Reviews in the Neurosciences最新文献_第9页

Empowering brain cancer diagnosis: harnessing artificial intelligence for advanced imaging insights. 增强脑癌诊断能力：利用人工智能获得先进的成像见解。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-01-30 Print Date: 2024-06-25 DOI: 10.1515/revneuro-2023-0115

Omar S Al-Kadi, Roa'a Al-Emaryeen, Sara Al-Nahhas, Isra'a Almallahi, Ruba Braik, Waleed Mahafza

引用次数: 0

Diversity of amyloid beta peptide actions. 淀粉样β肽作用的多样性。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-01-29 Print Date: 2024-06-25 DOI: 10.1515/revneuro-2023-0100

Sona Mardanyan, Svetlana Sharoyan, Alvard Antonyan

{"title":"Diversity of amyloid beta peptide actions.","authors":"Sona Mardanyan, Svetlana Sharoyan, Alvard Antonyan","doi":"10.1515/revneuro-2023-0100","DOIUrl":"10.1515/revneuro-2023-0100","url":null,"abstract":"Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number of incurable diseases. One of the most known amyloid diseases is Alzheimer's disease (AD). Traditionally, amyloidogenic beta peptides Aβ40 and Aβ42 (Aβs) are considered as main causes of AD and the foremost targets in AD fight. The main efforts in pharmacology are aimed at reducing Aβs concentration to prevent their accumulation, aggregation, formation of senile plaques, neuronal death, and neurodegeneration. However, a number of publications have demonstrated certain beneficial physiological effects of Aβs. Simultaneously, it is indicated that the effects of Aβs turn into pathological due to the development of certain diseases in the body. The accumulation of C- and N-terminal truncated Aβs under diverse conditions is supposed to play a role in AD development. The significance of transformation of glutamate residue at positions 3 or 11 of Aβs catalyzed by glutaminyl cyclase making them more degradation resistant, hydrophobic, and prone to aggregation, as well as the participation of dipeptidyl peptidase IV in these transformations are discussed. The experimental data presented confirm the maintenance of physiological, nonaggregated state of Aβs by plant preparations. In conclusion, this review suggests that in the fight against AD, instead of removing Aβs, preference should be given to the treatment of common diseases. Glutaminyl cyclase and dipeptidyl peptidase IV can be considered as targets in AD treatment. Flavonoids and plant preparations that possess antiamyloidogenic propensity are proposed as beneficial neuroprotective, anticancer, and antidiabetic food additives.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"387-398"},"PeriodicalIF":3.4,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving frontiers: endovascular strategies for the treatment of delayed cerebral ischemia. 不断发展的前沿：治疗迟发性脑缺血的血管内治疗策略。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-01-25 Print Date: 2024-06-25 DOI: 10.1515/revneuro-2023-0148

David-Dimitris Chlorogiannis, Athina-Maria Aloizou, Theodoros Mavridis, Jonathan Andreas Sänger, Anargyros Chlorogiannis, Nikolaos Madouros, Panagiotis Papanagiotou

引用次数: 0

Oxidative stress involvement in the molecular pathogenesis and progression of multiple sclerosis: a literature review. 氧化应激参与多发性硬化症的分子发病机制和进展：文献综述。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-01-02 Print Date: 2024-04-25 DOI: 10.1515/revneuro-2023-0091

Alfredo Sanabria-Castro, Alberto Alape-Girón, Marietta Flores-Díaz, Ann Echeverri-McCandless, Alexander Parajeles-Vindas

{"title":"Oxidative stress involvement in the molecular pathogenesis and progression of multiple sclerosis: a literature review.","authors":"Alfredo Sanabria-Castro, Alberto Alape-Girón, Marietta Flores-Díaz, Ann Echeverri-McCandless, Alexander Parajeles-Vindas","doi":"10.1515/revneuro-2023-0091","DOIUrl":"10.1515/revneuro-2023-0091","url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune debilitating disease of the central nervous system caused by a mosaic of interactions between genetic predisposition and environmental factors. The pathological hallmarks of MS are chronic inflammation, demyelination, and neurodegeneration. Oxidative stress, a state of imbalance between the production of reactive species and antioxidant defense mechanisms, is considered one of the key contributors in the pathophysiology of MS. This review is a comprehensive overview of the cellular and molecular mechanisms by which oxidant species contribute to the initiation and progression of MS including mitochondrial dysfunction, disruption of various signaling pathways, and autoimmune response activation. The detrimental effects of oxidative stress on neurons, oligodendrocytes, and astrocytes, as well as the role of oxidants in promoting and perpetuating inflammation, demyelination, and axonal damage, are discussed. Finally, this review also points out the therapeutic potential of various synthetic antioxidants that must be evaluated in clinical trials in patients with MS.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"355-371"},"PeriodicalIF":3.4,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vestibular function is associated with immune inflammatory response 前庭功能与免疫炎症反应有关

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-30 DOI: 10.1515/revneuro-2023-0114

Zhaohui Song, Yuchuan Ding, Nathan Sim, Ho Jun Yun, Jing Feng, Pan Gu, Xiaokun Geng

引用次数: 0

Exploring the latest findings on endovascular treatments for giant aneurysms: a review 探索巨型动脉瘤血管内治疗的最新发现：综述

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-30 DOI: 10.1515/revneuro-2023-0082

David-Dimitris Chlorogiannis, Athina-Maria Aloizou, Anargyros Chlorogiannis, Nefeli Kosta, Jonathan Andreas Sänger, Achilles Chatziioannou, Panagiotis Papanagiotou

引用次数: 0

Studying the Alzheimer’s disease continuum using EEG and fMRI in single-modality and multi-modality settings 在单模态和多模态环境下使用脑电图和 fMRI 研究阿尔茨海默病的连续性

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-29 DOI: 10.1515/revneuro-2023-0098

Jing Li, Xin Li, Futao Chen, Weiping Li, Jiu Chen, Bing Zhang

{"title":"Studying the Alzheimer’s disease continuum using EEG and fMRI in single-modality and multi-modality settings","authors":"Jing Li, Xin Li, Futao Chen, Weiping Li, Jiu Chen, Bing Zhang","doi":"10.1515/revneuro-2023-0098","DOIUrl":"https://doi.org/10.1515/revneuro-2023-0098","url":null,"abstract":"Alzheimer’s disease (AD) is a biological, clinical continuum that covers the preclinical, prodromal, and clinical phases of the disease. Early diagnosis and identification of the stages of Alzheimer’s disease (AD) are crucial in clinical practice. Ideally, biomarkers should reflect the underlying process (pathological or otherwise), be reproducible and non-invasive, and allow repeated measurements over time. However, the currently known biomarkers for AD are not suitable for differentiating the stages and predicting the trajectory of disease progression. Some objective parameters extracted using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are widely applied to diagnose the stages of the AD continuum. While electroencephalography (EEG) has a high temporal resolution, fMRI has a high spatial resolution. Combined EEG and fMRI (EEG–fMRI) can overcome single-modality drawbacks and obtain multi-dimensional information simultaneously, and it can help explore the hemodynamic changes associated with the neural oscillations that occur during information processing. This technique has been used in the cognitive field in recent years. This review focuses on the different techniques available for studying the AD continuum, including EEG and fMRI in single-modality and multi-modality settings, and the possible future directions of AD diagnosis using EEG–fMRI.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"51 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139071239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of retinal light damage models for preclinical studies on age-related macular degeneration: identifying molecular hallmarks and therapeutic targets. 用于老年性黄斑变性临床前研究的视网膜光损伤模型概述：确定分子标志和治疗目标。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-29 Print Date: 2024-04-25 DOI: 10.1515/revneuro-2023-0130

Giulia Carozza, Darin Zerti, Annamaria Tisi, Marco Ciancaglini, Mauro Maccarrone, Rita Maccarone

{"title":"An overview of retinal light damage models for preclinical studies on age-related macular degeneration: identifying molecular hallmarks and therapeutic targets.","authors":"Giulia Carozza, Darin Zerti, Annamaria Tisi, Marco Ciancaglini, Mauro Maccarrone, Rita Maccarone","doi":"10.1515/revneuro-2023-0130","DOIUrl":"10.1515/revneuro-2023-0130","url":null,"abstract":"Age-related macular degeneration (AMD) is a complex, multifactorial disease leading to progressive and irreversible retinal degeneration, whose pathogenesis has not been fully elucidated yet. Due to the complexity and to the multiple features of the disease, many efforts have been made to develop animal models which faithfully reproduce the overall AMD hallmarks or that are able to mimic the different AMD stages. In this context, light damage (LD) rodent models of AMD represent a suitable and reliable approach to mimic the different AMD forms (dry, wet and geographic atrophy) while maintaining the time-dependent progression of the disease. In this review, we comprehensively reported how the LD paradigms reproduce the main features of human AMD. We discuss the capability of these models to broaden the knowledge in AMD research, with a focus on the mechanisms and the molecular hallmarks underlying the pathogenesis of the disease. We also critically revise the remaining challenges and future directions for the use of LD models.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"303-330"},"PeriodicalIF":3.4,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxic ischemic brain injury: animal models reveal new mechanisms of melatonin-mediated neuroprotection. 缺氧缺血性脑损伤：动物模型揭示了褪黑激素介导的神经保护新机制。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-29 Print Date: 2024-04-25 DOI: 10.1515/revneuro-2023-0126

Serafina Perrone, Silvia Carloni, Valentina Giovanna Dell'Orto, Laura Filonzi, Virginia Beretta, Chiara Petrolini, Chiara Lembo, Giuseppe Buonocore, Susanna Esposito, Francesco Nonnis Marzano

{"title":"Hypoxic ischemic brain injury: animal models reveal new mechanisms of melatonin-mediated neuroprotection.","authors":"Serafina Perrone, Silvia Carloni, Valentina Giovanna Dell'Orto, Laura Filonzi, Virginia Beretta, Chiara Petrolini, Chiara Lembo, Giuseppe Buonocore, Susanna Esposito, Francesco Nonnis Marzano","doi":"10.1515/revneuro-2023-0126","DOIUrl":"10.1515/revneuro-2023-0126","url":null,"abstract":"Oxidative stress (OS) and inflammation play a key role in the development of hypoxic-ischemic (H-I) induced brain damage. Following H-I, rapid neuronal death occurs during the acute phase of inflammation, and activation of the oxidant-antioxidant system contributes to the brain damage by activated microglia. So far, in an animal model of perinatal H-I, it was showed that neuroprostanes are present in all brain damaged areas, including the cerebral cortex, hippocampus and striatum. Based on the interplay between inflammation and OS, it was demonstrated in the same model that inflammation reduced brain sirtuin-1 expression and affected the expression of specific miRNAs. Moreover, through proteomic approach, an increased expression of genes and proteins in cerebral cortex synaptosomes has been revealed after induction of neonatal H-I. Administration of melatonin in the experimental treatment of brain damage and neurodegenerative diseases has produced promising therapeutic results. Melatonin protects against OS, contributes to reduce the generation of pro-inflammatory factors and promotes tissue regeneration and repair. Starting from the above cited aspects, this educational review aims to discuss the inflammatory and OS main pathways in H-I brain injury, focusing on the role of melatonin as neuroprotectant and providing current and emerging evidence.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"331-339"},"PeriodicalIF":3.4,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Escape from X-chromosome inactivation and sex differences in Alzheimer’s disease 摆脱 X 染色体失活与阿尔茨海默病的性别差异

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-29 DOI: 10.1515/revneuro-2023-0108

Qing-Hua Song, Ke-Xuan Zhao, Shuai Huang, Tong Chen, Ling He

{"title":"Escape from X-chromosome inactivation and sex differences in Alzheimer’s disease","authors":"Qing-Hua Song, Ke-Xuan Zhao, Shuai Huang, Tong Chen, Ling He","doi":"10.1515/revneuro-2023-0108","DOIUrl":"https://doi.org/10.1515/revneuro-2023-0108","url":null,"abstract":"Sex differences exist in the onset and progression of Alzheimer’s disease. Globally, women have a higher prevalence, while men with Alzheimer’s disease experience earlier mortality and more pronounced cognitive decline than women. The cause of sex differences in Alzheimer’s disease remains unclear. Accumulating evidence suggests the potential role of X-linked genetic factors in the sex difference of Alzheimer’s disease (AD). During embryogenesis, a remarkable process known as X-chromosome inactivation (XCI) occurs in females, leading to one of the X chromosomes undergoing transcriptional inactivation, which balances the effects of two X chromosomes in females. Nevertheless, certain genes exceptionally escape from XCI, which provides a basis for dual expression dosage of specific genes in females. Based on recent research findings, we explore key escape genes and their potential therapeutic use associated with Alzheimer’s disease. Also, we discuss their possible role in driving the sex differences in Alzheimer’s disease. This will provide new perspectives for precision medicine and gender-specific treatment of AD.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"194 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139070968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0