Research Square (Research Square)最新文献

{"title":"Far UV light in water treatment via producing reactive oxidative species","authors":"Jingyun Fang, Kaiheng Guo, Sining Wu, Liping Wang, Wenlei Qin, Ruijie Xie, Xuchun Li","doi":"10.21203/rs.3.rs-3577108/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3577108/v1","url":null,"abstract":"Abstract Far UV light at 222 nm (UV 222 ) is gaining much attention for water treatment due to its high disinfection efficiency and safety to human, and the mechanism is deemed direct photolysis. We found that UV 222 is much more efficient than UV 254 for the abatement of 18 organic micropollutants and inactivation of pathogens, and the phenomenon is related to the production of reactive oxidative species (ROS). Multiple ROS are identified, including hydroxyl radical (HO • ), singlet oxygen ( 1 O 2 ), superoxide radical anion ( • O 2 − ) and ozone (O 3 ). The degradation of micropollutants is mainly due to HO • , which results from water homolysis and oxygen (O2) photodissociation. The quantum yield of HO• is 0.893, and the concentration of HO • reaches 10 -13 M under neutral conditions. This study is the first that reports the efficient production of ROS upon UV 222 photolysis, which facilitates chemical-free advanced oxidation processes in water.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136229356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Code-switching in mental health recovery narratives of Hong Kong storytellers","authors":"Stephanie Ng, Olga Zayts-Spence","doi":"10.21203/rs.3.rs-3440199/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3440199/v1","url":null,"abstract":"Abstract Background Considering persistently high levels of mental health stigma in Hong Kong in recent years, scholars and mental health professionals alike have demonstrated strong interest in combating this issue. Existing research suggests that recovery storytelling, which involves an individual with a lived experience of mental illness sharing their personal story publicly, is one of the most effective anti-stigma strategies to date. Methods Using a narrative inquiry approach, we examined the recovery stories of seven Cantonese-speaking individuals who participated in the More than a Label mental health anti-stigma campaign in Hong Kong. We specifically examined how the discursive strategy of code-switching functioned to clarify, emphasize, or distract from certain elements of the story. Results Our analysis demonstrated that code-switching in our data functioned in three distinct ways, namely as: (1) a distancing strategy when discussing troubling past experiences; (2) an authenticating strategy when recalling interactions carried out in English-speaking settings; and (3) a foregrounding strategy to highlighting the main points in the story. Conclusions Our study highlights the importance of linguistic research in informing the development of person-centred approaches in both mental health clinical and advocacy work. We suggest that recognizing linguistic behaviours such as code-switching allows mental health clinical and organizational staff to be more sensitive to signs of potential distress and probe further inquiry amongst clients and lived-experience storytellers. We discuss how these findings can be used to educate lived-experience storytellers on the rhetorical functions of language use such as code-switching.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphedema after Saphenous Harvesting for Coronary Artery Bypass Surgery: Case Report and Literature Review","authors":"Seyed Mohsen Mirhosseini, Masood Soltanipur, Hossein Yarmohammadi, Mahdi Rezaei, Zahra Sheikhi","doi":"10.21203/rs.3.rs-3468789/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3468789/v1","url":null,"abstract":"Abstract Different causes have been reported for secondary lymphedema as reported in this article. A 75-year-old man was diagnosed with lymphedema about one decade after saphenous harvesting for coronary artery bypass surgery. It took two years for him to find out his diagnosis and receive the proper treatment. After standard complete decongestive therapy, his volume and pain decreased and his quality of life was improved, especially its physical aspect. It is important to recognize the possibility of lymphedema development after saphenous harvesting among patients undergoing coronary artery bypass surgery to prevent significant disturbance of quality of life with timely management.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and acceptability of integrating an early childhood development intervention into the health-facility setting in Siaya County: findings of a qualitative study","authors":"Silas Onyango, Patricia Kitsao-Wekulo, Kenneth Okelo, Margaret Nampijja, Beatrice Oyugi, Christopher Obongo, Dickens Omedo, Debjeet Sen, Elizabeth Kimani-Murage","doi":"10.21203/rs.3.rs-3347606/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3347606/v1","url":null,"abstract":"Abstract Background This paper explores the perceptions and experiences of stakeholders to understand the feasibility and acceptability of integrating early childhood development (ECD) intervention into the health system. Method Data were derived from an endline qualitative survey, which was part of a larger ECD study conducted in Siaya County, Kenya. Purposive sampling was used to select participants for the qualitative interviews. We conducted KIIs, focus group discussions (FGDs), and in-depth interviews (IDIs). Analyses were organized according to the preselected thematic areas. Result Political goodwill, proper coordination and support, and good linkages between the community and the health facility facilitated the implementation despite the challenges of a shortage of personnel and staff transfers. Integration of ECD intervention into the health system seems feasible in terms of its performance, service provision, information provided, and efficiency. In addition, stakeholders willingly supported the implementation of the intervention at different levels and capacities, which led to perceived acceptability. Furthermore, there was general satisfaction with the implementation due to perceived benefits that could potentially improve children’s developmental outcomes. Conclusion This study demonstrates the feasibility of integrating ECD interventions into the health system. Future interventions integrating ECD messages into nutrition and health programs can leverage key drivers identified through this study for smooth and effective integration.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory study: Health promotion through Wikipedia outreach and educational activities","authors":"Thais Morata, Fernanda Zucki, Adriano Jorge Arrigo, Priscila C. Cruz, Wei Gong, Hector Gabriel Matos, Alexandre Montilha, João Peschanski, Maria Julia Cardoso, Adriana Lacerda, Ana Paula Berberian, Eliene Araujo, Débora Luders, Josilene Luciene Duarte, Regina T.S. Jacob, Shelly Chadha, Daniel Mietchen, Lane Rasberry, Katia F. Alvarenga, Lilian Cassia Jacob","doi":"10.21203/rs.3.rs-3568640/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3568640/v1","url":null,"abstract":"Abstract Background Several health institutions developed strategies to improve health content on Wikimedia platforms, given their unparalleled reach. The objective of this study was to compare an online a volunteer-based Wikimedia outreach campaign and Wikipedia university course assignments in terms of the reach of the contributions and evaluate the extent of the students' input. Methods In 2022, researchers from seven Brazilian universities and a Canadian university, in coordination with the National Institute for Occupational Safety and Health, the World Health Organization, the Ronin Institute, and Wiki Movimento Brasil, received a grant from the State of São Paulo (Brazil) that supported the 1) coordination of improvements in hearing and healthcare content through educational programs using Wikimedia platforms and 2) participation in the global campaign Wiki4WorldHearingDay2023. We examined the feasibility and the implementation of the two strategies and compared the contributions from those enrolled in educational activities versus volunteer activities from Wikipedia editors to a global campaign. Results The strategy was demonstrated to be feasible. It increased the availability of quality plain language information on hearing conditions and hearing care. By May 1, 2023, Wiki4WorldHearingDay2023, 145 participants (78 from educational programs) had contributed 167,000 words, 259 + references and 140 images to 322 Wikipedia articles (283 existing and 39 new ones), which were viewed by 16.5 million readers. Contributions occurred in 6 languages. Edits in Portuguese, mainly by those involved in educational programs, led the number of articles (226 or 70.2%) that were expanded or created during the 5-month tracking period. Conclusions The crowdsourcing of expertise and knowledge is relevant for public health. This study’s approach can be applied in other contexts. In addition to the coordination with educational programs, the elements that contributed to the success of these initiatives include an impact topic, international collaborations, the connection with a robust local Wikimedia affiliate, and the use of a technical infrastructure that gives us metrics and coordination mechanisms. The partnerships, the dissemination of the work in several platforms, the participation of multidisciplinary teams, and the availability of resources through institutional support and funding were additional elements that contributed to the success of these initiatives.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Country-specific roadmaps for scaling up integrated care in Belgium, Slovenia, and Cambodia - Lessons learned from the SCUBY project","authors":"Martin Heine, Monika Martens, Daniel Boateng, Grace Marie Ku, Roy Remmen, Edwin Wouters, Srean Chhim, Antonjia Poplas Susič, Wim van Damme, Josefien van Olmen, Kerstin Klipstein-Grobusch, on behalf of the SCUBY consortium","doi":"10.21203/rs.3.rs-3585711/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3585711/v1","url":null,"abstract":"Abstract Introduction The SCUBY project aimed to provide knowledge on the scaling-up of an Integrated Care Package (ICP) for type 2 diabetes and hypertension across three distinct health systems (Cambodia, Slovenia, and Belgium). Here, we analyse the different elements of the country-specific scale-up roadmaps to identify similarities and differences, and share lessons learned. Methods Thematic analysis was used to derive crucial roadmap elements from key SCUBY documents (n = 20), including policy briefs, interim reports, research outputs, and consortium meeting notes. Results Roadmap elements differed according to priority needs, features of the (health) systems, and partly reflected the position of the SCUBY research team within each country. Common cross-country elements were: task-shifting to patients themselves, nurses and community health workers; strengthening monitoring and evaluation; and creating an enabling environment for ICP implementation. Discussion Scale-up of complex interventions requires continuous engagement of multiple stakeholders and contextualization of action plans. The linkage of research teams with key implementation stakeholders and policy makers creates change-teams, allowing advancement from formative research to implementation of roadmap strategies and full scale-up in due time. Conclusion The development processes and contents of the roadmaps provided essential and reciprocal learnings. These help shape future policy dialogues and best practices to tackle chronic disease in each participating country.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of TLS Overhead with Forward Secrecy on Segmented Network for Multiple Cloud Database Systems","authors":"Jitendra Kurmi, Suresh Prasad Kannojia","doi":"10.21203/rs.3.rs-3589550/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3589550/v1","url":null,"abstract":"Abstract Cloud database serves flexible, affordable, and versatile database frameworks. Indeed, even the cloud database is secure with Transport Layer Security (TLS). However, the performance overhead that TLS presents while executing procedures on the five major No SQL databases: Mongo DB, Apache Cassandra DB, Amazon Dynamo DB, Redis DB, and Couch DB regarding dormancy. We proposed a Multiple Replica Database Architecture (MRD-ARC) to investigate TLS execution overhead with forward secrecy for five NoSql databases, we performed two tests mimicking average database utilization designs with TLS cipher suite ECDHE-prime256v1. We examined connection pooling, where an application involves a solitary connection for some databases activities. Then, we considered one request for each connection. An application opens a connection, executes an interaction, and quickly shuts the connection in the wake of finishing the activity based on read-only throughput, read-only response, and connection throughput. Our experimental result shows that applications that cannot persevere through tremendous overhead execution should be sent inside an appropriately portioned network instead of empowering TLS with forward secrecy. Applications utilizing TLS should utilize a connection pool instead of a connection for each request. We also compare the TLS overhead with forward secrecy in terms of latency of five databases and found that Mongo DB is the best cloud database system with less overhead.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136229129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of nitrogen management reduce nitrogen stress and enhance productivity of super- seeder sown wheat under rice residue incorporation","authors":"Peace Raising L, Virendra Pratap Singh, Subhash Chandra, Anil Shukla, Navneet Pareek, R Rustum Zhiipao, Kadapa Sreenivas Re, Hriipulou Duo, Lham Dorjee, Rayapati Karthik, VK Singh, Peace Raising L","doi":"10.21203/rs.3.rs-3406436/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3406436/v1","url":null,"abstract":"Abstract The in-situ management of rice straw incorporation is now an essential practice in the rice-wheat cropping system with the growing adoption of super-seeder among farmers. This machinery has made it easier to incorporate rice residues into the soil, crushing and spreading straw evenly for cleaner cultivation. However, the effect of nutrient immobilization due to incorporation of massive organic residues at the initial stage of the decomposition is a major constraint for enhancing yield and productivity. This study investigates the effect of bio-decomposer, nitrogen (N) level, and N scheduling on N immobilization status, dry matter, N accumulation, remobilization, productivity and soil quality variables in super-seeder sown wheat for two consecutive years (2020-21 and 2021-22). The experiment was laid in split-split-plot design without (B0) and with (B1) application of bio-decomposer in main plot and two nitrogen levels 150 (N1) and 180 (N2) kg ha -1 in sub-plot; and three N splits (%) viz ., 50: 25:25 (S1), 40: 30: 30 (S2), and 30 :35:35 (S3) in sub-sub-plot and replicated thrice. N concentration and uptake at pre- and post-anthesis were recorded significantly higher with N2 and S1 compared to N1 and S2 and S3 in both years. Post-anthesis N accumulation (post-NA) and N remobilization (NR) with N2 was significantly higher to the tune of 22% and 17% than N1. Dry matter accumulation (DMA) at anthesis and harvest with N2 was significantly higher by 5.7%, while with S1 there is an improvement of 6.2% over S3. The grain yield with N2 and S1 significantly improved by 8.3% and 10.9% (two years mean) compared to N1 and S3, respectively. Soil urease activity (UA) was significantly enhanced with the application of microbial formulation (bio-decomposer), N2, and S1 in comparison to B0, N1 and S3 at 30 and 60 DAS (days after sowing). Besides, use of bio-decomposer also improved soil microbial biomass carbon (SMBC). Hence, the present study revealed that the application of higher N level coupled with higher proportion of basal N resulted in overcoming N stress and could be propounded for sustainable production and higher productivity. The result presented here assumes great significance in proper utilization and conservation of rice residue under rice-wheat cropping system.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136229139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in impact of coinfections on antibiotic use in patients hospitalized with COVID- 19 between the Omicron-dominant period and the pre-Omicron period","authors":"Yasushi Murakami, Yasuhiro Nozaki, Mika Morosawa, Masanobu Toyama, Hitoshi Ogashiwa, Takashi Ueda, Kazuhiko Nakajima, Ryoya Tanaka, Yoshio Takesue","doi":"10.21203/rs.3.rs-3543280/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3543280/v1","url":null,"abstract":"Abstract Background Excessive antibiotic use in patients with coronavirus disease 2019 (COVID-19) can cause an increase in multidrug-resistant (MDR) organisms. This study evaluated antibiotic stewardship during the COVID-19 pandemic. Methods Antibiotic use in patients with COVID-19 was compared in a community hospital between 2022 when the Omicron variant was prevalent (n = 225) and 2021 when previous variants were prevalent (n = 257). Antibiotics were categorized as antibiotics predominantly used for community-acquired infections (CAIs) and antibiotics predominantly used for health care-associated infections (HAIs), and days of therapy per 100 bed days (DOT) was evaluated. Results Patients during the Omicron period were older and had more comorbidities. The rate of critically ill patients was around 10% in both periods. During the pre-Omicron period, > 90% of hospitalized patients were unvaccinated, whereas 41.8% of patients received a booster dose during the Omicron period. Ground-glass opacities, bilateral shadows, and a peripheral distribution on CT were observed in most patients in the pre-Omicron period and there were significant differences in comparison with the Omicron period. Although only 0.9% of patients had bacterial coinfection on admission in the pre-Omicron period, 38.9% of patients had the coinfection during the Omicron period and were less likely to receive COVID-19-directed therapy. Coinfection before /after admission was an independent risk factor for composite adverse events in both periods (odds ratio [OR] 3.77, 95% confidence interval [CI] 1.13–12.59, and OR 9.15, 95% CI 3.85–21.74). DOT in antibiotics for CAIs were significantly fewer in the COVID-19 ward than in general wards in the pre-Omicron period but increased in the Omicron period (from 3.60 ± 3.15 to 17.83 ± 10.00). Numerically lower DOT of antibiotics for HAIs was demonstrated in the COVID-19 ward than in the general wards (pre-Omicron, 3.33 ± 6.09 versus 6.37 ± 1.10; Omicron, 3.84 ± 2.93 versus 5.22 ± 0.79). No MDR gram-negative organisms were isolated in the COVID-19 ward. Conclusions Antibiotic use on admission was limited in the pre-Omicron period but increased in the Omicron period because of a high coinfection rate on admission. Excessive use of antibiotics for HAIs was avoided during both periods.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136229147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Silver Nanoparticles From Pineapple (Ananas Comosus) Peel Extract: Physical-chemical Characterization and in Vitro Biological Activities","authors":"Márcia Mourão Ramos Azevedo, Cléo Rodrigo Bressan, Lorena Pereira Ferreira, Carla Beatriz dos Santos Torres, Yan Vitor Silva Oliveira, Gerson Nakazato, Lucas Marcelino dos Santos Souza, Alan Kelbis Oliveira Lima, Mônica Pereira Garcia, Kashif Gul, Paulo Sérgio Taube","doi":"10.21203/rs.3.rs-3590638/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-3590638/v1","url":null,"abstract":"Abstract The objective of this work was to synthesize, characterize and evaluate silver nanoparticles (AgNPs) obtained from the aqueous extract of pineapple peel. After optimizing the synthesis of AgNPs, colloidal solutions of AgNPs showed maximum absorbance around 460 nm. The AgNPs in the final concentration of 1, 3 and 5 mmol L -1 showed average values of Z-average of 142.3, 127.0, 135.6 and, 153.2, 117.0 131.8 synthesized by water bath and ultrasound, respectively. Regarding PdI, all AgNPs showed low to moderate polydispersity. Zeta potential values ranged from -21.4 to -10.1. Images obtained by TEM for AgNPs prepared both by the water bath method and by the ultrasound method show particles with predominantly spherical morphologies, smooth and irregular edges. The synthesized AgNPs showed higher concentrations of total phenolic compounds (159.92 to 326.9 mg AG 100 g -1 ) when compared to the aqueous extract of pineapple peel (132.0 mg AG 100 g -1 ). The pineapple peel extract showed a higher ABTS radical inhibition value (88.16%) in relation to the value referring to AgNPs (19.11% to 77.90%). By the iron reduction method (FRAP), it was verified that the ability of AgNPs to reduce Fe 3+ to Fe 2+ was greater (4.49 to 6.83 mM of FeSO 4 for 10% solution) than that of the aqueous extract of the bark of pineapple (3.72 mM FeSO 4 for 10% solution). The AgNPs synthesized from the aqueous extract of pineapple peel were effective against Gram-negative bacteria E. coli and Pseudomonas aeruginosa and against Gram-positive bacteria S. aureus . The MIC varied between 2.6 and 21.25 mg.mL -1 for Gram-negative bacteria and from 21.25 to 42.25 mg.mL -1 for Gram-positive bacteria, pointing to Gram-negative bacteria as being the bacteria more susceptible to inhibitory and bactericidal actions after exposure to AgNPs. The results of the present study infer that the AgNPs obtained by water bath or ultrasound, regardless of the concentration, showed significant cytotoxic activity when tested in human breast cancer cells of the MCF-7 lineage and B16F10 murine melanoma cancer cells. IC50 values were similar for AgNPs obtained from different energy sources (water bath or ultrasound), but with the same AgNO3 concentration, indicating that there is no difference between using AgNPs obtained by water bath or ultrasound. These results suggest that the AgNPs synthesized from the aqueous extract of pineapple peel have potential and can be used in several areas, mainly in biomedical applications.","PeriodicalId":500086,"journal":{"name":"Research Square (Research Square)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136229875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}