Seminars in Neurology最新文献_第2页

Tremor. 的颤动。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-10-01 Epub Date: 2026-05-25 DOI: 10.1055/a-2870-2333

Sanjay Pandey, Aasef G Shaikh

引用次数: 0

Essential Tremor Pharmacotherapy: Bench to Bedside. 特发性震颤药物治疗：从工作台到床边。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-10-01 Epub Date: 2026-02-06 DOI: 10.1055/a-2789-0097

TinaMarie Lieu, Rich Able, Ian Smith, Sheng-Han Kuo

引用次数: 0

Tremors in Children. 儿童震颤。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-10-01 Epub Date: 2025-12-11 DOI: 10.1055/a-2769-6567

Nutan Sharma

引用次数: 0

Neurophysiological Basis of Tremor Disorders: Parkinson's Disease, Essential Tremor, Tremor in Dystonia, and Holmes Tremor. 震颤疾病的神经生理学基础：帕金森氏病、特发性震颤、肌张力障碍震颤和霍姆斯震颤。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-10-01 Epub Date: 2026-05-07 DOI: 10.1055/a-2870-6059

Aparna Wagle Shukla, Pattamon Panyakaew

{"title":"Neurophysiological Basis of Tremor Disorders: Parkinson's Disease, Essential Tremor, Tremor in Dystonia, and Holmes Tremor.","authors":"Aparna Wagle Shukla, Pattamon Panyakaew","doi":"10.1055/a-2870-6059","DOIUrl":"10.1055/a-2870-6059","url":null,"abstract":"Abstract: Tremor disorders encompass heterogeneous syndromes with distinct clinical, electrophysiological, and pathophysiological characteristics. Parkinson's disease tremor typically presents as a unilateral 4 to 6 Hz rest tremor, with re-emergent postural components or pure postural in some, driven by abnormal pallido-thalamo-cortical (PTC) oscillations and modulated by cerebellar inputs. Essential tremor is characterized by bilateral 4 to 8 Hz kinetic >postural tremor with regular, rhythmic EMG bursts, reflecting dysfunction within the cerebello-thalamo-cortical (CTC) pathway. Tremor in dystonia is frequently unilateral, irregular, and position- or task-specific, 3 to 5 Hz oscillations superimposed on dystonic co-contractions; the rhythmic component arises from CTC disturbances, while jerky dystonia involves PTC abnormalities. Holmes tremor is a slow (2.5-5 Hz) proximal tremor combining rest, postural, and kinetic features, resulting from multiple brain substrates in globus pallidus internus, red nucleus, and/or cerebellum (PTC and CTC). Understanding the underlying circuitry (or network) dysfunctions which are convergent as well as divergent across tremor syndromes can improve diagnostic accuracy and guide individualized therapeutic strategies.","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"509-520"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13297120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pendular Nystagmus and Oculopalatal Tremor. 钟摆性眼球震颤和眼腭震颤。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-10-01 Epub Date: 2026-06-01 DOI: 10.1055/a-2848-9343

Lucie Ahn, Ibada I Chowdhary, Aasef G Shaikh

{"title":"Pendular Nystagmus and Oculopalatal Tremor.","authors":"Lucie Ahn, Ibada I Chowdhary, Aasef G Shaikh","doi":"10.1055/a-2848-9343","DOIUrl":"10.1055/a-2848-9343","url":null,"abstract":"Abstract: Acquired pendular nystagmus consists of quasi-sinusoidal oscillations of the eyes that significantly impair gaze stability and visual clarity. It most commonly occurs in demyelinating disorders such as multiple sclerosis and in acquired degenerative conditions like oculopalatal tremor. Other etiologies-including drug toxicity, metabolic and genetic disorders, and granulomatous diseases-can also produce syndromes featuring pendular nystagmus. Analysis of its kinematic properties has provided clues to the underlying mechanisms of this otherwise enigmatic disorder. In this review, we examine the clinical features of neurological conditions associated with pendular nystagmus, with emphasis on its acquired forms, and summarize recent advances in diagnostic strategies and therapeutic development. Pendular nystagmus is defined by quasi-sinusoidal oscillations of the eyes that impair visual acuity and produce oscillopsia.1 Despite its designation as \"nystagmus,\" this disorder lacks the hallmark waveform of classical nystagmus-slow drifts followed by rapid corrective saccades. Instead, pendular nystagmus consists of consecutive slow phases of eye movement, giving it a pendular appearance. These oscillations typically exhibit a dominant frequency of 4 to 6 Hz, although certain conditions, such as oculopalatal tremor (OPT; see below), present with lower frequencies around 2 Hz, while demyelinating disorders may reach frequencies up to 8 Hz. The phenomenology of pendular nystagmus reflects diverse underlying pathophysiological mechanisms associated with neurodegenerative, toxic-metabolic, immune-mediated, and genetic disorders. This review aims to provide a comprehensive resource on the pathophysiology, phenomenology, etiology, and therapy of pendular nystagmus.","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"453-464"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Tremor. 功能性震颤。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-10-01 Epub Date: 2025-12-15 DOI: 10.1055/a-2769-7282

Kartika Gulati, Sanjay Pandey

{"title":"Functional Tremor.","authors":"Kartika Gulati, Sanjay Pandey","doi":"10.1055/a-2769-7282","DOIUrl":"10.1055/a-2769-7282","url":null,"abstract":"Abstract: Functional tremor (FT) is the most prevalent subtype of functional movement disorders, characterized by variability, distractibility, and entrainability on clinical examination. Diagnosis relies on positive clinical and electrophysiological signs, shifting emphasis from a diagnosis of exclusion to \"rule-in\" criteria. Surface electromyography and tremor analysis are essential tools in establishing the diagnosis. Pathophysiology involves abnormal motor co-activation, disrupted volitional awareness, and impaired predictive processing, resulting in tremor perceived as involuntary despite intact motor pathways. Management requires a multidisciplinary approach, including physiotherapy, occupational therapy, cognitive-behavioral interventions, biofeedback, and transcranial magnetic stimulation. FT often results in persistent disability, with limited treatment response. Management is hindered by diagnostic challenges, especially in functional overlay, limited training, cultural misconceptions, and underutilization of neurophysiological and rehabilitation interventions. Improving clinician training, expanding access to neurophysiology, and multidisciplinary care, along with high-quality prospective specific research and standardized care pathways, is essential to optimize outcomes.","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"492-501"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Syndromes of Peripheral Nervous System Neurotoxicity from Immune-Checkpoint Inhibitors. 免疫检查点抑制剂引起周围神经系统神经毒性的临床综合征。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-08-28 DOI: 10.1055/a-2936-5945

Isaac Smith, Minna Choi, Sakinah Sabadia

引用次数: 0

Neurologic Complications of Cancer Immunotherapy. 肿瘤免疫治疗的神经系统并发症。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-08-26 DOI: 10.1055/a-2936-4931

Alexandra Balshi, Prashanth Rajarajan, Caleb R S McEntire, Giovanna S Manzano

引用次数: 0

Equity in Neurotoxicity Care in the Era of Cancer Immunotherapy. 肿瘤免疫治疗时代神经毒性护理的公平性。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-08-20 DOI: 10.1055/a-2936-3979

Rosalina Magalhaes Pereira, Joshua A Budhu

{"title":"Equity in Neurotoxicity Care in the Era of Cancer Immunotherapy.","authors":"Rosalina Magalhaes Pereira, Joshua A Budhu","doi":"10.1055/a-2936-3979","DOIUrl":"10.1055/a-2936-3979","url":null,"abstract":"Abstract: Immunotherapies such as chimeric antigen receptor T cell (CAR-T) therapy and immune checkpoint inhibitors have improved cancer survival but are associated with potentially severe neurotoxicities that can impair neurologic function, quality of life, and survival. Despite their growing use, substantial disparities persist in the recognition, diagnosis, and management of cancer therapy-related neurotoxicities, disproportionately affecting underserved populations. In this review, we apply the social-ecological model (SEM) to examine how factors across individual, interpersonal, organizational, community, and policy levels contribute to inequities in neurotoxicology care. We synthesize evidence on barriers to early detection and access to neurologic expertise and highlight emerging strategies to promote equity, including early symptom recognition, improved specialty access, and supportive institutional infrastructure. We also explore the potential of behavioral economics-informed approaches and artificial intelligence-enabled tools, including telemedicine and remote monitoring, as scalable strategies to reduce inequities in neurotoxicity care.","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuro-Ophthalmic Manifestations of Immunotherapy Toxicity. 免疫治疗毒性的神经眼科表现。

IF 2.2 4区医学

Seminars in Neurology Pub Date : 2026-08-13 DOI: 10.1055/a-2928-7527

Abdulaziz Al-Abdulghani, Andrew Dugue, Scott N Grossman, Doria M Gold

引用次数: 0