Journal of the American Chemical Society最新文献

{"title":"Stereoselectivity of Aminoacyl-RNA Loop-Closing Ligation","authors":"Shannon Kim, Marco Todisco, Aleksandar Radakovic, Jack W. Szostak","doi":"10.1021/jacs.4c16905","DOIUrl":"https://doi.org/10.1021/jacs.4c16905","url":null,"abstract":"The origin of amino acid homochirality remains an unresolved question in the origin of life. The requirement of enantiopure nucleotides for nonenzymatic RNA copying strongly suggests that the homochirality of nucleotides and RNA arose early. However, this leaves open the question of whether and how homochiral RNA subsequently imposes biological homochirality on other metabolites, including amino acids. Previous studies have reported moderate stereoselectivity for various aminoacyl-RNA transfer reactions. Here, we examine aminoacyl-RNA loop-closing ligation, a reaction that “captures” aminoacylated RNA in a stable phosphoramidate product, such that the amino acid bridges two nucleotides in the RNA backbone. We find that the rate of this reaction is much higher for RNA aminoacylated with L-amino acids than for RNA aminoacylated with D-amino acids. We present an RNA sequence that nearly exclusively captures L-amino acids in loop-closing ligation. Finally, we demonstrate that ligation of aminoacyl-L-RNA results in an inverse stereoselectivity for D-amino acids. The observed stereochemical link between D-RNA and L-amino acids in the synthesis of RNA stem-loops containing bridging amino acids constitutes a stereoselective structure-building process. We suggest that this process led to a selection for the evolution of aminoacyl-RNA synthetase ribozymes that were selective for L-amino acids, thereby setting the stage for the subsequent evolution of homochiral peptides and, ultimately, protein synthesis.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"11 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization and Quantification of Base-Level SO2 in Live Cells without Intracellular Background Interference Using Sensitive 19F-NMR","authors":"Chao-Yu Cui, Bin Li, Xing Zhang, Shu-Li Guo, Bin-Bin Pan, Xun-Cheng Su","doi":"10.1021/jacs.5c04351","DOIUrl":"https://doi.org/10.1021/jacs.5c04351","url":null,"abstract":"Sulfur dioxide (SO₂), as an endogenous gasotransmitter, is involved in a variety of physiological processes in living systems, however, distinction and quantification of base-level SO₂ in live cells pose great challenges for the current analytical techniques. We report an efficient way to visualize and quantify base-level SO₂ in different live mammalian cells by ¹⁹F-NMR. This method relies on a high-performance ¹⁹F-probe (<b>P1-CF</b>_<b>3</b>) that reacts with the reactive sulfur species (RSS) in the generation of distinct chemical shift profiles, which are well-resolved in the NMR spectrum. The quantitative reaction of the ¹⁹F-probe with SO₂ is fast and produces a stable addition product that is well distinguishable between the intra- and extracellular environment. The high performance of this method discloses that the base-level SO₂ in live cells varies greatly in different cell lines. The high accuracy and precision of RSS measurement by the reactive ¹⁹F NMR probe allow simultaneous quantification of base-level SO₂ in living cells and culture medium in real time without interference from other RSS and potential competitors and also without background signals.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"98 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polarization-Induced Breaching of the Liquid/Liquid Interface Formed with Water-in-Salt Electrolytes","authors":"Lihao Feng, Michael Goldstein, Yang Wang, Udayan Mohanty, Alexis Grimaud","doi":"10.1021/jacs.5c04832","DOIUrl":"https://doi.org/10.1021/jacs.5c04832","url":null,"abstract":"The solvation properties of water-in-salt electrolytes (WiSEs) have been extensively studied by spectroscopic and computational means and were shown to impart them with unique chemical and physical properties when compared to more classical superconcentrated aqueous solutions. More specifically, the formation of ionic aggregates in solutions containing a large concentration of TFSI anions was shown to alter the water and anion reactivity at electrochemical interfaces, often improving the performance of aqueous rechargeable batteries. However, insights into the role of the WiSE solvation structure on ion transfer at electrochemical interfaces are scarce. Herein, interfaces between two immiscible electrolytes (ITIESs) are used to study the energetics for ion transfer between aqueous LiCl and LiTFSI solutions and dichloroethane. Combining electrochemical measurements at microinterfaces with metadynamics molecular dynamics (MD) simulations, the effect of solvation properties on the energy for transferring Li⁺ and Cl^–/TFSI^– ions across the liquid/liquid interface was studied. While increasing the LiCl concentration increases the amount of ion pairs, it only marginally impacts the ion transfer energy. Instead, using large LiTFSI concentrations at which ionic aggregates are formed, ion transfer across the liquid/liquid interface shows a unique behavior that departs from that observed for polarizable or nonpolarizable interfaces. Ions do not freely cross the interface, with a transfer energy found to be ≈8–10 kcal/mol. However, upon polarization, ionic aggregates are found to breach the liquid/liquid interface, locally mixing both solutions. We believe that such a finding calls for reevaluating our current understanding of ion transfer across chemical interfaces in superconcentrated electrolytes, including liquid/liquid interfaces used in membrane-less electrochemical systems.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"223 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domino Effect of Catalysis: Coherence between Reaction Network and Catalyst Restructuring Accelerating Surface Carburization for CO2 Hydrogenation","authors":"Pengfei Du, Yafeng Zhang, Rui Qi, Qingqing Gu, Xiaoyan Xu, Aiqin Wang, Beien Zhu, Bing Yang, Tao Zhang","doi":"10.1021/jacs.5c01435","DOIUrl":"https://doi.org/10.1021/jacs.5c01435","url":null,"abstract":"Dynamic carburization is a common and important phenomenon in many industrial reactions. Finding the critical factor governing this process is significant for catalyst optimization, which is complicated due to the coherence between catalyst dynamics and reaction dynamics. In this work, we manipulate the <i>in situ</i> formation of fast carburization on the Pd-FeO_<i>x</i> surface by revealing a domino effect between the reaction network and catalyst restructuring during long-term CO₂ hydrogenation reaction. We prepared catalysts of three sizes (5Pd-FeO_<i>x</i>, 0.5Pd-FeO_<i>x</i>, 0.05Pd-FeO_<i>x</i>) and found that the large size of Pd NP (5Pd-FeO_<i>x</i>) induces the reactive metal–support interaction, following the <i>in situ</i> Pd₃Fe formation, the reaction route change, the fast surface carburization (Fe₅C₂), and finally the superior catalytic performance. Among these changes, we identify that <i>in situ</i> alloying instead of the apparent size difference is crucial for the formation of the active Fe₅C₂ phase. As a proof of concept, we further design a presynthesized Pd₃Fe alloy on FeO_<i>x</i> and find an enhanced activity with reduced Pd loading by controlled fast carburization. This work not only demonstrates the controllability of dynamic carburization but also presents a benchmark of optimizing catalysts through the comprehensive understanding of <i>in situ</i> catalyst changes.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"64 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open the Pores: Particles with Fully Accessible Hierarchical Pore Networks by Controlling Phase Separation in Confinement","authors":"Umair Sultan, Alexander Götz, Nicolas Salcedo, Lukas Sandner, Johannes Martinus Peter Beunen, Alexander Kichigin, Carola Vorndran, Paolo Malgaretti, Benjamin Apeleo Zubiri, Matthias Thommes, Jens Harting, Erdmann Spiecker, Nicolas Vogel","doi":"10.1021/jacs.5c03923","DOIUrl":"https://doi.org/10.1021/jacs.5c03923","url":null,"abstract":"Hierarchical porous materials combine large surface area with efficient mass transport, in particular when macropores directly connect mesopores. Polymerization-induced spinodal decomposition of poly(ethylene glycol) and tetraethyl orthosilicate can produce such macro-mesoporous material in bulk. However, the confinement of this spinodal decomposition process to emulsion droplets typically produces porous particles with a dense silica shell that blocks pore accessibility. Here, we address this issue by controlling the interfacial energies of the two phases undergoing spinodal decomposition within the emulsion droplet. We use surfactant mixtures to induce neutral wetting to prevent shell formation and generate particles with fully open, accessible and interconnected pore systems. Lattice Boltzmann simulations corroborate the experimental findings and underline that neutral wetting conditions with a contact angle to the continuous phase of ∼90° for both phases are essential to form open surface pores. Our work provides a simple strategy for producing hierarchical porous particles with controlled surface and bulk porosity between ∼200 and ∼6000 nm, expanding their potential for applications in catalysis, separation technologies, and adsorption.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation Mechanism of Polycatenane by Direct Catenation","authors":"Weihao Wang, Zhenghong Chen, Shaodong Zhang","doi":"10.1021/jacs.5c05684","DOIUrl":"https://doi.org/10.1021/jacs.5c05684","url":null,"abstract":"Polycatenanes, a novel class of polymers consisting of interlocked macrocyclic monomers, have attracted significant attention. However, the mechanism of formation of polycatenanes through direct catenation remains poorly understood. Herein, we explore the structural diversity and unique chain termination mechanism inherent to polycatenanes. Unlike conventional linear polymers, a linear polycatenane exhibits a variety of topological configurations, with chain growth terminated upon the formation of completely interwoven structures. This intrinsic termination, characterized by the probability <i>q</i>, necessitates a modification of the classical Carothers equation to accurately determine the number-average degree of polymerization (DP<i>_n</i>). Using the importance of sampling-based Monte Carlo algorithms, we have investigated the influence of the interaction strength ϵ between monomers and the cavity size <i>l</i>(σ) of a monomer on the termination probability <i>q</i>. Our findings reveal that stronger intermolecular interactions increase <i>q</i>, while a larger cavity size promotes higher-order catenation with a lower <i>q</i>. To achieve polycatenanes with higher DP<i>_n</i>, we propose two strategies employing directional interactions and introducing steric hindrance to prevent the formation of completely interwoven structures. These approaches enable the synthesis of polycatenanes with sustained reactivity, offering new pathways for the design of polymers with sophisticated topologies and configurations.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"6 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planarity Is Not Plain: Closed- vs Open-Shell Reactivity of a Structurally Constrained, Doubly Reduced Arylborane toward Fluorobenzenes","authors":"Christoph D. Buch, Alexander Virovets, Eugenia Peresypkina, Burkhard Endeward, Hans-Wolfram Lerner, Felipe Fantuzzi, Shigehiro Yamaguchi, Matthias Wagner","doi":"10.1021/jacs.5c05588","DOIUrl":"https://doi.org/10.1021/jacs.5c05588","url":null,"abstract":"The ability to activate small molecules is imparted to 9,10-dihydro-9,10-diboraanthracenes (DBAs) through the injection of two electrons. We report on the activation of fluorobenzenes C₆F_<i>n</i>H_6–<i>n</i> by the doubly reduced, structurally constrained DBA [<b>1</b>]^2– in THF (<i>n</i>: 1,3,4,5,6). Compound <b>1</b> is a 9,10-diphenyl DBA, forced into planarity by methylene bridges between the phenyl substituents and the DBA core. This rigidity results in enhanced stability under ambient conditions and an elevated planar-to-pyramidal reorganization energy upon boron tetracoordination, unlocking new reactivity. The dianion salts M₂[<b>1</b>] were synthesized in excellent yields by stirring neutral <b>1</b> with alkali metals M in THF (M: Li, Na, K); comproportionation of Li₂[<b>1</b>] with <b>1</b> generates the blue radical salt Li[<b>1</b>], characterized by EPR spectroscopy and X-ray diffraction. While Li₂[<b>1</b>] is inert toward C₆FH₅ up to 120 °C, it reacts with 1,3,5-C₆F₃H₃ at 100 °C to yield a B(sp²)/B(sp³) adduct with a difluorophenyl ligand (Li[<b>2</b>]). Treatment of Li₂[<b>1</b>] with 1 eq. of C₆F₅H or C₆F₆ induces selective monohydrodefluorination, occurring in parallel with the formation of a unique B(sp²)/B(sp³) tetrahydrofuran-2-yl adduct (Li[<b>3</b>]). The three isomers of C₆F₄H₂ represent intermediate cases, where the competition between trifluorophenyl- and tetrahydrofuran-2-yl-adduct formation is governed by the relative positions of the F substituents and the nature of the countercation (M⁺: Li⁺, K⁺). Through experimental and quantum-chemical studies, we unveil the underlying reaction mechanisms and show that Li₂[<b>1</b>] acts either as a B-centered nucleophile in an S_NAr-type conversion (low benzene fluorination) or as a reducing agent in a single-electron transfer/H atom abstraction sequence (high benzene fluorination).","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"9 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of a Stable Tricobalt Carbide Cluster","authors":"Nicholas P. Litak, Shao-Liang Zheng, Dongtao Cui, Theodore A. Betley","doi":"10.1021/jacs.5c04760","DOIUrl":"https://doi.org/10.1021/jacs.5c04760","url":null,"abstract":"We report the synthesis and characterization of the anionic tricobalt carbide cluster [(^FtbsL)Co₃(μ³–C)]⁻. The source of the carbide ligand is a phosphorus ylide (R₂MePCH₂; R = Me, Ph) which substitutes pyridine in the all-cobalt(II) cluster (^FtbsL)Co₃(py) to afford the ylide adduct (^FtbsL)Co₃(CH₂PMeR₂). Deprotonation affords the anionic diylide cluster [(^FtbsL)Co₃(κ²-η¹:η¹–(CH₂)₂PR₂)]⁻ which eliminates MePR₂ upon heating to furnish the anionic methylidyne cluster [(^FtbsL)Co₃(μ³–CH)]⁻. Oxidation of the anionic methylidyne complex with ferrocenium hexafluorophosphate generates the diamagnetic methylidyne complex (^FtbsL)Co₃(μ³–CH). The methylidyne ligand can be deprotonated with Li- or KN(SiMe₃)₂ to afford carbide complexes (^FtbsL)Co₃(μ⁴–C)Li(OEt₂) or [K(C₂₂₂)][(^FtbsL)Co₃(μ³–C)], respectively. Isotopic enrichment of the carbide with ¹³C reveals downfield-shifted ¹³C NMR chemical shifts (δ/ppm) of 389, Co₃(μ³–<i>C</i>H); 731, Co₃(μ⁴–<i>C</i>Li); and 769, Co₃(μ³–<i>C</i>)⁻; the latter of which is the most downfield resonance for a transition metal carbide reported to date.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Ultra-High Ionic Conductivity in W-Doped Na3SbS4: Grain Boundary Effects and Pure Bulk Transport","authors":"Jana Königsreiter, Bernhard Gadermaier, H. Martin R. Wilkening","doi":"10.1021/jacs.5c05842","DOIUrl":"https://doi.org/10.1021/jacs.5c05842","url":null,"abstract":"W-doped Na₃SbS₄ is a promising solid electrolyte for all-solid-state sodium batteries, exhibiting a sodium (Na⁺) ionic conductivity higher than 30 mS cm^–1 (A. Hayashi, N. Masuzawa, S. Yubuchi, F. Tsuji, C. Hotehama, A. Sakuda, M. Tatsumisago, <i>Nat. Commun.</i> 2019, 10, 5266). This exceptional conductivity arises primarily from the introduction of sodium ion vacancies (V′_Na) via supervalent substitution of Sb⁵⁺ with W⁶⁺. Using low-temperature impedance spectroscopy down to <i>T</i> = 113 K (−160 °C), we demonstrate that previously reported room temperature conductivities of Na_2.9Sb_0.9W_0.1S₄ are influenced by grain boundary resistances, which can only be effectively separated from the total conductivity at such low temperatures. Our results indicate that the pure Na⁺ bulk conductivity can reach 96 mS cm^–1 (D_σ = 0.98 × 10^–10 m² s^–1) at room temperature, as extrapolated from accurately measured low-temperature data (1.8 mS cm^–1 at –130 °C). Our study suggests that further minimizing detrimental grain boundary effects enables extraordinarily fast long-range Na⁺ ion transport in this sulfide.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"146 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism-Guided Development of Directed C–H Functionalization of Bicyclo[1.1.1]pentanes","authors":"Alexander Bunnell, Michael W. Milbauer, Julia Viana Bento, S. Maryamdokht Taimoory, Paul M. Zimmerman, Dipannita Kalyani, Tiffany Piou, Melanie S. Sanford","doi":"10.1021/jacs.5c07190","DOIUrl":"https://doi.org/10.1021/jacs.5c07190","url":null,"abstract":"This report describes a detailed study of the palladium-mediated directed C(2)–H functionalization of bicyclo[1.1.1]pentanes (BCPs). Previous attempts to achieve this transformation were reported as unsuccessful. To understand why, a combination of stoichiometric organometallic experiments (to isolate and study the coordination chemistry of these substrates), H/D exchange (to directly probe the C–H activation step), and DFT calculations (to predict optimal directing groups and supporting ligands) was conducted. Collectively, these revealed that cyclometalation at Pd(II) is kinetically facile but thermodynamically unfavorable with aminoquinoline as a directing group and acetonitrile as a supporting ligand. However, changing to a pyridine N-oxide directing group or dimethyl sulfoxide (DMSO) supporting ligand enabled the isolation of stable BCP palladacycles. The functionalization of these complexes was low-yielding with two-electron aryl iodide oxidants. However, moving to single-electron reactions (using in situ-generated aryl radicals) or to electrophilic functionalization (using I₂) resulted in synthetically useful yields of C(2)-functionalized products at room temperature. This C–H functionalization approach was leveraged to access derivatives of a key intermediate in the synthesis of bioisosteric analogues of the angiotensin II receptor blocker telmisartan. A four-step sequence from commercially available BCP carboxylic acids, involving directing group installation, cyclopalladation, C(2) arylation, and directing group cleavage, afforded a comparable or improved overall yield, step-count, and functional group compatibility relative to state-of-the-art synthetic approaches. Overall, these studies uncovered a mild Pd-mediated route for the C(2)-diversification of the BCP scaffold. In addition, the lessons learned herein provide a blueprint for achieving directed C–H functionalization of a broader array of strained ring benzene bioisosteres.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"5 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}