Journal of Vascular and Interventional Radiology最新文献

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Simultaneous Portal and Hepatic Vein Embolization versus Portal Vein Embolization Only in Patients with Hepatocellular Carcinoma: A Retrospective Review of Safety and Effectiveness. 肝细胞癌患者门静脉和肝静脉同时栓塞与仅门静脉栓塞:安全性和有效性的回顾性评价。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-09-01 DOI: 10.1016/j.jvir.2025.08.033
Van Sy Than, Thanh Dung Le, Manh Thau Cao, Minh Thong Pham
{"title":"Simultaneous Portal and Hepatic Vein Embolization versus Portal Vein Embolization Only in Patients with Hepatocellular Carcinoma: A Retrospective Review of Safety and Effectiveness.","authors":"Van Sy Than, Thanh Dung Le, Manh Thau Cao, Minh Thong Pham","doi":"10.1016/j.jvir.2025.08.033","DOIUrl":"10.1016/j.jvir.2025.08.033","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the safety and effectiveness of simultaneous portal and hepatic vein embolization (PHVE) versus portal vein embolization (PVE) in enhancing future liver remnant (FLR) hypertrophy in patients with hepatocellular carcinoma (HCC).</p><p><strong>Materials and methods: </strong>This retrospective study included 97 patients with HCC who underwent transarterial chemoembolization followed by PVE (n = 34) or PHVE (n = 63) for preoperative liver augmentation. Volumetric analysis using contrast-enhanced computed tomography was performed at a median of 25 days (PHVE) and 31 days (PVE) after embolization (P = .011). Primary outcome was FLR absolute hypertrophy (FLRabh). Multivariable linear regression including interaction terms was used to identify predictors of FLRabh. Adverse events were graded using the Society of Interventional Radiology (SIR) classification.</p><p><strong>Results: </strong>PHVE achieved significantly greater FLRabh (51.3% vs 27.0%, P < .001), degree of hypertrophy (13.4% vs 10.1%, P = .01), and kinetic growth rate (4.2 vs 2.9 %/wk, P = .001) compared with PVE. Resection rates were higher in the PHVE group (95.2% vs 76.5%, P = .008), with fewer tumor progressions during follow-up (3.2% vs 14.7%, P = .049). Multivariable analysis confirmed PHVE as an independent predictor of greater FLR hypertrophy, particularly in patients with lower baseline FLR volumes. One adverse event occurred in each group (SIR Grades 1 and 3).</p><p><strong>Conclusions: </strong>PHVE induces greater liver hypertrophy and is associated with lower tumor progression during the hypertrophy interval, supporting its role as an effective and safe option for surgical preparation in HCC with limited FLR.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral Vasculature Embolization with the Onyx Liquid Embolic System in a Swine Model. 玛瑙液体栓塞系统在猪模型中的外周血管栓塞。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-09-01 DOI: 10.1016/j.jvir.2025.08.032
Gary P Siskin, Paul J Rochon, Ripal Gandhi, Austin Cocciolone, Andrew Winter, Rahul S Patel, Jafar Golzarian, Bulent Arslan
{"title":"Peripheral Vasculature Embolization with the Onyx Liquid Embolic System in a Swine Model.","authors":"Gary P Siskin, Paul J Rochon, Ripal Gandhi, Austin Cocciolone, Andrew Winter, Rahul S Patel, Jafar Golzarian, Bulent Arslan","doi":"10.1016/j.jvir.2025.08.032","DOIUrl":"10.1016/j.jvir.2025.08.032","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the histologic and inflammatory changes that resulted from peripheral embolization using ethylene vinyl alcohol ([EVOH]; Onyx) in an animal model. This study also assessed the radiopacity of the Onyx after a 1-minute mixing time.</p><p><strong>Materials and methods: </strong>Embolization using EVOH alone or in combination with coils/plugs was performed on large-vessel, small-vessel, and very-small-vessel (3-5 mm, 1-3 mm, and <1 mm in diameter, respectively) targets in the peripheral vasculature of Yucatan miniature pigs. Multiple formulations of EVOH were used. Angiography at 1, 3, and 12 months was used to assess embolic migration and vessel occlusion. Pathological evaluations were performed to assess the biological response to Onyx-mediated embolization.</p><p><strong>Results: </strong>Angiography demonstrated that the radiopacity of EVOH was sufficient for control during deployment in 98.2% of the procedures. Microcatheter removal was successful in all cases, and there was minimal migration of EVOH after delivery. Pathological findings indicated no significant tissue response or vessel trauma after embolization, and the occlusive material (consisting of EVOH, thrombus, and fibrotic tissue) evolved over time. The inflammatory response was minimal to mild, and vessel wall injury was observed in some cases. Complete to near-complete occlusion was achieved at every embolization site at the time of follow-up, although histologic evidence of recanalization was observed in 59.3% of the treated vessels.</p><p><strong>Conclusions: </strong>The study demonstrated the effectiveness of EVOH as an embolic agent in the peripheral vascular system with adequate radiopacity, minimal adverse effects, and acceptable long-term histologic outcomes in a swine model.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Age of Kidney Transplant and Hemorrhagic Adverse Events Following Transplant Kidney Biopsy. 肾移植年龄与移植肾活检后出血性不良事件的关系。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-08-27 DOI: 10.1016/j.jvir.2025.08.027
Chloe Issa, Jack Lin, Kenneth Richardson, Gaetano Ciancio, Giselle Guerra, Adela Mattiazzi, Hamed Jalaeian, Lindsay Thornton
{"title":"Association between Age of Kidney Transplant and Hemorrhagic Adverse Events Following Transplant Kidney Biopsy.","authors":"Chloe Issa, Jack Lin, Kenneth Richardson, Gaetano Ciancio, Giselle Guerra, Adela Mattiazzi, Hamed Jalaeian, Lindsay Thornton","doi":"10.1016/j.jvir.2025.08.027","DOIUrl":"10.1016/j.jvir.2025.08.027","url":null,"abstract":"<p><strong>Purpose: </strong>To identify factors associated with hemorrhagic adverse events requiring secondary intervention after ultrasound (US)-guided or computed tomography (CT)-guided transplant kidney biopsy.</p><p><strong>Materials and methods: </strong>A retrospective analysis of 1,017 patients who underwent transplant kidney biopsy between January 2019 and August 2023 was conducted. Data collected included patient demographics, age of kidney transplant at biopsy, number of cores sampled, serum creatinine levels, medication use, and hemorrhagic adverse events (AEs). AEs were graded using the Society of Interventional Radiology (SIR) classification system. Outcomes were analyzed on the basis of graft age at the time of biopsy.</p><p><strong>Results: </strong>Among 1,017 biopsies, 34 hemorrhagic AEs were recorded. Severe hemorrhagic AEs, defined as those requiring secondary intervention, occurred in 1% (10 of 1,017) of cases, with a significantly higher incidence in the ≤90-day graft group than in the >90-day graft group (1.57% [8 of 509] vs 0.39% [2 of 508], P = .04). Mild hemorrhagic AEs, managed conservatively, were observed in 2.4% (24 of 1,017) of cases, with no significant difference between the ≤90-day group (1.77% [9 of 509]) and the >90-day group (2.95% [15 of 508], P = .24). No graft failures were reported during the study period. The median time from biopsy to surgical evacuation for severe AEs was 3.5 hours (interquartile range, 2.8-5.1 hours).</p><p><strong>Conclusions: </strong>Biopsies performed within 90 days after transplantation were associated with a significantly increased risk of severe hemorrhagic AEs requiring secondary intervention. These findings underscore the need for careful risk stratification and precautionary measures when performing transplant kidney biopsies in early grafts.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Same-Day versus Multiday Planning/Treatment Radioembolization with Yttrium-90 Resin Microspheres in Patients with Liver Cancer ≥5 cm. ≥5 cm肝癌患者当日与多日计划/治疗:用钇-90树脂微球进行放射栓塞治疗
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-08-27 DOI: 10.1016/j.jvir.2025.08.028
Hyo-Cheol Kim, Minseok Suh, Jin Chul Paeng, Jin Woo Choi
{"title":"Same-Day versus Multiday Planning/Treatment Radioembolization with Yttrium-90 Resin Microspheres in Patients with Liver Cancer ≥5 cm.","authors":"Hyo-Cheol Kim, Minseok Suh, Jin Chul Paeng, Jin Woo Choi","doi":"10.1016/j.jvir.2025.08.028","DOIUrl":"10.1016/j.jvir.2025.08.028","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the safety and effectiveness of resin microsphere same-day planning/treatment radioembolization with conventional multiday radioembolization for treating liver cancer ≥5 cm.</p><p><strong>Materials and methods: </strong>This single-center retrospective study included 80 patients who tried same-day radioembolization and 120 patients who received multiday radioembolization with resin microspheres between January 2022 and December 2023. For same-day radioembolization, once operators determined the required number and activity of vials, daughter vials were dispensed from a mother vial in the hospital nuclear medicine facility and then delivered to the angiography room. Tumor responses and toxicity between same-day radioembolization and multiday radioembolization were compared using the chi-square test.</p><p><strong>Results: </strong>Among 80 patients who were scheduled to receive same-day radioembolization, 4 were excluded because of a high estimated lung dose, leading to the rejection of the radioembolization procedure. The remaining 76 patients (median tumor size, 8.3 cm) were treated with resin microspheres, using a median activity of 2.7 GBq. The median time interval from the initiation of planning angiography to the completion of radioembolization was 215 minutes. Among patients with hepatocellular carcinoma, the objective response rates by modified Response Evaluation Criteria in Solid Tumors were 87.7% (50/57) for same-day radioembolization and 89.2% (99/111) for multiday radioembolization (P = .776). The overall incidences of Grade 3 or higher adverse events were 15.8% (12/76) for same-day radioembolization and 21.7% (26/120) for multiday radioembolization (P = .312).</p><p><strong>Conclusions: </strong>Same-day planning/treatment radioembolization with resin microspheres is as effective and safe as multiday radioembolization for large liver tumors ≥5 cm.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous Biliopancreatic Dual-Duct Intervention in Altered Anatomy Using Digital Cholangioscopy. 经皮胆管双管介入在数字胆道镜下的解剖改变。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-08-26 DOI: 10.1016/j.jvir.2025.08.022
João Paulo K Matushita, Franklin Wilson Caires Gois, Aline Cristine Barbosa S Cavalcante, Charles E Zurstrassen, Thiago Franchi Nunes
{"title":"Percutaneous Biliopancreatic Dual-Duct Intervention in Altered Anatomy Using Digital Cholangioscopy.","authors":"João Paulo K Matushita, Franklin Wilson Caires Gois, Aline Cristine Barbosa S Cavalcante, Charles E Zurstrassen, Thiago Franchi Nunes","doi":"10.1016/j.jvir.2025.08.022","DOIUrl":"10.1016/j.jvir.2025.08.022","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Anesthesia Type and Vasoconstrictor Use with Intranodal Lymphangiography Duration: A Multicenter Retrospective Cohort Study. 麻醉类型和血管收缩剂使用与结内淋巴管造影时间的关系:一项多中心回顾性队列研究。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-08-26 DOI: 10.1016/j.jvir.2025.08.026
Brian J Kinsman, Sara Smolinski-Zhao, Fran D Soljacic, Lingshan Liu, Matthew R Smith, Ariel L Mueller, Timothy T Houle, Katarina J Ruscic
{"title":"Association of Anesthesia Type and Vasoconstrictor Use with Intranodal Lymphangiography Duration: A Multicenter Retrospective Cohort Study.","authors":"Brian J Kinsman, Sara Smolinski-Zhao, Fran D Soljacic, Lingshan Liu, Matthew R Smith, Ariel L Mueller, Timothy T Houle, Katarina J Ruscic","doi":"10.1016/j.jvir.2025.08.026","DOIUrl":"10.1016/j.jvir.2025.08.026","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether anesthesia type (sedation vs general anesthesia [GA]) or α<sub>1</sub>-adrenergic agonist vasoconstrictor administration is associated with faster intralymphatic contrast agent transit during intranodal lymphangiography in an effort to identify modifiable nonprocedural factors that may reduce procedure duration.</p><p><strong>Materials and methods: </strong>This retrospective observational study reviewed intranodal lymphangiography from 2 academic hospitals (2015-2022). A multiple linear regression model assessed the association of anesthesia type and vasoconstrictor administration with intralymphatic contrast agent transit time, controlled for confounders.</p><p><strong>Results: </strong>A total of 147 lymphangiograms from 141 patients (median age, 64 years [interquartile range, 56-72 years]) were reviewed. Sedation (vs GA) was associated with 43% shorter log-transformed contrast agent transit time (βˆ = 1.43; 95% CI, 1.04-1.97; P = .029), reflecting a 13-minute faster median contrast agent transit time (absolute standardized difference, 0.44). Vasoconstrictor administration was not associated with contrast agent transit time (bolus administration, βˆ = 0.79 [95% CI, 0.53-1.18; P = .251]; infusion and bolus administration, βˆ = 0.89 [95% CI, 0.63-1.25; P = .495]). In addition to its association with increased contrast agent transit time, GA also added a median of 16 minutes (range, 11.0-22.3 minutes) of anesthesiology care time to cases.</p><p><strong>Conclusions: </strong>Sedation (vs GA), but not vasoconstrictor administration, was associated with shorter contrast agent transit time and anesthesiology care time. This proof-of-concept clinical evidence that anesthesia may modulate lymphatic function sheds light on the lymphatic system as a collateral pharmacologic target of anesthetics.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Articular Cartilage-Preserving Doxycycline Sclerotherapy for Recurrent Osteoid Osteoma after Radiofrequency Ablation. 保留关节软骨的强力霉素硬化治疗射频消融后复发的骨样骨瘤。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-08-26 DOI: 10.1016/j.jvir.2025.08.025
Connor Roncagli, Brandon Jonard, Salim Abboud
{"title":"Articular Cartilage-Preserving Doxycycline Sclerotherapy for Recurrent Osteoid Osteoma after Radiofrequency Ablation.","authors":"Connor Roncagli, Brandon Jonard, Salim Abboud","doi":"10.1016/j.jvir.2025.08.025","DOIUrl":"10.1016/j.jvir.2025.08.025","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Talonavicular Joint Embolization for Refractory Ankle Osteoarthritis. 距舟关节栓塞治疗难治性踝关节骨关节炎。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-08-26 DOI: 10.1016/j.jvir.2025.08.024
Jabre Millon, Alex Dabrowiecki
{"title":"Talonavicular Joint Embolization for Refractory Ankle Osteoarthritis.","authors":"Jabre Millon, Alex Dabrowiecki","doi":"10.1016/j.jvir.2025.08.024","DOIUrl":"10.1016/j.jvir.2025.08.024","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcatheter Arterial Embolization for Colonic Diverticular Bleeding: Outcomes and Risk Factors for Rebleeding. 经导管动脉栓塞治疗结肠憩室出血:再出血的结果和危险因素。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-08-25 DOI: 10.1016/j.jvir.2025.08.021
Ryoichi Kitamura, Wataru Higashiura, Morihiro Katsura, Tadashi Yasutani, Hiroaki Takara
{"title":"Transcatheter Arterial Embolization for Colonic Diverticular Bleeding: Outcomes and Risk Factors for Rebleeding.","authors":"Ryoichi Kitamura, Wataru Higashiura, Morihiro Katsura, Tadashi Yasutani, Hiroaki Takara","doi":"10.1016/j.jvir.2025.08.021","DOIUrl":"10.1016/j.jvir.2025.08.021","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate transarterial embolization (TAE) outcomes in patients with diverticular bleeding and explore factors associated with rebleeding.</p><p><strong>Materials and methods: </strong>This retrospective, single-center study included patients with colonic diverticular bleeding who showed active bleeding on contrast-enhanced computed tomography (CT) and underwent angiography between January 2008 and March 2021. Data included demographics, embolization details, and clinical outcomes. The primary outcome was rebleeding; secondary outcomes were ischemic adverse events and in-hospital mortality. Univariable analysis assessed rebleeding factors.</p><p><strong>Results: </strong>Among 132 patients (median age, 79 years; interquartile range, 71-84 years; 49% male), active bleeding was detected by angiography in 72% (n = 95) and 67% (n = 89) of patients who underwent TAE. Ninety-four (71%) patients had right-sided colonic bleeding, and 38 (29%) had left-sided colonic bleeding. Rebleeding occurred in 12% (n = 16/132) of patients. The rebleeding rate was significantly lower in patients who underwent TAE compared with who did not (3.4% [n = 3/89] vs 30% [n = 13/43], respectively; P < .001). The rebleeding rate was significantly higher in patients with right-sided than that in those with left-sided colonic bleeding (16% [n = 15/94] vs 2.6% [n = 1/38], respectively; P = .039). Among patients with right-sided colonic bleeding, the rebleeding rate was significantly lower in those who underwent TAE compared with those who did not underwent TAE (3.0% [n = 2/66] vs 46% [n = 13/28], respectively; P < .001). Adverse events were limited to grade 1, and no in-hospital deaths occurred.</p><p><strong>Conclusions: </strong>TAE is a safe and effective treatment for colonic diverticular bleeding and may reduce rebleeding, particularly for bleeding from the right colon.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Toxicity of Ethiodized Oil in the Venous Circulation in Mice: Radiological Findings and Pathological Correlation. 乙二碘化油在小鼠静脉循环中的肺毒性:影像学表现和病理相关性。
IF 2.6 3区 医学
Journal of Vascular and Interventional Radiology Pub Date : 2025-08-22 DOI: 10.1016/j.jvir.2025.08.017
Shimpei Kato, Haruto Sugawara, Naomasa Okimoto, Toshihiro Furuta, Osamu Abe, Yasunori Ota, Hiroyuki Akai
{"title":"Pulmonary Toxicity of Ethiodized Oil in the Venous Circulation in Mice: Radiological Findings and Pathological Correlation.","authors":"Shimpei Kato, Haruto Sugawara, Naomasa Okimoto, Toshihiro Furuta, Osamu Abe, Yasunori Ota, Hiroyuki Akai","doi":"10.1016/j.jvir.2025.08.017","DOIUrl":"10.1016/j.jvir.2025.08.017","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the acute and chronic pulmonary toxicity and determine the median lethal dose (lethal dose 50% [LD50]) of intravenously administered ethiodized oil given the limited data on its systemic toxicity despite its known risk of inadvertent venous entry during lymphangiography.</p><p><strong>Materials and methods: </strong>Twenty female BALB/c mice received tail vein injections of saline (n = 4) or ethiodized oil (Lipiodol; Guerbet, Villepinte, France) at 10 μL (n = 4), 30 μL (n = 8), or 50 μL (n = 4). Survival outcomes, computed tomography (CT) imaging findings, and histopathological features including hemosiderin deposition were evaluated. Chronic effects were assessed at 10 weeks through histopathology and hemosiderin deposition quantification. Human equivalent doses (HEDs) were calculated using body weight ratio conversion.</p><p><strong>Results: </strong>The LD50 was determined to be 30 μL in mice, corresponding to an HED of 94.7 mL for a 60-kg human. All mice receiving 50 μL died immediately, whereas the 30-μL group showed 50% survival. CT imaging revealed dose-dependent ethiodized oil accumulation predominantly in pulmonary vasculature, with regional heterogeneity in distribution patterns. Surviving mice from the 30-μL group exhibited significantly higher hemosiderin deposition compared with the 10-μL group (P = .0054), indicating chronic microvascular damage.</p><p><strong>Conclusions: </strong>Intravenous ethiodized oil induces dose-dependent pulmonary embolism with an LD50 of 30 μL in mice, and even sublethal doses cause chronic pulmonary injury, highlighting the need for clinical monitoring in cases of suspected venous exposure.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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