Impact of resveratrol on neutrophil extracellular traps

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Mutation Research-Reviews in Mutation Research Pub Date : 2025-07-01 DOI:10.1016/j.mrrev.2025.108550

Mahboobeh Ghasemzadeh Rahbardar , Prashant Kesharwani , Amirhossein Sahebkar

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引用次数: 0

Abstract

Neutrophil extracellular traps (NETs) and the process of NETosis have emerged as critical participants in various pathological conditions. Resveratrol, a natural polyphenol found in several plants, has received significant attention due to its potential therapeutic properties. The purpose of this review is to investigate how resveratrol affects NETs and NETosis. The molecular mechanisms underlying NET formation and its role in disease pathogenesis are discussed, highlighting the involvement of various cellular and molecular factors. Moreover, the effects of resveratrol on NET formation, release, and stability are reported, focusing on its potential as a modulator of NET-associated diseases. Studies investigating the effect of resveratrol on NETosis in different disease models, including lung injury, COVID-19, cancer, and hepatic ischemia-reperfusion injury, are also summarized. Furthermore, the potential mechanisms through which resveratrol exerts its effects on NETosis, including anti-inflammatory, antioxidant, and immunomodulatory properties, are elucidated. The review also addresses the challenges and future perspectives in the field, emphasizing the need for further research to fully understand the therapeutic potential of resveratrol in targeting NET-associated disorders. Generally, this review provides a comprehensive analysis of the impact of resveratrol on NETs and NETosis, shedding light on its potential as a therapeutic intervention in various pathological conditions characterized by excessive NET formation. However, further research is essential to clarify the detailed mechanisms through which resveratrol exerts its effects on NETosis and to determine optimal dosages and treatment procedures.

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白藜芦醇对中性粒细胞胞外陷阱的影响

中性粒细胞胞外陷阱（NETs）和NETosis过程已成为各种病理条件下的关键参与者。白藜芦醇是一种在多种植物中发现的天然多酚，由于其潜在的治疗特性而受到广泛关注。本综述的目的是研究白藜芦醇如何影响NETs和NETosis。本文讨论了NET形成的分子机制及其在疾病发病中的作用，强调了各种细胞和分子因素的参与。此外，白藜芦醇对NET形成、释放和稳定性的影响也有报道，重点关注其作为NET相关疾病调节剂的潜力。综述了白藜芦醇在不同疾病模型（包括肺损伤、COVID-19、癌症和肝缺血再灌注损伤）中对NETosis影响的研究。此外，白藜芦醇在NETosis中发挥作用的潜在机制，包括抗炎、抗氧化和免疫调节特性，也得到了阐明。该综述还讨论了该领域的挑战和未来前景，强调需要进一步研究以充分了解白藜芦醇针对net相关疾病的治疗潜力。总的来说，这篇综述全面分析了白藜芦醇对NET和NETosis的影响，揭示了其在以NET过度形成为特征的各种病理条件下作为治疗干预的潜力。然而，需要进一步的研究来阐明白藜芦醇对NETosis作用的详细机制，并确定最佳剂量和治疗程序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.