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Perinatal Substance Use and the Documentation of Stigmatizing Language in Clinical Notes. 围产期药物使用与临床记录中污名化语言的记录。
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-03-20 DOI: 10.1097/NNR.0000000000000907
Sarah E Harkins, Ismael Ibrahim Hulchafo, Arielle K Hazi, Jihye Kim Scroggins, Marianne Sharko, Maxim Topaz, Veronica Barcelona
{"title":"Perinatal Substance Use and the Documentation of Stigmatizing Language in Clinical Notes.","authors":"Sarah E Harkins, Ismael Ibrahim Hulchafo, Arielle K Hazi, Jihye Kim Scroggins, Marianne Sharko, Maxim Topaz, Veronica Barcelona","doi":"10.1097/NNR.0000000000000907","DOIUrl":"10.1097/NNR.0000000000000907","url":null,"abstract":"<p><strong>Background: </strong>Patients with substance use disorders (SUD) experience bias from clinicians when receiving pregnancy care. Stigmatizing language documented in electronic health records is a marker of clinician bias and it can reinforce inequitable care practices.</p><p><strong>Objective: </strong>The purpose of this study was to examine the associations between substance use and stigmatizing language documented in clinical notes from the birth hospitalization.</p><p><strong>Methods: </strong>This was a cross-sectional study of electronic health record data from patients 20 weeks of gestation admitted to labor and birth at two urban hospitals between 2017 and 2019 ( N =19,094). We identified patients with SUD through ICD-10 codes and natural language processing (NLP)-based keyword searches. We employed an NLP algorithm to identify four categories of stigmatizing language in clinical narratives. We conducted multivariable logistic regression and calculated adjusted odds ratios and 95% confidence intervals for each stigmatizing language category.</p><p><strong>Results: </strong>Approximately 1.5% of patients had a documented SUD. Patients with SUD had higher odds of any stigmatizing language compared with patients without SUD. Patients with SUD also had higher odds of language representing marginalized language/identities and difficult patient categories. There were no significant differences in the unilateral/authoritarian language category between patients with and without SUD.</p><p><strong>Discussion: </strong>Patients with SUD were more likely to have stigmatizing language documented by clinicians during labor and birth. Findings underscore the need for clinician training on person-centered language and the implementation of abolitionist approaches to reduce the stigmatization of patients with SUD.</p>","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":" ","pages":"249-257"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiometabolic Disease in Rural Southeastern Communities. 东南农村社区的心脏代谢疾病
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-02-16 DOI: 10.1097/NNR.0000000000000899
Christopher M Smith, Carolyn E Horne, Brittany Butts
{"title":"Cardiometabolic Disease in Rural Southeastern Communities.","authors":"Christopher M Smith, Carolyn E Horne, Brittany Butts","doi":"10.1097/NNR.0000000000000899","DOIUrl":"10.1097/NNR.0000000000000899","url":null,"abstract":"<p><strong>Background: </strong>Cardiometabolic disease disproportionately affects rural communities, but early behavioral and physiological risk indicators are understudied in these populations.</p><p><strong>Objectives: </strong>The aim of this study was to characterize cardiometabolic health in a rural southeastern U.S. community. Primary objectives included assessing the prevalence of blood pressure and glycemic alterations and examining associations between modifiable factors such as sleep, nutrition, and educational attainment. A secondary objective was to assess community interest in future hypertension research.</p><p><strong>Methods: </strong>A cross-sectional study was conducted during a nurse-led community health screening event at a rural street festival. Participants were recruited using nonprobability convenience sampling and completed structured surveys and clinical screenings. Regression models evaluated relationships between predictors and blood pressure outcomes. Moderation analyses evaluated the role of sex.</p><p><strong>Results: </strong>Participants with high school education had significantly higher SBP and MAP readings compared with those with bachelor's degrees. Sleeping ≤6 hours predicted higher SBP, MAP, and glucose. Younger adults exhibited significantly higher BP levels across all models. The effects of education and sleep on BP were considerably stronger among men, but women exhibited higher BP across models, which was a reversal of typical epidemiological patterns.</p><p><strong>Discussion: </strong>Modifiable factors such as education and sleep were associated with early cardiometabolic risk in rural communities. Findings support biobehavioral models integrating metabolic, inflammatory, and behavioral indicators for early risk detection, especially in younger ages. Nurses are well-positioned to lead interdisciplinary initiatives addressing cardiometabolic risk in rural communities. Future studies should prioritize scalable prevention strategies targeting young adults before clinical disease emerges.</p>","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":" ","pages":"258-267"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Client Priorities for Improving PrEP and doxy-PEP Awareness, Uptake, and Persistence in Primary Care. 提高初级保健中PrEP和doxy-PEP意识、吸收和坚持的客户优先事项。
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-02-16 DOI: 10.1097/NNR.0000000000000898
Nate Albright, Kayla Herbell, Ethan Morgan, Brittany Punches, Dianne Morrison-Beedy
{"title":"Client Priorities for Improving PrEP and doxy-PEP Awareness, Uptake, and Persistence in Primary Care.","authors":"Nate Albright, Kayla Herbell, Ethan Morgan, Brittany Punches, Dianne Morrison-Beedy","doi":"10.1097/NNR.0000000000000898","DOIUrl":"10.1097/NNR.0000000000000898","url":null,"abstract":"<p><strong>Background: </strong>Sexual and gender minorities (SGMs) remain disproportionately affected by HIV and bacterial sexually transmitted infections (STIs). Despite the efficacy of pre-exposure prophylaxis (PrEP) for HIV prevention and the emerging promise of doxycycline post-exposure prophylaxis (doxy-PEP) for STI prevention, awareness, uptake, and persistence remain limited.</p><p><strong>Objectives: </strong>In this qualitative, we study explored client perspectives on barriers and facilitators influencing the use of same-day PrEP and doxy-PEP to inform strategies for broader implementation in primary care. Informed by the stages of the PrEP Care Continuum and the levels of the SGM Health Disparities Framework, we sought to better understand the barriers and facilitators at each stage of the clinical continuum (i.e., awareness, uptake, and persistence) and at various levels of influence (i.e., individual, interpersonal, community, and societal).</p><p><strong>Methods: </strong>Four virtual focus groups with 26 SGM clients with experience using PrEP and/or doxy-PEP were conducted. Data were analyzed using deductive thematic analysis guided by the PrEP Care Continuum and the SGM Framework.</p><p><strong>Results: </strong>Consistent barriers to uptake and persistence exist, including health care access, cost, stigma, and discriminatory clinical encounters. Participants highlighted the burden of the current medical model, which involves multiple procedural steps and frequent health care visits. Facilitators included community support, targeted social media messaging, and affirming providers. Notably, participants drew motivation from historical and communal narratives, including the legacy of the HIV/AIDS epidemic, and emphasized the need for visible public and political support for biomedical prevention.</p><p><strong>Discussion: </strong>The results underscore the importance of integrating client-informed approaches to improve biomedical prevention delivery. To advance HIV and STI prevention among SGMs, there is a critical need for culturally tailored education to support increasing awareness and flexible clinical models to support the uptake and persistence in care. PrEP and doxy-PEP are vital, synergistic tools that require coordinated strategies in primary care, to expand access and address persistent health disparities and end the HIV and STI epidemics.</p>","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":" ","pages":"277-286"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Bibliometric Mapping of Nurses' Working Environment From 1997 to 2024. 1997 - 2024年全球护士工作环境文献计量测绘。
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-03-16 DOI: 10.1097/NNR.0000000000000905
Menevse Yildirim
{"title":"Global Bibliometric Mapping of Nurses' Working Environment From 1997 to 2024.","authors":"Menevse Yildirim","doi":"10.1097/NNR.0000000000000905","DOIUrl":"10.1097/NNR.0000000000000905","url":null,"abstract":"<p><strong>Background: </strong>Interest in exploring and improving nurses' work environments has increased globally. Nevertheless, a comprehensive evaluation of the research, concepts, and trends in this field is lacking.</p><p><strong>Objective: </strong>To examine the patterns, characteristics, trends, and development of studies conducted to date on nurses' working environment.</p><p><strong>Methods: </strong>A retrospective descriptive analysis. The data obtained from the Web of Science (WoS) database on March 28, 2024, were analyzed bibliometrically. The keywords \"nurse work environment,\" \"nurse workplaces,\" and\" nurse work setting\" were used; articles published between 1997 and 2024 were included. Data analysis was performed using VOSviewer and MS Excel.</p><p><strong>Results: </strong>A total of 1,218 authors from 617 institutions across 47 countries and 67 journals contributed to articles on nurses' working environment during the years included in the analysis; 835 keywords were used. The authors who contributed the most documents and have a wide network of connections are Aiken and Patrician, while the most cited author is Laschinger. Although the University of Pennsylvania has the highest number of publications and the widest network, the University of Western Ontario is the institution with the most citations. The United States ranked first among countries with 173 publications and a total link strength of 28. The keyword with the highest total link strength and the most frequently used keyword was work environment. The prominent journals are International Journal of Nursing Studies , Journal of Nursing Management , and Nursing Research .</p><p><strong>Discussion: </strong>Since the 2000s, studies on the working environment of nurses have increased. While many researchers have contributed to this topic, advancements in sustainability have been limited following the initial publications. This analysis provides a reference for nurses, nurse managers, researchers, and policymakers to recognize and disseminate developments and trends related to nurses' working environment by summarizing the trends of macro-level studies on the working environment. By clarifying the global situation, all stakeholders interested in and committed to the issue can establish new collaborations.</p>","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":" ","pages":"E225-E230"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recruitment and Retention of Patients With Ischemic Heart Disease Reporting Hopelessness in a Randomized Controlled Trial. 在一项随机对照试验中报告绝望的缺血性心脏病患者的招募和保留
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-02-18 DOI: 10.1097/NNR.0000000000000896
Madison P Goodyke, Anna Davis, Eleanor Rivera, Nathan Tintle, Heather Pauls Hrynyk, Susan L Dunn
{"title":"Recruitment and Retention of Patients With Ischemic Heart Disease Reporting Hopelessness in a Randomized Controlled Trial.","authors":"Madison P Goodyke, Anna Davis, Eleanor Rivera, Nathan Tintle, Heather Pauls Hrynyk, Susan L Dunn","doi":"10.1097/NNR.0000000000000896","DOIUrl":"10.1097/NNR.0000000000000896","url":null,"abstract":"<p><strong>Background: </strong>Identifying effective methods to recruit and retain participants in research is imperative to maximize the generalizability of findings and reduce bias in interventional studies. Historically, studies of hopelessness, defined as a negative outlook and sense of helplessness about the future, have struggled with both recruitment and retention.</p><p><strong>Objective: </strong>The purpose of this paper is to describe strategies utilized for recruitment and retention, and quantify their results, in a randomized controlled trial (RCT; Heart Up!) that enrolled participants with ischemic heart disease (IHD) who reported moderate to severe hopelessness.</p><p><strong>Methods: </strong>At a single U.S. hospital, 681 patients with IHD were screened for state hopelessness using the Dunn State-Trait Hopelessness Scale. Of the 279 eligible for the study, 224 participants chose to enroll (80.2%) in the RCT. Analysis for this paper focused on recruitment and retention results and associated strategies.</p><p><strong>Results: </strong>Of the 224 enrolled, 66 reconsidered study participation before baseline data collection and 27 of the remaining 158 dropped out between the baseline and final 6-month follow-up time point.</p><p><strong>Discussion: </strong>Successful recruitment strategies included regularly meeting with study recruiters to promote fidelity of enrollment strategies, discussing progress towards goals, and identifying the optimal time frame to meet with hospitalized patients to discuss the study. Successful retention strategies included building rapport with both participants and research staff, responding quickly and thoroughly to participant feedback, and consistently meeting with interventionists and data collectors to ensure study fidelity, troubleshoot challenges, and provide encouragement. The results reinforce that individuals reporting moderate to severe hopelessness require ample time from study staff at enrollment and throughout the study. Future researchers should consider expanding the recruitment timeline to reduce attrition between enrollment and first data collection visit.</p>","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":" ","pages":"306-315"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ENRS President's Message. ENRS总裁致辞。
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-06-25 DOI: 10.1097/NNR.0000000000000926
{"title":"ENRS President's Message.","authors":"","doi":"10.1097/NNR.0000000000000926","DOIUrl":"https://doi.org/10.1097/NNR.0000000000000926","url":null,"abstract":"","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":"75 4","pages":"331"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theory in Science. 科学理论。
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-02-05 DOI: 10.1097/NNR.0000000000000895
Rita H Pickler
{"title":"Theory in Science.","authors":"Rita H Pickler","doi":"10.1097/NNR.0000000000000895","DOIUrl":"https://doi.org/10.1097/NNR.0000000000000895","url":null,"abstract":"","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":"75 4","pages":"247-248"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and Acceptability of Remote Hair Sample Collection in Parent-Child Dyads. 亲子二联体远程毛发采集的可行性和可接受性。
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-02-03 DOI: 10.1097/NNR.0000000000000892
Tsui-Sui Annie Kao, Jiying Ling
{"title":"Feasibility and Acceptability of Remote Hair Sample Collection in Parent-Child Dyads.","authors":"Tsui-Sui Annie Kao, Jiying Ling","doi":"10.1097/NNR.0000000000000892","DOIUrl":"10.1097/NNR.0000000000000892","url":null,"abstract":"<p><strong>Background: </strong>Chronic stress contributes to adverse health outcomes and may be transmitted intergenerationally. Hair cortisol concentration is a noninvasive biomarker of chronic stress; yet the feasibility and acceptability of optional remote collection in rural families remains unclear.</p><p><strong>Objectives: </strong>We evaluated the feasibility and acceptability of remote hair sample collection, identified factors associated with hair sample completion, and assessed the preliminary effects of a family-centered, mindfulness-based, motivational interviewing intervention on hair cortisol concentration.</p><p><strong>Methods: </strong>In this pilot randomized trial, 46 rural parent-child dyads were assigned to either a remote mindfulness meditation-based motivational interviewing intervention or an active control. Hair sample collection was optional at baseline and post-intervention. Families opting in received mailed kits with written/video instructions, optional Zoom support, and a $40 incentive. Descriptive and exploratory analyses assessed participation patterns and associations with demographic and behavioral characteristics.</p><p><strong>Results: </strong>Of 46 families, 36 (78%) consented to hair collection; 24 (67%) returned baseline samples, and 12 (50%) returned post-intervention samples. The average turnaround from mailing to receipt was 14 days. Participants rated instructions as clear and helpful; no families used Zoom assistance. Demographics were not significantly associated with completion, though trends indicated lower return rates among minority and full-time employed parents. At baseline, noncompleters reported higher physical activity and greater child sugary beverage intake. Nonsignificant trends also suggested that completers had more depressive symptoms and greater body fat percentage compared with noncompleters. No significant intervention effects on HCC were observed.</p><p><strong>Discussions: </strong>Optional remote HCC collection is feasible and acceptable among many rural families, though retention declined over time. Future studies should investigate strategies to reduce barriers and promote sustained engagement when biospecimen submission is voluntary.</p>","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":" ","pages":"316-321"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of Vaccine-Hesitant and Nonhesitant Parents in Italy: A Cross-Sectional Study. 意大利疫苗犹豫和非犹豫父母的特征:一项横断面研究
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-02-09 DOI: 10.1097/NNR.0000000000000890
Camilla Elena Magi, Andrea Poliani, Alessia Campoli, Ilaria Marcomini, Giulia Villa, Stefano Bambi, Laura Rasero, Paolo Iovino, Yari Longobucco
{"title":"Characteristics of Vaccine-Hesitant and Nonhesitant Parents in Italy: A Cross-Sectional Study.","authors":"Camilla Elena Magi, Andrea Poliani, Alessia Campoli, Ilaria Marcomini, Giulia Villa, Stefano Bambi, Laura Rasero, Paolo Iovino, Yari Longobucco","doi":"10.1097/NNR.0000000000000890","DOIUrl":"10.1097/NNR.0000000000000890","url":null,"abstract":"<p><strong>Background: </strong>Vaccine hesitancy remains a significant public health challenge, even in countries with high vaccination coverage, such as Italy. Understanding the sociodemographic, informational, and psychological characteristics associated with hesitancy is essential for designing effective, targeted interventions.</p><p><strong>Objective: </strong>To describe and compare the sociodemographic, behavioral, informational, and psychological profiles of vaccine-hesitant and non-hesitant Italian parents.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted between October 2024 and February 2025 using an anonymous online survey distributed through social media and parenting websites. Eligible participants were parents or legal guardians of children aged 0-18 years, residing in Italy. Vaccine hesitancy was assessed using the Parent Attitudes about Childhood Vaccines short form (PACV-5), alongside validated measures of health literacy (HLS-EU-Q6), vaccine literacy (HLVa-IT), adult vaccine hesitancy (aVHS), vaccine confidence (VCI), and parental health locus of control (PHLOC). Descriptive and bivariate analyses were performed to examine the differences between hesitant and nonhesitant parents.</p><p><strong>Results: </strong>Of the 308 participants, 13% were classified as vaccine-hesitant. Hesitancy was significantly associated with lower educational attainment, absence of a health care background, reliance on television and health assistants for vaccine information, lower health and vaccine literacy, lower vaccine confidence, and higher scores in the Fate subscale of the Chance domain and the Child subscale of the Internal domain of the Health Locus. A total of 89.94% of parents reported full adherence to vaccination schedules, yet hesitant parents were more likely to partially vaccinate their children and express selective vaccination intentions. Discrepancies between past vaccination behavior and future intentions were observed, suggesting that hesitancy is dynamic and potentially unstable.</p><p><strong>Discussion: </strong>Vaccine hesitancy among Italian parents is associated with low health literacy and confidence levels, distinct health beliefs, and specific information-seeking patterns. These findings suggest public health efforts should include trust-building approaches that address cognitive skills, fatalistic beliefs, and preferred communication channels. Longitudinal research is necessary to monitor changes in parental attitudes and to guide adaptive intervention strategies.</p>","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":" ","pages":"E216-E224"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep and Cognitive Health Interventions to Prevent Cognitive Decline in Older Adult Survivors of Critical Illness: Randomized Clinical Trial Protocol. 睡眠和认知健康干预预防老年危重疾病幸存者认知能力下降:随机临床试验方案
IF 2.5 4区 医学
Nursing Research Pub Date : 2026-07-01 Epub Date: 2026-04-28 DOI: 10.1097/NNR.0000000000000912
Maya N Elias, Hilaire J Thompson, Erin K Kross, Nancy R Temkin, Babar A Khan, Phyllis C Zee, Cindy L Munro
{"title":"Sleep and Cognitive Health Interventions to Prevent Cognitive Decline in Older Adult Survivors of Critical Illness: Randomized Clinical Trial Protocol.","authors":"Maya N Elias, Hilaire J Thompson, Erin K Kross, Nancy R Temkin, Babar A Khan, Phyllis C Zee, Cindy L Munro","doi":"10.1097/NNR.0000000000000912","DOIUrl":"10.1097/NNR.0000000000000912","url":null,"abstract":"<p><strong>Background: </strong>Older adults frequently experience acute and long-term cognitive impairment following critical illness hospitalization in an intensive care unit (ICU). Delirium affects up to 80% of ICU patients and is linked to cognitive dysfunction and increased risk of cognitive decline associated with Alzheimer's disease and related dementias (ADRD). Sleep and circadian rhythm disturbances are present in about 75%-80% of ICU patients and may exacerbate delirium and undermine cognitive interventions. Nonpharmacological interventions such as earplugs, eye masks, and computerized cognitive training show promise in reducing delirium and improving sleep but have not been rigorously tested-separately or combined-in older adult ICU survivors. Moreover, prior studies have not leveraged chronotherapeutic timing to align cognitive training with individual circadian rhythms.</p><p><strong>Objectives: </strong>We propose a multimodal combination of sleep promotion intervention [SLEEP] and computerized cognitive training program timed daily according to individual chronotype [COG], to improve cognitive function in hospitalized older adult ICU survivors. The primary aim is to test the feasibility, acceptability, and preliminary separate and combined effects of SLEEP and COG [SLEEP, COG, SLEEP+COG] versus an active control condition [AC] in improving cognitive function after the intervention period. The secondary aims are to explore (1) circadian rhythm parameters of continuous body temperature to determine the optimal window for chronotherapeutic timing of cognitive interventions; (2) if the effects of each intervention on cognitive function are mediated by sleep and activity; (3) if biopsychosocial and clinical factors moderate the effects of each intervention on cognitive function; and (4) the effects of each intervention on cognitive function at 1, 6, and 12 months.</p><p><strong>Methods: </strong>After discharge from ICU, English- or Spanish-speaking older adult ICU survivors ( n =100) are randomly assigned to 7 days of (1) SLEEP, (2) COG, (3) SLEEP+COG, or (4) AC. Cognitive function, delirium severity, sleep and circadian rhythms, patient-reported symptoms, and data regarding biopsychosocial and clinical factors are collected.</p><p><strong>Results: </strong>Results are pending study completion.</p><p><strong>Discussion: </strong>We aim to target sleep and circadian rhythm disturbances, mitigate ICU delirium, and reduce cognitive decline associated with ADRD. If hypotheses are supported, this combination of low-cost, nonpharmacological interventions could be integrated into standard care to accelerate cognitive recovery during hospitalization.</p>","PeriodicalId":49723,"journal":{"name":"Nursing Research","volume":" ","pages":"322-330"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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