Neurology Asia最新文献

{"title":"Cerebral venous sinus thrombosis in young children with inflammatory bowel disease: A report of two cases","authors":"Norashikin Mohd Ranai, Kee Seang Chew, Wei Kang Lim, Choong Yi Fong, Limin Li, Ruey Terng Ng, Way Seah Lee","doi":"10.54029/2023nnk","DOIUrl":"https://doi.org/10.54029/2023nnk","url":null,"abstract":"We describe two young children aged 2 and 5-year-old with very early onset inflammatory bowel disease (IBD), who developed focal seizures during an acute flare of disease. Cerebral venous sinus thrombosis (CVST) was confirmed with magnetic resonance imaging and magnetic resonance venography of the brain. CVST is a rare complication of paediatric IBD that can cause significant morbidity and mortality. The important risk factor for CVST in our children was active disease, which exposed them to an increased prothrombic state. Aggressive treatment of IBD resulted in full neurological recovery of our patients and resolution of the CVST. Our case report is the youngest reported age of CVST associated with IBD to date and highlights the need for clinicians to be vigilant for this rare complication, even in young children with IBD.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135638078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early detection of diabetic peripheral neuropathy using EMLA-induced skin wrinkling","authors":"Bennaree Chuesawai, None Suwat Srisuwannanukorn","doi":"10.54029/2023pxr","DOIUrl":"https://doi.org/10.54029/2023pxr","url":null,"abstract":"Background & Objective: Screening for early diabetic peripheral neuropathy (DN) is essential for foot ulcer prevention. The Semmes–Weinstein monofilament (SWMF) is commonly used to detect DN in Thailand. However, SWMF interpretation requires patient participation, which is susceptible to risk of error in patients with impaired cognitive function or uncooperative patients. In contrast, stimulated skin wrinkling (SSW) can be interpreted by trained investigators, which is more appropriate. This study aimed to investigate the utility of SSW using a eutectic mixture of local anesthetic (SSW-EMLA) for early DN diagnosis. Methods: This cross-sectional study, recruited 102 patients with diabetes (DM group), 33 with diabetes with foot ulcer (DN control group), and 30 without diabetes (non-DN control group) from the Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Thailand, from February 3, 2021 to November 30, 2021. SSW was conducted by applying EMLA on the tips of the 2nd, 3rd, and 4th fingers of both hands. SWMF, sensory perception of pain (SPP), vibration perception threshold (VPT), joint position sense (JPS), and deep tendon reflexes (DTR) were also evaluated on the same day. Results: The Interrater agreement of two investigators for SSW-EMLA was high with intraclass correlation coefficients of 0.87 (0.824–0.904) for the right hand and 0.874 (0.830–0.907) for the left hand. The kappa coefficients of agreement of SSW-EMLA for SPP, SWMF, VPT, JPS, and DTR testing were 0.411, 0.478, 0.714, 0.444, and 0.681, respectively. The sensitivity and specificity of SSW-EMLA testing for DN detection were 83.3%, was 85.7%, respectively. Conclusion: The SSW-EMLA test can be considered as an alternative method for DN detection, due to its noninvasiveness, inexpensiveness (50THB), being a simple procedure, high sensitivity and specificity, and acceptable rater variation.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135638079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic kidney disease is an independent risk factor of postoperative seizures after burr hole surgery for chronic subdural hematomas","authors":"Tao Zheng, Nian-Hua Wang, Hai-Bin Leng, Si-Wei Que, None Meng Nie, None Hua Chen, Li-Xin Xu","doi":"10.54029/2023pep","DOIUrl":"https://doi.org/10.54029/2023pep","url":null,"abstract":"Background: Postoperative seizures are serious neurological complications of chronic subdural hematomas (CSDH). The identification of risk factors of seizures after CSDH is needed to determine which patients require antiepileptic prophylaxis. Methods: We retrospectively collected data on patients diagnosed with CSDH from 2015 to 2018. Postoperative seizures are defined as those occurring within 30 days after surgery. Non-hemorrhagic subdural effusion and acute subdural hemorrhage after craniotomy were precluded in the study. We collected data from 221 patients who had burr hole surgery. We retrospectively recorded patient characteristics, hematoma characteristics, symptoms at admission, comorbid conditions, and other related parameters to evaluate the impact of these parameters on postoperative seizures. Results: Postoperative seizures occurred in 16 patients (7.24%). The univariate analysis showed that previous chronic kidney disease (31.25% vs. 5.37%, p= 0.001), age (60.44 vs. 66.54 y, p = 0.029), low Glasgow Coma Score (GCS) at admission (13.69 vs. 14.46, p = 0.015), and preoperative midline shift (9.79 vs. 8.57 mm, p = 0.021) were significantly correlated with postoperative seizures. The multivariate analysis revealed that previous chronic kidney disease (odds ratio [OR] = 27.103; 95% confidence interval [CI] = 4.887-150.296; p < 0.001), younger age (OR = 0.921; 95% CI = 0.866-0.979; p = 0.009) and preoperative midline shift (OR = 1.782; 95% CI = 1.175-2.702; p = 0.007) were independent risk factors of seizures. However, there was no significant difference in GCS at admission. Conclusions: The independent predictors of postoperative seizures in patients with CSDH were preoperative midline shift, chronic kidney disease, and younger age. For younger patients with chronic kidney disease and preoperative midline displacement, we recommend antiepileptic preventive measures during the perioperative period.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophagocytic lymphohistiocytosis associated with sodium valproate","authors":"Xiang-Dong Zeng, Ping Liu, Wen-Guang Hu","doi":"10.54029/2023rzw","DOIUrl":"https://doi.org/10.54029/2023rzw","url":null,"abstract":"Hemophagocytic lymphohistiocytosis(HLH) is known to have numerous causes, such as chronic inflammation, infection, malignancy, drug use, and primary or familial HLH. HLH triggered by valproate (VPA) has rarely been reported in the literature. Here we describe a pediatric patient with HLH induced by VPA. A 5-years-old girl presented to our center with recurrent fever accompanied by diffuse generalized rash after 2 weeks of taking oral VPA. Physical examination revealed hepatosplenomegaly; laboratory findings showed bicytopenia (hemoglobin and platelet), hemophagocytic cells on the bone marrow smear, hypofibrinogenaemia and hypertriglyceridaemia, and a high ferritin level. She was diagnosed to have HLH associated with VPA. She was treated with intravenous immunoglobulin, glucocorticoid and withdrawal of the sodium valproate, and she completely recovered. In conclusion, VPA can trigger HLH, a potentially fatal condition.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rescue treatment with tPA for refractory thromboembolism during stent-assisted coiling of a ruptured intracranial aneurysm: A case report","authors":"Sanghyeon Kim, Myongjin Kang","doi":"10.54029/2023pcj","DOIUrl":"https://doi.org/10.54029/2023pcj","url":null,"abstract":"Thromboembolic complications during stent-assisted coiling of ruptured intracranial aneurysms are major complications that can cause serious neurological deficits. Management strategies include medical thrombolysis, mechanical thrombectomy with suction aspiration or stent retrieval, and rescue stenting. The existing literature suggests that tissue plasminogen activator agents should be used cautiously because of the high risk of severe bleeding at the aneurysm. We present the case of a ruptured anterior communicating artery aneurysm. Acute in-stent thrombosis occurred during the stent-assisted coiling of the aneurysm. Rescue therapy with tirofiban, suction aspiration, and rescue stenting was attempted; however, these methods failed. Finally, tissue plasminogen activator infusion was performed, which successfully dissolved the thrombus and restored blood flow. Follow-up brain computed tomography revealed no increase in hemorrhage volume.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135638088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of treatment durations before Covid-19 pandemic, pre- and post-vaccination periods in acute ischemic stroke patients in a Turkish tertiary hospital","authors":"None Gozde Baran, None Ezgi Vural, None Sema Nur Erdem, None Secil Irmak, None Sena Zeynep Cetin, Ipek Midi","doi":"10.54029/2023pxi","DOIUrl":"https://doi.org/10.54029/2023pxi","url":null,"abstract":"Objective: This study aimed to compare the frequency of admission to hospital in patients with acute ischemic stroke before the COVID 19 pandemic, during the pre-vaccination period, and after the start of vaccination for COVID 19, and to evaluate the time window period between symptom onset to door time, door to CT scan time, door to needle time, and door to puncture time. In addition, it aimed to investigate the effects of the COVID-19 pandemic on the admission, evaluation, and initiation of acute treatment of patients with acute ischemic stroke. Methods: Patients presenting with acute ischemic stroke between March 2019 - December 2019 (pre-pandemic), March 2020 - December 2020 (pre- vaccination pandemic period), and March 2021 - December 2021 (post-vaccination pandemic period) were included in the study. NIHSS was calculated by accordance with the neurological examination findings of the patients, cranial CT for the exclusion of bleeding and CT angiography images for the large vessel occlusions were performed, and the vital signs of the patients were recorded. IV tPA treatment was applied within the first 4.5 hours, and mechanical thrombectomy (MT) was performed in patients with large vessel occlusion. Results: Three hundred nineteen patients were included in the study. The times from symptom onset to emergency admission and from symptom onset to CT scan were found to be similar in all periods. The time from symptom onset to examine by a neurologist was found to be significantly longer in the vaccination period compared to the pandemic period. It was observed that the time from the door to needle time and the time from examine by a neurology doctor to needle time was statistically significantly shorter during the pandemic period (p<0.05). Conclusion: In our study in a tertiary hospital in Turkey, it was determined that the number of patients who was admitted with acute stroke clinic during the pandemic period was similar to other years and there was no delay in the initiation of treatment during the pandemic period. Door to needle times, as well as the time taken by the neurologist to examine and initiate IV-tPA treatment, were found to be shorter in the pre-vaccination pandemic period than in the pre-pandemic and post-vaccination periods.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free vitamin D and vitamin D binding protein in multiple sclerosis patients","authors":"Recep Dönmez, Özlem Kayım Yıldız, Ümit Görgülü","doi":"10.54029/2023hhe","DOIUrl":"https://doi.org/10.54029/2023hhe","url":null,"abstract":"Objective: In multiple sclerosis (MS), where low vitamin D level is a risk factor, there is no previous study evaluating the level of free vitamin D by direct measurement, and there is little information about vitamin D binding protein (DBP). This study assessed free vitamin D and DBP in patients with MS. Methods: The study subjects consisted of 43 MS patients and 25 controls. Free vitamin D and DBP levels were measured through an enzyme-linked immunosorbent (ELISA) kit. Results: The patient group had a mean age of 36.58 ± 9.4 (19-60) and the control group had a mean age of 33.56 ± 9.65 (24-52) years (p=0.210). The patient had free vitamin D level of 21.51 ±9.72 pg/ml and the free vitamin D level of the control group was 26.02 ±9.29 pg/ml. Free vitamin D levels did not significantly differ across the groups (p=0.065). The patient group (34.78 ±18.24 ng/ml) had a significantly higher DBP level than the control group (15.36 ±10.64 ng/ml) (p<0.001). Conclusion: MS patients have higher DBP than healthy control, while the free vitamin D levels of the patients tend to be lower.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of vitamin D levels in children with motor development delay and asthma","authors":"Özge DEDEOGLU, Bahadır KONUŞKAN, Murat CANSEVER, Özlem Yayici Köken","doi":"10.54029/2023npa","DOIUrl":"https://doi.org/10.54029/2023npa","url":null,"abstract":"Background &amp; Objective: Vitamin D plays an important role in musculoskeletal health and is also potentially involved in the pathogenesis of chronic diseases. In this study, we aimed to determine the vitamin D status of children aged 2-6 years with motor developmental delay and compare them with asthmatic children. Method: Serum 25-Hydroxy cholecalciferol 25 (OH) D vitamin levels of children were measured between June 2020 and September 2020. Vitamin D deficiency was defined as a serum 25 (OH) vitamin D level less than 20 ng/mL and insufficiency as levels between 20 and 30 ng/mL. The deficiency and insufficiency rates and mean 25 (OH) vitamin D levels between the two groups were compared. Results: The study population included 818 children (192 children with asthma, 368 children with motor development delay and 258 healthy controls). There was no statistically significant difference between groups in terms of age and gender (p=0.130 and p= 0.082, respectively). Vitamin D deficiency and insufficiency were detected in one thirds of children with motor developmental delay (33.7%; 35.6% respectively). The rate of vitamin D deficiency of children with motor development delay between 24 - 47 months of age was found to be significantly higher than control and asthma group (p=0.001 and p=0.034). Conclusions: Vitamin D deficiency and insufficiency were common between 2-6 years of age children with motor development delay. Acceleration of2 motor development between 24 - 47 months of age may be a cause of high incidence of D vitamin deficiency. Clinicians should check and optimize vitamin D status in children with motor development delay especially between 24 - 47 months of age.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between plaque characteristics and severity of acute ischemic stroke","authors":"None Abhas Kumar, None Pushpendra Nath Renjen, None Harsh Rastogi, None Dinesh Mohan Chaudhari, None Priyal, None Arushee Bhatnagar, None Kamal Ahmad, None Anjali Mishra","doi":"10.54029/2023few","DOIUrl":"https://doi.org/10.54029/2023few","url":null,"abstract":"Background &amp; Objective: Cerebrovascular atherosclerotic disease is the major cause of ischemic stroke and transient ischemia attack (TIA). Atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously. Plaque characteristics are significantly associated with the severity of ischemic stroke. We studied the characteristics of atheromatous plaques in ischemic stroke patients and correlated characteristics of atheromatous plaques with the patient’s National Institute of Health Score (NIHSS) at the time of presentation with ischemic stroke. Methods: We conducted a cross-sectional analysis of 83 in-patient adults presenting with complaints of acute stroke within seven days of stroke. Those who consented were included in the study. The management, investigations and treatment of the cases were according to the hospital’s stroke protocol. An NIHSS score was calculated. MRI brain and MRA/HR-MRI (vessel wall imaging) were done as stroke protocol. The data was analyzed using SPSS 22.0 and R.3.2.0. Results: A total of 83 patients were enrolled, of which 59% were males and 41% were females, with a mean age of 52.8 ± 11.6 years and 54.5 ± 11 years, respectively. The mean NIHSS score, internal carotid artery stenosis, and lumen area of ICA (mm2) for all plaques were statistically significant (p< 0.001). Conclusion: We established a strong association between carotid atherosclerotic plaque characteristics and ischemic stroke severity. We found that a CT scan is better for diagnosing calcified plaques than HR-MRI.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"374 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbance and depressive tendency in bed partners of patients with obstructive sleep apnea","authors":"Chih-Yu Huang, Shao-Yun Wu, Chung-Chieh Yu, Chien-Ming Chu","doi":"10.54029/2023xze","DOIUrl":"https://doi.org/10.54029/2023xze","url":null,"abstract":"Background: Snoring, apnea, and arousal are commonly observed during sleep in patients with obstructive sleep apnea (OSA), and these nocturnal symptoms frequently disturb their bed partners. We aimed to evaluate the sleep disturbance and depressive tendency in the bed partners of patients with OSA. Methods: A cross-sectional, prospective study was conducted. A total of 136 patients with OSA and their bed partners were recruited. We analyzed the demographic data of both patients with OSA and bed partners and the polysomnography parameters of patients with OSA. The sleep quality of bed partners was assessed using the Chinese version of the Pittsburgh Sleep Quality Index (PSQI), and depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale (CES-D). Results: The mean apnea–hypopnea index (AHI) was 43.5/h among all participants. Among bed partners, the mean PSQI score was 7.8 and the mean CES-D score was 15.4. The prevalence of chronic disease was significantly higher in bed partners with sleep disturbance (PSQI > 5) and depressive tendency (CES-D ≥ 16). The AHI and snore index of patients with OSA were not associated with bed partners’ sleep disturbance and depressive tendency respectively. The CES-D score was positively correlated with the PSQI score in the bed partners of patients with OSA (r = 0.426, p < 0.001). Conclusions: Bed partners tended to have sleep disturbance, which was unrelated to the severity of AHI and snoring in patients with OSA. Poor sleep quality may cause depressive tendency and chronic disease in the bed partners of patients with OSA.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136250038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}