Mathematical Medicine and Biology-A Journal of the Ima最新文献_第8页

Functional optimality of the sulcus pattern of the human brain. 人类大脑沟模式的功能优化。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2019-06-13 DOI: 10.1093/imammb/dqy007

S Heyden, M Ortiz

{"title":"Functional optimality of the sulcus pattern of the human brain.","authors":"S Heyden, M Ortiz","doi":"10.1093/imammb/dqy007","DOIUrl":"https://doi.org/10.1093/imammb/dqy007","url":null,"abstract":"We develop a mathematical model of information transmission across the biological neural network of the human brain. The overall function of the brain consists of the emergent processes resulting from the spread of information through the neural network. The capacity of the brain is therefore related to the rate at which it can transmit information through the neural network. The particular transmission model under consideration allows for information to be transmitted along multiple paths between points of the cortex. The resulting transmission rates are governed by potential theory. According to this theory, the brain has preferred and quantized transmission modes that correspond to eigenfunctions of the classical Steklov eigenvalue problem, with the reciprocal eigenvalues quantifying the corresponding transmission rates. We take the model as a basis for testing the hypothesis that the sulcus pattern of the human brain has evolved to maximize the rate of transmission of information between points in the cerebral cortex. We show that the introduction of sulci, or cuts, in an otherwise smooth domain indeed increases the overall transmission rate. We demonstrate this result by means of numerical experiments concerned with a spherical domain with a varying number of slits on its surface.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"36 2","pages":"207-221"},"PeriodicalIF":1.1,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/imammb/dqy007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36175684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Modeling dynamics for oncogenesis encompassing mutations and genetic instability. 包括突变和遗传不稳定性在内的肿瘤发生动力学建模。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2019-06-13 DOI: 10.1093/imammb/dqy010

Artur C Fassoni, Hyun M Yang

{"title":"Modeling dynamics for oncogenesis encompassing mutations and genetic instability.","authors":"Artur C Fassoni, Hyun M Yang","doi":"10.1093/imammb/dqy010","DOIUrl":"https://doi.org/10.1093/imammb/dqy010","url":null,"abstract":"Tumorigenesis has been described as a multistep process, where each step is associated with a genetic alteration, in the direction to progressively transform a normal cell and its descendants into a malignant tumour. Into this work, we propose a mathematical model for cancer onset and development, considering three populations: normal, premalignant and cancer cells. The model takes into account three hallmarks of cancer: self-sufficiency on growth signals, insensibility to anti-growth signals and evading apoptosis. By using a nonlinear expression to describe the mutation from premalignant to cancer cells, the model includes genetic instability as an enabling characteristic of tumour progression. Mathematical analysis was performed in detail. Results indicate that apoptosis and tissue repair system are the first barriers against tumour progression. One of these mechanisms must be corrupted for cancer to develop from a single mutant cell. The results also show that the presence of aggressive cancer cells opens way to survival of less adapted premalignant cells. Numerical simulations were performed with parameter values based on experimental data of breast cancer, and the necessary time taken for cancer to reach a detectable size from a single mutant cell was estimated with respect to some parameters. We find that the rates of apoptosis and mutations have a large influence on the pace of tumour progression and on the time it takes to become clinically detectable.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"36 2","pages":"241-267"},"PeriodicalIF":1.1,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/imammb/dqy010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36262099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Optimal number and sizes of the doses in fractionated radiotherapy according to the LQ model. 根据LQ模型确定分段放疗中最优剂量数和剂量大小。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2019-03-14 DOI: 10.1093/imammb/dqx020

C Bruni, F Conte, F Papa, C Sinisgalli

{"title":"Optimal number and sizes of the doses in fractionated radiotherapy according to the LQ model.","authors":"C Bruni, F Conte, F Papa, C Sinisgalli","doi":"10.1093/imammb/dqx020","DOIUrl":"https://doi.org/10.1093/imammb/dqx020","url":null,"abstract":"We address a non-linear programming problem to find the optimal scheme of dose fractionation in cancer radiotherapy. Using the LQ model to represent the response to radiation of tumour and normal tissues, we formulate a constrained non-linear optimization problem in terms of the variables number and sizes of the dose fractions. Quadratic constraints are imposed to guarantee that the damages to the early and late responding normal tissues do not exceed assigned tolerable levels. Linear constraints are set to limit the size of the daily doses. The optimal solutions are found in two steps: i) analytical determination of the optimal sizes of the fractional doses for a fixed, but arbitrary number of fractions n; ii) numerical simulation of a sequence of the previous optima for n increasing, and for specific tumour classes. We prove the existence of a finite upper bound for the optimal number of fractions. So, the optimum with respect to n is found by means of a finite number of comparisons amongst the optimal values of the objective function at the first step. In the numerical simulations, the radiosensitivity and repopulation parameters of the normal tissue are fixed, while we investigate the behaviour of the optimal solution for wide variations of the tumour parameters, relating our optima to real clinical protocols. We recognize that the optimality of hypo or equi-fractionated treatment schemes depends on the value of the tumour radiosensitivity ratio compared to the normal tissue radiosensitivity. Fast growing, radioresistant tumours may require particularly short optimal treatments.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"36 1","pages":"1-53"},"PeriodicalIF":1.1,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/imammb/dqx020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35746989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Limit-cycle oscillatory coexpression of cross-inhibitory transcription factors: a model mechanism for lineage promiscuity. 交叉抑制转录因子的极限环振荡共表达:谱系混杂的模式机制。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2019-03-14 DOI: 10.1093/imammb/dqy003

Pavol Bokes, John R King

{"title":"Limit-cycle oscillatory coexpression of cross-inhibitory transcription factors: a model mechanism for lineage promiscuity.","authors":"Pavol Bokes, John R King","doi":"10.1093/imammb/dqy003","DOIUrl":"https://doi.org/10.1093/imammb/dqy003","url":null,"abstract":"Lineage switches are genetic regulatory motifs that govern and maintain the commitment of a developing cell to a particular cell fate. A canonical example of a lineage switch is the pair of transcription factors PU.1 and GATA-1, of which the former is affiliated with the myeloid and the latter with the erythroid lineage within the haematopoietic system. On a molecular level, PU.1 and GATA-1 positively regulate themselves and antagonize each other via direct protein-protein interactions. Here we use mathematical modelling to identify a novel type of dynamic behaviour that can be supported by such a regulatory architecture. Guided by the specifics of the PU.1-GATA-1 interaction, we formulate, using the law of mass action, a system of differential equations for the key molecular concentrations. After a series of systematic approximations, the system is reduced to a simpler one, which is tractable to phase-plane and linearization methods. The reduced system formally resembles, and generalizes, a well-known model for competitive species from mathematical ecology. However, in addition to the qualitative regimes exhibited by a pair of competitive species (exclusivity, bistable exclusivity, stable-node coexpression) it also allows for oscillatory limit-cycle coexpression. A key outcome of the model is that, in the context of cell-fate choice, such oscillations could be harnessed by a differentiating cell to prime alternately for opposite outcomes; a bifurcation-theory approach is adopted to characterize this possibility.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"36 1","pages":"113-137"},"PeriodicalIF":1.1,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/imammb/dqy003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37054361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Simulated ablation for detection of cells impacting paracrine signalling in histology analysis. 模拟消融检测细胞影响旁分泌信号在组织学分析。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2019-03-14 DOI: 10.1093/imammb/dqx022

Jake P Taylor-King, Etienne Baratchart, Andrew Dhawan, Elizabeth A Coker, Inga Hansine Rye, Hege Russnes, S Jon Chapman, David Basanta, Andriy Marusyk

{"title":"Simulated ablation for detection of cells impacting paracrine signalling in histology analysis.","authors":"Jake P Taylor-King, Etienne Baratchart, Andrew Dhawan, Elizabeth A Coker, Inga Hansine Rye, Hege Russnes, S Jon Chapman, David Basanta, Andriy Marusyk","doi":"10.1093/imammb/dqx022","DOIUrl":"https://doi.org/10.1093/imammb/dqx022","url":null,"abstract":"Intra-tumour phenotypic heterogeneity limits accuracy of clinical diagnostics and hampers the efficiency of anti-cancer therapies. Dealing with this cellular heterogeneity requires adequate understanding of its sources, which is extremely difficult, as phenotypes of tumour cells integrate hardwired (epi)mutational differences with the dynamic responses to microenvironmental cues. The later comes in form of both direct physical interactions, as well as inputs from gradients of secreted signalling molecules. Furthermore, tumour cells can not only receive microenvironmental cues, but also produce them. Despite high biological and clinical importance of understanding spatial aspects of paracrine signaling, adequate research tools are largely lacking. Here, a partial differential equation (PDE)-based mathematical model is developed that mimics the process of cell ablation. This model suggests how each cell might contribute to the microenvironment by either absorbing or secreting diffusible factors, and quantifies the extent to which observed intensities can be explained via diffusion-mediated signalling. The model allows for the separation of phenotypic responses to signalling gradients within tumour microenvironments from the combined influence of responses mediated by direct physical contact and hardwired (epi)genetic differences. The method is applied to a multi-channel immunofluorescence in situ hybridisation (iFISH)-stained breast cancer histological specimen, and correlations are investigated between: HER2 gene amplification, HER2 protein expression and cell interaction with the diffusible microenvironment. This approach allows partial deconvolution of the complex inputs that shape phenotypic heterogeneity of tumour cells and identifies cells that significantly impact gradients of signalling molecules.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"36 1","pages":"93-112"},"PeriodicalIF":1.1,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/imammb/dqx022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35840131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mathematical modelling of glob-driven tear film breakup. 球体驱动的泪膜破裂的数学模型。

IF 0.8 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2019-03-14 DOI: 10.1093/imammb/dqx021

L Zhong, C F Ketelaar, R J Braun, C G Begley, P E King-Smith

{"title":"Mathematical modelling of glob-driven tear film breakup.","authors":"L Zhong, C F Ketelaar, R J Braun, C G Begley, P E King-Smith","doi":"10.1093/imammb/dqx021","DOIUrl":"10.1093/imammb/dqx021","url":null,"abstract":"Evaporation is a recognized contributor to tear film thinning and tear breakup (TBU). Recently, a different type of TBU is observed, where TBU happens under or around a thick area of lipid within a second after a blink. The thick lipid corresponds to a glob. Evaporation alone is too slow to offer a complete explanation of this breakup. It has been argued that the major reason of this rapid tear film thinning is divergent flow driven by a lower surface tension of the glob (via the Marangoni effect). We examine the glob-driven TBU hypothesis in a 1D streak model and axisymmetric spot model. In the model, the streak or spot glob has a localized high surfactant concentration, which is assumed to lower the tear/air surface tension and also to have a fixed size. Both streak and spot models show that the Marangoni effect can lead to strong tangential flow away from the glob and may cause TBU. The models predict that smaller globs or thinner films will decrease TBU time (TBUT). TBU is located underneath small globs, but may occur outside larger globs. In addition to tangential flow, evaporation can also contribute to TBU. This study provides insights about mechanism of rapid thinning and TBU which occurs very rapidly after a blink and how the properties of the globs affect the TBUT.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"36 1","pages":"55-91"},"PeriodicalIF":0.8,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416486/pdf/dqx021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35784408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggregation and travelling wave dynamics in a two-population model of cancer cell growth and invasion. 两种群模型中癌细胞生长和侵袭的聚集和行波动力学。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2018-12-05 DOI: 10.1093/imammb/dqx019

Vasiliki Bitsouni, Dumitru Trucu, Mark A J Chaplain, Raluca Eftimie

{"title":"Aggregation and travelling wave dynamics in a two-population model of cancer cell growth and invasion.","authors":"Vasiliki Bitsouni, Dumitru Trucu, Mark A J Chaplain, Raluca Eftimie","doi":"10.1093/imammb/dqx019","DOIUrl":"https://doi.org/10.1093/imammb/dqx019","url":null,"abstract":"Cells adhere to each other and to the extracellular matrix (ECM) through protein molecules on the surface of the cells. The breaking and forming of adhesive bonds, a process critical in cancer invasion and metastasis, can be influenced by the mutation of cancer cells. In this paper, we develop a nonlocal mathematical model describing cancer cell invasion and movement as a result of integrin-controlled cell-cell adhesion and cell-matrix adhesion, for two cancer cell populations with different levels of mutation. The partial differential equations for cell dynamics are coupled with ordinary differential equations describing the ECM degradation and the production and decay of integrins. We use this model to investigate the role of cancer mutation on the possibility of cancer clonal competition with alternating dominance, or even competitive exclusion (phenomena observed experimentally). We discuss different possible cell aggregation patterns, as well as travelling wave patterns. In regard to the travelling waves, we investigate the effect of cancer mutation rate on the speed of cancer invasion.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"35 4","pages":"541-577"},"PeriodicalIF":1.1,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/imammb/dqx019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35747853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Fluid dynamics in heart development: effects of hematocrit and trabeculation. 心脏发育过程中的流体动力学：血细胞比容和小梁的影响。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2018-12-05 DOI: 10.1093/imammb/dqx018

Nicholas A Battista, Andrea N Lane, Jiandong Liu, Laura A Miller

{"title":"Fluid dynamics in heart development: effects of hematocrit and trabeculation.","authors":"Nicholas A Battista, Andrea N Lane, Jiandong Liu, Laura A Miller","doi":"10.1093/imammb/dqx018","DOIUrl":"10.1093/imammb/dqx018","url":null,"abstract":"Recent in vivo experiments have illustrated the importance of understanding the haemodynamics of heart morphogenesis. In particular, ventricular trabeculation is governed by a delicate interaction between haemodynamic forces, myocardial activity, and morphogen gradients, all of which are coupled to genetic regulatory networks. The underlying haemodynamics at the stage of development in which the trabeculae form is particularly complex, given the balance between inertial and viscous forces. Small perturbations in the geometry, scale, and steadiness of the flow can lead to changes in the overall flow structures and chemical morphogen gradients, including the local direction of flow, the transport of morphogens, and the formation of vortices. The immersed boundary method was used to solve the two-dimensional fluid-structure interaction problem of fluid flow moving through a two chambered heart of a zebrafish (Danio rerio), with a trabeculated ventricle, at 96 hours post fertilization (hpf). Trabeculae heights and hematocrit were varied, and simulations were conducted for two orders of magnitude of Womersley number, extending beyond the biologically relevant range (0.2-12.0). Both intracardial and intertrabecular vortices formed in the ventricle for biologically relevant parameter values. The bifurcation from smooth streaming flow to vortical flow depends upon the trabeculae geometry, hematocrit, and Womersley number, $Wo$. This work shows the importance of hematocrit and geometry in determining the bulk flow patterns in the heart at this stage of development.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"35 4","pages":"493-516"},"PeriodicalIF":1.1,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7970531/pdf/nihms-1677147.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35273011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global well-posedness of infectious disease models without life-time immunity: the cases of cholera and avian influenza. 没有终身免疫的传染病模型的全球完备性:霍乱和禽流感病例。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2018-12-05 DOI: 10.1093/imammb/dqx016

Kazuo Yamazaki

{"title":"Global well-posedness of infectious disease models without life-time immunity: the cases of cholera and avian influenza.","authors":"Kazuo Yamazaki","doi":"10.1093/imammb/dqx016","DOIUrl":"https://doi.org/10.1093/imammb/dqx016","url":null,"abstract":"We study the systems of partial differential equations with diffusion that model the dynamics of infectious diseases without life-time immunity, in particular the cases of cholera from Wang & Wang (2015, J. Biol. Dyn., 9, 233-261) and avian influenza from Vaidya et al. (2012, Discrete Contin. Dyn. Syst. Ser. B, 17, 2829-2848). In both works, similarly to all others in the literature on various models of infectious diseases and more, it had to be assumed for a technical reason that the diffusivity coefficients of the susceptible, infected and recovered individuals, humans or birds, had to be identical in order to prove the existence of their unique solutions for all time. Considering that such uniform diffusivity strengths among the susceptible, infected and recovered hosts may not always be plausible in real world, we investigate the global well-posedness issue when such conditions are relaxed. In particular for the cholera model from Wang & Wang (2015, J. Biol. Dyn., 9, 233-261), we prove the global well-posedness with no condition on the diffusivity coefficients at all. For the avian influenza model from Vaidya et al. (2012, Discrete Contin. Dyn. Syst. Ser. B, 17, 2829-2848), we prove the global well-posedness with no condition on the diffusivity coefficients if the spatial dimension is one, and under a partial condition that the diffusivity coefficients of the susceptible and the infected hosts are same otherwise.","PeriodicalId":49863,"journal":{"name":"Mathematical Medicine and Biology-A Journal of the Ima","volume":"35 4","pages":"427-445"},"PeriodicalIF":1.1,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/imammb/dqx016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35209186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Numerical optimal control for HIV prevention with dynamic budget allocation. 动态预算分配的HIV预防数值最优控制。

IF 1.1 4区数学

Mathematical Medicine and Biology-A Journal of the Ima Pub Date : 2018-12-05 DOI: 10.1093/imammb/dqx015

Dmitry Gromov, Ingo Bulla, Oana Silvia Serea, Ethan O Romero-Severson

引用次数: 12