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Seminars in Neurology最新文献

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Persisting Symptoms After Concussion and Functional Neurological Disorder: Points of Intersection. 脑震荡后持续症状与功能性神经障碍：交叉点
IF 2 4区 医学
Seminars in Neurology Pub Date : 2026-04-01 Epub Date: 2025-12-03 DOI: 10.1055/a-2752-8940
Adriano Mollica, Michael Dedominicis, Noah D Silverberg, Matthew J Burke
{"title":"Persisting Symptoms After Concussion and Functional Neurological Disorder: Points of Intersection.","authors":"Adriano Mollica, Michael Dedominicis, Noah D Silverberg, Matthew J Burke","doi":"10.1055/a-2752-8940","DOIUrl":"10.1055/a-2752-8940","url":null,"abstract":"<p><strong>Abstract: </strong>Persistent symptoms after concussion (PSaC) and functional neurological disorder (FND) are frequently encountered in clinical practice and are often challenging to manage due to heterogeneous and polysymptomatic presentations, as well as fragmented care pathways. This review outlines key points of intersection between PSaC and FND across pathophysiology, illness beliefs, rehabilitation models, and emerging treatments. We describe when FND should be considered in the differential diagnosis of patients with PSaC, and provide guidance on history-taking, examination, diagnostic communication, and rehabilitation planning that can be applied to both conditions. We also examine the influence of expectations, clinical messaging, and interactions with the healthcare system on recovery. Integrating principles from FND into concussion care may help clinicians more accurately formulate cases and support individualized rehabilitation pathways.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"196-205"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of Functional Neurological Disorder: The Clinical Spectrum. 功能性神经障碍的流行病学-临床谱。
IF 2 4区 医学
Seminars in Neurology Pub Date : 2026-04-01 Epub Date: 2025-11-25 DOI: 10.1055/a-2753-9092
Emma Woo, Gabriela S Gilmour
{"title":"Epidemiology of Functional Neurological Disorder: The Clinical Spectrum.","authors":"Emma Woo, Gabriela S Gilmour","doi":"10.1055/a-2753-9092","DOIUrl":"10.1055/a-2753-9092","url":null,"abstract":"<p><strong>Abstract: </strong>Functional neurological disorder (FND) is a prevalent, neuropsychiatric condition characterized by symptoms of impaired motor, sensory, cognitive, or perceptual systems. This study reviews the incidence, prevalence, demographic factors, risk factors, comorbidities, prognosis, and economic impact of FND and its subtypes. FND affects individuals across the lifespan and is more common in women, with socioeconomic and cultural factors also playing critical roles. FND is frequently comorbid with other functional syndromes, psychiatric and neurological disorders. Incidence estimates range from 10 to 16 per 100,000, with prevalence estimates between 79 and 144 per 100,000. Prognosis is poor without early intervention, with long diagnostic delays contributing to chronic symptoms and disability. FND accounts for significant healthcare utilization and economic burden. Evidently, there is a clear need for standardized diagnostic approaches and interdisciplinary collaboration to improve epidemiological accuracy and clinical outcomes.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"134-141"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Medicolegal Implications of Functional Neurological Disorder. 功能性神经障碍的医学法律意义。
IF 2.2 4区 医学
Seminars in Neurology Pub Date : 2026-04-01 Epub Date: 2026-03-06 DOI: 10.1055/a-2820-4053
Mahinda Yogarajah, Tiago Teodoro, Niruj Agrawal
{"title":"The Medicolegal Implications of Functional Neurological Disorder.","authors":"Mahinda Yogarajah, Tiago Teodoro, Niruj Agrawal","doi":"10.1055/a-2820-4053","DOIUrl":"10.1055/a-2820-4053","url":null,"abstract":"<p><strong>Abstract: </strong>Functional neurological disorder (FND) commonly arises in the context of injury, trauma, or litigation and poses distinctive medicolegal challenges. This review outlines how positive clinical signs and contemporary neurobiological models support FND as a robust diagnosis, while distinguishing it from factitious disorder and malingering. We discuss approaches to assessing authenticity of reported disability, the role and limitations of symptom and performance validity tests, and the pitfalls of equating inconsistency with deception. We then consider causation within common legal frameworks using a predisposing-precipitating-perpetuating model to analyze the contribution of index events, background vulnerabilities, and the litigation process itself. Finally, we summarize current evidence on treatment and prognosis, highlighting the limits of prediction and the need to offer courts transparent, probabilistic opinions on long-term outcome and care needs. Our aim is to support clinicians in providing balanced, clinically grounded expert evidence for patients with FND.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"225-233"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach to the Patient with FND: Evaluation, Diagnosis, and Developing a Treatment Plan. 治疗FND患者的方法：评估、诊断和制定治疗计划。
IF 2.2 4区 医学
Seminars in Neurology Pub Date : 2026-04-01 Epub Date: 2026-04-09 DOI: 10.1055/a-2835-0301
Michael Daniel DeDominicis, Sarah Lidstone
{"title":"Approach to the Patient with FND: Evaluation, Diagnosis, and Developing a Treatment Plan.","authors":"Michael Daniel DeDominicis, Sarah Lidstone","doi":"10.1055/a-2835-0301","DOIUrl":"10.1055/a-2835-0301","url":null,"abstract":"<p><strong>Abstract: </strong>The evaluation, diagnosis, and treatment of functional neurological disorder (FND) requires a specific skillset, an individualized approach to care, and resilience to navigate clinical challenges. Elements of care have evolved alongside a maturing understanding of the disease in a manner that has improved diagnostic accuracy, patient experience, patient outcomes, and health care utilization. This article reviews current evidence-based approaches to the evaluation of patients with FND, the delivery of the FND diagnosis, and the selection of an appropriate treatment plan.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"142-154"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Dawn of Functional Neurologic Disorder. 功能性神经障碍的曙光。
IF 2 4区 医学
Seminars in Neurology Pub Date : 2026-04-01 Epub Date: 2025-12-03 DOI: 10.1055/a-2753-9066
Mary A O'Neal, Barbara Dworetzky
{"title":"The Dawn of Functional Neurologic Disorder.","authors":"Mary A O'Neal, Barbara Dworetzky","doi":"10.1055/a-2753-9066","DOIUrl":"10.1055/a-2753-9066","url":null,"abstract":"","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"131-133"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mary Angela O'Neal, MD, FAAN, and Barbara A. Dworetzky, MD, FAAN, FANA, FAES. Mary Angela O'Neal，医学博士和Barbara A. Dworetzky，医学博士。
IF 2 4区 医学
Seminars in Neurology Pub Date : 2026-04-01 Epub Date: 2026-02-27 DOI: 10.1055/a-2815-7859
David M Greer
{"title":"Mary Angela O'Neal, MD, FAAN, and Barbara A. Dworetzky, MD, FAAN, FANA, FAES.","authors":"David M Greer","doi":"10.1055/a-2815-7859","DOIUrl":"10.1055/a-2815-7859","url":null,"abstract":"","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"129"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and Vulnerabilities in Functional Neurological Disorder. 功能性神经障碍的机制和脆弱性。
IF 2.2 4区 医学
Seminars in Neurology Pub Date : 2026-04-01 Epub Date: 2026-01-07 DOI: 10.1055/a-2772-7100
Eleonora Prudente, Valentine Savioz, Cristina Concetti, Selma Aybek
{"title":"Mechanisms and Vulnerabilities in Functional Neurological Disorder.","authors":"Eleonora Prudente, Valentine Savioz, Cristina Concetti, Selma Aybek","doi":"10.1055/a-2772-7100","DOIUrl":"10.1055/a-2772-7100","url":null,"abstract":"<p><strong>Abstract: </strong>Functional neurological disorder (FND) is a disabling neuropsychiatric condition characterized by altered voluntary motor or sensory functions and cognitive symptoms. Unlike other neurological disorders, FND is not caused by structural brain damage but by disruptions across brain networks involved in agency, attention, emotion processing, sensory-motor control, and interoception. These alterations align with alterations in predictive coding, which propose that abnormal prior beliefs override sensory input, contributing to symptom generation. Early-life trauma is a significant risk factor, interacting with genetic and epigenetic vulnerabilities that influence emotional regulation, stress sensitivity, and brain connectivity. Psychiatric comorbidities are also common and may affect symptom severity and prognosis. This review synthesizes recent research to clarify the complex mechanisms underlying FND by integrating neurobiological, environmental, and psychological factors. By doing so, we aim to advance the understanding of FND pathophysiology and promote a more comprehensive conceptual framework that highlights the role of individual vulnerability.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"167-175"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Overview of Artificial Intelligence in Neurology. 神经病学人工智能研究综述。
IF 2 4区 医学
Seminars in Neurology Pub Date : 2026-02-01 Epub Date: 2025-09-01 DOI: 10.1055/a-2693-0547
T Maxwell Parker, Benjamin Brush
{"title":"An Overview of Artificial Intelligence in Neurology.","authors":"T Maxwell Parker, Benjamin Brush","doi":"10.1055/a-2693-0547","DOIUrl":"10.1055/a-2693-0547","url":null,"abstract":"<p><p>The convergence of artificial intelligence (AI) and neuroscience represents one of medicine's most profound intellectual partnerships. Neuronal architecture has inspired computational methods, while computational models, evolving from theoretical constructs to transformative clinical tools, are reshaping neurological practice. As AI systems attempt to augment diagnostic accuracy, treatment planning, and patient care, neurologists must develop fluency in these technologies to harness their potential while navigating their limitations and dangers. AI-related publications have exponentially increased in recent years, yet many neurologists lack the foundational computer science background needed to critically evaluate and most safely and effectively implement these tools in clinical practice. This article serves to outline the historical foundations linking neuroscience to computing, examine core concepts of the past and current AI landscape in neurology, and describe methodologies that aim to revolutionize neurological care.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"3-15"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Applications of Artificial Intelligence in Neurology Education. 人工智能在神经学教育中的潜在应用。
IF 2.2 4区 医学
Seminars in Neurology Pub Date : 2026-02-01 Epub Date: 2026-03-13 DOI: 10.1055/a-2832-4638
Rohan Mainali, Arlinda Deng, Harika Rayala, Andrew M Southerland
{"title":"Potential Applications of Artificial Intelligence in Neurology Education.","authors":"Rohan Mainali, Arlinda Deng, Harika Rayala, Andrew M Southerland","doi":"10.1055/a-2832-4638","DOIUrl":"10.1055/a-2832-4638","url":null,"abstract":"<p><p>Artificial intelligence (AI) is rapidly transforming clinical practice, necessitating that neurology educators prepare trainees for this shift. This review outlines how AI tools are currently being trialed for integration into clinical care and demonstrates potential applications within neurology education. We highlight practical models for curriculum development from other specialties and underscore the need for structured, competency-driven approaches. Ultimately, integrating AI education into neurology training is essential to equip future clinicians for a healthcare system increasingly shaped by AI.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"e1-e4"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence and Multiple Sclerosis: Past, Present, and Future. 人工智能与多发性硬化症：过去、现在和未来。
IF 2 4区 医学
Seminars in Neurology Pub Date : 2026-02-01 Epub Date: 2025-11-10 DOI: 10.1055/a-2730-8997
Moein Amin, Kunio Nakamura, Daniel Ontaneda
{"title":"Artificial Intelligence and Multiple Sclerosis: Past, Present, and Future.","authors":"Moein Amin, Kunio Nakamura, Daniel Ontaneda","doi":"10.1055/a-2730-8997","DOIUrl":"10.1055/a-2730-8997","url":null,"abstract":"<p><p>Artificial intelligence (AI) in multiple sclerosis (MS) is an area of growing importance of growing importance. We review the historical context, current applications, and future prospects of AI and machine learning (ML) in MS. The review highlights AI's potential to address critical challenges in MS management, including early and accurate diagnosis, individualized treatment strategies, prognostication, and efficient patient monitoring. By leveraging large datasets and high-dimensional data, AI promises profound insights and augments clinical decision-making processes. Additionally, the manuscript covers potential limitations and challenges facing AI use in MS clinical practice and research.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"96-104"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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