Luminescence最新文献_第2页

Droplet-Enhanced Chemiluminescence Strategy for Enrofloxacin Detection Based on Porous Carbon Z-8 Encapsulated Luminol

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-27 DOI: 10.1002/bio.70145

Wanfeng Zhang, Liyuan Yu, Liangyu Chen, Xu Hun

{"title":"Droplet-Enhanced Chemiluminescence Strategy for Enrofloxacin Detection Based on Porous Carbon Z-8 Encapsulated Luminol","authors":"Wanfeng Zhang, Liyuan Yu, Liangyu Chen, Xu Hun","doi":"10.1002/bio.70145","DOIUrl":"https://doi.org/10.1002/bio.70145","url":null,"abstract":"<div>\u0000 \u0000 A droplet-enhanced chemiluminescence (CL) assay for enrofloxacin was fabricated. After preparation ZIF-8 carbonization, porous carbon material Z-800 was obtained and aptamer and cDNA were immobilizated onto the surface of Z-800. Luminol was encapsulated into Z-800 with the help of aptamer and cDNA. In the presence of enrofloxacin, aptamer accurately recognizes it, enrofloxacin specifically binds to aptamer, and the switch that encapsulateed luminol is turned on, causing luminol to be released into the supernatant. The supernatant reacts with H2O2 to produce a strong CL signal. The immiscible organic droplets, benzyl benzoate (Bnbzo), greatly enhances the CL signal. This assay shows a linear relationship between enhanced CL signals and enrofloxacin concentrations in the range from 0.1 to 500.0 nM with LOD of 30 pM (S/N = 3). The sample measurement was performed with the recoveries of 92.00% to 95.63% and relative standard deviation of 3.9%–5.2%. It proves that droplet-enhanced CL is a promising method for enhancing CL signals in real sample and trace analysis.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Coumarin-Based Probe for Spectrofluorometric Lead Determination in the Human Plasma: Exploring an Association With Otitis Media

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-27 DOI: 10.1002/bio.70155

Mohamed S. Imam, Amal M. Aladwani, Rahaf M. Aladwani, Jasmine N. Albukhari, Abrar A. Omayrah, Jenaan A. S. Alshahrani, Joud M. A. Alamri, Ghuyum S. A. Al Zamil, Danah M. Alahmri, Reuof A. N. Alotaibi, Mahmoud E. Alsobky

{"title":"Development of Coumarin-Based Probe for Spectrofluorometric Lead Determination in the Human Plasma: Exploring an Association With Otitis Media","authors":"Mohamed S. Imam, Amal M. Aladwani, Rahaf M. Aladwani, Jasmine N. Albukhari, Abrar A. Omayrah, Jenaan A. S. Alshahrani, Joud M. A. Alamri, Ghuyum S. A. Al Zamil, Danah M. Alahmri, Reuof A. N. Alotaibi, Mahmoud E. Alsobky","doi":"10.1002/bio.70155","DOIUrl":"https://doi.org/10.1002/bio.70155","url":null,"abstract":"<div>\u0000 \u0000 Chronic otitis media poses a significant global health challenge, particularly burdening low socioeconomic areas, notably in developing nations. Despite its prevalence, the role of lead in chronic otitis media remains largely overlooked. This study introduces an innovative spectrofluorometric technique for highly sensitive lead detection in human plasma samples at the nano-level. The method capitalizes on the interaction between lead ions and 7,8-dihydroxy-4-phenylcoumarin, generating a distinct fluorescent product. This complex exhibit modified fluorescence characteristics compared to free 7,8-dihydroxy-4-phenylcoumarin, emitting at 505 nm when excited at 330 nm. This shift, accompanied by an increase in fluorescence intensity, enables precise lead quantification even within complex plasma matrices. Validation confirmed a consistent linear relationship within the 200–4000 ng/mL range. Application of the validated method revealed elevated lead levels in plasma samples from chronic otitis media patients compared to healthy controls. These findings suggest a potential link between lead exposure and chronic otitis media development, though further research is warranted for confirmation. This research underscores the importance of considering lead's impact on chronic otitis media etiology and progression, especially in vulnerable populations.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ratiometric Detection of Carboxylesterase In Vitro and In Vivo via a BODIPY-Styryl Platform

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-25 DOI: 10.1002/bio.70152

Ni-Ni Wang, Kexin Wang, Xinyi Li, Can Zhang, Jianhao Wang, Zhongyan Chen, Yang Bai

{"title":"Ratiometric Detection of Carboxylesterase In Vitro and In Vivo via a BODIPY-Styryl Platform","authors":"Ni-Ni Wang, Kexin Wang, Xinyi Li, Can Zhang, Jianhao Wang, Zhongyan Chen, Yang Bai","doi":"10.1002/bio.70152","DOIUrl":"https://doi.org/10.1002/bio.70152","url":null,"abstract":"<div>\u0000 \u0000 Hepatocellular carcinoma (HCC) is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase (CE) is abundantly present in liver tissue, which shows promise as an innovative diagnostic biomarker for HCC. Herein, we designed and synthesized a novel fluorescent probe BDPPh-CES, based on a boron dipyrromethenes (BODIPY)-styryl framework, for the ratiometric detection of CE. Upon interaction with CEs, the probe demonstrates a characteristic fluorescence emission red shift, completing the reaction within 30 min. Notably, BDPPh-CES maintains specificity against acetylcholinesterase (AChE) and various biological species, while exhibiting robust performance across physiological pH conditions. Comprehensive mechanistic investigations, combining high-resolution mass spectrometry (HRMS) analysis, density functional theory (DFT) computational studies, and molecular docking simulations, provided insights into the binding and sensing mechanisms. The high sensitivity and low cytotoxicity facilitated real-time ratiometric imaging of CEs at the cellular level, successfully distinguishing elevated CE expression in Hepa 1–6 hepatic cancer cells over AML 12 normal hepatocytes. Further validation through in vivo experiments confirmed the liver-specific accumulation and efficient CE detection capabilities. This research presents an innovative approach for ratiometric CE monitoring, with potential implications for the early detection and therapeutic management of CE-associated disorders such as HCC.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Novel Photoactive Metal–Organic Frameworks for Fluorescence Sensing of Fe3+

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-24 DOI: 10.1002/bio.70147

Jing Li, Hongjiang Ren, Yunhui Zhai, Liuchang Wang, Jiangtao Li

{"title":"Synthesis and Characterization of Novel Photoactive Metal–Organic Frameworks for Fluorescence Sensing of Fe3+","authors":"Jing Li, Hongjiang Ren, Yunhui Zhai, Liuchang Wang, Jiangtao Li","doi":"10.1002/bio.70147","DOIUrl":"https://doi.org/10.1002/bio.70147","url":null,"abstract":"<div>\u0000 \u0000 Coordination polymers (CPs) have garnered attention for their versatile structures and applications in fluorescence sensing and photochromic materials. Addressing the need for sensitive and selective detection of Fe3+, a crucial ion in biological, environmental, and industrial systems, this study synthesized two novel CPs, [Zn (cmmb)(bpy)1/2] (CP1) and [Cd5(μ3-OH)2(cmmb)4] (CP2) [bpy = 4,4′-bipyridine], via hydrothermal reactions with 4-(carboxymethyl)-2-methoxybenzoic acid (H2cmmb). Structural analysis confirmed their frameworks, which facilitate strong host–guest interactions and electron transfer modulation. Both CPs exhibited excellent Fe3+ sensing capabilities, with fluorescence quenching constants of 4.922 × 104 M−1 (CP1) and 3.294 × 104 M−1 (CP2), outperforming their responses to other ions. These results underscore the potential of CP1 and CP2 as effective materials for Fe3+ detection, providing valuable insights for designing functional CPs for ion sensing applications.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hantzsch Reaction–Based Fluorimetric Approach for Sensitive Determination of Besifloxacin in Pharmaceutical Eye Drops and Aqueous Humor

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-24 DOI: 10.1002/bio.70154

Islam M. Mostafa, Mahmoud A. Omar, Mohamed Ahmed Elsayed, Abobakr A. Mohamed

引用次数: 0

Advances in Covalent Organic Frameworks as Fluorescent Sensors for pH

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-22 DOI: 10.1002/bio.70153

Zhaowei Jia, Siyu Yang, Yuduo Wang, Xiangyu Liang, Yuhui Tang, Ruimeng Wang

引用次数: 0

Defect Regulation Induced Luminescence Improvement of the Broadband Orange Phosphor Lu2CaMg2Si3O12:Ce3+ for WLED

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-22 DOI: 10.1002/bio.70151

Yubo Feng, Yingkai Fu, Yicheng Zhang, Sitong Feng, Runtao Chen, Kaiyang Li, Mengjie Liu, Xu Qian, Lin Gao, Quan Liu

{"title":"Defect Regulation Induced Luminescence Improvement of the Broadband Orange Phosphor Lu2CaMg2Si3O12:Ce3+ for WLED","authors":"Yubo Feng, Yingkai Fu, Yicheng Zhang, Sitong Feng, Runtao Chen, Kaiyang Li, Mengjie Liu, Xu Qian, Lin Gao, Quan Liu","doi":"10.1002/bio.70151","DOIUrl":"10.1002/bio.70151","url":null,"abstract":"<div>\u0000 \u0000 Phosphors for white light emitting diode (WLED) have been attracting the attention of researchers to obtain devices with a high color rendering index (CRI) and low correlated color temperature (CCT). Herein, the broadband orange phosphor Lu2CaMg2Si3O12:Ce3+ is prepared, and Lu3+ vacancy is created in the lattice to regulate the structure of this phosphor. This orange phosphor can be excited well by blue light and emit orange light ranging from 500 to 750 nm. By decreasing Lu3+ content in the lattice, the band gap of the matrix is widened. Besides, the emission of Ce3+ in this garnet structure is improved, and the emission of Lu1.84CaMg2Si3O12:Ce3+ reached the maximum of all the samples. The thermal stability of this orange phosphor is improved, and the emission of the phosphor Lu1.84CaMg2Si3O12:Ce3+ maintains 75.5% at 423 K compared to that at 298 K. WLED device is fabricated via coating the mixtures of Lu1.84CaMg2Si3O12:Ce3+ and the cyan phosphor Ca3Sc2Si3O12:Ce3+ onto the blue chip. This WLED device shows a high CRI of 87.9 and a low CCT of 4167 K, verifying the great potential of this orange phosphor in WLED.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Hydrogels for Implantable Bioelectronic Devices 用于植入式生物电子器件的功能性水凝胶

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-18 DOI: 10.1002/bio.70148

Mingxi Tu, Tianming Zhao, Hongji Guo, Chengzhi Zhang, Meihan Liu, Zeyu Zhang, Bo Wang, Haibo Yu

{"title":"Functional Hydrogels for Implantable Bioelectronic Devices","authors":"Mingxi Tu, Tianming Zhao, Hongji Guo, Chengzhi Zhang, Meihan Liu, Zeyu Zhang, Bo Wang, Haibo Yu","doi":"10.1002/bio.70148","DOIUrl":"https://doi.org/10.1002/bio.70148","url":null,"abstract":"<div>\u0000 \u0000 In recent years, with the rapid development of flexible electronics, implantable electronic devices have received increasing attention, and they provide new solutions for medical diagnosis and treatment. To ensure the long-term and stable operation of electronic devices in the internal environment, materials with conductivity, flexibility, biocompatibility, and other properties are in high demand. Hydrogels are polymers with three-dimensional network structures that not only have physical and chemical properties similar to those of biological tissues but can be also modulated by introducing functional groups to regulate the conductivity, adhesion, self-healing, and other functions. Therefore, hydrogel-based implantable bioelectronic devices are considered to be a candidate development direction in the future of the biomedical field. Here, this paper reviews the research progress in the molecular design and performance modulation of functionalized hydrogels based on four key properties of hydrogels: conductivity, self-healing, adhesion, and toughness. The latest progress in the use of functionalized hydrogels in implantable bioelectronic device applications is summarized below. Finally, discussions are given on the challenges and opportunities of hydrogels for implantable bioelectronic devices.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Ultrasensitive and Environmentally Benign Synchronous Spectrofluorimetric Strategy for Determining the Anti-Inflammatory (Celecoxib) and the Antidepressant (Citalopram) in Different Matrices

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-18 DOI: 10.1002/bio.70143

Israa M. Nour, Mohamed Badrawy, Mohamed A. Hasan, Omar M El-Abassy

{"title":"An Ultrasensitive and Environmentally Benign Synchronous Spectrofluorimetric Strategy for Determining the Anti-Inflammatory (Celecoxib) and the Antidepressant (Citalopram) in Different Matrices","authors":"Israa M. Nour, Mohamed Badrawy, Mohamed A. Hasan, Omar M El-Abassy","doi":"10.1002/bio.70143","DOIUrl":"https://doi.org/10.1002/bio.70143","url":null,"abstract":"<div>\u0000 \u0000 Depression is one of the leading global public health problems. Studies have shown that patients with rheumatoid arthritis are at high risk for depression. In pharmacokinetic studies, determining co-administered medicines is highly important to achieve the best potential therapeutic results. Herein, two co-administered drugs were determined by the second derivative synchronous spectrofluorimetric method in their pharmaceuticals and spiked human plasma; the first was celecoxib and the second was citalopram. Both celecoxib and citalopram had a native florescence, but their emission spectra showed a large overlap that complicated their determination by traditional fluorescence, this obstruction could be solved by measuring the synchronous fluorescence at Δλ = 70 nm, then deriving the second derivative allowing separation of celecoxib and citalopram with a zero-crossing point at 347 and 306 nm, respectively. In accordance with ICH instructions, method parameters were validated showing excellent sensitivity of the method, encompassing the concentration interval of 100.0–2000.0 ng/mL and 20.0–900.0 ng/mL for celecoxib and citalopram, respectively. The Green Analytical Procedure Index, Analytical GREEnness Metric approach, and the Green Solvents Selecting tool found that these procedures have a high level of environmental friendliness. In addition, the Blue Applicability Grade Index evaluation tool determined that the suggested technique was workable.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Quantitative Analysis of Aspirin, Telmisartan, and Bisoprolol in Spiked Human Plasma Using Green Spectrofluorimetric Analysis

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-18 DOI: 10.1002/bio.70149

Osama I. Abdel Sattar, Hamed H. M. Abuseada, Sherif Ramzy, Mahmoud M. Abuelwafa

{"title":"A Quantitative Analysis of Aspirin, Telmisartan, and Bisoprolol in Spiked Human Plasma Using Green Spectrofluorimetric Analysis","authors":"Osama I. Abdel Sattar, Hamed H. M. Abuseada, Sherif Ramzy, Mahmoud M. Abuelwafa","doi":"10.1002/bio.70149","DOIUrl":"https://doi.org/10.1002/bio.70149","url":null,"abstract":"<div>\u0000 \u0000 Herein, precise and straightforward spectrofluorimetric method was developed for the determination of aspirin, telmisartan, and bisoprolol in spiked human plasma. Bisoprolol was measured directly by detecting its native fluorescence spectra at 301 nm following excitation at 230 nm, with no interference from aspirin or telmisartan. However, direct fluorescence detection of aspirin and telmisartan proved challenging because their native emission spectra at 406 and 375 nm overlapped. As a result, aspirin and telmisartan were measured utilizing synchronous fluorescence spectroscopy coupled with first-derivative spectroscopy, allowing for the entire resolution of their overlapping spectra and the measurement of aspirin and telmisartan at 416 and 349 nm, respectively. The method was validated according to the requirements outlined in ICH M10 for bioanalytical method validation. The approach demonstrated satisfactory linearity in the working ranges of 30–1000 ng/mL for aspirin, 50–900 ng/mL for telmisartan, and 75–1300 ng/mL for bisoprolol. The method was accurate and precise, and it was effectively used to measure the studied drugs in spiked plasma with minimal matrix influence. The method's greenness was further evaluated using the Green Analytical Procedure Index and the Analytical GREEnness metrics. The results showed that the employed procedure was environmentally friendly.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0