Journal of the History of the Neurosciences最新文献

Serendipity in antiseizure medication discovery: Unveiling accidental breakthroughs in epilepsy treatments. 抗癫痫药物发现的意外发现：揭示癫痫治疗的意外突破。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-10-01 DOI: 10.1080/0964704X.2025.2560438

Hussein Algahtani, Bader Shirah, Nuha Osailan

{"title":"Serendipity in antiseizure medication discovery: Unveiling accidental breakthroughs in epilepsy treatments.","authors":"Hussein Algahtani, Bader Shirah, Nuha Osailan","doi":"10.1080/0964704X.2025.2560438","DOIUrl":"https://doi.org/10.1080/0964704X.2025.2560438","url":null,"abstract":"Serendipity has played a significant role in the discovery of several key antiseizure medications, when unexpected observations have led to groundbreaking treatments. This narrative review explores the historical context of serendipitous discoveries in epilepsy pharmacotherapy, highlighting how drugs such as potassium bromide, phenobarbital, valproic acid, and levetiracetam emerged through unintended observations rather than rational drug design. Whereas early antiseizure medications were often identified by chance, modern drug development has shifted toward a target-based approach, leveraging advances in molecular biology and high-throughput screening to identify promising therapeutic agents. Despite this evolution, serendipity remains relevant, as unanticipated findings continue to shape epilepsy treatment and expand the therapeutic landscape. By analyzing past discoveries, this review underscores the interplay between structured scientific inquiry and chance observations, emphasizing the need for prepared minds to recognize and capitalize on unexpected breakthroughs in epilepsy drug development.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"1-12"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Henry Hun and his family: Three foundational stories in the history of nineteenth-century American neurology, part III. Henry Hun (1854-1924), a nineteenth-century academic neurologist's collision with the forces of twentieth-century American medicine. 亨利·亨和他的家人：19世纪美国神经病学史上的三个基本故事，第三部分。亨利·洪（1854-1924），19世纪的学术神经学家与20世纪美国医学力量的碰撞。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-09-24 DOI: 10.1080/0964704X.2025.2554058

Spencer Weig

{"title":"Henry Hun and his family: Three foundational stories in the history of nineteenth-century American neurology, part III. Henry Hun (1854-1924), a nineteenth-century academic neurologist's collision with the forces of twentieth-century American medicine.","authors":"Spencer Weig","doi":"10.1080/0964704X.2025.2554058","DOIUrl":"https://doi.org/10.1080/0964704X.2025.2554058","url":null,"abstract":"Along with his father Thomas (1808-96) and brother Edward (1842-1880), Henry Hun (1854-1924) was the final member of a family of physicians who helped establish the clinical specialty and academic discipline of neurology in nineteenth- and early twentieth-century America. Educated at Yale and with an MD from Harvard, he spent three years in Heidelberg, Vienna, and Paris, studying under Meynert and Charcot. On returning to the United States, he succeeded his brother as Albany Medical College's Professor of Diseases of the Nervous System, a title he held for the next three decades. He authored numerous papers and achieved national prominence as president of the American Neurological Association (ANA) in 1914. In 1897, he described the clinical and neuropathological correlations in a form of stroke that came to be known as Wallenberg syndrome. His most famous work was An Atlas of the Differential Diagnosis of the Diseases of the Nervous System, which went through three editions from 1913 through 1922. Following the upheaval produced by the Flexner Report of 1910, Hun abruptly resigned his academic position in 1914 and spent the final 10 years of his life in private practice.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"1-33"},"PeriodicalIF":0.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Desert hallucination, or "ragle": A first description by Stanislas d'Escayrac de Lauture (1826-1868). 沙漠幻觉，或“混乱”：斯坦尼斯拉斯·德·埃斯凯拉克·德·劳图尔（1826-1868）首次描述。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-09-24 DOI: 10.1080/0964704X.2025.2557342

Gilles Fénelon, Flavie Waters

引用次数: 0

Illustrations of the cerebrovascular system in Florentius Schuyl's Latin editions (1662, 1664) of René Descartes' Treatise on Man. 弗洛伦提乌斯·舒尔（Florentius Schuyl） 1662年、1664年拉丁文版《笛卡尔人性论》中的脑血管系统插图。

IF 0.5 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-09-23 DOI: 10.1080/0964704X.2025.2557331

Douglas J Lanska

{"title":"Illustrations of the cerebrovascular system in Florentius Schuyl's Latin editions (1662, 1664) of René Descartes' Treatise on Man.","authors":"Douglas J Lanska","doi":"10.1080/0964704X.2025.2557331","DOIUrl":"https://doi.org/10.1080/0964704X.2025.2557331","url":null,"abstract":"The Treatise on Man (1662, 1664) by French philosopher René Descartes (1596-1650) is the primary source for Cartesian physiology, but the accompanying illustrations were created after Descartes' death by a group of Descartes' disciples who were forced to create illustrations for Descartes' unfinished, and often vague and confusing, text. The iconographic tradition originating in the French edition (L'Homme, 1664) has predominated since the 17th century, whereas the Latin editions (De Homine, 1662, 1664) and their illustrations remain little known. Dutch physician and botanist Florentius Schuyl (1619-1669) both edited and illustrated the Latin editions with woodcuts and copperplate engravings. Although Schuyl faithfully illustrated Descartes' mistaken notions concerning the location and motility of the pineal gland, other mistakes and innovations were due to Schuyl rather than Descartes. These include (1) the mistake of illustrating the mythical human rete mirabile more than a century after Jacopo Berengario da Carpi (1460-1530) and Andreas Vesalius (1514-1564) had denied its existence in humans; (2) the mistake of illustrating an ungulate aortic arch as that of a human; and (3) the insight and courage to modify a Vesalian diagram to show a pre-Willisian circle of Willis, following Giulio Casseri (1552-1616) and Johann Vesling (1598-1649).","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"1-25"},"PeriodicalIF":0.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pierre Marie, 1916-1917: Functional radiographic imaging of vision and aphasia. 皮埃尔·玛丽，1916-1917：视觉和失语症的功能性放射成像。

IF 0.3 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-07-08 DOI: 10.1080/0964704X.2025.2511625

Richard Leblanc

引用次数: 0

From testicles to brain: Understanding Dante's dream through medieval medicine. 从睾丸到大脑：通过中世纪医学理解但丁的梦。

IF 0.3 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-07-01 Epub Date: 2025-03-02 DOI: 10.1080/0964704X.2025.2461785

Francesco Brigo, Paolo Benna, Lorenzo Lorusso, Enrico Volpe, Giorgio Zanchin

{"title":"From testicles to brain: Understanding Dante's dream through medieval medicine.","authors":"Francesco Brigo, Paolo Benna, Lorenzo Lorusso, Enrico Volpe, Giorgio Zanchin","doi":"10.1080/0964704X.2025.2461785","DOIUrl":"10.1080/0964704X.2025.2461785","url":null,"abstract":"This article examines Dante da Maiano's response to Dante Alighieri's dream in the Vita Nova, often seen as a mocking reply to the young poet's vision. Building on Bruno Nardi's reinterpretation (1959), which suggests a medical explanation rather than mere ridicule, this study analyzes the sonnet through medieval physiological and medical theories. Dante da Maiano's diagnosis, influenced by Galenic and Aristotelian thought, links the poet's delirious dream to harmful vapors rising from the testicles to the brain. These vapors, produced by excessive heat and imbalance in the reproductive organs, were thought to cause mental disturbances by drying out the brain, a common medieval explanation for lovesickness. The article highlights the conceptual connection between the brain and the testicles, recognized in medieval medical theory, especially in the works of Galen and Albert the Great. By situating Dante da Maiano's response within this scientific framework, the article reinterprets his advice-like washing the testicles to mitigate harmful vapors-as a serious medical recommendation rather than as derision. This perspective enhances our understanding of the interplay between physical health and mental states in medieval thought, offering fresh insights into Dante's dream and its broader medical and philosophical implications.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"517-525"},"PeriodicalIF":0.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

David Ferrier's "complex whole": Early traces of a "brain network" concept. 戴维-费里尔的 "复杂整体"：大脑网络 "概念的早期痕迹。

IF 0.3 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-07-01 Epub Date: 2024-09-24 DOI: 10.1080/0964704X.2024.2405116

Cornelis Stam

{"title":"David Ferrier's \"complex whole\": Early traces of a \"brain network\" concept.","authors":"Cornelis Stam","doi":"10.1080/0964704X.2024.2405116","DOIUrl":"10.1080/0964704X.2024.2405116","url":null,"abstract":"Currently, the idea that the brain is a complex network of interacting brain regions is hardly controversial. The rapid development of this field is often attributed to the emergence of powerful brain-imaging techniques and, around the millennium, the merging of the neuroscience of brain networks with modern mathematical graph theory. However, little is known about the historical roots of this concept. It is interesting to know when the first traces of a concept of brain networks can be found in the work of early neuroscientists, how this concept evolved over time, and what factors may have influenced this evolution. This study aims to set a first step in addressing these questions by a detailed analysis of David Ferrier's classic study, The Functions of the Brain. From this analysis it will become clear that, in addition to a clear notion of localized functions in the brain, Ferrier speculated in several places about the need for several of these brain regions to communicate and interact in order to bring about higher brain functions. He referred to this perspective on the brain as a \"complex whole,\" which could be interpreted as an early precursor of the modern concept of brain networks.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"461-471"},"PeriodicalIF":0.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ivan Pavlov's conditioned reflexes and Ivane Beritashvili's doctrine of image-driven behavior: Materialism, myth, and politics. 伊万-巴甫洛夫的条件反射和伊万-贝里塔什维利的形象驱动行为学说：唯物主义、神话与政治

IF 0.3 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-07-01 Epub Date: 2024-09-26 DOI: 10.1080/0964704X.2024.2405110

S Brian Hood

{"title":"Ivan Pavlov's conditioned reflexes and Ivane Beritashvili's doctrine of image-driven behavior: Materialism, myth, and politics.","authors":"S Brian Hood","doi":"10.1080/0964704X.2024.2405110","DOIUrl":"10.1080/0964704X.2024.2405110","url":null,"abstract":"Ivane Beritashvili has been regarded as an \"anti-Pavlovian\" for nearly a century. One respect in which Beritashvili is said to be anti-Pavlovian is in granting an explanatory role to subjective mental states in his doctrine of image-driven behavior. In this article, I aim to problematize the anti-Pavlovian assessment and argue that Beritashvili did not deviate from Pavlovian scientific norms, minor points of theoretical and methodological differences between them notwithstanding. Furthermore, several respects in which Beritashvili is claimed to be anti-Pavlovian are ways in which he resembles Pavlov. Turning my attention to Beritashvili's critics in the Soviet Union, those responsible for his censure, I argue that it is the critique of Beritashvili that runs counter to the norms Pavlov embraced. I contest the claim that his alleged deviations from Pavlovian orthodoxy justify classification as anti-Pavlovian in a sense that is either historically accurate or philosophically interesting, and submit that the grounds on which Beritashvili is derided as anti-Pavlovian would also justify labeling Pavlov himself as anti-Pavlovian. Informed by the case of Beritashvili and others who were politically persecuted for their scientific work in the Soviet Union, I conclude with reflections on science, politics, and the intrusion of the latter in the former.","PeriodicalId":49997,"journal":{"name":"Journal of the History of the Neurosciences","volume":" ","pages":"443-460"},"PeriodicalIF":0.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

David Ferrier's second monkey ('monkey F'): The inaugural experimental studies of the auditory cortex. David Ferrier的第二只猴子（“猴子F”）：听觉皮层的首次实验研究。

IF 0.3 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-07-01 Epub Date: 2025-01-06 DOI: 10.1080/0964704X.2024.2436676

Andrew J Larner, Timothy D Griffiths

引用次数: 0

Sesquicentenary of the knee jerk reflex: The contributions of Hughlings Jackson, Horsley, and Sherrington. 膝跳反射一百五十周年：休林斯·杰克逊、霍斯利和谢林顿的贡献。

IF 0.3 3区哲学

Journal of the History of the Neurosciences Pub Date : 2025-07-01 Epub Date: 2025-01-07 DOI: 10.1080/0964704X.2024.2443142

Guleed Adan, Andrew J Larner

引用次数: 0