Journal of the History of the Neurosciences最新文献_第4页

Camillo Golgi and the pathology of Huntington's disease: An unresolved controversy. 卡米洛·高尔基和亨廷顿舞蹈病的病理：一个未解决的争议。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2026-01-01 Epub Date: 2025-10-23 DOI: 10.1080/0964704X.2025.2554056

Sergio Rebora, Mauro Colombo, Marjolein Breur, Marianna Bugiani, Maria Carla Garbarino, Cinzia Gellera, Orso Bugiani

{"title":"Camillo Golgi and the pathology of Huntington's disease: An unresolved controversy.","authors":"Sergio Rebora, Mauro Colombo, Marjolein Breur, Marianna Bugiani, Maria Carla Garbarino, Cinzia Gellera, Orso Bugiani","doi":"10.1080/0964704X.2025.2554056","DOIUrl":"10.1080/0964704X.2025.2554056","url":null,"abstract":"In 1874, Camillo Golgi published the neuropathological study of a patient with chronic chorea and dementia, demonstrating impairments in  the frontal-parietal and temporal cortices, striatum, and cerebellum. This study anticipated by fifty years those traditionally recognized as the first to link choreic movements with cortico-striatal involvement, but regardless of the author's intention, has also come to be considered the first on the neuropathology of Huntington's disease. This has given rise to a dispute between one position in favor of this diagnosis based on the clinical-anatomical correlation and the other opposed to the diagnosis, based on the lack of a family history of chorea. Given the absence of remains and slides to be used for DNA and histological analyses, we attempted to fill this gap by carrying out genealogical studies, but have so far been unable to identify any other choreic patients in the patient's family or any association with homonymous families with Huntington's disease currently living in the same region as Golgi's patient. This does not end the controversy and indeed raises the issue of diagnosis, but it does not deprive Golgi of the merit of having first identified the neuropathology of chronic chorea.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"20-37"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How did Johann Christian Reil feel the insular cortex? Gemeingefühl as a seat of mind. 约翰·克里斯蒂安·雷尔是如何感受岛叶皮层的？gemeingefhl是一种心灵的寄托。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2026-01-01 Epub Date: 2025-05-12 DOI: 10.1080/0964704X.2025.2495948

Michiaki Nagai, Satoshi Kato

{"title":"How did Johann Christian Reil feel the insular cortex? Gemeingefühl as a seat of mind.","authors":"Michiaki Nagai, Satoshi Kato","doi":"10.1080/0964704X.2025.2495948","DOIUrl":"10.1080/0964704X.2025.2495948","url":null,"abstract":"Johann Christian Reil was the first to coin the term \"psychiatry\" in 1808, prior to that he had proposed Gemeingefühl (coenaesthesis), which is interpreted as referring to the integrated information of all senses and emotions. On the other hand, in 1809, Reil formally described the insular cortex as die Insel and considered the insular cortex to serve as the pedestal of mental activity. The background to Reil's research had been the social, religious, cultural, and political context of social upheaval in Europe at the time, particularly in Germany and France, which had a major impact on the academic and medical systems he advocated. For over 200 years, the relationship between Gemeingefühl and the insular cortex has remained a mystery. However, recent neuroimaging studies are beginning to shed light on the function of the insular cortex. This article provides an overview of Reil's life as reported to date and summarizes Reil's achievements in medicine from the perspectives of physiology, neuroanatomy, and psychiatry. Furthermore, we interpreted the Gemeingefühl as proposed by Reil in relation to gemeinsinn (sensus communis) and common sense, and provide a perspective on the role of the insular cortex as a seat of the mind, society and culture.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"38-54"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From shock to the diencephalon: ECT inventor Ugo Cerletti's theory of consciousness. 从休克到间脑：ECT发明者乌戈·切莱蒂的意识理论。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2026-01-01 Epub Date: 2025-10-27 DOI: 10.1080/0964704X.2025.2541163

Elisabetta Sirgiovanni

{"title":"From shock to the diencephalon: ECT inventor Ugo Cerletti's theory of consciousness.","authors":"Elisabetta Sirgiovanni","doi":"10.1080/0964704X.2025.2541163","DOIUrl":"10.1080/0964704X.2025.2541163","url":null,"abstract":"This article uncovers an overlooked aspect of Ugo Cerletti's intellectual journey, highlighting how his work on mental illness, electroconvulsive therapy (ECT), and acroagonines reflected a broader and profound interest in the nature of consciousness. Starting with practical therapeutic innovations, Cerletti ventured into theoretical domains that were both original and pioneering. Understanding epileptic seizures as instances of loss of consciousness, Cerletti proposed that consciousness, primarily associated with sensation-including vigilance, emotion, and memory-arises not from a singular, isolated brain region but through complex interactions among various structures within the diencephalon. In doing so, he challenged several ideas of his time. He criticized the absence of unconscious psychism in the perspectives of Emil Kraepelin and Walter O. Jahrreiss. More remarkably, he opposed the prevailing views of his time, including John Hughlings Jackson's belief that the cortex was the brain's superior region responsible for rationality and consciousness. Cerletti sought to disprove this model through evidence drawn from neurological observations, ECT experiments, and contemporary insights from sleep medicine. Moreover, he rejected the dichotomy between rational and emotional brain functions, emphasizing the deeply interconnected nature of these processes.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"1-19"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illustrations of the cerebrovascular system in Florentius Schuyl's Latin editions (1662, 1664) of René Descartes' Treatise on Man. 弗洛伦提乌斯·舒尔（Florentius Schuyl） 1662年、1664年拉丁文版《笛卡尔人性论》中的脑血管系统插图。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2026-01-01 Epub Date: 2025-09-23 DOI: 10.1080/0964704X.2025.2557331

Douglas J Lanska

{"title":"Illustrations of the cerebrovascular system in Florentius Schuyl's Latin editions (1662, 1664) of René Descartes' Treatise on Man.","authors":"Douglas J Lanska","doi":"10.1080/0964704X.2025.2557331","DOIUrl":"10.1080/0964704X.2025.2557331","url":null,"abstract":"The Treatise on Man (1662, 1664) by French philosopher René Descartes (1596-1650) is the primary source for Cartesian physiology, but the accompanying illustrations were created after Descartes' death by a group of Descartes' disciples who were forced to create illustrations for Descartes' unfinished, and often vague and confusing, text. The iconographic tradition originating in the French edition (L'Homme, 1664) has predominated since the 17th century, whereas the Latin editions (De Homine, 1662, 1664) and their illustrations remain little known. Dutch physician and botanist Florentius Schuyl (1619-1669) both edited and illustrated the Latin editions with woodcuts and copperplate engravings. Although Schuyl faithfully illustrated Descartes' mistaken notions concerning the location and motility of the pineal gland, other mistakes and innovations were due to Schuyl rather than Descartes. These include (1) the mistake of illustrating the mythical human rete mirabile more than a century after Jacopo Berengario da Carpi (1460-1530) and Andreas Vesalius (1514-1564) had denied its existence in humans; (2) the mistake of illustrating an ungulate aortic arch as that of a human; and (3) the insight and courage to modify a Vesalian diagram to show a pre-Willisian circle of Willis, following Giulio Casseri (1552-1616) and Johann Vesling (1598-1649).","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"55-79"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serendipity in antiseizure medication discovery: Unveiling accidental breakthroughs in epilepsy treatments. 抗癫痫药物发现的意外发现：揭示癫痫治疗的意外突破。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2026-01-01 Epub Date: 2025-10-01 DOI: 10.1080/0964704X.2025.2560438

Hussein Algahtani, Bader Shirah, Nuha Osailan

{"title":"Serendipity in antiseizure medication discovery: Unveiling accidental breakthroughs in epilepsy treatments.","authors":"Hussein Algahtani, Bader Shirah, Nuha Osailan","doi":"10.1080/0964704X.2025.2560438","DOIUrl":"10.1080/0964704X.2025.2560438","url":null,"abstract":"Serendipity has played a significant role in the discovery of several key antiseizure medications, when unexpected observations have led to groundbreaking treatments. This narrative review explores the historical context of serendipitous discoveries in epilepsy pharmacotherapy, highlighting how drugs such as potassium bromide, phenobarbital, valproic acid, and levetiracetam emerged through unintended observations rather than rational drug design. Whereas early antiseizure medications were often identified by chance, modern drug development has shifted toward a target-based approach, leveraging advances in molecular biology and high-throughput screening to identify promising therapeutic agents. Despite this evolution, serendipity remains relevant, as unanticipated findings continue to shape epilepsy treatment and expand the therapeutic landscape. By analyzing past discoveries, this review underscores the interplay between structured scientific inquiry and chance observations, emphasizing the need for prepared minds to recognize and capitalize on unexpected breakthroughs in epilepsy drug development.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"80-91"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating evidence for the cortical localization for language: Systematic reviews in the 1860s and 1870s. 语言皮层定位的证据评估：19世纪60年代和70年代的系统回顾。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-10-01 Epub Date: 2025-05-01 DOI: 10.1080/0964704X.2025.2487419

Marjorie Lorch

{"title":"Evaluating evidence for the cortical localization for language: Systematic reviews in the 1860s and 1870s.","authors":"Marjorie Lorch","doi":"10.1080/0964704X.2025.2487419","DOIUrl":"10.1080/0964704X.2025.2487419","url":null,"abstract":"The specialization of cortical function for language was proposed by Paul Broca (1824-1880) in 1861 and further elaborated to include the principle of hemispheric lateralization in 1865. Broca and other French colleagues argued for and against these hypotheses, employing clinical and pathological observations of individuals with acquired language disorders as evidence. These ideas became a topic of widespread interest after the debates at the Paris Academy of Medicine in 1865 were reported internationally. During this period until the end of the decade, hundreds of publications appeared on the localization and laterality of findings in aphasic individuals and case series. Several large-scale systematic reviews of historic (pre-1861) and contemporary (post-1861) clinical findings were published only a few years after the syndrome had been proposed. These aimed to determine the strength and quality of evidence regarding the specialization and lateralization of brain areas for language. However, their authors held distinct theoretical assumptions and ideological concerns and were motivated by varied research questions. These comprehensive efforts using systematic review methodology to assess the evidence for and against hypotheses about the organization of language in the brain are examined to expose the issues of live debate in early neuroscience.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"543-560"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pierre Marie, 1916-1917: Functional radiographic imaging of vision and aphasia. 皮埃尔·玛丽，1916-1917：视觉和失语症的功能性放射成像。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-10-01 Epub Date: 2025-07-08 DOI: 10.1080/0964704X.2025.2511625

Richard Leblanc

引用次数: 0

Henry Hun and his family: Three foundational stories in the history of nineteenth-century American neurology, part III. Henry Hun (1854-1924), a nineteenth-century academic neurologist's collision with the forces of twentieth-century American medicine. 亨利·亨和他的家人：19世纪美国神经病学史上的三个基本故事，第三部分。亨利·洪（1854-1924），19世纪的学术神经学家与20世纪美国医学力量的碰撞。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-10-01 Epub Date: 2025-09-24 DOI: 10.1080/0964704X.2025.2554058

Spencer Weig

{"title":"Henry Hun and his family: Three foundational stories in the history of nineteenth-century American neurology, part III. Henry Hun (1854-1924), a nineteenth-century academic neurologist's collision with the forces of twentieth-century American medicine.","authors":"Spencer Weig","doi":"10.1080/0964704X.2025.2554058","DOIUrl":"10.1080/0964704X.2025.2554058","url":null,"abstract":"Along with his father Thomas (1808-96) and brother Edward (1842-1880), Henry Hun (1854-1924) was the final member of a family of physicians who helped establish the clinical specialty and academic discipline of neurology in nineteenth- and early twentieth-century America. Educated at Yale and with an MD from Harvard, he spent three years in Heidelberg, Vienna, and Paris, studying under Meynert and Charcot. On returning to the United States, he succeeded his brother as Albany Medical College's Professor of Diseases of the Nervous System, a title he held for the next three decades. He authored numerous papers and achieved national prominence as president of the American Neurological Association (ANA) in 1914. In 1897, he described the clinical and neuropathological correlations in a form of stroke that came to be known as Wallenberg syndrome. His most famous work was An Atlas of the Differential Diagnosis of the Diseases of the Nervous System, which went through three editions from 1913 through 1922. Following the upheaval produced by the Flexner Report of 1910, Hun abruptly resigned his academic position in 1914 and spent the final 10 years of his life in private practice.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"602-634"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gemelli's legacy in the knowledge of spatial orientation in flight. Gemelli在飞行空间定位知识方面的遗产。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI: 10.1080/0964704X.2025.2511619

Paola Verde, Laura Piccardi

{"title":"Gemelli's legacy in the knowledge of spatial orientation in flight.","authors":"Paola Verde, Laura Piccardi","doi":"10.1080/0964704X.2025.2511619","DOIUrl":"10.1080/0964704X.2025.2511619","url":null,"abstract":"Agostino Gemelli, an Italian Franciscan physician and psychologist, was a pioneer in aviation psychology and spatial orientation research in the early twentieth century. This historical article explores Gemelli's groundbreaking contributions to understanding spatial cognition, particularly in aviation contexts, decades before contemporary scientific findings. During World War I, Gemelli, a medical officer and pilot, focused on selecting pilots based on their attitudes rather than their physical abilities. His work predated crucial developments in spatial cognition, including concepts of field dependence/independence and environmental representation. Gemelli examined perception through Gestalt psychology, showing that people create mental images of space instead of just recording what they see. Gemelli critically analyzed spatial orientation, distinguishing between ground and aerial navigation and recognizing the complex interaction between internal cognitive characteristics and external environmental factors. He anticipated modern research on spatial representation, emphasizing the dynamic nature of spatial perception and individual differences in cognitive processing. This article highlights Gemelli's insights in relation to modern science, showcasing his keen understanding of spatial cognition, pilot skills, and perception. His contributions, largely ignored after World War II, were an important early exploration of the cognitive mechanisms behind spatial orientation and aviation psychology.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"561-576"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Desert hallucination, or "ragle": A first description by Stanislas d'Escayrac de Lauture (1826-1868). 沙漠幻觉，或“混乱”：斯坦尼斯拉斯·德·埃斯凯拉克·德·劳图尔（1826-1868）首次描述。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-10-01 Epub Date: 2025-09-24 DOI: 10.1080/0964704X.2025.2557342

Gilles Fénelon, Flavie Waters

引用次数: 0