Southern African Journal of Hiv Medicine最新文献

{"title":"Incidence of hepatitis C virus infection among people living with HIV: An Egyptian cohort study.","authors":"Fatma Elrashdy,&nbsp;Suzan Hagag,&nbsp;Rahma Mohamed,&nbsp;Shereen Abdel Alem,&nbsp;Safa Meshaal,&nbsp;Ahmed Cordie,&nbsp;Aisha Elsharkawy,&nbsp;Gamal Esmat","doi":"10.4102/sajhivmed.v23i1.1442","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1442","url":null,"abstract":"<p><strong>Background: </strong>Egypt used to have one of the highest hepatitis C virus (HCV) infection prevalence rates worldwide, with an estimated HCV prevalence of around 4.5% to 6.7%.</p><p><strong>Objectives: </strong>To determine the HCV infection incidence rate amid Egyptian patients living with HIV.</p><p><strong>Method: </strong>A total of 460 HIV-positive patients were recruited in a retrospective cohort study from Imbaba Fever Hospital, Cairo, between January 2016 and March 2019. The patients had a negative baseline and at least one other HCV antibody test. Hepatitis C virus antibody testing was done by antibody sandwich third-generation enzyme-linked immunosorbent assay. The hepatitis C virus infection incidence rate among HIV-infected patients was calculated using the person-time incidence rate.</p><p><strong>Results: </strong>Two hundred and eighteen patients were finally included: 146 (31.7%) patients were excluded for having a positive baseline HCV Ab result and 96 patients were excluded for not having a follow-up HCV Ab test. Eighteen patients had HCV seroconversion (8.3%), achieving an incidence rate of 4.06 cases per 100 person-years (95% confidence interval: 3.87-4.24). Injection drug use (IDU) was the commonest risk factor among seroconverters, with an HCV incidence rate of 7.08 cases per 100 person-years. Injection drug use history was reported in 83.3% of the seroconverters and in only 47.2% of non-seroconverters; <i>P</i> = 0.005.</p><p><strong>Conclusion: </strong>Egyptian HIV-infected patients show a high incidence rate of HCV infection especially among those who have a history of IDU. Accordingly, attention should be paid for prevention, screening and timely treatment of HCV in patients infected with HIV.</p><p><strong>What this study adds: </strong>The demonstration of a high HCV infection incidence rate among HIV-infected patients and shows the need for screening and prevention in this population.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1442"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10433286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice.","authors":"Remco P H Peters,&nbsp;Nigel Garrett,&nbsp;Nomathemba Chandiwana,&nbsp;Ranmini Kularatne,&nbsp;Adrian J Brink,&nbsp;Karen Cohen,&nbsp;Katherine Gill,&nbsp;Thato Chidarikire,&nbsp;Camilla Wattrus,&nbsp;Jeremy S Nel,&nbsp;Mahomed Y S Moosa,&nbsp;Linda-Gail Bekker","doi":"10.4102/sajhivmed.v23i1.1450","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1450","url":null,"abstract":"","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1450"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10717775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COP27 Climate Change Conference: Urgent action needed for Africa and the world.","authors":"Lukoye Atwoli,&nbsp;Gregory E Erhabor,&nbsp;Aiah A Gbakima,&nbsp;Abraham Haileamlak,&nbsp;Jean-Marie Kayembe Ntumba,&nbsp;James Kigera,&nbsp;Laurie Laybourn-Langton,&nbsp;Robert Mash,&nbsp;Joy Muhia,&nbsp;Fhumulani M Mulaudzi,&nbsp;David Ofori-Adjei,&nbsp;Friday Okonofua,&nbsp;Arash Rashidian,&nbsp;Maha El-Adawy,&nbsp;Siaka Sidibé,&nbsp;Abdelmadjid Snouber,&nbsp;James Tumwine,&nbsp;Sahar Yassien Mohammad,&nbsp;Paul Yonga,&nbsp;Lilia Zakhama,&nbsp;Chris Zielinski","doi":"10.4102/sajhivmed.v23i1.1467","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1467","url":null,"abstract":"Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present, and future impacts of climate change. The 2022 report of the Intergovernmental Panel on Climate Change paints a dark picture of the future of life on earth, characterised by ecosystem collapse, species extinction, and climate hazards such as heatwaves and floods. These are all linked to physical and mental health problems, with direct and indirect consequences of increased morbidity and mortality. To avoid these catastrophic health effects across all regions of the globe, there is broad agreement— as 231 health journals argued together in 2021—that the rise in global temperature must be limited to less than 1·5C compared with pre-industrial levels. Although the Paris Agreement of 2015 outlines a global action framework that incorporates providing climate finance to developing countries, this support has yet to materialise. COP27 is the fifth Conference of the Parties (COP) to the United Nations Framework Convention on Climate Change to be organised in Africa since its inception in 1995. Ahead of this meeting, we—as health journal editors from across the continent—call for urgent action to ensure it is the COP that finally delivers climate justice for Africa and vulnerable countries. This is essential not just for the health of those countries, but also for the health of the whole world. Africa has suffered disproportionately from the climate crisis, although it has done little to cause the crisis. The climate crisis has had an impact on the environmental and social determinants of health across Africa, leading to devastating health effects. Impacts on health can result directly from environmental shocks and indirectly through socially mediated effects. Climatechange-related risks in Africa include flooding, drought, heatwaves, reduced food production, and reduced labour productivity. Droughts in sub-Saharan Africa have tripled between 1970–79 and 2010–19. In 2018, devastating cyclones impacted 2·2 million people in Malawi, Mozambique, and Zimbabwe. In west and central Africa, severe flooding resulted in mortality and forced migration from loss of shelter, cultivated land, and livestock. Changes in vector ecology brought about by floods and damage to environmental hygiene has led to increases in diseases across sub-Saharan Africa, with rises in malaria, dengue fever, Lassa fever, Rift Valley fever, Lyme disease, Ebola virus disease, West Nile virus, and other infections. Rising sea levels reduce water quality, leading to waterborne diseases, including diarrhoeal diseases, a leading cause of mortality in Africa. Extreme weather damages water and food supply, increasing food insecurity and malnutrition, which causes 1·7 million deaths annually in Africa. According to the Food and Agriculture Organization of the United Nations, malnutrition has increased by almost 50% since 2012, owing to the central role agriculture has in African economies. Environ","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1467"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and HIV viral load suppression in children and adolescents in Durban, South Africa.","authors":"Asandile Mathamo,&nbsp;Kimesh L Naidoo,&nbsp;Jienchi Dorward,&nbsp;Thashir Archary,&nbsp;Christian Bottomley,&nbsp;Moherndran Archary","doi":"10.4102/sajhivmed.v23i1.1424","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1424","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic poses challenges to paediatric and adolescent HIV treatment programme. Modelling exercises raised concerns over potential impact of disruptions.</p><p><strong>Objectives: </strong>To describe the impact of the COVID-19 pandemic on viral load (VL) testing among infants, children and adolescents on antiretroviral treatment (ART) in Durban, South Africa.</p><p><strong>Method: </strong>Routinely collected, aggregated data of monthly VL counts done on all those less than 19 years old from January 2018 to January 2022 was analysed. An interrupted time series analysis using a Prais-Winsten linear regression model, including terms for lockdowns and excess mortality determined VL trends.</p><p><strong>Results: </strong>The unadjusted mean VL was 2166 (confidence interval [CI]: 252.2) and 2016 (CI: 241.9), <i>P</i> = 0.039, and percentage VL suppression rates (72.9%, CI: 2.4% vs 73.6%, CI: 1.8%) across COVID and pre-COVID periods, showing no significant difference, <i>P</i> = 0.262. In the interrupted time series analysis, modelled monthly VL counts did not differ significantly by lockdown level (e.g., level 5 lockdown: -210.5 VLs, 95% CI: -483.0 to +62.1, <i>P</i> = 0.138) or excess mortality (-0.1, 95% CI: -6.3 to 6.1, <i>P</i> = 0.969). A significant downward trend in VL testing over time, including during the pre-COVID-19 period (-6.6 VL per month, 95% CI: -10.4 to -2.7, <i>P</i> = 0.002), was identified.</p><p><strong>Conclusion: </strong>Viral load suppression for children and adolescents were not negatively affected by COVID-19. A trend of decrease in VL testing predated COVID-19.</p><p><strong>What this study adds: </strong>Evidence presented that HIV VL testing and suppression rates in children and adolescents in a high burden setting were sustained through the COVID pandemic.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1424"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9477982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight gain in children from birth to 10 years on antiretroviral treatment.","authors":"Janine Scholtz,&nbsp;Susanna M Ellis,&nbsp;Herculina S Kruger","doi":"10.4102/sajhivmed.v23i1.1413","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1413","url":null,"abstract":"<p><strong>Background: </strong>Inadequate weight gain could indicate clinical deterioration in infants and children living with HIV (CLHIV). The World Health Organization's (WHO) weight-for-age z-score (WAZ) growth standards and reference charts are currently used in South Africa to assess weight gain in CLHIV on antiretroviral treatment (ART).</p><p><strong>Objectives: </strong>To assess weight gain patterns of infants and children initiated on ART and to compare weight gain patterns between the WHO WAZ growth standards and population-specific curves constructed from data of CLHIV on ART.</p><p><strong>Method: </strong>A quantitative, retrospective and descriptive-comparative design was used. The weight gain patterns of 98 infants and children from birth to 10 years old during the 24-month period following ART initiation were recorded and assessed using two different growth charts.</p><p><strong>Results: </strong>The children's rate of weight and length gain improved significantly over 24 months since ART initiation, but complete catch-up growth was never achieved. Most (69%) of the children had increased weight gain according to the WAZ growth standard and reference charts versus only 16% according to the HIV-specific weight gain curves.</p><p><strong>Conclusion: </strong>Antiretroviral treatment improved weight and height gain in CLHIV, but the interpretations of weight gain differed significantly between the WHO chart and HIV-specific weight gain curves. Population- and treatment-specific references could improve weight monitoring in CLHIV and assist in the timeous identification of malnutrition.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1413"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10722539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice.","authors":"Remco P H Peters,&nbsp;Nigel Garrett,&nbsp;Nomathemba Chandiwana,&nbsp;Ranmini Kularatne,&nbsp;Adrian J Brink,&nbsp;Karen Cohen,&nbsp;Katherine Gill,&nbsp;Thato Chidarikire,&nbsp;Camilla Wattrus,&nbsp;Jeremy S Nel,&nbsp;Mahomed Y S Moosa,&nbsp;Linda-Gail Bekker","doi":"10.4102/sajhivmed.v23i1.1465","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1465","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.4102/sajhivmed.v23i1.1450.].</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1465"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10370826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a ward-based outreach team and adherence game on retention and viral load suppression.","authors":"Sanele Ngcobo,&nbsp;Steve Olorunju,&nbsp;Tshifhiwa Nkwenika,&nbsp;Theresa Rossouw","doi":"10.4102/sajhivmed.v23i1.1446","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1446","url":null,"abstract":"<p><strong>Background: </strong>Only 66% of South African people living with HIV (PLWH) are virologically suppressed. Therefore, it is important to develop strategies to improve outcomes.</p><p><strong>Objectives: </strong>Assess the effect of interventions on 12-month retention in care and virological suppression in participants newly initiated on antiretroviral therapy.</p><p><strong>Method: </strong>Fifty-seven clinics were randomised into four arms: Ward-based primary health care outreach teams (WBPHCOTs); Game; WBPHCOT-Game in combination; and Control (standard of care). Sixteen clinics were excluded and four re-allocated because lay counsellors and operational team leaders failed to attend the required training. Seventeen clinics were excluded due to non-enrolment.</p><p><strong>Results: </strong>A total of 558 participants from Tshwane district were enrolled. After excluding ineligible participants, 467 participants were included in the analysis: WBPHCOTs (<i>n</i> = 72); Games (<i>n</i> = 126); WBPHCOT-Games (<i>n</i> = 85); and Control (<i>n</i> = 184). Retention in care at 12 months was evaluable in 340 participants (86.2%) were retained in care and 13.8% were lost to follow-up. The intervention groups had higher retention in care than the Control group, but this only reached statistical significance in the Games group (96.8% vs 77.8%; relative risk [RR] 1.25; 95% confidence interval [CI]: 1.13-1.38; <i>P</i> = 0.01). The 12 month virologic suppression rate was 75.3% and was similar across the four arms.</p><p><strong>Conclusion: </strong>This study demonstrated that an adherence game intervention could help keep PLWH in care.</p><p><strong>What this study adds: </strong>Evidence that interventions, especially Games, could improve retention in care.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1446"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10733073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergent dolutegravir resistance in integrase-naïve, treatment experienced patients from Zimbabwe.","authors":"Linda A Mandikiyana Chirimuta,&nbsp;Margaret J Pascoe,&nbsp;Sara Lowe","doi":"10.4102/sajhivmed.v23i1.1435","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1435","url":null,"abstract":"<p><p>We report two cases of dolutegravir (DTG) resistance in highly treatment experienced patients. Monitoring for treatment failure and adherence support is important in highly treatment experienced patients taking DTG.</p><p><strong>What this study adds: </strong>Dolutegravir is the mainstay of HIV treatment programmes and emergence of drug resistance to DTG is of public health relevance.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1435"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10433288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral pre-exposure prophylaxis uptake, adherence, and adverse events among South African men who have sex with men and transgender women.","authors":"Linda-Gail Bekker,&nbsp;Danielle Giovenco,&nbsp;Stefan Baral,&nbsp;Karen Dominguez,&nbsp;Rachel Valencia,&nbsp;Travis Sanchez,&nbsp;A D McNaghten,&nbsp;Ryan Zahn,&nbsp;Clarence S Yah,&nbsp;Zinhle Sokhela,&nbsp;Richard Kaplan,&nbsp;Refliwe N Phaswana-Mafuya,&nbsp;Chris Beyrer,&nbsp;Patrick S Sullivan","doi":"10.4102/sajhivmed.v23i1.1405","DOIUrl":"https://doi.org/10.4102/sajhivmed.v23i1.1405","url":null,"abstract":"<p><strong>Background: </strong>HIV prevention programmes that include pre-exposure prophylaxis (PrEP) for men who have sex with men (MSM) and transgender women (TGW) in South Africa have not been widely implemented.</p><p><strong>Objectives: </strong>The authors examined oral PrEP uptake, adherence, and adverse events among HIV-uninfected MSM and TGW to inform intervention acceptability and feasibility.</p><p><strong>Method: </strong>In 2015, MSM and TGW in two South African cities were offered a comprehensive package of HIV prevention services, including daily oral PrEP, and were followed for one year. Different models of PrEP delivery were used at each site. Adherence was measured using self-report and pill-count data and tenofovir-diphosphate (TFV-DP) concentrations.</p><p><strong>Results: </strong>Among 135 participants who were eligible for PrEP, 82 (61%) initiated PrEP, of whom 67 (82%) were on PrEP at study end. Participants were on PrEP for a median of 294 out of 314.5 possible days (93% protected days). The median time from PrEP initiation to discontinuation or study end was 305 days (interquartile range: 232-325 days). Across the follow-up time points, 57% - 72% of participants self-reported taking protective levels of PrEP and 59% - 74% were adherent to PrEP as indicated by pill counts. Fewer (≤ 18%) achieved protective TFV-DP concentrations of ≥ 700 fmol/punch in dried blood spots. Side effects, while typically mild, were the most commonly cited reason by participants for early PrEP discontinuation.</p><p><strong>Conclusion: </strong>Many MSM and TGW initiated and maintained PrEP, demonstrating that PrEP can be successfully delivered to South African MSM and TGW in diverse programmatic contexts. Biologic adherence measures suggest MSM and TGW may experience challenges taking PrEP regularly. Counselling for coping with side effects and motivating daily pill taking is recommended to support South African MSM and TGW in achieving protection with PrEP.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"23 1","pages":"1405"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Table of Contents Vol 22, No 1 (2021)","authors":"Editorial Office","doi":"10.4102/sajhivmed.v22i1.1365","DOIUrl":"https://doi.org/10.4102/sajhivmed.v22i1.1365","url":null,"abstract":"No abstract available.","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"17 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138539219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}