MEDS Clinical Medicine最新文献

{"title":"Mechanisms and Research Progress of Type 2 Diabetes Mellitus and Its Hepatic Complications","authors":"","doi":"10.23977/medsc.2023.040514","DOIUrl":"https://doi.org/10.23977/medsc.2023.040514","url":null,"abstract":"Type 2 diabetes (T2DM) is the most common form of diabetes and is a heterogeneous disease that is typically associated with compensatory insulin secretion impairment and insulin resistance. Insulin resistance (IR) is a common pathological feature of metabolic diseases, including obesity, non-alcoholic fatty liver disease (NAFLD), and T2DM, which can reduce the metabolic response of target cells to insulin, leading to impaired ability of circulating or injected insulin to lower blood glucose levels at the whole-body level. This review summarizes the common pathogenic mechanism of T2DM and NAFLD, IR and its concomitant factors, and the current status of traditional Chinese medicine compound therapy, providing a theoretical basis for clinical medicine treatment.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135502131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Research and Applications of Cardiac Organoids","authors":"","doi":"10.23977/medsc.2023.040612","DOIUrl":"https://doi.org/10.23977/medsc.2023.040612","url":null,"abstract":"Cardiovascular disease (CVD) prevalence and mortality have been in an increasing stage globally, which is one of the main causes of death and poses a serious threat to human health. The research related to cardiovascular diseases is mainly based on traditional two-dimensional (2D) cell models and animal models, but due to some limitations, they cannot be fully applied to the research of cardiovascular disease pathogenesis and treatment methods. Organoid technology is a kind of three-dimensional (3D) biological tissue engineering constructed in vitro, which can highly simulate the cellular structure and physiological function of organs in vivo, providing a new direction and idea for the research of cardiovascular diseases. Therefore, cardiac organoid, as an effective complement to traditional cardiovascular disease models, has great potential in the study of disease mechanisms, drug experimentation, regenerative medicine and many other fields. This paper summarizes the construction methods of cardiac organoids and their applications in cardiovascular diseases, and also presents its development prospects, challenges and directions to be improved.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135102838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lynch Syndrome-Associated Colorectal Cancer with Tumor Disappearing after Toripalimab Injection Treatment: A Case Report","authors":"","doi":"10.23977/medsc.2023.040701","DOIUrl":"https://doi.org/10.23977/medsc.2023.040701","url":null,"abstract":"This study aims to investigate the effect of immune checkpoint inhibitors in Lynch syndrome-associated colorectal cancer patients and provide a reference for treatment. A retrospective analysis of a case with multiple recurrences in colorectal cancer. The immune-related adverse effects and effect of Toripalimab Injection treatment is a case series study with a 2-year follow-up. The patient showed stable disease with immunotherapy for ten months. The tumor disappeared along with the download trend of blood tumor marker measurement. The immune-related adverse events were in remission during the treatment and eventually disappeared upon discontinuation of the medication. We believe our report can provide some references for treating this case and treating immune-related adverse reactions.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135260788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of mNGS in the diagnosis and treatment of chlamydia psittaci pneumonia","authors":"","doi":"10.23977/medsc.2023.040615","DOIUrl":"https://doi.org/10.23977/medsc.2023.040615","url":null,"abstract":"Chlamydia psittaci pneumonia is an atypical pathogen pneumonia that ranges in severity from mild to severe with multiple organ failure. Due to the lack of specific clinical features and rapid and simple means of diagnosis, there is a high rate of misdiagnosis and missed diagnosis in clinical work. Therefore, this article reviews the clinical characteristics of chlamydia ptactaci pneumonia patients, the application of mNGS technology in diagnosis and treatment, in order to improve the diagnosis rate of the disease by clinicians for accurate treatment.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135156206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on the Differences in Adverse Reactions and Reorientation Ability between Right Unilateral and Bilateral Electroconvulsive Therapy for Severe Depressive Disorder","authors":"","doi":"10.23977/medsc.2023.040513","DOIUrl":"https://doi.org/10.23977/medsc.2023.040513","url":null,"abstract":"To investigate the difference of repositioning ability between right and bilateral electroconvulsive therapy in patients with major depression. A total of 40 hospitalized patients with severe depression were randomly divided into right unilateral group (n=20) and bilateral group (n=20).On the basis of original drug treatment, right unilateral and bilateral ECT were administered, respectively. The treatment course was set at 3 times a week for a total of 8 sessions (3 times per week in the first 2 weeks and 2 times in the last week). Both groups also took antidepressants. The Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Treatment Emergent Symptom Scale (TESS) and clinical observation of adverse reactions were used to evaluate efficacy and safety. The orientation recovery time was tested using an orientation test to study differences in reorientation ability. The study found that both unilateral and bilateral ECT improved symptoms of major depressive disorder. The reduction time after right spasm is shorter than that after bilateral spasm, and the safety is better.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135502123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Idea of Establishing the Animal Model of Qi Deficiency and Blood Stasis in Chronic Renal Failure from the Perspective of Combining Disease and Syndrome Based on the Quantitative Model","authors":"","doi":"10.23977/medsc.2023.040516","DOIUrl":"https://doi.org/10.23977/medsc.2023.040516","url":null,"abstract":"Based on the animal model of chronic renal failure at the present stage, we used the clinical identification method of integrated Chinese and western medicine, to explore the idea of constructing the syndrome model of Qi deficiency and blood stasis under the mode of combining disease and syndrome. The establishment and evaluation methods of animal models of chronic renal failure in recent years were summarized, and the advantages and disadvantages of different models were compared and analyzed. The establishment methods, anastomosis, reliability and practicability of the model combining disease and syndrome were explored in connection with the clinical symptoms of traditional Chinese and western medicine. Resultly, it was found that the animal model of disease and syndrome combination established at the present stage was only the simple addition of Western medicine disease name and TCM syndrome type, which could not completely simulate the occurrence, development and outcome of TCM syndrome.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135502332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nar Skin Nodositas in Cattle Research on Treatment and Prevention and Control","authors":"","doi":"10.23977/medsc.2023.040605","DOIUrl":"https://doi.org/10.23977/medsc.2023.040605","url":null,"abstract":"Bovine nodular dermatitis is an infectious disease caused by bovine nodular skin virus. The main clinical symptoms are high fever in infected cattle, widespread lumps and nodules on the skin. It is a national second class of infectious disease, decreased milk yield, and irreversible pit and scab on the skin, which seriously affects the production performance of dairy cows. We explore this problem from the perspective of comprehensive prevention and control at the grass-roots level to help prevent and control the disease. Bovine nodular skin dermatitis, also known as bovine nodular skin rash. This disease is characterized by a high fever, nodules of varying sizes on the skin, and a significant decrease in appetite. The high incidence of this disease is mainly caused by mosquitoes, horse flies and other blood-sucking insects, which spread fast and wide range. Once the cattle get sick, it will often cause a large range of infection of the whole cattle and the surrounding cattle.\" In this paper, scientific and reasonable suggestions are put forward to strengthen the prevention and control effect of bovine nodular skin disease, which will play a positive role in promoting the development and construction of animal husbandry.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of anticoagulant therapy on patients with hemorrhagic stroke: a retrospective observational study from eICU database","authors":"","doi":"10.23977/medsc.2023.040614","DOIUrl":"https://doi.org/10.23977/medsc.2023.040614","url":null,"abstract":"The timing and effectiveness of anticoagulant therapy (AT) are controversial in patients with hemorrhagic stroke (HS). We aim to evaluate the potential impact of AT on in-hospital mortality in HS, and how this impact is influenced by the Acute Physiological and Chronic Health Evaluation (APACHE) IV score. We identified individuals with hemorrhagic stroke as the primary diagnosis (n=1654) using individual patient data from a national multicenter cohort study (eICU database; n=200859). With in-hospital mortality as the primary outcome, hemorrhagic stroke patients were split into the anticoagulant therapy group and the other treatment (OT) group. First, univariate and multivariate logistic regression analyses were conducted to identify independent predictors of in-hospital mortality in patients receiving different forms of treatment. Next, the independent predictor's interaction with the AT status was evaluated.Resultly, 8.3%(n=137) of patients were in AT group. The survival rate in the AT group was significantly higher than that in the OT group (87.6% vs. 78.8%; P < 0.05). AT was an independent predictor of in-hospital mortality risk in the entire cohort [OR= 0.542, 95%CI(0.298-0.985), P<0.05], and APACHE IV score [OR= 1.055, 95%CI(1.048-1.061), P<0.05] score was an independent predictor of in-hospital mortality in the OT group in multivariate logistic regression (P< 0.05). The APACHE IV score was used to predict the risk for the entire cohort (the area under the receiver operator characteristic curve was 0.825 [(95% CI (0.799-0.851)]. Patients who started anticoagulant therapy seemed to benefit more when the predicted in-hospital mortality risk was more than 6.9%, and patients without anticoagulant therapy seemed to benefit more when the predicted in-hospital mortality risk was less than 6.9%. In conclusion, patients diagnosed with hemorrhagic stroke benefit from AT. APACHE IV score has a better ability to predict in-hospital mortality risk. Specifically, the higher the predicted risk of in-hospital mortality, the greater the benefits of anticoagulant therapy.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Non-Coding RNA in Amyotrophic Lateral Sclerosis","authors":"","doi":"10.23977/medsc.2023.040519","DOIUrl":"https://doi.org/10.23977/medsc.2023.040519","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron degeneration. It begins to show some muscle abnormalities, and eventually it is usually due to respiratory muscle atrophy leading to ventilatory dysfunction death. The prevalence of male is higher than that of female, which is divided into sporadic and familial types. At present, only two drugs can be used for treatment. Therefore, it is urgent to find biomarkers that can diagnose ALS or predict the progression of ALS. Studies have shown that miRNA in non-coding RNA as biomarkers can reflect disease progression or disease severity or diagnosis. This review aims to describe the detection of non-coding RNAs in blood or cerebrospinal.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135502128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Petroleum Ether Extract from Rhizoma Amorphophalli (SLG) on Proliferation and Apoptosis of Non-small Cell Lung Cancer A549 Cells","authors":"","doi":"10.23977/medsc.2023.040706","DOIUrl":"https://doi.org/10.23977/medsc.2023.040706","url":null,"abstract":"Lung cancer has become one of the cancers that seriously threaten human life, with the highest morbidity and mortality in all countries of the world. At present, the treatment of lung cancer is mainly based on surgery, adjuvant chemotherapy and radiotherapy, but these treatments have adverse consequences for the prognosis and quality of life of patients with lung cancer. With the development of traditional Chinese medicine technology, traditional Chinese medicine and traditional Chinese medicine compound have achieved good clinical efficacy in the treatment of lung cancer. The traditional Chinese medicine Sheliugu has the effect of clearing heat and detoxifying, dispersing and detumescence, and the clinical curative effect is remarkable. In this paper, lung cancer A549 cells were used as the research object to explore the effect of petroleum ether extract of traditional Chinese medicine Heliugu on the proliferation and apoptosis of lung cancer A549 cells.","PeriodicalId":497271,"journal":{"name":"MEDS Clinical Medicine","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135446839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}