Somatosensory and Motor Research最新文献

{"title":"The effects of ethyl pyruvate against experimentally induced cisplatin ototoxicity in rats.","authors":"Muhammed Ayral,&nbsp;Serdar Ferit Toprak","doi":"10.1080/08990220.2021.1984875","DOIUrl":"https://doi.org/10.1080/08990220.2021.1984875","url":null,"abstract":"<p><strong>Introduction: </strong>Cisplatin (CDDP) is a widely used antineoplastic drug. However, its use is limited due to the ototoxic side effects. In this study, the effects of ethyl pyruvate (EP), known for its antioxidant and anti-inflammatory effects, against CDDP ototoxicity were investigated.</p><p><strong>Methods: </strong>Thirty-two Wistar albino rats (n:8) were used in this study. CDDP was administered i.p. as a single dose of 15 mg/kg/day in order to cause ototoxicity. EP was applied i.p. at a dose of 50 mg/kg/day for 7 days.</p><p><strong>Results: </strong>When the Auditory Brainstem Responses (ABR) and Distortion Product Otoacoustic Emissions (DPOAE) tests carried out in the pre-treatment and post-treatment periods were examined, it was observed that the hearing functions were significantly impaired with the CDDP application, while a significant improvement was observed in the CDDP + EP group. Compared to the control group, the CDDP group had significantly higher malondialdehyde (MDA) levels and significantly lower glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) levels. In the CDDP + EP group, there was no deterioration in MDA, SOD and CAT levels that was observed in the CDDP group. The increase in pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) levels caused by CDDP administration was observed to be significantly decreased in the CDDP + EP group.</p><p><strong>Conclusions: </strong>Hearing tests and biochemical results show that ethyl pyruvate is protective against cisplatin ototoxicity with its antioxidant and anti-inflammatory effects.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 4","pages":"347-352"},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39507468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visuospatial working memory abilities and spontaneous sensations perception.","authors":"Sara Salgues,&nbsp;Gaën Plancher,&nbsp;George A Michael","doi":"10.1080/08990220.2021.1914018","DOIUrl":"https://doi.org/10.1080/08990220.2021.1914018","url":null,"abstract":"<p><p><b>Aim:</b> Body awareness arises when attending to and maintaining awareness of visuospatial body representations. By the same token, focussing on representations transfers them to working memory. Body awareness and working memory seemingly rely on similar processes and recruit common parietal areas involved in perception. Therefore, we asked whether visuospatial working memory abilities would define individual differences in the perception of spontaneous sensations (SPS), i.e., bodily sensations perceived in the absence of triggers (e.g., tactile stimulation or movement), when attending to the body.<b>Method:</b> Participants completed two visuospatial working memory tasks to assess various mechanisms: (i) the decay of representations was assessed through a Brown-Peterson task in which the delay between the memorandum presentation and its recall was manipulated, and (ii) the impact of distractors' interference and cognitive load (i.e., complexity) on recall performances were assessed through a complex span task that required the processing of distractors while maintaining a memorandum. A standard SPS task involving localization and characterization of SPS perceived on the hands was completed afterwards.<b>Results:</b> Low performance due to decay, distractors' interference and cognitive load in visuospatial working memory was associated with a decrease in the frequency of SPS. Additionally, low performance due to distractors' cognitive load predicted a decrease in the perception of surface-type sensations, and high performance despite distractors' interference led to a better perception of SPS on less sensitive areas of the hand.<b>Conclusion:</b> We discuss how visuospatial working memory processes might contribute to body awareness and perceptual distortions of the body.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"164-177"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08990220.2021.1914018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39115861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between physical activity, kinesiophobia and fear of falling in older adults with chronic pain.","authors":"Meral Sertel,&nbsp;Saniye Aydoğan Arslan,&nbsp;Eylem Tütün Yümin,&nbsp;Cevher Savcun Demirci,&nbsp;Tülay Tarsuslu Şimşek","doi":"10.1080/08990220.2021.1958774","DOIUrl":"https://doi.org/10.1080/08990220.2021.1958774","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to investigate the relationship between physical activity, fear of movement and fear of falling in older adults with chronic pain.</p><p><strong>Materials and methods: </strong>The study includes 163 older adults aged 65 years and over, who live in a private nursing home. The cognitive functions of the individuals who participated in the study were evaluated with the mini-mental examination scale (MMES), fears of movement with the Tampa Scale of Kinesiophobia (TSK), fear-avoidance behaviour with the Fear-avoidance Beliefs Questionnaire (FABQ), physical activity levels with the Physical Activity Scale for Older (PASE), and the fears of falling were assessed with Tinetti's Falls Efficacy Scale (FES).</p><p><strong>Results: </strong>In the correlation analysis, there was a weak correlation between age and fall risk (<i>r</i> = 0.349, <i>p</i> < 0.001), and PASE_Total score (<i>r</i> = -0.020, <i>p</i> = 0.011). There was a weak positive correlation between Tinetti FES and FABQ scores (<i>r</i> = 0.349, <i>p</i> < 0.001), and kinesiophobia value (<i>r</i> = 0.259, <i>p</i> < 0.001), there was a weak negative correlation between Tinetti FES and PASE_Total (<i>r</i> = -0.241, <i>p</i> = 0.002). A positive mid correlation was determined between kinesiophobia and the FABQ scores (<i>r</i> = 0.41, <i>p</i> < 0.001). The established regression model was found to be significant (<i>F</i> = 12.175; <i>p</i> < 0.001). Among the independent variables included in the model, FABQ_Total (<i>t</i> = 3.589; <i>p</i> < 0.0001) and PASE_Total (<i>t</i> = -3.325; <i>p</i> < 0.0001) significantly affected the fear of falling.</p><p><strong>Conclusion: </strong>The presence of chronic pain in older adults who have problems related to physical activity, fear of falling, and kinesiophobia due to advancing age may affect social participation, functional level, and quality of life significantly. Therefore, pain should be addressed in older adults and should be considered as an important issue in rehabilitation programs.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"241-247"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08990220.2021.1958774","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39263961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-point discrimination assessment of the lower extremities of healthy young Turkish individuals.","authors":"Cem Erçalık,&nbsp;Seçil Özkurt","doi":"10.1080/08990220.2021.1959310","DOIUrl":"https://doi.org/10.1080/08990220.2021.1959310","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the normative two-point discrimination (TPD) values of the lower extremities of healthy young Turkish individuals.</p><p><strong>Patients and methods: </strong>Fifty-five healthy, young adults were recruited in this prospective study. Ten lower extremity parts were tested with esthesiometer: proximal thigh, midlateral thigh, midmedial thigh, midposterior thigh, proximal lateral leg, distal lateral leg, medial leg, the tip of great toe, skin over 1-2 metatarsal interspace, skin over 5th metatars at both dominant and non-dominant sides.</p><p><strong>Results: </strong>There were 27 (49.1%) female and 28 (50.9%) male participants with a mean age of 22.06 ± 1.76 years. The reference values of the TPD of the lower extremities were between 42.4 ± 5.4 mm and 4.0 ± 1.3 mm by females and between 42.6 ± 6.4 mm and 4.4 ± 2.4 mm by males. Test values in the combined group of men and women were statistically greater at the dominant sides than the non-dominant sides at the following areas: proximal lateral leg (<i>p</i> = 0.01), distal lateral leg (<i>p</i> = 0.046), medial leg (<i>p</i> = 0.001), tip of great toe (<i>p</i> = 0.02), skin over 1-2 metatarsal interspace (<i>p</i> = 0.010), skin over 5th metatars (<i>p</i> = 0.002). There was no statistical difference in the test scores of men and women in any of the measured areas, with additional evaluation of both the dominant and the non-dominant sides (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The results of the present study demonstrated that TPD ability varied in different skin areas within the same individual. We found that laterality, though with lower scores on the non-dominant side in some lower extremity parts, but not the gender had an effect on TPD.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"253-257"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39291870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The characteristics, disabilities, and spinal alignment of women with double crush syndrome: a case-control study.","authors":"Derya Ozer Kaya,&nbsp;Seyda Toprak Celenay,&nbsp;Senem Sas","doi":"10.1080/08990220.2021.1908250","DOIUrl":"https://doi.org/10.1080/08990220.2021.1908250","url":null,"abstract":"<p><strong>Aims: </strong>Double crush syndrome is a clinical condition composed of neurological dysfunction due to compressive pathology at multiple sites along a single peripheral nerve. The aims were to investigate the characteristics and disabilities of women with double crush syndrome, to compare the spinal alignment to healthy women, and to determine the cut-offs for the spinal alignment characteristics.</p><p><strong>Methods: </strong>Twenty women with double crush syndrome (age: 49.50 ± 8.64 years) and 21 asymptomatic healthy controls (age: 44.76 ± 7.82 years) were included in the study. The physical characteristics, pain intensity, and symptoms were questioned. Disability with Disability of Arm and Shoulder Questionnaire and Neck Disability Index and spinal alignment with Spinal Mouse^® (Idiag, Fehraltorf, Switzerland) were assessed.</p><p><strong>Results: </strong>The pain intensity at rest, night, and during activity was 3.70 ± 3.25, 6.01 ± 2.77, and 7.15 ± 2.68 cm, respectively. The most bothersome symptom was numbness (65%). The symptoms were seen in hands and/or fingers (55%), arms (15%), shoulder blade (15%), and neck (15%). The Disability of Arm and Shoulder Questionnaire and Neck Disability Index scores were 58.64 ± 15.41 and 19.55 ± 6.37, respectively. The sagittal thoracic curvature (<i>p</i>: .011) and lumbar curvature (<i>p</i>: .049) increased, and the overall spine mobility (<i>p</i><.001) decreased in the double crush syndrome patients. The cut-off points were detected as 54.5° (area under the curve: 0.680, <i>p</i>: .049, 40% sensitivity, 99.9% specificity) for the thoracic spinal curvature, and 113.5° (area under the curve: 0.667, <i>p</i><.000, 65% sensitivity, 99.9% specificity) for the overall spine mobility.</p><p><strong>Conclusions: </strong>The double crush syndrome patients had moderate to severe pain and disability, increased thoracic and lumbar curvature, and decreased spine mobility. The cut-off values were found as 54.5° for thoracic curvature and 113.5° for spine mobility.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"157-163"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08990220.2021.1908250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25560680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot trial of a mouthpiece as treatment for signs and symptoms of Parkinson disease.","authors":"David Scott May,&nbsp;Kerri Sharp Rawson,&nbsp;Donald Richard Moeller,&nbsp;Lauren Elizabeth Tueth,&nbsp;Gammon M Earhart","doi":"10.1080/08990220.2021.1953462","DOIUrl":"https://doi.org/10.1080/08990220.2021.1953462","url":null,"abstract":"<p><strong>Purpose: </strong>Several case studies and anecdotal reports have shown assorted motor and quality of life benefits from use of a dental mouthpiece among people with Parkinson disease (PD). A larger exploratory study is necessary to assess potential efficacy and feasibility of this treatment strategy. If shown to be effective and feasible in a larger sample of people with PD, mechanistic studies may be warranted to examine a potential relationship between orofacial sensory input and motor function in people with PD.</p><p><strong>Materials and methods: </strong>This study was registered on clinicaltrials.gov (NCT: 04082663). Twenty people with PD, Hoehn and Yahr stages I-III, participated in this study. Each participant completed various baseline motor and quality of life assessments before being fitted with a custom mouthpiece. Motor assessments were completed a second time after 25 min of mouthpiece wear. Participants were asked to wear the mouthpiece for 1 month before completing follow-up quality of life assessments and providing feedback about the mouthpiece. Wilcoxon signed-rank tests were used to compare results across conditions.</p><p><strong>Results: </strong>Gait velocity and cadence showed significant (<i>p</i> < .05) improvement while wearing the mouthpiece. However, these changes were not significant after correcting for multiple comparisons. Thirteen participants indicated they would be unlikely to continue wearing the mouthpiece.</p><p><strong>Conclusions: </strong>These results do not provide adequate evidence to pursue further this type of mouthpiece as a treatment strategy for motor signs and symptoms or quality of life in people with PD.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"223-229"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08990220.2021.1953462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39231655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sensorimotor training on spatiotemporal parameters of gait among middle and older age adults with diabetic peripheral neuropathy.","authors":"Irshad Ahmad,&nbsp;Shalini Verma,&nbsp;Majumi Mohamad Noohu,&nbsp;Mohd Ejaz Hussain","doi":"10.1080/08990220.2021.1955671","DOIUrl":"https://doi.org/10.1080/08990220.2021.1955671","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to evaluate the effect of sensorimotor training on spatiotemporal parameters of gait among middle-aged and older adults with diabetic peripheral neuropathy (DPN).</p><p><strong>Methods: </strong>A randomised controlled study with four parallel arms (two intervention groups and two control groups) was conducted. Thirty-seven DPN patients were selected on the basis of inclusion and exclusion criteria. Of these, 16 middle-aged and 21 older adults were randomly allocated to the intervention and control groups. Participants in the intervention group were administered eight weeks (three days/week) of sensorimotor training along with diabetes and foot care education whereas participants in the control group received only diabetes and foot care education. Outcome measures involved spatiotemporal parameters of gait at self-paced and maximal-paced, measured before and after eight weeks.</p><p><strong>Results: </strong>Age difference was found to be significant in velocity (<i>p</i> ≤ 0.013) and stride length (<i>p</i> ≤ 0.017) at self-paced and maximal-paced walking. After the intervention, velocity was found to be a significant group effect and time × group interaction at self-paced (<i>p</i> = 0.003) and maximal-paced (<i>p</i> = 0.003) walking. Stride length (<i>p</i> = 0.006) was found to be a significant group effect and time × group interaction at self-paced only. Cadence (<i>p</i> = 0.041) and gait cycle (<i>p</i> = 0.05) were found to be significant time × group interaction only at maximal-paced walking. Stance (<i>p</i> ≤ 0.047) and double limb support (<i>p</i> ≤ 0.02) were found to be significant group effect and time × group interaction at self-paced and maximal-paced walking.</p><p><strong>Conclusion: </strong>Sensorimotor training improves spatiotemporal parameters of gait after eight weeks in similar fashion in middle-aged and older age DPN patients, regardless of age.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"230-240"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39263558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a textured insole on anticipatory postural adjustments.","authors":"Etem Curuk,&nbsp;Alexander S Aruin","doi":"10.1080/08990220.2021.1918659","DOIUrl":"https://doi.org/10.1080/08990220.2021.1918659","url":null,"abstract":"<p><strong>Purpose: </strong>To obtain preliminary data on the effect of a textured insole on postural control.</p><p><strong>Methods: </strong>Nine healthy subjects were exposed to external perturbations applied to their shoulders while standing with or without a single textured insole. Body weight distribution and bilateral electromyographic activity (EMG) of trunk and leg muscles were recorded. Onsets of EMG activity of muscles were calculated and analyzed within the interval typical for anticipatory postural adjustments.</p><p><strong>Results: </strong>When a textured insole was provided under one foot, subjects shifted their body weight towards the contralateral foot. With no insole, the anticipatory onsets of EMG activity of the left and right muscles were symmetrical; when a textured insole was used, the EMG onsets of the muscles on the contralateral side of the body were seen earlier as compared to the insole side. This early activation was more pronounced in the trunk muscles (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Using a single textured insole under one-foot induced asymmetry of anticipatory onsets of EMG activity in healthy subjects. The outcome highlights the importance of investigating the role of a single textured insole in control of vertical posture and provides a foundation for future studies focussed on improvement of postural control in individuals with body asymmetry due to unilateral weakness.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"188-193"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08990220.2021.1918659","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39014851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does somatosensory feedback from the plantar foot sole contribute to verticality perception?","authors":"A Nedelkou,&nbsp;V Hatzitaki,&nbsp;K Chatzinikolaou,&nbsp;G Grouios","doi":"10.1080/08990220.2021.1949977","DOIUrl":"https://doi.org/10.1080/08990220.2021.1949977","url":null,"abstract":"<p><strong>Aim of the study: </strong>In upright standing, the human foot sole is the only point of contact with the ground conveying information about the pressure distribution under the feet. We examined how the altered somatosensory input from the plantar foot receptors, when standing on a soft surface, affects the subjective estimation of the earth vertical in different sensory contexts.</p><p><strong>Materials and methods: </strong>Twelve (12) healthy young females (mean age: 21.8 ± 2.4 years) adjusted the orientation of a visual line (35 × 1.5 cm) representing the roll orientation of a hand-held (attached on a 24.9 × 4 cm cylinder) or head-attached electromagnetic tracking sensor (Nest of Birds, Ascension Technologies Inc., VT. USA, 60 Hz) under two visual conditions (eyes open, eyes closed) while standing on a soft or firm surface. The mean absolute (accuracy) and variable (precision) error in the verticality estimate was depicted in the sensor's roll deviation from the gravitational vertical.</p><p><strong>Results: </strong>The accuracy and the precision of the estimate decreased in the absence of vision, while standing on the soft surface and when the estimate was provided by an active hand rather than head rotation. The surface effect was significant only in the absence of vision and when the estimate was provided by the hand.</p><p><strong>Conclusions: </strong>The contribution of the plantar foot mechanoreceptors to gravity perception is sensory context dependent. Perception of the earth vertical is more accurate when estimated by active head rotation due to the integration of the vestibular and neck proprioceptive afferents.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"214-222"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39180029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of stimulus response curves obtained with transcranial magnetic stimulation from bilateral anterior digastric muscles in healthy subjects.","authors":"Paul Herbert,&nbsp;Jeanmarie R Burke","doi":"10.1080/08990220.2021.1914019","DOIUrl":"https://doi.org/10.1080/08990220.2021.1914019","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of the study was to describe measurements of stimulus-response curves in the anterior digastric muscle (ADM) bilaterally following transcranial magnetic stimulation (TMS) to the right and left hemispheres. The first dorsal interosseous muscle (FDI) was the control muscle.</p><p><strong>Materials and methods: </strong>The subjects were 20 healthy young adults. Test sessions determined motor thresholds (MT) and stimulus-response curves (1.0, 1.2, 1.4, 1.6 × MT) from either the FDI or ADM following TMS to left and right hemispheres using the double cone coil. Bilateral recordings of MEPs in the left and right ADM allowed us to generate stimulus response curves following ipsilateral and contralateral TMS.</p><p><strong>Results: </strong>Intraclass correlation coefficients (ICC) for MEP amplitudes from ipsilateral and contralateral ADMs were >0.60 at motor threshold (MT) and >0.90 at stimulus intensities above MT. There was a linear increase in MEP amplitudes across stimulus intensities for the FDI following contralateral TMS, while MEP amplitudes from the ADM following contralateral and ipsilateral TMS increased linearly across stimulus intensities [<i>F</i>_{(3, 57) [Muscle × Recording Site × Stim Intensity]} = 33.57; <i>p</i> < 0.05]; <math><msubsup><mrow><mo>(</mo><mi>η</mi></mrow><mrow><mi>p</mi></mrow><mrow><mn>2</mn></mrow></msubsup></math> = 0.64). The slopes of the stimulus-response curve of the contralateral FDI was greater than the slopes of the stimulus response curves of the ipsilateral and contralateral ADM (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The current study provided insights on the methodology for recording stimulus response curves in the ADM with TMS. These findings may translate into a valid, reliable, and relevant clinical outcome to study the pathophysiology of the corticobulbar motor system.</p>","PeriodicalId":49498,"journal":{"name":"Somatosensory and Motor Research","volume":"38 3","pages":"178-187"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08990220.2021.1914019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39231018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}