Journal of Physiology-London最新文献

{"title":"Exposing mice to extremely hypertonic treatments: a recurring problem in lactate research.","authors":"Jens Lund, Zachary Gerhart-Hines, Christoffer Clemmensen","doi":"10.1113/JP287781","DOIUrl":"https://doi.org/10.1113/JP287781","url":null,"abstract":"","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical closing pressure and resistance-area product as markers of cerebral autoregulation dynamics.","authors":"Stephen Payne","doi":"10.1113/JP287876","DOIUrl":"https://doi.org/10.1113/JP287876","url":null,"abstract":"","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-1β signalling in muscle atrophy: linking inflammation, sex-specific responses and exercise in cancer cachexia","authors":"Vito A. Pipitone, Mackenzie Q. Graham, Lauren S. Perkins, Daniel L. Scurto, Jacob M. Ouellette, Fasih A. Rahman","doi":"10.1113/JP287733","DOIUrl":"10.1113/JP287733","url":null,"abstract":"","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":"602 24","pages":"6641-6643"},"PeriodicalIF":4.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annual Prize Lecture 2024: Endogenous physiological mechanisms as basis for the treatment of obesity and type 2 diabetes","authors":"Jens Juul Holst","doi":"10.1113/JP287461","DOIUrl":"10.1113/JP287461","url":null,"abstract":"<p>In 1964, it was proven that postprandial insulin secretion is largely regulated by gut hormones and, in 1973, it was proposed that a gut hormone would also regulate appetite and food intake. Several gut hormones were tested for metabolic actions with disappointing results until the discovery of the proglucagon derivative, glucagon-like peptide-1 (GLP-1). This peptide from the distal intestine has preserved activity on insulin secretion in people with type 2 diabetes and turned out to regulate both secretion and motility in the gastrointestinal tract and importantly, appetite and food intake, thus functioning as an efficient ‘ileal brake’ hormone. However, the natural hormone acts predominantly via sensory afferent systems and is extremely rapidly removed from the circulation by enzymatic degradation and renal elimination, and increasing the doses merely results in nausea and vomiting. Lipidation of analogs turned out to provide both stability and limit renal elimination, and very slow up-titration of dosing improves tolerance. Indeed, the most recent agonists may near-normalize glycaemic control in type 2 diabetes, may cause weight losses of up to 25% of body weight, and significantly reduce cardiovascular risk, effects that resemble those of bariatric surgery. Thus, a solution to one of the most serious health problems of modern civilization, the increased morbidity and mortality of the metabolic syndrome, may be addressed by mobilization of one of the body's own regulatory mechanisms.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":"602 24","pages":"6613-6629"},"PeriodicalIF":4.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1113/JP287461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily GDF15 treatment has sex-specific effects on body weight and food intake and does not enhance the effects of voluntary physical activity in mice","authors":"Stewart Jeromson,&nbsp;Michael Akcan,&nbsp;Bradley Baranowski,&nbsp;Meagan Arbeau,&nbsp;Annalaura Bellucci,&nbsp;David C. Wright","doi":"10.1113/JP287256","DOIUrl":"10.1113/JP287256","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 \u0000 &lt;div&gt;Growth differentiation factor 15 (GDF15) is a stress-induced cytokine that suppresses food intake and causes weight loss. GDF15 also reduces voluntary physical activity and, thus, it is not clear whether combining GDF15 with exercise will be beneficial or if reductions in food intake would be offset by decreases in physical activity. We investigated how GDF15 treatment combined with voluntary wheel running (VWR) would impact weight gain, food intake, adiposity and indices of metabolic health in mice. High-fat fed male and female mice underwent daily GDF15 treatments and were given access to voluntary running wheels, or not, for 11 days. In both sexes, VWR prevented weight gain. In males, GDF15 reduced food intake, as well as attenuated weight gain and the accumulation of adipose tissue, with no additional effect of VWR. In female mice, GDF15 did not impact body weight gain or body composition. GDF15 acutely reduced food intake in female mice but this was followed by a period of rebound hyperphagia and consequently GDF15 did not reduce total food intake in female mice. GDF15 treatment reduced wheel running distance in both sexes. There were main effects of VWR to improve glucose tolerance in female but not male mice. These findings show that GDF15 has sex-specific effects on food intake and consequently weight gain and adiposity. There is no added benefit of combining GDF15 and voluntary physical activity for weight loss. Adaptive responses to acute caloric restriction induced by GDF15 might limit its effectiveness as a weight loss tool in females.\u0000\u0000 &lt;figure&gt;\u0000 &lt;div&gt;&lt;picture&gt;\u0000 &lt;source&gt;&lt;/source&gt;&lt;/picture&gt;&lt;p&gt;&lt;/p&gt;\u0000 &lt;/div&gt;\u0000 &lt;/figure&gt;\u0000 &lt;/div&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Key points&lt;/h3&gt;\u0000 \u0000 &lt;div&gt;\u0000 &lt;ul&gt;\u0000 \u0000 &lt;li&gt;GDF15 is a stress-induced signalling factor that reduces food intake and voluntary physical activity.&lt;/li&gt;\u0000 \u0000 &lt;li&gt;It is not known whether combining GDF15 treatment with voluntary wheel running would impart beneficial combined effects in attenuating weight gain and the accumulation of adipose tissue.&lt;/li&gt;\u0000 \u0000 &lt;li&gt;In the present study, we demonstrate that GDF15 reduces food intake and prevents weight gain in male but not female mice consuming a high-fat diet and also that combining GDF15 with voluntary wheel running (VWR) does not lead to a greater dampening of weight gain.&lt;/li&gt;\u0000 \u0000 &lt;li&gt;In female mice, GDF15 acutely reduced food intake, but this was followed by a period of rebound hyperphagia resulting in no differences in total food intake.&lt;/li&gt;\u0000 \u0000 ","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":"602 24","pages":"6813-6826"},"PeriodicalIF":4.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1113/JP287256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal muscle reactive oxygen species and microvascular endothelial function in age-related hypertension: a study protocol using a microdialysis technique.","authors":"Hollie Speer, Mostafa M Ali, Nathan M D'Cunha, Nenad Naumovski, Stephan F E Praet, Robert C Hickner, Andrew J McKune","doi":"10.1113/JP287187","DOIUrl":"https://doi.org/10.1113/JP287187","url":null,"abstract":"<p><p>Increased reactive oxygen species (ROS) generation and microvascular endothelial disruptions occur with natural ageing, but often transpire before the detection of cardiometabolic conditions including hypertension. Age-related increases in blood pressure are driven by complex systemic changes with poorly understood integrated mechanisms. The deconditioning experienced by ageing skeletal muscle from mid-life is associated with reduced microvascular blood flow and increased peripheral resistance, suggesting that vasodilatory decrements in the muscle may precede the age-related increases in blood pressure. Structural and functional changes within the vascular and skeletal muscle systems with advancing age can influence redox homeostasis, and vice versa, further compounding microvascular endothelial dysfunction. Therefore, comparisons between the microvascular environments of healthy and hypertensive cohorts can provide insights into the changes that occur during significant periods of functional decline. This comprehensive study protocol describes a microdialysis technique to assess the interactions of microvascular health and functional changes in the muscle, which currently cannot be otherwise addressed. Here, we detail an experimental protocol to simultaneously detect skeletal muscle ROS (H₂O₂ and indirect O₂ ^-), determine nutritive blood flow and assess microvascular endothelial function in response to acetylcholine stimulation. We expect that healthy middle-aged individuals should not have increased ROS generation in the muscle at rest, compared to their hypertensive or older counterparts, but may exhibit perturbed microvascular function. The described technique allows for intricate exploration of microvascular physiology that will provide a critically novel insight into benchmarking potential age-related mechanisms involved in the development of age-related hypertension, and aid in early identification and prevention. KEY POINTS: Increased reactive oxygen species (ROS) production and microvascular endothelial dysfunction precede the onset of age-related cardiometabolic and vascular conditions such as hypertension. The profound structural and functional changes that occur within the vasculature and in skeletal muscle from middle age prompt a need to mechanistically explore the microvascular environment in healthy and hypertensive individuals. Using a novel microdialysis technique, we detail an experimental protocol to simultaneously detect skeletal muscle ROS (H₂O₂ and indirect O₂ ^-), determine nutritive blood flow and assess microvascular endothelial function in response to acetylcholine stimulation. With this technique and study protocol, we can reveal functional insights into potential perturbations in ROS generation at rest and the microvascular endothelium, which play important roles in the development of age-related hypertension.</p>","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional cerebral perfusion and sympathetic activation during exercise in hypoxia and hypercapnia: preliminary insight into 'Cushing's mechanism'.","authors":"Hsuan-Yu Wan, Kanokwan Bunsawat, Catherine L Jarrett, Katherine L Shields, Angela V Bisconti, Joshua C Weavil, Markus Amann","doi":"10.1113/JP287181","DOIUrl":"10.1113/JP287181","url":null,"abstract":"&lt;p&gt;&lt;p&gt;We examined the interactive influence of hypoxia and exercise, and hypercapnia and exercise, on regional cerebral perfusion and sympathetic activation. Twenty healthy young adults (seven women) completed study trials including (1) rest in normoxia ( &lt;math&gt; &lt;semantics&gt;&lt;msub&gt;&lt;mi&gt;S&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;/msub&gt; &lt;annotation&gt;${{S}_{{mathrm{p}}{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; : ∼96%, &lt;math&gt; &lt;semantics&gt;&lt;msub&gt;&lt;mi&gt;P&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;ETC&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;/msub&gt; &lt;annotation&gt;${{P}_{{mathrm{ETC}}{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; : ∼36 mmHg), normocapnic hypoxia ( &lt;math&gt; &lt;semantics&gt;&lt;msub&gt;&lt;mi&gt;S&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;/msub&gt; &lt;annotation&gt;${{S}_{{mathrm{p}}{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; : ∼84%, &lt;math&gt; &lt;semantics&gt;&lt;msub&gt;&lt;mi&gt;P&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;ETC&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;/msub&gt; &lt;annotation&gt;${{P}_{{mathrm{ETC}}{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; : ∼36 mmHg), and normoxic hypercapnia ( &lt;math&gt; &lt;semantics&gt;&lt;msub&gt;&lt;mi&gt;S&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;/msub&gt; &lt;annotation&gt;${{S}_{{mathrm{p}}{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; : ∼98%, &lt;math&gt; &lt;semantics&gt;&lt;msub&gt;&lt;mi&gt;P&lt;/mi&gt; &lt;mrow&gt;&lt;mi&gt;ETC&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;/msub&gt; &lt;annotation&gt;${{P}_{{mathrm{ETC}}{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; : ∼46 mmHg) and (2) unilateral rhythmic handgrip exercise (45% of maximal voluntary contraction at 1 Hz for 3 min) under the same gas conditions. Based on the exercising arm, blood flow in the contralateral internal carotid (ICA&lt;sub&gt;BF&lt;/sub&gt;) and ipsilateral vertebral (VA&lt;sub&gt;BF&lt;/sub&gt;) arteries, anterior and posterior cerebral O&lt;sub&gt;2&lt;/sub&gt; delivery ( &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;C&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;D&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;${mathrm{C}}{{{mathrm{D}}}_{{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ), and muscle sympathetic nerve activity (MSNA) were measured in each trial. During exercise in hypoxia, ICA&lt;sub&gt;BF&lt;/sub&gt;, VA&lt;sub&gt;BF&lt;/sub&gt;, anterior and posterior &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;C&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;D&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;${mathrm{C}}{{{mathrm{D}}}_{{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; were significantly lower, whereas total MSNA was significantly greater, than the sum of the responses evoked by either hypoxia or exercise alone. During exercise in hypercapnia, ICA&lt;sub&gt;BF&lt;/sub&gt; and anterior &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;C&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;D&lt;/mi&gt; &lt;msub&gt;&lt;mi&gt;O&lt;/mi&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/msub&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;${mathrm{C}}{{{mathrm{D}}}_{{{{mathrm{O}}}_{mathrm{2}}}}}$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; were significantly greater, whereas MSNA was lower, than the sum of the responses evoked by either hyperc","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cycling away from cancer: can aerobic training enhance interleukin-15 response to acute exercise?","authors":"Stine Bitsch-Olsen,&nbsp;Max Flemming Ravn Merkel,&nbsp;Maria Lisette Ravn Merkel","doi":"10.1113/JP287749","DOIUrl":"10.1113/JP287749","url":null,"abstract":"","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":"602 24","pages":"6649-6651"},"PeriodicalIF":4.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative specialization of intrinsic cardiac neurons in humans, mice and pigs.","authors":"John D Tompkins, Donald B Hoover, Leif A Havton, Janaki C Patel, Youngjin Cho, Elizabeth H Smith, Natalia P Biscola, Olujimi A Ajijola, Kalyanam Shivkumar, Jeffrey L Ardell","doi":"10.1113/JP286714","DOIUrl":"10.1113/JP286714","url":null,"abstract":"<p><p>Intrinsic cardiac neurons (ICNs) play a crucial role in the proper functioning of the heart; yet a paucity of data pertaining to human ICNs exist. We took a multidisciplinary approach to complete a detailed cellular comparison of the structure and function of ICNs from mice, pigs and humans. Immunohistochemistry of whole and sectioned ganglia, transmission electron microscopy, intracellular microelectrode recording and dye filling for quantitative morphometry were used to define the neurophysiology, histochemistry and ultrastructure of these neurons across species. The densely packed, smaller ICNs of mouse lacked dendrites, formed axosomatic connections and had high synaptic efficacy constituting an obligatory synapse. At pig ICNs, a convergence of subthreshold cholinergic inputs onto extensive dendritic arbors supported greater summation and integration of synaptic input. Human ICNs were tonically firing, with synaptic stimulation evoking large suprathreshold EPSPs like mouse, and subthreshold potentials like pig. Ultrastructural examination of synaptic terminals revealed conserved architecture, yet small clear vesicles were larger in pigs and humans. The presence and localization of ganglionic neuropeptides was distinct, with abundant vasoactive intestinal polypeptide observed in human but not pig or mouse ganglia, and little substance P or calcitonin gene-related peptide in pig ganglia. Action potential waveforms were similar, but human ICNs had larger after-hyperpolarizations. Intrinsic excitability differed; 95% of human neurons were tonic, all pig neurons were phasic, and both phasic and tonic phenotypes were observed in mouse. In combination, this publicly accessible, multimodal atlas of ICNs from mice, pigs and humans identifies similarities and differences in the evolution of ICNs. KEY POINTS: Intrinsic cardiac neurons (ICNs) are essential to the regulation of cardiac function. We investigated the neurochemistry, morphology, ultrastructure, membrane physiology and synaptic transmission of ICNs from donated human hearts in parallel with identical studies of ICNs from mice and pigs to create a publicly accessible cellular atlas detailing the structure and function of these neurons across species. In addition to presenting foundational data on human ICNs, this comparative study identifies both conserved and derived attributes of these neurons within mammals. The findings have significant implications for understanding the regulation of cardiac autonomic function in humans and may greatly influence strategies for neuromodulation in conditions such as atrial fibrillation and heart failure.</p>","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone and androgen receptors in females: what is possible with resistance training?","authors":"Sandra K Hunter","doi":"10.1113/JP287660","DOIUrl":"https://doi.org/10.1113/JP287660","url":null,"abstract":"","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}