The effects of ethyl pyruvate against experimentally induced cisplatin ototoxicity in rats.

IF 1.3 4区医学 Q4 NEUROSCIENCES

Somatosensory and Motor Research Pub Date : 2021-12-01 Epub Date: 2021-10-12 DOI:10.1080/08990220.2021.1984875

Muhammed Ayral, Serdar Ferit Toprak

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引用次数: 1

Abstract

Introduction: Cisplatin (CDDP) is a widely used antineoplastic drug. However, its use is limited due to the ototoxic side effects. In this study, the effects of ethyl pyruvate (EP), known for its antioxidant and anti-inflammatory effects, against CDDP ototoxicity were investigated.

Methods: Thirty-two Wistar albino rats (n:8) were used in this study. CDDP was administered i.p. as a single dose of 15 mg/kg/day in order to cause ototoxicity. EP was applied i.p. at a dose of 50 mg/kg/day for 7 days.

Results: When the Auditory Brainstem Responses (ABR) and Distortion Product Otoacoustic Emissions (DPOAE) tests carried out in the pre-treatment and post-treatment periods were examined, it was observed that the hearing functions were significantly impaired with the CDDP application, while a significant improvement was observed in the CDDP + EP group. Compared to the control group, the CDDP group had significantly higher malondialdehyde (MDA) levels and significantly lower glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) levels. In the CDDP + EP group, there was no deterioration in MDA, SOD and CAT levels that was observed in the CDDP group. The increase in pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) levels caused by CDDP administration was observed to be significantly decreased in the CDDP + EP group.

Conclusions: Hearing tests and biochemical results show that ethyl pyruvate is protective against cisplatin ototoxicity with its antioxidant and anti-inflammatory effects.

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丙酮酸乙酯对实验性大鼠顺铂耳毒性的影响。

顺铂(CDDP)是一种应用广泛的抗肿瘤药物。然而，由于耳毒性副作用，其使用受到限制。本文研究了具有抗氧化和抗炎作用的丙酮酸乙酯(EP)对CDDP耳毒性的影响。方法:选用32只Wistar白化大鼠(8只)。CDDP单次给药15 mg/kg/d，以引起耳毒性。EP以50mg /kg/天的剂量ig，连用7天。结果:对治疗前后的听觉脑干反应(ABR)和畸变产物耳声发射(DPOAE)测试进行对比，发现CDDP组听力功能明显受损，而CDDP + EP组听力功能明显改善。与对照组相比，CDDP组丙二醛(MDA)水平显著升高，谷胱甘肽过氧化物酶(GPx)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)水平显著降低。在CDDP + EP组中，MDA、SOD和CAT水平未见CDDP组的下降。在CDDP + EP组中，CDDP引起的促炎细胞因子(IL-1β、IL-6和TNF-α)水平升高明显降低。结论:丙酮酸乙酯具有抗氧化和抗炎作用，对顺铂耳毒性具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Somatosensory and Motor Research 医学-神经科学

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Somatosensory & Motor Research publishes original, high-quality papers that encompass the entire range of investigations related to the neural bases for somatic sensation, somatic motor function, somatic motor integration, and modeling thereof. Comprising anatomical, physiological, biochemical, pharmacological, behavioural, and psychophysical studies, Somatosensory & Motor Research covers all facets of the peripheral and central processes underlying cutaneous sensation, and includes studies relating to afferent and efferent mechanisms of deep structures (e.g., viscera, muscle). Studies of motor systems at all levels of the neuraxis are covered, but reports restricted to non-neural aspects of muscle generally would belong in other journals.