Luminescence最新文献

{"title":"Spectroscopic Properties and Orange-Red Emission of Sm³⁺-Doped SWN Glasses for LED Applications.","authors":"Guesmia Nesrine, Hamzaoui Majda, Beghdadi Lina, Rezgui Sayah, Soltani Mohamed Toufik","doi":"10.1002/bio.70490","DOIUrl":"10.1002/bio.70490","url":null,"abstract":"<p><p>Sm³⁺-doped antimony-tungsten-phosphate glasses (designated SWNSm) with the composition (40 - x) Sb₂O₃-10WO₃-50NaPO₃-xSm₂O₃ (x = 0.15, 0.30, 0.45, 0.60, and 0.75 mol%) were prepared by the conventional melt-quenching-annealing technique. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses confirmed the amorphous nature and excellent thermal stability of the prepared glasses. Both experimental and theoretical elastic parameters, including Young's modulus (E) and Poisson's ratio (ν), were evaluated to verify that the incorporation of Sm³⁺ ions does not compromise the mechanical stiffness of the host glass. The measured density increased with increasing Sm₂O₃ content. Vibrational modes were identified using IR and FTIR spectroscopy. The optical bandgap values for all glass compositions were determined to lie in the range of 2.84-2.87 eV, confirming the insulating character of these glasses. Under 402 nm excitation, the down-conversion emission spectra exhibited characteristic transitions: ⁴G_5/2 → ⁶H_5/2 (560 nm), ⁴G_5/2 → ⁶H_7/2 (596 nm), ⁴G_5/2 → ⁶H_9/2 (643 nm), and ⁴G_5/2 → ⁶H_11/2 (707 nm). The observed up-conversion luminescence was interpreted in terms of excited-state absorption (ESA), energy transfer (ET), and cross-relaxation (CR) mechanisms. IR analysis revealed that the low phonon energy of the antimony-based glass host-evidenced by the dominant Sb-O-Sb stretching band at 602 cm^-1-results in a reduced multiphonon relaxation rate, thereby facilitating efficient up-conversion processes. With increasing Sm³⁺ content, the measured fluorescence lifetime decreased from 1.815 to 1.710 ms, which is attributed to the increased concentration of OH^- groups and the enhanced probability of ET among Sm³⁺ ions. The CIE chromaticity coordinates (x, y) fall within the orange-red region, indicating that these glasses are promising candidates for orange-red LED and solid-state laser applications.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 5","pages":"e70490"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc (II)-Chelation-Enhanced Spectrofluorimetric Determination of Moxifloxacin: Development, Validation, Application to Eye Drops, and Greenness Assessment.","authors":"Tamer Z Attia, Asmaa Mohamed Abbas, Deena A M Nour El-Deen, Mahmoud A Omar","doi":"10.1002/bio.70483","DOIUrl":"https://doi.org/10.1002/bio.70483","url":null,"abstract":"<p><p>A sensitive and straightforward spectrofluorimetric method was developed for determination of moxifloxacin (MOX) based on its complexation with zinc ion (Zn²⁺) in acetate buffer (pH 5). A formation of the MOX-Zn chelate produced a pronounced fluorescence enhancement, measured at 487 nm after excitation at 287 nm. Experimental conditions influencing the fluorescence response, including metal ion type and volume, buffer system, pH, diluting solvent, and reaction time, were optimized. Under the optimized conditions, the calibration curve exhibited excellent linearity over 10.00-70.00 ng mL^-1 with a correlation coefficient of 0.9997. The limits of detection and quantitation were 1.29 and 3.90 ng mL^-1, confirming the high sensitivity of the method. Stoichiometric analysis indicated a 2:1 MOX-Zn complex formed through bidentate coordination via carboxylate and carbonyl oxygen atoms. The method was validated in accordance with ICH guidelines, showing satisfactory accuracy, precision, robustness, and reproducibility. It was successfully applied to commercial ophthalmic formulations, yielding results statistically comparable with a reported reference method. The method's environmental sustainability was validated through greenness assessment using both the AGREE metric and GAPI approaches, confirming its favorable ecological profile. The proposed strategy offers a rapid, cost-effective, and eco-conscious alternative to chromatographic techniques for routine pharmaceutical quality control.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70483"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring Hypoxic Alleviation With Dexmedetomidine Protection via Glutathione Detection by a Benzo-Imidazole-Derived Fluorescent Probe.","authors":"Linhui Weng, Yuanliang Chen, Zhongquan Zhu, Junfeng Liao, Yujin Liu","doi":"10.1002/bio.70479","DOIUrl":"https://doi.org/10.1002/bio.70479","url":null,"abstract":"<p><p>In this work, a benzo-imidazole-derived fluorescent probe BIENBD-GSH was developed for monitoring the hypoxic alleviation with dexmedetomidine protection via the glutathione (GSH) detection. The structural modification of moving the recognition site and extending the meta-group was performed. The normoxia and hypoxia conditions did not affect the absorption and fluorescence variation during the response of BIENBD-GSH to GSH. BIENBD-GSH exhibited a dose-dependent response to the GSH level to report the fluorescence signal at 500 nm under the excitation of 365 nm. The structural modification introduced the advantages of higher synthetic yield and emission red-shift, with the retention of a wide linear interval and relatively high sensitivity. Other advantages of BIENBD-GSH included stable performance in various working conditions, high selectivity towards GSH, and low cytotoxicity upon living pulmonary cells. BIENBD-GSH achieved monitoring the intracellular GSH level, while for the hypoxia-related situations, both the post hoc recovery and prior dexmedetomidine protection were visualized. This work provided some useful information on the pathological processes in clinical operations and the nursing schedules.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70479"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the Interaction Between Thioacetamide Fungicide and Bovine Serum Albumin Through Fluorescence, Electrochemical, and Docking Analyses.","authors":"Zeynep Murathan, Hülya Silah, Merve Yıldırım, Ipek Kucuk, İsmail Çelik, Bengi Uslu","doi":"10.1002/bio.70477","DOIUrl":"10.1002/bio.70477","url":null,"abstract":"<p><p>Thioacetamide (TAA) is used in pharmaceutical and industrial applications and has also been reported as a fungicidal agent; however, it poses serious health risks due to its hepatotoxic and immunosuppressive effects. Despite this toxicological importance, the molecular interplay of TAA with serum albumins, major plasma proteins that regulate transport, distribution, and bioavailability, remains insufficiently defined. Here, we systematically examined the binding of TAA to bovine serum albumin (BSA) under physiological conditions. UV-visible absorption, steady-state fluorescence spectroscopy (including synchronous and three-dimensional fluorescence), dynamic light scattering (DLS), Fourier-transform infrared (FTIR) spectroscopy, and differential pulse voltammetry (DPV) were integrated with molecular docking and molecular dynamics (MD) simulations. Fluorescence titration revealed concentration-dependent quenching with temperature dependence and moderate affinity (Ka on the order of 10³-10⁴ M^-1), with approximately one dominant binding site per BSA molecule. Thermodynamic analysis indicated a spontaneous process (ΔG < 0) with predominantly hydrophobic contributions. Synchronous and 3D fluorescence measurements showed pronounced microenvironmental changes around tryptophan residues, consistent with conformational rearrangements of BSA upon TAA binding. DLS further supported complex formation by showing an increase in the hydrodynamic diameter of BSA after TAA addition. DPV measurements exhibited a gradual decrease in the TAA oxidation current in the presence of BSA.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70477"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial-Engineered Fluorescent Nanocarrier for Ion Ratiometric Sensing and sTREM-1-Mediated EBV Inhibition.","authors":"Mingliang Chen, Jie Ji, Xiaoliu Li, Cong Luo, Ye Jiang, Fulin Xu, Yongyan Bi","doi":"10.1002/bio.70480","DOIUrl":"10.1002/bio.70480","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV), a widespread human γ-herpesvirus, is associated with infectious mononucleosis and several malignancies, posing a major public health challenge. Acyclovir (ACV), the first-line antiviral drug, is limited by poor solubility, short half-life, and low bioavailability. To overcome these drawbacks, we designed a hyaluronic acid-based nanocarrier modified with microbial extracts and a fluorescent small molecule (1-HA-2), and constructed an ACV-loaded nanosystem (1-HA-2@ACV) with improved drug loading, fluorescence responsiveness, and aqueous stability, enabling both therapeutic delivery and ion sensing. Notably, 1-HA-2@ACV allows sensitive detection of Na⁺ and PO₄ ^3-, two clinically relevant ions whose dysregulation is closely linked to EBV-associated disease progression, drug safety, and therapeutic monitoring. In EBV-susceptible cells, EBV infection markedly increased EBNA1 and sTREM-1 expression, whereas treatment with 1-HA-2@ACV significantly inhibited viral replication and reduced sTREM-1 overexpression more effectively than free ACV, while blank nanoparticles showed no effect. These findings suggest that 1-HA-2@ACV not only enhances the therapeutic efficacy of ACV but also provides a dual-function platform for EBV-targeted therapy and real-time monitoring through modulation of sTREM-1 pathways and ion-associated biomarkers.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70480"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxide Glass-Based Phosphors for White Light Emitting Diodes: Current Status, Challenges, and Future Perspective.","authors":"Pardeep Kaur, Satwinder Singh Danewalia, K Singh","doi":"10.1002/bio.70475","DOIUrl":"https://doi.org/10.1002/bio.70475","url":null,"abstract":"<p><p>Glass-based phosphors are widely studied materials for white light-emitting diodes (WLEDs) due to their tunable structural, thermal, and optical properties. The amorphous glass network allows uniform dispersion of activator and sensitizer ions, offering broad compositional flexibility and efficient control over emission wavelength, quantum yield, and color purity. Various oxide and fluoride glass systems including silicate, borate, phosphate, and oxyfluoride provide distinct phonon energies and structural environments that directly influence radiative and nonradiative processes and hence the performance of the phosphor. Embedding phosphor particles into low-melting glass matrices enhances heat dissipation, refractive-index matching, and long-term reliability, making phosphor in glass (PiG) structures suitable for high-brightness and high-temperature LED operation. This review provides a comprehensive overview of the fundamental photoluminescence (PL) properties of glass-based phosphors, including their energy-transfer pathways, host-matrix selection criteria, and quenching mechanisms that influence overall performance. It also examines major fabrication approaches, such as melt-quenching, sol-gel, chemical vapor deposition (CVD), physical vapor deposition (PVD), and advanced crystallization methods. Finally, the review highlights current challenges and outlines future opportunities for enhancing glass-based phosphors, with the goal of achieving higher luminous efficacy, improved color rendering, and stable white-light emission.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70475"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perovskite Quantum Dot-Based Luminescent Sensors for Cu²⁺ Detection: Stability Engineering and Performance Across Aqueous, Organic, and Confined Media.","authors":"Mohamed Abu Shuheil, G PadmaPriya, Subhashree Ray, Talal Aziz Qassem, Gunjan Garg, Renu Sharma, Bekzod Madaminov, Sabokhat Sadikova, Shaima Messa","doi":"10.1002/bio.70485","DOIUrl":"10.1002/bio.70485","url":null,"abstract":"<p><p>Perovskite quantum dots (PQDs) have emerged as highly promising luminescent materials for sensitive and selective detection of heavy metal ions, particularly Cu²⁺, owing to their exceptional photophysical properties, defect-tolerant structures, and tunable surface chemistry. However, their practical implementation remains limited by intrinsic instability, environmental sensitivity, and incomplete mechanistic understanding. This review provides a design-driven framework that integrates fundamental principles, advanced engineering strategies, and mechanistic insights essential for developing next-generation PQD-based luminescent sensors. Key aspects discussed include the evolution of synthesis routes, the impact of surface defects and ligand dynamics on optical response, and the roles of encapsulation, compositional tuning, polymeric confinement, and MOF-based architectures in overcoming moisture, oxygen, and thermal degradation pathways. Signal transduction mechanisms such as electron transfer, FRET, ratiometric emission, and aggregation-induced modulation are critically analyzed with emphasis on their relevance to Cu²⁺ sensing performance. By summarizing analytical metrics, stability barriers, and emerging hybrid platforms, this review highlights strategic directions for achieving high-performance, reproducible, and durable PQD sensors. The insights presented establish a foundation for rational design and application-oriented development of luminescent PQD-based Cu²⁺ detection technologies.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70485"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Sugaring-Out Microextraction Coupled With Synchronous Fluorescence for Multiplexed Diuretic Detection in Pharmaceuticals and Biofluids.","authors":"Samah Abo El Abass, Manal A Alossaimi, Abdulmalik S A Altamimi, Asmaa Kamal El-Deen","doi":"10.1002/bio.70476","DOIUrl":"https://doi.org/10.1002/bio.70476","url":null,"abstract":"<p><p>An environmentally friendly approach was developed for the precise determination of bumetanide and amiloride, two diuretics with complementary therapeutic applications. The method employs an integrated sugaring-out homogeneous liquid-liquid microextraction (SULLME) technique in conjunction with synchronous fluorescence spectroscopy. This approach eliminates toxic organic solvents typically used in liquid-liquid extraction. The two drugs exhibit distinct synchronous fluorescence signatures at a Δλ of 140 nm, facilitating baseline-resolved signals and thereby reducing analysis time and costs. The method was linear for bumetanide (0.05-0.5 μg/mL) and amiloride (0.04-1.0 μg/mL). Additionally, it exhibits low limits of detection (LODs) of 0.006 and 0.012 μg/mL for bumetanide and amiloride, respectively, demonstrating high sensitivity. The approach was successfully applied for the determination of both drugs in coformulation with a challenging ratio and in spiked human urine. A multifaceted assessment that included performance, technique innovation, and sustainability measures was carried out to determine the approach's overall feasibility. By combining environmentally friendly sample preparation and low reagent usage, the proposed strategy adheres to green analytical chemistry principles while preserving good analytical performance. This study shows how advanced spectroscopic techniques combined with green chemistry concepts may produce high-performing, affordable, and ecologically friendly analytical solutions for pharmaceutical multianalyte monitoring.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70476"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Thermoluminescence Characteristics and Kinetics of Natural Obsidian.","authors":"Hamide Avci","doi":"10.1002/bio.70488","DOIUrl":"10.1002/bio.70488","url":null,"abstract":"<p><p>This study investigates the thermoluminescence (TL) properties of natural obsidian samples collected from the Aksaray region in Turkey. The obsidian samples were ground into powder and sieved into five particle size ranges between 63 and 500 μm. The grain size range of 63-125 μm was identified as the most suitable for TL measurements, as it produced a sharper and more intense peak in the dosimetric region of the spectrum. Subsequently, detailed analyses were conducted on the TL glow curves, reusability, dose response, and heating rate behavior of the selected sample. The effect of heating rate was tested over a range of 0.1°C-10°C/s, revealing an anomalous heating rate dependence. Kinetic analysis using the <math> <semantics> <mrow><msub><mi>T</mi> <mi>m</mi></msub> <mo>-</mo> <msub><mi>T</mi> <mtext>stop</mtext></msub> </mrow> <annotation>$$ {T}_m-{T}_{stop} $$</annotation></semantics> </math> method identified multiple peaks, indicating the presence of various energy levels. TL curve deconvolution using the general order kinetics model yielded activation energies ranging from 0.82 to 1.68 eV and demonstrated a strong correlation between the experimental data and theoretical predictions.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70488"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Green Spectrofluorimetric-Derived Quenching Assay for the Efficient Determination of 3-Chlorotyrosine Marker of Myeloperoxidase-Catalyzed Protein Oxidation in Pure Form and Biological Fluids.","authors":"Hazim M Ali, Amr A Essawy, Hassan M A Hassan, AbdElaziz A Nayl, Ahmed Hamad Alanazi, Tamer H A Hasanin, Mohammed Gamal","doi":"10.1002/bio.70478","DOIUrl":"10.1002/bio.70478","url":null,"abstract":"<p><p>3-Chlorotyrosine (Cl-Tyr) serves as a distinct biomarker of myeloperoxidase (MPO)-induced protein oxidation. For the first time, this work developed a spectrofluorimetric assay for Cl-Tyr using a 2-naphthol-mediated, slightly alkaline micelle-fluorescent platform that is quantitatively quenched upon addition of Cl-Tyr. At λ_ex 243 nm, the fluorescence emission peak of 2-naphth (λ_em 420 nm), in the presence of sodium hydroxide (2 mM) and 1.54-mM cetyl tetraammonium bromide (CTAB), is decreased linearly by the addition of Cl-Tyr in the range from 0.1 to 15 μg/mL with a correlation coefficient of 0.9988, and the detection limit was 0.044-μg/mL Cl-Tyr. The intraday and interday percent recoveries ranged from 95.392% to 99.280%, with a percent relative standard deviation (%RSD) of 0.332%-2.128%, indicating that the developed method is both accurate and precise for the determination of Cl-Tyr. Moreover, the proposed method was successfully applied to determine Cl-Tyr in human serum samples, with recovery percentages ranging from 94.842% to 101.192%, confirming its reliability and applicability to biological matrices. Accordingly, the 2-naphtholate/CTAB fluorescent platform offers an inexpensive, accessible, and environmentally considerate alternative to other sophisticated and time-consuming technicalities utilized for routine Cl-Tyr monitoring.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"41 4","pages":"e70478"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}