Mutation Research-Reviews in Mutation Research最新文献

{"title":"Elucidation of the pathogenesis of peroxisome biogenesis disorders (PBDs): From molecular mechanisms to diagnosis-therapy linkages and AI-assisted potential","authors":"Rongke Xiang,&nbsp;Minggao Jiang,&nbsp;Hanrui Xu,&nbsp;Ying-Qiang Shen","doi":"10.1016/j.mrrev.2025.108579","DOIUrl":"10.1016/j.mrrev.2025.108579","url":null,"abstract":"<div><div>Peroxisomes are essential, highly conserved organelles in eukaryotic cells, with well-characterized roles in fatty acid β-oxidation, ether phospholipid (a key component of myelin lipid) synthesis, and maintaining redox homeostasis. Peroxisomal disorders primarily arise from abnormalities in peroxisome biogenesis or degradation, as well as enzyme deficiencies, often with genetic mutations serving as their underlying drivers. To date, effective therapeutic strategies for these disorders remain scarce. This review focuses on elucidating the pathogenesis of peroxisome biogenesis disorders (PBDs), while also clarifying the diagnostic and therapeutic approaches for PBDs specifically. It also includes a brief discussion on the role of artificial intelligence (AI) in the management of these disorders. This ultimately aims to provide a theoretical basis and practical reference for future clinical interventions.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108579"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The comet assay as a tool in human biomonitoring exposure to antineoplastic drugs – A systematic review and meta-analysis","authors":"Carina Ladeira ,&nbsp;Amaya Azqueta ,&nbsp;Lisa Giovannelli ,&nbsp;Goran Gajski ,&nbsp;Marko Gerić ,&nbsp;Anja Haveric ,&nbsp;Helga Stopper ,&nbsp;Ezgi Eyluel Bankoglu ,&nbsp;Andrew Collins ,&nbsp;Peter Møller","doi":"10.1016/j.mrrev.2026.108590","DOIUrl":"10.1016/j.mrrev.2026.108590","url":null,"abstract":"<div><div>Antineoplastic agents are toxic compounds, generally used in the treatment of cancers, which are recognized as carrying a cancer development risk. In this systematic review and meta-analysis of human biomonitoring studies, we have assessed the effects of exposure to antineoplastic drugs on levels of DNA strand breaks in leukocytes, measured by the comet assay. Focusing on the application of the comet assay in human biomonitoring of occupational exposure to antineoplastic agents, we have analyzed 458 original research studies which used this assay, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA-ScR). The systematic review led to 23 studies, of which 20 studies met the criteria for inclusion in the meta-analysis. Using standardized mean difference and 95% confidence interval (CI), the meta-analyses show increased levels of DNA strand breaks in subjects exposed to antineoplastic drugs (1.26, 95% CI: 0.78, 1.73). Results originate mainly from studies on healthcare workers, with only one study in an industrial setting. Subgroup analysis indicates that all studies combined from middle-income countries have a higher effect size (1.77, 95% CI: 1.00, 2.55) than studies from high-income countries (0.49, 95% CI: 0.09, 0.90). This difference between middle- and high-income countries may be attributable in part to differences in exposure levels or exposure assessment. Additionally, sensitivity analysis indicates that studies with moderate/high risk of comet assay measurement bias have higher effect size (2.07, 95% CI: 0.82, 3.31) than studies with low risk of bias (0.73, 95% CI: 0.34, 1.13); and that studies with high risk of exposure misclassification have higher effect size (1.47, 95% CI: 0.89, 2.06) than studies with low/moderate risk (0.13, 955 CI: −0.08, 0.33). Most studies have low/moderate risk of bias related to the comet assay procedure (15 out of 20 studies), absence of reporting the use of assay controls (1 out of 20 studies), blinded analysis of samples (7 out 20 studies); exposure assessment (16 out of 20 studies). In conclusion, this systematic review and meta-analysis shows that exposure to antineoplastic drugs is associated with increased levels of DNA strand breaks in human leukocytes.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108590"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological effects and potential genetic/epigenetic adaptive responses to chronic natural background radiation","authors":"Monika Rajput ,&nbsp;Manoj Pandey","doi":"10.1016/j.mrrev.2026.108585","DOIUrl":"10.1016/j.mrrev.2026.108585","url":null,"abstract":"<div><div>Natural background radiation (NBR) delivers chronic low-dose-rate ionizing radiation worldwide, with a global average annual effective dose of ∼2.4 mSv. In certain high-background radiation areas (HBRAs), annual doses range from 10 to &gt; 200 mSv. While the linear no-threshold (LNT) model assumes any radiation dose carries some cancer risk, epidemiological studies in HBRAs (Kerala-India, Ramsar-Iran, Yangjiang-China, Guarapari-Brazil) have consistently failed to detect the predicted cancer excess. Some cytogenetic and molecular investigations suggest enhanced DNA repair proficiency or lower-than-expected chromosomal damage in chronically exposed residents. This narrative review critically synthesizes epidemiological, cytogenetic, and limited molecular evidence from HBRAs, evaluates the ability of current dose–response models (LNT versus non-linear alternatives) to explain these observations, identifies major knowledge gaps, and discusses implications for low-dose radiation risk assessment and public health policy.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108585"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The comet assay as a tool in human biomonitoring exposure to combustion-derived air pollution − A systematic review and meta-analysis","authors":"Peter Møller ,&nbsp;Goran Gajski ,&nbsp;Marko Gerić ,&nbsp;Anja Haveric ,&nbsp;Helga Stopper ,&nbsp;Ezgi Eyluel Bankoglu ,&nbsp;Amaya Azqueta ,&nbsp;Lisa Giovannelli ,&nbsp;Andrew Collins ,&nbsp;Carina Ladeira","doi":"10.1016/j.mrrev.2025.108583","DOIUrl":"10.1016/j.mrrev.2025.108583","url":null,"abstract":"<div><div>Humans are exposed to environmental or occupational air pollution from combustion emissions in outdoor and indoor environments. Irrespective of the sources, combustion emissions are characterized by being a complex mixture of particles, volatile compounds and gases. The present systematic review summarizes results on DNA strand breaks measured by the comet assay in leukocytes, from studies on human exposure to traffic-related vehicle exhaust, biomass combustion and coke oven work environments. These exposures have in common the combustion of fuel, which generates particles and polycyclic aromatic hydrocarbons. Standardized mean differences (SMDs) have been calculated by random effects models. Meta-analyses show increased levels of DNA strand breaks in studies on traffic-related exhausts (SMD = 0.62, 95 % CI: 0.36, 0.89, n = 21), biomass combustion (1.73, 95 % CI: 0.72, 2.74, n = 10) and coke oven emission (0.84, 95 % CI: 0.30, 1.37, n = 10). Studies from high-income countries have reported much smaller differences in DNA strand break levels than have studies from middle-income countries. These differences may be attributed to higher exposures related to less strict emission control, and more susceptible populations in middle-income populations; unrecognized confounding despite efforts to match subjects on traditional confounders; or higher risk of comet assay measurement bias and exposure misclassification. In conclusion, this systematic review and meta-analysis show that exposure to combustion-derived air pollution, with clear exposure gradients in terms of particulate matter or polycyclic aromatic hydrocarbons, is associated with increased levels of DNA strand breaks in human leukocytes.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108583"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCR based site-directed mutagenesis: An extensively used tool for the functional genomics studies in begomoviruses","authors":"Gnanaprakash Jeyaraj ,&nbsp;Alok Kumar ,&nbsp;A. Swapna Geetanjali","doi":"10.1016/j.mrrev.2026.108589","DOIUrl":"10.1016/j.mrrev.2026.108589","url":null,"abstract":"<div><div>Site-directed mutagenesis (SDM) is an important tool that allows the quick and efficient manipulations of specific residues in DNA sequences for investigating their importance in structure and function of proteins. Out of several techniques available for this purpose, SDM coupled with PCR are widely used because of its simplicity and effectiveness, and are less time consuming. The technique uses pairs of oligonucleotide primers carrying the desired mutation for introducing specific changes in the target DNA sequence. Begomoviruses alone, or in combination with satellite molecules pose significant threat to global agriculture for their worldwide occurrence on a broad range of crops. Understanding the functions of genes available on the begomoviral genome and satellite molecules is the key for devising effective disease control strategies. PCR-based SDM has proven to be instrumental in unravelling the functions of genes and molecular mechanism of disease development by understanding the dynamic interplay between begomoviruses and the host plants. This has paved a way for the development of innovative antiviral interventions and sustainable agricultural practices to mitigate the impact of these economically important plant pathogens on global food security and crop production. This review briefly summarized about the overall concept and methods of SDM with emphasis on PCR based SDM and its applications so far in the functional genomics studies of begomoviruses.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108589"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotoxic and mutagenic potential of non-thermal plasma: Mechanistic insights from eukaryotic cell studies","authors":"Stanislav Kyzek ,&nbsp;Sára Pišteková ,&nbsp;Ivana Kyzeková ,&nbsp;Mária Peťková ,&nbsp;Veronika Medvecká ,&nbsp;Jana Makuková ,&nbsp;Terézia Zajičková ,&nbsp;Samantha Hughes ,&nbsp;Eliška Gálová ,&nbsp;Andrea Ševčovičová","doi":"10.1016/j.mrrev.2025.108581","DOIUrl":"10.1016/j.mrrev.2025.108581","url":null,"abstract":"<div><div>Non-thermal plasma (NTP), a partially ionized gas enriched with reactive oxygen and nitrogen species (RONS) and UV radiation, is increasingly used in medicine, agriculture, and food processing applications. While its oxidative and antimicrobial effects are well documented, the molecular mechanisms underlying its genotoxic and mutagenic effects in eukaryotic systems remain poorly understood. This review consolidates the current evidence on how NTP interacts with cellular and molecular targets to induce DNA damage. Key mechanisms are identified that link plasma-generated RONS and physical components to base oxidation (8-oxoG formation), single- and double-strand breaks (γ-H2AX foci), and chromosomal instability (micronuclei formation). The extent and nature of these effects are further influenced by plasma parameters—including source configuration, working gas composition, exposure duration, and delivered dose—as well as by intrinsic cellular factors such as DNA repair capacity, antioxidant defenses, and overall metabolic state. In addition to cataloguing genotoxic outcomes, this review synthesizes mechanistic insights across unicellular, plant, and animal models, emphasizing comparative sensitivity, methodological variability, and the influence of plasma dosimetry on biological responses. By integrating these findings, we highlight both the potential therapeutic selectivity of NTP—particularly against tumor cells—and the remaining challenges for safe biomedical translation.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108581"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The comet assay as a tool in human biomonitoring exposure to anaesthetic gases – A systematic review and meta-analysis","authors":"Goran Gajski ,&nbsp;Anja Haveric ,&nbsp;Peter Møller ,&nbsp;Amaya Azqueta ,&nbsp;Lisa Giovannelli ,&nbsp;Marko Gerić ,&nbsp;Helga Stopper ,&nbsp;Ezgi Eyluel Bankoglu ,&nbsp;Andrew Collins ,&nbsp;Carina Ladeira","doi":"10.1016/j.mrrev.2026.108586","DOIUrl":"10.1016/j.mrrev.2026.108586","url":null,"abstract":"<div><div>Anaesthetic gases are agents used to induce and maintain general anaesthesia during surgical procedures. Common examples include sevoflurane, isoflurane, and desflurane, which act by depressing the central nervous system to produce unconsciousness and analgesia. These gases are administered through a vaporiser and inhaled via a mask or endotracheal tube. While effective, they can contribute to environmental pollution and increase the risk of occupational exposure. Medical personnel working in operating or post-operating facilities are unavoidably exposed to anaesthetic gases. Several adverse health effects have been associated with anaesthetic gas exposure; therefore, this review aims to summarise findings on DNA strand breaks, assessed by the comet assay in leucocytes of exposed medical workers. Standardised mean differences (SMDs) have been calculated by random effects models. The meta-analysis included 16 studies. Of these, 11 showed statistically significant increased levels of DNA strand breaks, whereas another five studies showed no significant effect. Overall, there is an increased level of DNA strand breaks in exposed subjects in unadjusted analysis (SMD = 1.17, 95 % confidence interval: 0.71, 1.62) as well as analysis adjusted for missing studies by the trim-and-fill method (SMD = 0.53, 95 % confidence interval: −0.14, 1.21). In conclusion, this systematic review and meta-analysis demonstrate that exposure to anaesthetic gases in an occupational setting induces primary DNA damage in human leucocytes, warranting further research to minimise any adverse effects on exposed medical personnel. Besides, the relevance of the use of the comet assay in assessing DNA damage in human biomonitoring studies is proven.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108586"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The comet assay as a tool in human biomonitoring exposure to volatile organic compounds – A systematic review and meta-analysis","authors":"Lisa Giovannelli ,&nbsp;Peter Møller ,&nbsp;Goran Gajski ,&nbsp;Helga Stopper ,&nbsp;Amaya Azqueta ,&nbsp;Ezgi Eyluel Bankoglu ,&nbsp;Anja Haveric ,&nbsp;Marko Gerić ,&nbsp;Andrew Collins ,&nbsp;Carina Ladeira","doi":"10.1016/j.mrrev.2025.108584","DOIUrl":"10.1016/j.mrrev.2025.108584","url":null,"abstract":"<div><div>Exposure to volatile organic compounds (VOCs) such as benzene, styrene, toluene and formaldehyde is associated with genotoxicity and increased risk of cancer. In this systematic review and meta-analysis, we have assessed the effects of VOCs exposure on levels of DNA strand breaks in leukocytes, measured by the comet assay, in human biomonitoring studies. The literature search led to 57 studies included in the review. Of these, 50 studies met the criteria to be used in the meta-analysis. Using standardized mean difference and 95 % confidence interval (CI), the meta-analyses show increased levels of DNA strand breaks in subjects exposed to benzene (1.59, 95 % CI: 0.94, 2.24), styrene (0.87, 95 % CI: 0.23, 1.51), formaldehyde (0.39, 95 % CI: −0.15, 0.92) and other organic solvents (2.14, 95 % CI: 1.48, 2.81). Results originate mainly from studies on workers, with only a few studies on environmental benzene exposure. Subgroup analysis indicates that all studies combined from middle-income countries have a higher effect size (1.81, 95 % CI: 1.26, 2.36, n = 28) than studies from high-income countries (0.87, 95 % CI: 0.49, 1.24, n = 22). This difference between middle- and high-income countries may be due to differences in exposure levels or exposure assessment. However, this might not be the only reason, as sensitivity analysis indicates that effect sizes are at risk of comet assay measurement bias, as 78 % (39 out of 50 studies) and 60 % (30 studies) have not reported the use of assay controls and blinded analysis of samples, respectively. Relatively few studies have a high risk of bias due to an inadequate comet assay procedure description (14 %, 7 studies) and exposure misclassification (16 %, 8 studies). Limitations of the study were the differences in protocols, comet descriptors, exposure assessment and control for confounding factors among the studies. In conclusion, this systematic review and meta-analysis shows that exposure to VOCs – benzene, styrene, formaldehyde and others – is associated with increased levels of DNA strand breaks in human leukocytes.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108584"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health effects of ionizing radiation exposure in the brain: MELODI perspectives on potential implications of emerging evidence for radiation protection","authors":"Nobuyuki Hamada ,&nbsp;Marie-Odile Bernier ,&nbsp;Katalin Lumniczky ,&nbsp;Dominique Laurier","doi":"10.1016/j.mrrev.2025.108582","DOIUrl":"10.1016/j.mrrev.2025.108582","url":null,"abstract":"<div><div>There is a growing body of epidemiological evidence for elevated risks of a variety of multifactorial diseases such as cancer, neurodegenerative diseases (e.g., Parkinson’s disease and dementia) and cerebrovascular diseases (e.g., stroke) following radiation exposure of the brain. Implications of available scientific evidence for radiation protection need to be assessed, e.g., in terms of radiation effect classification (tissue reactions vs stochastic effects), dose and dose-rate effectiveness, target identification (at levels of cells, tissues and organs inside/outside the brain) for dose monitoring and risk management, radiation weighting approach for the mixed radiation field, and individual differences in radiation responses (e.g., with sex, age, populations, genetics, epigenetics, comorbidity, co-exposure). On the other hand, whole brain irradiation has clinically been tested to treat neurodegenerative diseases, particularly Alzheimer’s disease. Action of radiation seems to represent a double-edged sword (i.e., detrimental to the healthy brain vs therapeutic to the diseased brain) not only for cancer, but also for non-cancer diseases. Justification of radiation exposure and optimization of radiation protection would therefore be of critical importance. This paper gives a brief overview of emerging evidence for radiation effects in the brain, and considers its potential implications for radiation protection.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108582"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles and clinical implications of N6-methyladenosine in digestive system tumors","authors":"Shixin Luo ,&nbsp;Lusheng Liu ,&nbsp;Min Sun ,&nbsp;Jianwei Wang ,&nbsp;Fangyu Sui ,&nbsp;Miao Zhang ,&nbsp;Xinyu Wu ,&nbsp;Miao Qu","doi":"10.1016/j.mrrev.2026.108588","DOIUrl":"10.1016/j.mrrev.2026.108588","url":null,"abstract":"<div><div>Digestive system tumors such as gastric, colorectal, esophageal, hepatocellular, pancreatic and gallbladder cancers are a huge global health burden, featuring high incidence, high malignancy, difficult early diagnosis and poor prognosis. Identifying novel diagnostic biomarkers and innovative therapeutic interventions has therefore become an urgent clinical need. N6-methyladenosine (m6A) RNA modification is the most prevalent epigenetic mark on eukaryotic mRNAs and plays a key and multifaceted regulatory control role in the pathobiology of a variety of digestive system malignancies mainly through its \"author\", \"eraser\" and \"reader\" proteins. Dysregulation of these m6A regulators and the resulting abnormal m6A are closely related to tumor development and treatment outcomes, M6A critically regulates the pathobiology and therapeutic effects of digestive cancers, and its regulators are expected to be biomarkers and therapeutic targets, and this review helps to guide the diagnosis, treatment and prevention of digestive system tumors in the future.</div></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"797 ","pages":"Article 108588"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}