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Seminars in Musculoskeletal Radiology最新文献

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Bone Biomarkers Based on Magnetic Resonance Imaging. 基于磁共振成像的骨生物标志物
IF 0.9 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.1055/s-0043-1776431
Saeed Jerban, Hyungseok Jang, Eric Y Chang, Susan Bukata, Jiang Du, Christine B Chung
{"title":"Bone Biomarkers Based on Magnetic Resonance Imaging.","authors":"Saeed Jerban, Hyungseok Jang, Eric Y Chang, Susan Bukata, Jiang Du, Christine B Chung","doi":"10.1055/s-0043-1776431","DOIUrl":"10.1055/s-0043-1776431","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) is increasingly used to evaluate the microstructural and compositional properties of bone. MRI-based biomarkers can characterize all major compartments of bone: organic, water, fat, and mineral components. However, with a short apparent spin-spin relaxation time (T2*), bone is invisible to conventional MRI sequences that use long echo times. To address this shortcoming, ultrashort echo time MRI sequences have been developed to provide direct imaging of bone and establish a set of MRI-based biomarkers sensitive to the structural and compositional changes of bone. This review article describes the MRI-based bone biomarkers representing total water, pore water, bound water, fat fraction, macromolecular fraction in the organic matrix, and surrogates for mineral density. MRI-based morphological bone imaging techniques are also briefly described.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 1","pages":"62-77"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging Biomarkers of Peripheral Nerves: Focus on Magnetic Resonance Neurography and Ultrasonography. 外周神经的成像生物标志物：聚焦磁共振神经成像和超声波成像。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.1055/s-0043-1776427
Alireza Eajazi, Cindy Weinschenk, Avneesh Chhabra
{"title":"Imaging Biomarkers of Peripheral Nerves: Focus on Magnetic Resonance Neurography and Ultrasonography.","authors":"Alireza Eajazi, Cindy Weinschenk, Avneesh Chhabra","doi":"10.1055/s-0043-1776427","DOIUrl":"10.1055/s-0043-1776427","url":null,"abstract":"<p><p>Peripheral neuropathy is a prevalent and debilitating condition affecting millions of individuals globally. Magnetic resonance neurography (MRN) and ultrasonography (US) are noninvasive methods offering comprehensive visualization of peripheral nerves, using anatomical and functional imaging biomarkers to ensure accurate evaluation. For optimized MRN, superior and high-resolution two-dimensional and three-dimensional imaging protocols are essential. The anatomical MRN and US imaging markers include quantitative measures of nerve and fascicular size and signal, and qualitative markers of course and morphology. Among them, quantitative markers of T2-signal intensity ratio are sensitive to nerve edema-like signal changes, and the T1-mapping technique reveals nerve and muscle tissue fatty and fibrous compositional alterations.The functional markers are derived from physiologic properties of nerves, such as diffusion characteristics or blood flow. They include apparent diffusion coefficient from diffusion-weighted imaging and fractional anisotropy and tractography from diffusion tensor imaging to delve into peripheral nerve microstructure and integrity. Peripheral nerve perfusion using dynamic contrast-enhanced magnetic resonance imaging estimates perfusion parameters, offering insights into nerve health and neuropathies involving edema, inflammation, demyelination, and microvascular alterations in conditions like type 2 diabetes, linking nerve conduction pathophysiology to vascular permeability alterations.Imaging biomarkers thus play a pivotal role in the diagnosis, prognosis, and monitoring of nerve pathologies, thereby ensuring comprehensive assessment and elevating patient care. These biomarkers provide valuable insights into nerve structure, function, and pathophysiology, contributing to the accurate diagnosis and management planning for peripheral neuropathy.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 1","pages":"92-102"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic Resonance Imaging Biomarkers of Bone and Soft Tissue Tumors. 骨与软组织肿瘤的磁共振成像生物标志物。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.1055/s-0043-1776433
Ali Ghasemi, Shivani Ahlawat, Laura Marie Fayad
{"title":"Magnetic Resonance Imaging Biomarkers of Bone and Soft Tissue Tumors.","authors":"Ali Ghasemi, Shivani Ahlawat, Laura Marie Fayad","doi":"10.1055/s-0043-1776433","DOIUrl":"10.1055/s-0043-1776433","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) is essential in the management of musculoskeletal (MSK) tumors. This review delves into the diverse MRI modalities, focusing on anatomical, functional, and metabolic sequences that provide essential biomarkers for tumor detection, characterization, disease extent determination, and assessment of treatment response. MRI's multimodal capabilities offer a range of biomarkers that enhance MSK tumor evaluation, aiding in better patient management.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 1","pages":"39-48"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers in Musculoskeletal Imaging. 肌肉骨骼成像中的生物标记物。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.1055/s-0043-1778018
Richard Kijowski
{"title":"Biomarkers in Musculoskeletal Imaging.","authors":"Richard Kijowski","doi":"10.1055/s-0043-1778018","DOIUrl":"10.1055/s-0043-1778018","url":null,"abstract":"","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 1","pages":"1-2"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gustav Peter Bucky: An Engineer in the Service of Health. 古斯塔夫-彼得-巴奇：为健康服务的工程师。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.1055/s-0043-1776053
Iwona Sudoł-Szopińska, Marta Panas-Goworska, Christian Glaser
{"title":"Gustav Peter Bucky: An Engineer in the Service of Health.","authors":"Iwona Sudoł-Szopińska, Marta Panas-Goworska, Christian Glaser","doi":"10.1055/s-0043-1776053","DOIUrl":"10.1055/s-0043-1776053","url":null,"abstract":"<p><p>This history page in the series \"Leaders in MSK radiology\" is dedicated to the memory and achievements of the German radiologist Gustav Peter Bucky who invented the Bucky diaphragm grids. He wanted to become an engineer but bowed to his parents' wishes and went to medical school. By using his technical skills, he made revolutionary contributions to the early X-ray technique.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 1","pages":"103-104"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Diagnostics and Patient Care: The Role of Biomarkers in Radiology. 推进诊断和患者护理：生物标志物在放射学中的作用。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.1055/s-0043-1776426
Ronnie Sebro
{"title":"Advancing Diagnostics and Patient Care: The Role of Biomarkers in Radiology.","authors":"Ronnie Sebro","doi":"10.1055/s-0043-1776426","DOIUrl":"10.1055/s-0043-1776426","url":null,"abstract":"<p><p>The integration of biomarkers into medical practice has revolutionized the field of radiology, allowing for enhanced diagnostic accuracy, personalized treatment strategies, and improved patient care outcomes. This review offers radiologists a comprehensive understanding of the diverse applications of biomarkers in medicine. By elucidating the fundamental concepts, challenges, and recent advancements in biomarker utilization, it will serve as a bridge between the disciplines of radiology and epidemiology. Through an exploration of various biomarker types, such as imaging biomarkers, molecular biomarkers, and genetic markers, I outline their roles in disease detection, prognosis prediction, and therapeutic monitoring. I also discuss the significance of robust study designs, blinding, power and sample size calculations, performance metrics, and statistical methodologies in biomarker research. By fostering collaboration between radiologists, statisticians, and epidemiologists, I hope to accelerate the translation of biomarker discoveries into clinical practice, ultimately leading to improved patient care.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"28 1","pages":"3-13"},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Up-and-coming Radiotracers for Imaging Pain Generators. 即将推出的用于疼痛发生器成像的放射性示踪剂。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2023-12-01 Epub Date: 2023-11-07 DOI: 10.1055/s-0043-1775745
Rianne A van der Heijden, Sandip Biswal
{"title":"Up-and-coming Radiotracers for Imaging Pain Generators.","authors":"Rianne A van der Heijden, Sandip Biswal","doi":"10.1055/s-0043-1775745","DOIUrl":"10.1055/s-0043-1775745","url":null,"abstract":"<p><p>Chronic musculoskeletal pain is among the most highly prevalent diseases worldwide. Managing patients with chronic pain remains very challenging because current imaging techniques focus on morphological causes of pain that can be inaccurate and misleading. Moving away from anatomical constructs of disease, molecular imaging has emerged as a method to identify diseases according to their molecular, physiologic, or cellular signatures that can be applied to the variety of biomolecular changes that occur in nociception and pain processing and therefore have tremendous potential for precisely pinpointing the source of a patient's pain. Several molecular imaging approaches to image the painful process are now available, including imaging of voltage-gated sodium channels, calcium channels, hypermetabolic processes, the substance P receptor, the sigma-1 receptor, and imaging of macrophage trafficking. This article provides an overview of promising molecular imaging approaches for the imaging of musculoskeletal pain with a focus on preclinical methods.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"27 6","pages":"661-675"},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffusion Tensor Imaging of Peripheral Nerves: Current Status and New Developments. 周围神经的扩散张量成像：现状和新进展。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2023-12-01 Epub Date: 2023-11-07 DOI: 10.1055/s-0043-1775742
Daehyun Yoon, Amelie M Lutz
{"title":"Diffusion Tensor Imaging of Peripheral Nerves: Current Status and New Developments.","authors":"Daehyun Yoon, Amelie M Lutz","doi":"10.1055/s-0043-1775742","DOIUrl":"10.1055/s-0043-1775742","url":null,"abstract":"<p><p>Diffusion tensor imaging (DTI) is an emerging technique for peripheral nerve imaging that can provide information about the microstructural organization and connectivity of these nerves and complement the information gained from anatomical magnetic resonance imaging (MRI) sequences. With DTI it is possible to reconstruct nerve pathways and visualize the three-dimensional trajectory of nerve fibers, as in nerve tractography. More importantly, DTI allows for quantitative evaluation of peripheral nerves by the calculation of several important parameters that offer insight into the functional status of a nerve. Thus DTI has a high potential to add value to the work-up of peripheral nerve pathologies, although it is more technically demanding. Peripheral nerves pose specific challenges to DTI due to their small diameter and DTI's spatial resolution, contrast, location, and inherent field inhomogeneities when imaging certain anatomical locations. Numerous efforts are underway to resolve these technical challenges and thus enable wider acceptance of DTI in peripheral nerve MRI.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"27 6","pages":"641-648"},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee. 膝关节疼痛的高级磁共振成像和分子成像。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2023-12-01 Epub Date: 2023-11-07 DOI: 10.1055/s-0043-1775741
Jacob M Mostert, Niels B J Dur, Xiufeng Li, Jutta M Ellermann, Robert Hemke, Laurel Hales, Valentina Mazzoli, Feliks Kogan, James F Griffith, Edwin H G Oei, Rianne A van der Heijden
{"title":"Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.","authors":"Jacob M Mostert, Niels B J Dur, Xiufeng Li, Jutta M Ellermann, Robert Hemke, Laurel Hales, Valentina Mazzoli, Feliks Kogan, James F Griffith, Edwin H G Oei, Rianne A van der Heijden","doi":"10.1055/s-0043-1775741","DOIUrl":"10.1055/s-0043-1775741","url":null,"abstract":"<p><p>Chronic knee pain is a common condition. Causes of knee pain include trauma, inflammation, and degeneration, but in many patients the pathophysiology remains unknown. Recent developments in advanced magnetic resonance imaging (MRI) techniques and molecular imaging facilitate more in-depth research focused on the pathophysiology of chronic musculoskeletal pain and more specifically inflammation. The forthcoming new insights can help develop better targeted treatment, and some imaging techniques may even serve as imaging biomarkers for predicting and assessing treatment response in the future. This review highlights the latest developments in perfusion MRI, diffusion MRI, and molecular imaging with positron emission tomography/MRI and their application in the painful knee. The primary focus is synovial inflammation, also known as synovitis. Bone perfusion and bone metabolism are also addressed.</p>","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"27 6","pages":"618-631"},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and Functional Imaging of Musculoskeletal Pain, Inflammation, and Arthritis. 肌肉骨骼疼痛、炎症和关节炎的分子和功能成像。
IF 1.4 4区 医学
Seminars in Musculoskeletal Radiology Pub Date : 2023-12-01 Epub Date: 2023-11-07 DOI: 10.1055/s-0043-1776052
Sandip Biswal
{"title":"Molecular and Functional Imaging of Musculoskeletal Pain, Inflammation, and Arthritis.","authors":"Sandip Biswal","doi":"10.1055/s-0043-1776052","DOIUrl":"10.1055/s-0043-1776052","url":null,"abstract":"","PeriodicalId":49545,"journal":{"name":"Seminars in Musculoskeletal Radiology","volume":"27 6","pages":"599-600"},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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