Southern African Journal of Hiv Medicine最新文献

{"title":"Outcomes and characteristics of patients on protease inhibitors at a tertiary level antiretroviral clinic","authors":"Michele Perks, D. Reddy, Francois Venter","doi":"10.4102/sajhivmed.v24i1.1536","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1536","url":null,"abstract":"Background: Protease inhibitors (PIs) have been recommended as World Health Organization second-line antiretroviral therapy (ART) for low- to middle-income countries for two decades. As dolutegravir-based regimens have become widely available, the future role of PIs is uncertain.Objectives: To describe the characteristics of patients on PI-based ART (in first-line and second-line regimens), double-boosted protease inhibitors (DBPI) and patients who received recycled nucleoside reverse transcriptase inhibitors (NRTI) in second-line regimens at a tertiary level ART clinic.Method: We conducted a descriptive retrospective record review of adult patients on PI-based ART who attended Nthabiseng Adult Infectious Diseases Clinic at Chris Hani Baragwanath Academic Hospital in Soweto, South Africa, between January 2021 and April 2022.Results: Of the 900 patients sampled, 543 (60.3%) were female, the median age was 45 and 703 (79.1%) had viral loads (VL) below 1000 copies/mL. In contrast, 21 (58.3%) of 36 vertically infected patients had VLs below 1000 copies/mL. Thirty-seven (4.1%) patients were on DBPIs. The commonest reason for DBPI use in 24 (64.9%) patients was drug resistance test (DRT)-guided switch after virological failure. Forty-nine (5.4%) patients were on recycled NRTIs with no DRT, and 24 (2.6%) patients were on NRTIs to which there was documented resistance. Outcomes for these patients were similar to the total sample.Conclusion: PIs have long been a cornerstone of second-line ART. This study demonstrates the real-world utility of PIs, as well as their disadvantages. There was no difference in the outcomes of patients who received recycled NRTIs in second-line regimens.","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"14 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138952083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rural nurses' antiretroviral prescribing practices in children, Limpopo province, South Africa.","authors":"Linneth N Mabila, Patrick H Demana, Tebogo M Mothiba","doi":"10.4102/sajhivmed.v24i1.1470","DOIUrl":"10.4102/sajhivmed.v24i1.1470","url":null,"abstract":"<p><strong>Background: </strong>Errors in antiretroviral therapy (ART) use are common in children living with HIV (CLHIV), but there is limited evidence from rural primary healthcare (PHC) facilities where trained professional nurses initiate and manage most CLHIV.</p><p><strong>Objectives: </strong>To assess antiretroviral prescribing practices of trained professional nurses in Mopani District's rural facilities and compare them to the 2015 national consolidated guidelines to evaluate the appropriateness of ART use.</p><p><strong>Method: </strong>A four-year (2015-2018) retrospective cross-sectional medical record review was conducted of CLHIV in 94 rural PHC facilities of Mopani District. Inclusion criteria were: age under 15 years, initiated on ART by nurses in 2015 and virally unsuppressed (viral load ≥ 400 copies/mL) by the end of December 2018.</p><p><strong>Results: </strong>A total of 16 669 antiretrovirals were prescribed from 7035 clinic visits. A correct ART regimen and dosage form was prescribed in 7045 (96%) and 15 502 (93%) of the cases. However, errors were common: 2928 (23%) incorrect doses, 15 502 (93%) incorrect dosing frequencies, and 4122 (61%) incorrectly dispensed antiretrovirals, and 3636 (28%) incorrect dosing frequencies.</p><p><strong>Conclusion: </strong>Antiretroviral prescribing errors in the form of drug omissions in ART regimens, incorrect dosing and dosing frequencies, lack of formulation considerations, and inadequate monthly supplies of antiretrovirals were commonly observed in this review. Antiretroviral stewardship programmes should be considered to develop and establish a fundamental strategy for improving quality in managing CLHIV.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"1 1","pages":"1470"},"PeriodicalIF":1.7,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10713496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42512023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight gain on dolutegravir: Association is not the same as causation.","authors":"Gary Maartens,&nbsp;Phumla Sinxadi,&nbsp;W D Francois Venter","doi":"10.4102/sajhivmed.v24i1.1500","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1500","url":null,"abstract":"","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"24 1","pages":"1500"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9610382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival outcomes of HIV-positive adults on peritoneal dialysis at Helen Joseph renal unit.","authors":"Kagisho L Thomas,&nbsp;Malcolm Davies","doi":"10.4102/sajhivmed.v24i1.1471","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1471","url":null,"abstract":"<p><strong>Background: </strong>HIV is a risk factor for the development of chronic kidney disease. People with chronic kidney disease in the state sector are likely to be prescribed continuous ambulatory peritoneal dialysis (CAPD). Previous studies have raised concern about the safety of CAPD in people living with HIV (PLWH) compared to HIV-negative patients.</p><p><strong>Objectives: </strong>To compare the risk of peritonitis, and modality and patient survival by HIV status in patients receiving CAPD at Helen Joseph Hospital.</p><p><strong>Method: </strong>A retrospective study of patients receiving CAPD between 01 January 2007 and 31 December 2017 was undertaken. Five-year patient and modality survival were modelled for PLWH and HIV-negative subgroups and analysed using the log-rank test; the effect of CD4 count, HIV viral load, and duration of antiretroviral therapy on these parameters in PLWH were additionally modelled using the Cox Proportional Hazards technique.</p><p><strong>Results: </strong>Eighty-four patients, comprising of 21 PLWH and 63 HIV-negative patients, were analysed. No difference was observed in the proportion of patients who had at least one episode of peritonitis between PLWH (61.2%) and HIV-negative patients (63.5%) (<i>P</i> = 0.547). A trend towards increased risk of peritonitis due to Gram-negative organisms in PLWH was noted (odds ratio: 3.20, 95% confidence interval: 0.86-11.9, <i>P</i> = 0.083). No difference was observed in 5-year patient or modality survival on CAPD between PLWH (log-rank <i>P</i> = 0.161) and HIV-negative patients (log-rank <i>P</i> = 0.240).</p><p><strong>Conclusion: </strong>People living with HIV should not be excluded from CAPD as a mode of kidney replacement therapy (KRT).</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"24 1","pages":"1471"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9610384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of HIV on mortality among hospitalised patients in South Africa.","authors":"Dirk J Lamprecht,&nbsp;Neil Martinson,&nbsp;Ebrahim Variava","doi":"10.4102/sajhivmed.v24i1.1477","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1477","url":null,"abstract":"<p><strong>Background: </strong>HIV and AIDS continues to impose substantial healthcare challenges in sub-Saharan Africa, but there are limited local data comparing inpatient outcomes between people with HIV (PLWH) and those uninfected.</p><p><strong>Objectives: </strong>To compare cause-specific mortality among hospitalised adolescents and adults, stratified by HIV-serostatus.</p><p><strong>Method: </strong>A cross-sectional analysis was performed, analysing cause-specific inpatient mortality data and total admissions, from 01 January 2017 to 30 June 2020, at Tshepong Hospital, North West province, South Africa.</p><p><strong>Results: </strong>The overall inpatient mortality rate decreased from 14.5% (95% confidence interval [CI]: 13.4-16.0) in 2017, to 11.3% (95% CI: 10.6-11.9) in 2020; <i>P</i> < 0.001. People living with HIV accounted for 53.9% (<i>n</i> = 2342) of inpatient deaths, 22.6% (<i>n</i> = 984) were HIV-seronegative patients and 23.5% (<i>n</i> = 1020) patients with unknown HIV-serostatus. People with HIV died at younger ages (median: 44 years, interquartile range [IQR]: 35.8-54.2) compared to HIV-seronegative inpatients (median: 64.4 years, IQR: 55.5-73.9); <i>P</i> < 0.001. Leading causes of death were pneumonia (19.9%, <i>n</i> = 863), then pulmonary and extrapulmonary tuberculosis (15.0%, <i>n</i> = 654). People with HIV who had CD4+ counts < 350 cells/mL or viral load ≥ 1000 copies/mL had increased risk of death from tuberculosis compared to virally suppressed patients (adjusted relative risk: 2.10 [95% CI: 1.44-3.04, <i>P</i> < 0.009] and 1.56 [95% CI: 1.22-2.00, <i>P</i> < 0.001]).</p><p><strong>Conclusion: </strong>Our study, conducted in a regional hospital in South Africa, showed PLWH had higher mortality rates and died at younger ages compared to HIV-seronegative patients.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"24 1","pages":"1477"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of a model for re-testing HIV-negative index contacts in Sedibeng, South Africa.","authors":"Ditebogo L Phiri,&nbsp;Kate Rees,&nbsp;Natasha Davies","doi":"10.4102/sajhivmed.v24i1.1482","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1482","url":null,"abstract":"<p><strong>Background: </strong>Index contact testing is an HIV case-finding approach that elicits sexual or needle-sharing partners, as well as biological children, of people living with HIV (PLHIV) and offers them HIV testing services.</p><p><strong>Objectives: </strong>We aim to describe the results of an innovative project in Sedibeng District that expanded index testing by retesting previously negative contacts and incorporating status-neutral testing.</p><p><strong>Method: </strong>We used registers to identify people who previously tested HIV-negative through index testing from March 2019 to September 2021. The individuals were telephonically traced and offered HIV retesting. Data were collected on a weekly basis using REDCap^®. We monitored the number of individuals called, those who came back for retest, and their HIV results.</p><p><strong>Results: </strong>Fifteen counsellors contacted 968 people over 12 months. Forty-eight percent (462 out of 968) of those called returned for testing. Of those, 121 (26%) tested positive. Overall, 66 out of 276 (24%) men with HIV and 55 out of 186 (30%) women with HIV were identified and linked to antiretroviral treatment (ART). Fifty-seven percent (194 out of 341) of clients who tested HIV-negative were offered, and 124 out of 194 (64%) initiated, pre-exposure prophylaxis (PrEP). All individuals who retested HIV-positive had a new diagnosis; none reported having had another positive test result between the original negative and the positive retest.</p><p><strong>Conclusion: </strong>Revisiting index clients with a previous negative HIV test result is worthwhile, creating an opportunity to identify undiagnosed PLHIV and high-risk people for PrEP. The high positivity rate highlights the importance of providing a sero-neutral approach to HIV testing, including integrating prevention messaging and linkage to PrEP services.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"24 1","pages":"1482"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9610383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human rights violations among men who have sex with men and transgender people in South Africa.","authors":"Raymond Chimatira,&nbsp;Dumo Jebese-Mfenqe,&nbsp;Joram Chikwanda,&nbsp;Edward Sibanda,&nbsp;Qhawekazi Thengwa,&nbsp;Bulumko Futshane,&nbsp;Sisanda Gaga","doi":"10.4102/sajhivmed.v24i1.1417","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1417","url":null,"abstract":"<p><strong>Background: </strong>Men who have sex with men (MSM) and transgender (TG) people face human rights violations (HRVs) which impact their access to critical interventions for HIV prevention, treatment, and related services.</p><p><strong>Objectives: </strong>This study describes how Beyond Zero, a not-for-profit organisation in South Africa, built an HRV reporting system and discusses data on the HRVs experienced by MSM and TG people who accessed HIV prevention services between 01 January 2021 and 31 December 2021.</p><p><strong>Method: </strong>This was a cross-sectional study using secondary analysis of programmatic data routinely collected as part of HIV prevention programmes for MSM and TG in 10 rural districts of South Africa.</p><p><strong>Results: </strong>A total of 249 individuals reported having experienced HRVs. Of these, 113 (54.6%) were physical violations, 145 (58.2%) were psychosocial harassment, 15 (18.3%) were experienced within the workplace, and 59 (23.7%) were experienced at a healthcare or social services institution. Overall, 77% of the physical violations and 70.4% of the psychosocial violations occurred in the home and local community settings; 76.1% of the perpetrators of physical violence and 79.3% of the perpetrators of psychosocial harassment were known. Most incidents of physical violence (80.5%) and psychosocial harassment (92.4%) were not reported due to fear of homophobic or transphobic violence.</p><p><strong>Conclusion: </strong>Our findings demonstrate the feasibility of documenting HRVs among MSM and TG people within HIV prevention programmes. Men who have sex with men and TG people should be systematically screened for HRVs and linked to legal or other services.</p><p><strong>What this study adds: </strong>Our findings present data on the nature of HRVs in 10 districts outside of the large urban centres where research documenting the lived experiences of MSM, TG people and other key populations is traditionally conducted in South Africa. This data contribute to addressing the gap in the literature on the needs of MSM and TG people in South Africa caused by the delayed inclusion of rural MSM and TG people in research.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"24 1","pages":"1417"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10666280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of cervical abnormalities: Comparison of youth with perinatally acquired HIV and older women in Botswana.","authors":"Thabo Phologolo,&nbsp;Mogomotsi Matshaba,&nbsp;Bathusi Mathuba,&nbsp;Keboletse Mokete,&nbsp;Ontibile Tshume,&nbsp;Elizabeth Lowenthal","doi":"10.4102/sajhivmed.v24i1.1455","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1455","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer burden and prevalence of precursor lesions is unknown among young women living with HIV in high prevalence settings. Current cervical cancer screening guidelines in resource-limited settings with high HIV prevalence typically exclude adolescents and young women. After observing two cases of advanced cervical cancer among young women with perinatally acquired HIV, a pilot screening programme was established in Botswana.</p><p><strong>Objectives: </strong>To compare the prevalence of cervical abnormalities in young women with perinatally acquired HIV with women aged 30-49 years, regardless of HIV status.</p><p><strong>Method: </strong>We conducted a cross-sectional study of 30-49-year-old women who had visual inspection with acetic acid screening through the Botswana public sector programme, and youth (aged 15-24 years) with perinatally acquired HIV, at a single referral site between 2016 and 2018. We describe the prevalence of cervical abnormalities in each group as well as the crude prevalence ratio.</p><p><strong>Results: </strong>The prevalence of cervical abnormalities in women 30-49 years of age was 10.9% (95% confidence interval [CI]: 10.4, 11.4), and 10.1% (95% CI: 4.7, 18.3) for youth. The crude prevalence ratio was 1.07 (95% CI: 0.58, 2.01).</p><p><strong>Conclusion: </strong>Inclusion of youth living with HIV in cervical cancer screening services should be considered in settings with a high prevalence of HIV and cervical cancer.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"24 1","pages":"1455"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9309496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An audit of adherence to cervical cancer screening guidelines in a tertiary-level HIV clinic.","authors":"Jeffrey Bolon,&nbsp;Amy Samson,&nbsp;Natalie Irwin,&nbsp;Lyle Murray,&nbsp;Langanani Mbodi,&nbsp;Sarah Stacey,&nbsp;Nicholas Aikman,&nbsp;Louell Moonsamy,&nbsp;Jarrod Zamparini","doi":"10.4102/sajhivmed.v24i1.1490","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1490","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is the most common malignancy affecting South African women aged 15-44 years, with a higher prevalence among women living with HIV (WLWH). Despite recommendations for a screening target of 70%, the reported rate of cervical cancer screening in South Africa is 19.3%.</p><p><strong>Objectives: </strong>To investigate the adherence of healthcare workers to cervical cancer screening guidelines in a tertiary-level HIV clinic.</p><p><strong>Method: </strong>A retrospective cross-sectional record audit of women attending the Charlotte Maxeke Johannesburg Academic Hospital HIV Clinic over a 1-month period.</p><p><strong>Results: </strong>Out of 403 WLWH who attended the clinic, 180 (44.7%) were screened for cervical cancer in the 3 years prior to the index consultation. Only 115 (51.6%) of those women with no record of prior screening were subsequently referred for screening. Women who had undergone screening in the previous 3 years were significantly older (47 years vs 44 years, <i>P</i> = 0.046) and had a longer time since diagnosis of their HIV (12 years vs 10 years, <i>P</i> = 0.001) compared to women who had not undergone screening. There was no significant difference in CD4 count or viral suppression between women who had and had not undergone screening.</p><p><strong>Conclusion: </strong>The rate of cervical cancer screening in our institution is below that recommended by the World Health Organization and the South African National Department of Health.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"24 1","pages":"1490"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9610379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the unbreakable: A paediatric case of dolutegravir resistance from KwaZulu-Natal.","authors":"Sibongiseni Malinga,&nbsp;Aabida Khan,&nbsp;Moherndran Archary","doi":"10.4102/sajhivmed.v24i1.1458","DOIUrl":"https://doi.org/10.4102/sajhivmed.v24i1.1458","url":null,"abstract":"<p><p>We report a case of dolutegravir resistance in KwaZulu-Natal in a 13-year-old male two years after starting dolutegravir. Resistance most likely developed due to poor adherence as a result of psychosocial issues. This case highlights the importance of the role of the family unit in impacting adherence and close monitoring of treatment-experienced patients with virologic failure following switching to dolutegravir-based regimens.</p>","PeriodicalId":49489,"journal":{"name":"Southern African Journal of Hiv Medicine","volume":"24 1","pages":"1458"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9610381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}