse ALF.</p><p><strong>Conclusions: </strong>High level of citrulline, tyrosine, TBIL, ALP, γ-GT, and ammonia, low level of albumin, and low Fisher ratio were predictors to suggest severe liver damage in NICCD patients who may go on to develop fatal metabolic disorder. Early identification and proper therapy is particularly important for these patients.</p>","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":" ","pages":"1154-1160"},"PeriodicalIF":1.4,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Carbamezapine and Valproic Acid on Bone Mineral Density, IGF-I and IGFBP-3. 卡巴米氮平和丙戊酸对骨矿密度、IGF-I 和 IGFBP-3 的影响
IF 1.3 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190411
Sefer Kumandas, Esad Koklu, Hakan Gümüs, Selmin Koklu, Selim Kurtoglu, Musa Karakukcu, Mehmet Keskin
{"title":"Effect of Carbamezapine and Valproic Acid on Bone Mineral Density, IGF-I and IGFBP-3.","authors":"Sefer Kumandas, Esad Koklu, Hakan Gümüs, Selmin Koklu, Selim Kurtoglu, Musa Karakukcu, Mehmet Keskin","doi":"10.1515/jpem-2006-190411","DOIUrl":"10.1515/jpem-2006-190411","url":null,"abstract":"","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":"19 4","pages":"529-534"},"PeriodicalIF":1.3,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Growing Child with Thalassaemia. 地中海贫血症儿童的成长。
IF 1.3 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190403
Nicos Skordis
{"title":"The Growing Child with Thalassaemia.","authors":"Nicos Skordis","doi":"10.1515/jpem-2006-190403","DOIUrl":"10.1515/jpem-2006-190403","url":null,"abstract":"","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":"19 4","pages":"467-470"},"PeriodicalIF":1.3,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Combined Pituitary Hormone Deficiency Attributable to a Novel PROP1 Mutation (467insT). 一种新的PROP1突变引起的先天性联合垂体激素缺乏症（467insT）。
IF 1.4 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190406
O Nose, K Tatsumi, Y Nakano, N Amino
{"title":"Congenital Combined Pituitary Hormone Deficiency Attributable to a Novel PROP1 Mutation (467insT).","authors":"O Nose, K Tatsumi, Y Nakano, N Amino","doi":"10.1515/jpem-2006-190406","DOIUrl":"10.1515/jpem-2006-190406","url":null,"abstract":"","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":"19 4","pages":"491-498"},"PeriodicalIF":1.4,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Carbamezapine and Valproic Acid on Bone Mineral Density, IGF-I and IGFBP-3. 卡马西平和丙戊酸对骨密度、IGF-I和IGFBP-3的影响。
IF 1.4 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190411
Sefer Kumandas, Esad Koklu, Hakan Gümüs, Selmin Koklu, Selim Kurtoglu, Musa Karakukcu, Mehmet Keskin
{"title":"Effect of Carbamezapine and Valproic Acid on Bone Mineral Density, IGF-I and IGFBP-3.","authors":"Sefer Kumandas, Esad Koklu, Hakan Gümüs, Selmin Koklu, Selim Kurtoglu, Musa Karakukcu, Mehmet Keskin","doi":"10.1515/jpem-2006-190411","DOIUrl":"10.1515/jpem-2006-190411","url":null,"abstract":"","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":"19 4","pages":"529-534"},"PeriodicalIF":1.4,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Worster-Drought Syndrome (Congenital Bilateral Perisylvian Syndrome) with Posterior Pituitary Ectopia, Pituitary Hypoplasia, Empty Sella and Panhypopituitarism: A Patient Report. Worster Dry综合征（先天性双侧侧脑室周围综合征）伴后垂体异位、垂体发育不良、Sella排空和垂体全功能减退：一例患者报告。
IF 1.4 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190412
Firdevs Baş, Feyza Darendeliler, Zuhal Zuhal Yapici, Selman Gokalp, Rüveyde Bundak, Nurçin Saka, Hülya Günöz
{"title":"Worster-Drought Syndrome (Congenital Bilateral Perisylvian Syndrome) with Posterior Pituitary Ectopia, Pituitary Hypoplasia, Empty Sella and Panhypopituitarism: A Patient Report.","authors":"Firdevs Baş, Feyza Darendeliler, Zuhal Zuhal Yapici, Selman Gokalp, Rüveyde Bundak, Nurçin Saka, Hülya Günöz","doi":"10.1515/jpem-2006-190412","DOIUrl":"10.1515/jpem-2006-190412","url":null,"abstract":"","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":"19 4","pages":"535-540"},"PeriodicalIF":1.4,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth Hormone and Premature Atherosclerosis in Childhood Obesity. 生长激素与儿童肥胖症早期动脉粥样硬化。
IF 1.4 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190402
Margarita Smotkin-Tangorra, Henry Anhalt, Svetlana Ten
{"title":"Growth Hormone and Premature Atherosclerosis in Childhood Obesity.","authors":"Margarita Smotkin-Tangorra, Henry Anhalt, Svetlana Ten","doi":"10.1515/jpem-2006-190402","DOIUrl":"10.1515/jpem-2006-190402","url":null,"abstract":"","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":"19 4","pages":"455-466"},"PeriodicalIF":1.4,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical Diagnosis of Testotoxicosis in a Boy with an Activating Mutation of the Luteinizing Hormone Receptor. 黄体生成激素受体激活突变的男孩睾丸毒性的临床前诊断。
IF 1.4 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190413
Milena Teles, Vinicius Nahime Brito, Ivo Jorges Prado Arnhold, Berenice Bilharinho Mendonca, Ana Claudia Latronico
{"title":"Preclinical Diagnosis of Testotoxicosis in a Boy with an Activating Mutation of the Luteinizing Hormone Receptor.","authors":"Milena Teles, Vinicius Nahime Brito, Ivo Jorges Prado Arnhold, Berenice Bilharinho Mendonca, Ana Claudia Latronico","doi":"10.1515/jpem-2006-190413","DOIUrl":"10.1515/jpem-2006-190413","url":null,"abstract":"","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":"19 4","pages":"541-544"},"PeriodicalIF":1.4,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Value of Fine-Needle Aspiration Biopsy of Thyroid Nodules in Children and Adolescents. 儿童和青少年甲状腺结节细针抽吸活检的诊断价值
IF 1.4 4区 医学
Journal of Pediatric Endocrinology & Metabolism Pub Date : 2023-11-02 Print Date: 2006-04-01 DOI: 10.1515/jpem-2006-190408
H Willgerodt, E Keller, J Bennek, P Emmrich
{"title":"Diagnostic Value of Fine-Needle Aspiration Biopsy of Thyroid Nodules in Children and Adolescents.","authors":"H Willgerodt, E Keller, J Bennek, P Emmrich","doi":"10.1515/jpem-2006-190408","DOIUrl":"https://doi.org/10.1515/jpem-2006-190408","url":null,"abstract":"","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":"19 4","pages":"507-516"},"PeriodicalIF":1.4,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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