Turkiye Klinikleri Tip Bilimleri Dergisi最新文献_第5页

Comparison of Pleth Variability Index and Inferior Vena Cava Distensibility as a Perfusion Indicator in Sepsis Patients: An Observational Study 脓毒症患者容积变异性指数与下腔静脉扩张率作为灌注指标的比较:一项观察性研究

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2021-85651

Orhan Göktürk, Onur Avcı, Oğuz Gündoğdu, A. C. Işbir, İclal Özdemir Kol, S. Gürsoy, K. Kaygusuz

{"title":"Comparison of Pleth Variability Index and Inferior Vena Cava Distensibility as a Perfusion Indicator in Sepsis Patients: An Observational Study","authors":"Orhan Göktürk, Onur Avcı, Oğuz Gündoğdu, A. C. Işbir, İclal Özdemir Kol, S. Gürsoy, K. Kaygusuz","doi":"10.5336/medsci.2021-85651","DOIUrl":"https://doi.org/10.5336/medsci.2021-85651","url":null,"abstract":"ABS TRACT Objective: The aim of this study was to compare the sensitivity and specificity of Pleth Variability Index (PVI) and distensibility of inferior vena cava (dIVC) in fluid responsiveness of patients with sepsis. Material and Methods: Forty patients over 18 years of age who underwent fluid replacement for sepsis in the intensive care unit were included in the study. In our study, the patients were divided into 2 groups as those who had less than 15% increase in cardiac output (CO), and those who had more than 15% increase in CO after fluid replacement (fluid responders and non-responders). Before fluid replacement, demographic data of the patients (age, weight, cause of sepsis, body surface area, SOFA score), vital parameters (systolic arterial pressure, diastolic arterial pressure, mean arterial pressue, heart rate) and measuredd val- ues (maximum diameter of vena cava inferior, minimum diameter of vena cava inferior, central venous pressure, PVI, CO, and stroke volume) were recorded. After applying crystalloid in a dose of 10 mL/kg for 15 minutes, the recorded parameters were repeated at 15 th minute. Results: When receiver operating characteristic (ROC) analysis was performed for dIVC, the area under the curve (AUC) was found to be 0.833 (0.739-0.926). The threshold value was found to be 17.52%, sensitivity was 77.5%, and specificity was 72.5%. When ROC analysis was performed for PVI, AUC was found to be 0.889 (0.817-0.962). The threshold value was found as 12.50%, sensitivity was 72.5%, and specificity was 92.5%. Conclusion: PVI was found to be more specific but less sensitive than dIVC. dIVC is less sensitive and less specific than central venous pressure. However, dIVC and PVI can give useful results in patients who have con- traindication of an invasive technique.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Evaluation of SNPs Occurring in DCX and PAFAH1B1 Genes Involved in Embryonic Brain Development: Bioinformatic Study 参与胚胎脑发育的DCX和PAFAH1B1基因snp的计算机评价:生物信息学研究

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2021-86727

Ahmet Tamer

引用次数: 0

Alterations of Monoaminergic Systems in Alzheimer's Disease: A Traditional Review 阿尔茨海默病单胺能系统的改变:传统综述

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2022-89011

Raviye ÖZEN KOCA, Z. I. SOLAK GÖRMÜŞ, H. Solak

{"title":"Alterations of Monoaminergic Systems in Alzheimer's Disease: A Traditional Review","authors":"Raviye ÖZEN KOCA, Z. I. SOLAK GÖRMÜŞ, H. Solak","doi":"10.5336/medsci.2022-89011","DOIUrl":"https://doi.org/10.5336/medsci.2022-89011","url":null,"abstract":"Alzheimer’s disease (AD) is an age-related, neurodegenerative disease with characteristic clinical and pathological features. The death rate from AD was exacerbated by the coronavirus disease 2019 pandemic in 2020. The most common neuropathological findings are extraneuronal senile plaques and intraneuronal neurofibrillary tangles. AD is a multisystemic disease that affects many neuronal structures, including monoaminergic systems. Functional changes in neurotransmitters are closely related to the pathophysiology of AD. It is known that many neurotransmitters such as acetylcholine decrease as a result of loss of neuronal synapses and neuronal death. In the monoaminergic system, basically, the substantia nigra nucleus providing the dopaminergic innervation, the dorsal raphe nucleus providing the serotonergic innervation, the locus ceruleus nucleus providing the noradrenergic innervation, and the tuberomamillar nucleus providing the histaminergic innervation are exposed to significant degeneration in AD. There are changes in the levels of relevant neurotransmitters in the regions projected from these nuclei. Combined therapy (cognitive enhancing treatments, drugs to treat neuropsychiatric symptoms, disease-modifying therapies) important to reduce behavioral abnormalities and effectively restore cognitive functions in AD patients. Treatment strategies for AD require understanding the molecular mechanism behind the monoaminergic system. With this traditional review, we aim to discuss in detail the changes that occur in the monoaminergic system, especially in dopamine, noradrenaline, serotonin and histamine mechanisms in AD, and present a perspective on this issue. As a result;more studies in humans and animal models are needed to better understand the signaling mechanism of the monoaminergic system and the effects of monoaminergic receptors. Thus, the development of new treatment strategies for AD will accelerate. © 2022 by Türkiye Klinikleri.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy and Safety of Denosumab for Treating Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis Denosumab治疗骨巨细胞瘤的疗效和安全性:一项系统综述和荟萃分析

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2021-85869

Chairul Arby Desiyanto, Rady Dwipayana, R. Ermawan, Iwan Sutanto, Astri Soetanto, J. Fajar

引用次数: 0

Frailty Predicts Outcomes and Prognosis of Liver Cirrhosis Patients: A Meta-Analysis and Systematic Review 虚弱可以预测肝硬化患者的预后:荟萃分析和系统评价

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2021-87150

Putu Ijiya DANTA AWATARA, A. Kuncoro, Levrita Nindya Poetri, Nuansa Firgie Paramita, J. Fajar, Syifa Mustika

引用次数: 0

Effectiveness of Proprioceptive Exercise on Balance and Sensory Function in Nursing Home Geriatric Individuals with Diabetes: Randomized Controlled Trial 本体感觉运动对养老院老年糖尿病患者平衡和感觉功能的影响:随机对照试验

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2021-86357

F. Demir, M. Şahin, Gizem Ergezen

引用次数: 0

Turkish Plastic Surgeons' Preferences Related to the Inframammary Approach in Breast Augmentation Surgery: A Descriptive Study 土耳其整形外科医生对隆胸手术中乳房下入路的偏好:一项描述性研究

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2022-89113

A. Erdal

引用次数: 0

Retrospective Evaluation of the Cases Presenting to the Pediatric Intensive Care Unit with Cardiogenic Shock in Terms of Etiology, Treatment and Long-Term Prognosis 儿童重症监护病房心源性休克病例的病因、治疗和长期预后回顾性评价

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2022-89203

E. Azapağası, S. Kesici, Bilge Akkaya, Tamer Yoldaş, M. Uysal Yazıcı, Zeynelabidin Öztürk, M. Taşar, U. Örün

{"title":"Retrospective Evaluation of the Cases Presenting to the Pediatric Intensive Care Unit with Cardiogenic Shock in Terms of Etiology, Treatment and Long-Term Prognosis","authors":"E. Azapağası, S. Kesici, Bilge Akkaya, Tamer Yoldaş, M. Uysal Yazıcı, Zeynelabidin Öztürk, M. Taşar, U. Örün","doi":"10.5336/medsci.2022-89203","DOIUrl":"https://doi.org/10.5336/medsci.2022-89203","url":null,"abstract":"ABS TRACT Objective: Cardiogenic shock is acute circulation failure emerg- ing with a linkage to disrupted myocardial contraction. The aim of this study is to identify the underlying etiology, assess the treatment methods, and the long- term prognoses of survivors among the patients admitted to intensive care with cardiogenic shock for the first time and without a previous heart disease history. Material and Methods: This study included patients admitted to the intensive care unit in our hospital for the first time with cardiogenic shock from March 2016 to March 2020. The age interval was 1 month to 18 years. The demographic, clinical, laboratory, and radiological findings for patients were recorded. All pa- tients were evaluated with echocardiography at admission and 12 months after discharge. Results: Of the 24 patients included in this study, 50% were girls (n=12). Nineteen (79.1%) of the 24 patients had acute myocarditis as the underlying cause. Three (12.5%) patients had hypocalcaemia linked to vitamin D de- ficiency, 1 (4.2%) patient had anomalous left coronary artery from the pulmonary artery syndrome, and 1 (4.2%) patient had cardiac tamponade linked to purulent pericarditis. In echocardiographic examinations performed at a 12-month interval, left ventricle ejection fraction increased from 32.45±9.26% to 49.18±15.53%, and left ventricle end-diastolic diameter Z score decreased from 5.65 (4.4) to 2.02 (4.76). Conclusion: With appropriate fluids, diuretic treatment, inotrope man- agement, and extracorporeal support, the prognosis for these patients has clearly improved in recent years.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospital Infection Rates in Neurology Intensive Care Unit of a University Hospital: Retrospective Study 某大学医院神经内科重症监护病房医院感染率回顾性研究

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2022-89293

Güliz Uyar Güleç, Hatice Benli̇can

引用次数: 0

Comparison of Postoperative Analgesic Efficacy Between Ultrasonography-Guided Quadratus Lumborum and Transversus Abdominis Plane Blocks in Infants Undergoing Inguinal Hernia Surgery: Randomized Controlled Trial 超声引导下腰方肌与腹横平面阻滞对婴儿腹股沟疝术后镇痛效果的比较:随机对照试验

Turkiye Klinikleri Tip Bilimleri Dergisi Pub Date : 2022-01-01 DOI: 10.5336/medsci.2022-87968

P. Sayın, H. S. Türk, Mustafa Altınay, Melis TÜRKEL ÖZKAN, Serkan İslamoğlu, S. Çınar

{"title":"Comparison of Postoperative Analgesic Efficacy Between Ultrasonography-Guided Quadratus Lumborum and Transversus Abdominis Plane Blocks in Infants Undergoing Inguinal Hernia Surgery: Randomized Controlled Trial","authors":"P. Sayın, H. S. Türk, Mustafa Altınay, Melis TÜRKEL ÖZKAN, Serkan İslamoğlu, S. Çınar","doi":"10.5336/medsci.2022-87968","DOIUrl":"https://doi.org/10.5336/medsci.2022-87968","url":null,"abstract":"ABS TRACT Objective: We compared the analgesic efficacy of ultrasonography (USG)-guided quadratus lumborum (QL) and transversus abdominis plane (TAP) blocks in infants undergoing elective unilateral inguinal hernia surgery (IHS). Material and Methods: This single-center, randomized, single-blind, 2-arm clinical trial included 60 infants undergoing elective IHS (aged 1 month to 1 year) with ASA I–II. The patients were randomized into QL block (Group A) and TAP block (Group B) groups. For both groups, 0.3 mL/kg of 0.25% bupivacaine was injected under USG guidance. Age, sex, weight, anesthesia duration (min), surgery duration (min), and recovery duration (min) were recorded. The heart rate (HR) was recorded at baseline, after anesthesia induction, and at 15 and 30 min after the blocks. Postoperatively, patients were evaluated based on their Face, Legs, Activity, Cry, and Consolability (FLACC) scores at 0, 1, 2, 6, 12, and 24 We also recorded the first analgesic duration, analgesic requirement, rescue analgesic requirement, and complications. The primary outcome of the study was FLACC score. Results: Sixty patients completed the study protocol. There were no significant differences between the groups in terms of age, sex, weight, anesthesia duration, surgery duration, recovery duration, or FLACC score or HR in the first 24 h postoperatively. The analgesic requirement, first analgesic requirement time, and rescue analgesic requirement were not significantly different between the groups (p>0.05 for all comparisons). Conclusions: QL and TAP blocks showed similar analgesic efficacy in infants undergoing IHS.","PeriodicalId":49403,"journal":{"name":"Turkiye Klinikleri Tip Bilimleri Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70785143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0