Ultraschall in Der Medizin最新文献

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Introducing Ultrasound to students - Is it useful or is it just "fashion"? 向学生介绍超声波--是有用还是只是 "时尚"?
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-08-01 DOI: 10.1055/a-2329-2521
Alina Popescu, Ioan Sporea, Roxana Șirli
{"title":"Introducing Ultrasound to students - Is it useful or is it just \"fashion\"?","authors":"Alina Popescu, Ioan Sporea, Roxana Șirli","doi":"10.1055/a-2329-2521","DOIUrl":"https://doi.org/10.1055/a-2329-2521","url":null,"abstract":"","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":"45 4","pages":"344-346"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing the number of valid measurements for the attenuation coefficient to assess hepatic steatosis in MAFLD patients: A study of 139 patients who underwent liver biopsy. 优化评估 MAFLD 患者肝脏脂肪变性的衰减系数的有效测量次数:对 139 名接受肝活检患者的研究。
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-08-01 Epub Date: 2023-12-11 DOI: 10.1055/a-2178-5022
Xueqi Li, Xianjue Huang, Guangwen Cheng, Jing Liang, Luping Qiu, Jubo Zhang, Qiyuan Yao, Hong Ding
{"title":"Optimizing the number of valid measurements for the attenuation coefficient to assess hepatic steatosis in MAFLD patients: A study of 139 patients who underwent liver biopsy.","authors":"Xueqi Li, Xianjue Huang, Guangwen Cheng, Jing Liang, Luping Qiu, Jubo Zhang, Qiyuan Yao, Hong Ding","doi":"10.1055/a-2178-5022","DOIUrl":"10.1055/a-2178-5022","url":null,"abstract":"<p><strong>Purpose: </strong>We investigated the optimal number of valid measurements (VMs) for the attenuation coefficient (AC) to assess liver steatosis using attenuation imaging (ATI) and explored factors that may affect AC measurement in patients with metabolic dysfunction-associated fatty liver disease (MAFLD).</p><p><strong>Materials and methods: </strong>A total of 139 patients with MAFLD who underwent ATI and liver biopsy were enrolled. Hepatic steatosis was graded as S0-3 according to the SAF scoring system. The AC values from 1, 2, 3, 5, and 7 VMs were compared with the degree of liver steatosis. The correlation between AC values from different VMs was analyzed. The diagnostic performance of AC from different VMs at each steatosis grade was compared. The factors related to AC were identified using linear regression analysis.</p><p><strong>Results: </strong>The mean AC values from 1, 2, 3, 5, and 7 VMs were not significantly different between grades S0-3 (p=n.s. for all). Bland-Altman analysis showed the mean difference in AC values of 3 VMs and 7 VMs was 0.003 dB/cm/MHz, which was smaller compared with 2 VMs, and close to 5 VMs. The intraclass correlation coefficients of AC were all > 0.90 among different VM groups. AC values from different VMs all significantly predicted steatosis grade ≥S1, ≥S2, and S3 without significant statistical differences (p=n.s. for all). The multivariate analysis showed that the hepatic steatosis grade and triglyceride level were factors independently associated with AC.</p><p><strong>Conclusion: </strong>Three valid measurements of AC may be adequate to ensure the accuracy and reproducibility of hepatic steatosis assessment. The degree of liver steatosis and the triglyceride level significantly affected AC values.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":"395-404"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138812353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Student ultrasound education - current views and controversies. 学生超声波教育--当前的观点和争议。
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-08-01 Epub Date: 2024-03-14 DOI: 10.1055/a-2265-1070
Christoph F Dietrich, Roxana Lucia Sirli, Gregor Barth, Michael Blaivas, Nils Daum, Yi Dong, Manfred Essig, Anna Maria Gschmack, Adrian Goudie, Tino Hofmann, Beatrice Hoffmann, Christian Jenssen, Michael Kallenbach, Thomas Karlas, Alexander Krutz, Axel Löwe, Claudia Lucius, Kathleen Möller, Ricarda Neubauer, Dieter Nurnberg, Michael Prats, Helmut Prosch, Florian Recker, Johannes P Ruppert, Sophie-Luise Sänger, Friederike Wangenheim, Johannes M Weimer, Susan Campbell Westerway, Constantinos Zervides
{"title":"Student ultrasound education - current views and controversies.","authors":"Christoph F Dietrich, Roxana Lucia Sirli, Gregor Barth, Michael Blaivas, Nils Daum, Yi Dong, Manfred Essig, Anna Maria Gschmack, Adrian Goudie, Tino Hofmann, Beatrice Hoffmann, Christian Jenssen, Michael Kallenbach, Thomas Karlas, Alexander Krutz, Axel Löwe, Claudia Lucius, Kathleen Möller, Ricarda Neubauer, Dieter Nurnberg, Michael Prats, Helmut Prosch, Florian Recker, Johannes P Ruppert, Sophie-Luise Sänger, Friederike Wangenheim, Johannes M Weimer, Susan Campbell Westerway, Constantinos Zervides","doi":"10.1055/a-2265-1070","DOIUrl":"10.1055/a-2265-1070","url":null,"abstract":"<p><p>As an extension of the clinical examination and as a diagnostic and problem-solving tool, ultrasound has become an established technique for clinicians. A prerequisite for high-quality clinical ultrasound practice is adequate student ultrasound training. In light of the considerable heterogeneity of ultrasound curricula in medical studies worldwide, this review presents basic principles of modern medical student ultrasound education and advocates for the establishment of an ultrasound core curriculum embedded both horizontally and vertically in medical studies.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":"389-394"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic, noninvasive endometriosis diagnosis in transvaginal sonography by the Swiss Society of Ultrasound in Medicine. 瑞士医学超声协会通过经阴道超声进行系统的无创子宫内膜异位症诊断。
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-08-01 Epub Date: 2024-05-24 DOI: 10.1055/a-2241-5233
Julian Matthias Metzler, Leana Finger, Tilo Burkhardt, Markus Eugen Hodel, Gwendolin Manegold-Brauer, Sara Imboden, Janna Pape, Patrick Imesch, Isabell Witzel, Michael Bajka
{"title":"Systematic, noninvasive endometriosis diagnosis in transvaginal sonography by the Swiss Society of Ultrasound in Medicine.","authors":"Julian Matthias Metzler, Leana Finger, Tilo Burkhardt, Markus Eugen Hodel, Gwendolin Manegold-Brauer, Sara Imboden, Janna Pape, Patrick Imesch, Isabell Witzel, Michael Bajka","doi":"10.1055/a-2241-5233","DOIUrl":"10.1055/a-2241-5233","url":null,"abstract":"<p><p>We present a new systematic, comprehensive, checklist-based sonographic assessment of endometriosis in the female true pelvis. Emphasis is placed on practical skills teaching. The newly introduced White Sliding Line (WSL) is the core structure. The WSL separates five compartments (anterior, central, posterior, and lateral right and left) containing dedicated endometriosis signs of mobility and morphology to be checked. This approach relies on the 2016 IDEA Consensus and further developments. It directly connects to the 2021 #ENZIAN Classification Standard. In practice, evaluation follows the proposed checklist in all compartments, judging first sliding mobility between organs and structures in a highly dynamic investigation. A rigorous search for deep endometriosis (DE) is then performed. We treat adhesions due to their great clinical importance and possible, reliable diagnosis by TVS as the fifth endometriosis unit, next to endometrioma, DE, adenomyosis, and superficial endometriosis. Including superficial (peritoneal) endometriosis is a future goal.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":"367-388"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brainstem raphe hypoechogenicity is an independent predictor of post-stroke depression. 脑干神经节瘀血过多是脑卒中后抑郁的独立预测因素。
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-06-25 DOI: 10.1055/a-2296-3484
Daniel Richter, Andreas Ebert, Lisa Mazul, Quirin Ruland, Jeyanthan Charles James, Ralf Gold, Georgios Tsivgoulis, Lina Palaiodimou, Georg Juckel, Christos Krogias
{"title":"Brainstem raphe hypoechogenicity is an independent predictor of post-stroke depression.","authors":"Daniel Richter, Andreas Ebert, Lisa Mazul, Quirin Ruland, Jeyanthan Charles James, Ralf Gold, Georgios Tsivgoulis, Lina Palaiodimou, Georg Juckel, Christos Krogias","doi":"10.1055/a-2296-3484","DOIUrl":"https://doi.org/10.1055/a-2296-3484","url":null,"abstract":"<p><strong>Purpose: </strong>Post-stroke depression (PSD) is a common complication after stroke and has a substantial effect on the quality of life of patients. Nevertheless, reliable individual prediction of PSD is not possible. As depressive symptoms have been associated with brainstem raphe (BR) hypoechogenicity on transcranial sonography (TCS), we aimed to explore the association of BR hypoechogenicity and the occurrence of PSD.</p><p><strong>Materials and methods: </strong>The Prognostic Markers of Post-Stroke Depression (PROMoSD) study is a prospective, observational, single-center, investigator-initiated study that included patients with acute ischemic stroke (AIS) to investigate the presence of BR hypoechogenicity by TCS early after symptom onset. The primary outcome was the presence of PSD assessed at the three-month follow-up investigation by a blinded psychiatrist and defined according to the fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V criteria).</p><p><strong>Results: </strong>From 105 included AIS patients, 99 patients completed the study. AIS patients with a hypoechogenic BR developed a PSD at three months more frequently compared to patients with normal echogenicity (48.0% versus 4.1%, P <0.001). After adjustment for confounders (sex, mRS at follow-up, previous depressive episode), a hypoechogenic BR remained independently associated with a substantial increase in the appearance of PSD (adjusted OR: 6.371, 95%-CI: 1.181-34.362).</p><p><strong>Conclusion: </strong>A hypoechogenic BR is a strong and independent predictor of PSD at three months after AIS. TCS could be a routine tool to assess PSD risk in clinical practice, thereby streamlining diagnostic and therapeutic algorithms.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contrast-enhanced ultrasound features as a potential biomarker for the prediction of breast cancer recurrence. 对比增强超声波特征是预测乳腺癌复发的潜在生物标志物。
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-06-24 DOI: 10.1055/a-2333-7589
Youn Joo Lee, Sung Hun Kim, Bong Joo Kang, Yun Ju Kim
{"title":"Contrast-enhanced ultrasound features as a potential biomarker for the prediction of breast cancer recurrence.","authors":"Youn Joo Lee, Sung Hun Kim, Bong Joo Kang, Yun Ju Kim","doi":"10.1055/a-2333-7589","DOIUrl":"10.1055/a-2333-7589","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the associations between contrast-enhanced ultrasound imaging features and disease recurrence among patients with locally advanced breast cancer treated with neoadjuvant chemotherapy.</p><p><strong>Materials and methods: </strong>In the study, pre- and post-neoadjuvant chemotherapy contrast-enhanced ultrasound images of 43 patients with breast cancer were retrospectively analysed. Post-acquisition image processing involved the placement of freehand-drawn regions of interest, followed by the generation of blood flow kinetics representing blood volume and velocity for these regions of interest. Qualitative and quantitative contrast-enhanced ultrasound parameters were compared to predict recurrence, and receiver operating characteristic analysis was used to evaluate predictive ability.</p><p><strong>Results: </strong>Among the 43 patients, 10 (23%) exhibited disease recurrence (median [range]: 27 [4-68] months). Post-neoadjuvant chemotherapy peak enhancement, wash-in area under the curve, wash-out area under the curve, and wash-in and wash-out area under the curve (p=0.003, p=0.004, p=0.026, and p=0.014, respectively) differed between the no-recurrence and recurrence groups. The area under the receiver operating characteristic curve (0.88; 95% confidence interval: 0.75-1.00) for post-neoadjuvant chemotherapy peak enhancement was the highest among the contrast-enhanced ultrasound parameters, with a cut-off of 13.33 arbitrary units.</p><p><strong>Conclusion: </strong>Higher peak enhancement on post-neoadjuvant chemotherapy contrast-enhanced ultrasound images was associated with recurrence in women with locally advanced breast cancer and is a potential biomarker of tumor recurrence.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-guided breast-conserving surgery compared to conventional breast-conserving surgery. 超声引导下的保乳手术与传统保乳手术的比较。
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-06-20 DOI: 10.1055/a-2290-1543
Bettina Boeer, Jennifer Obermoser, Mario Marx, Birgitt Schönfisch, Marcel Grube, Carmen Röhm, Gisela Helms, Regina Fugunt, Andreas D Hartkopf, Sara Y Brucker, Markus Hahn
{"title":"Ultrasound-guided breast-conserving surgery compared to conventional breast-conserving surgery.","authors":"Bettina Boeer, Jennifer Obermoser, Mario Marx, Birgitt Schönfisch, Marcel Grube, Carmen Röhm, Gisela Helms, Regina Fugunt, Andreas D Hartkopf, Sara Y Brucker, Markus Hahn","doi":"10.1055/a-2290-1543","DOIUrl":"https://doi.org/10.1055/a-2290-1543","url":null,"abstract":"<p><strong>Purpose: </strong>The goal of breast-conserving surgery is to achieve negative tumor margins, since insufficient marginal distance is associated with more local and distant recurrences. This study investigates whether IOUS (intraoperative ultrasound) can reduce the re-resection rate compared to standard breast surgery, regardless of tumor biology and focality.</p><p><strong>Materials and methods: </strong>The present study is a monocentric, prospective, randomized, and non-blinded parallel group study conducted between 7/2015 and 2/2018. Patients with sonographically visible breast cancer were randomized into two study arms: 1) breast-conserving surgery with IOUS; 2) conventional arm.</p><p><strong>Results: </strong>364 patients were included in the study and underwent surgery. Tumor biology, size, and focality were equally distributed in both groups (p = 0.497). The study arms did not differ significantly in the proportion of preoperative wire markings (p= 0.084), specimen weight (p = 0.225), surgery duration (p = 0.849), and the proportion of shavings taken intraoperatively (p = 0.903). Positive margins were present in 16.6% of the cases in the IOUS arm and in 20.8% in the conventional arm (p = 0.347). Re-operation was necessary after intraoperative shavings in 14.4% of cases in the US arm and in 21.3% in the conventional arm (p = 0.100).</p><p><strong>Conclusion: </strong>Although the present study showed a clear difference in the rate of positive tumor margins with IOUS compared to conventional breast surgery without IOUS, this was not statistically significant in contrast to the current literature. This could be due to the high expertise of the breast surgeons, the precise wire marking, or the fact that the IOUS technique was not standardized.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transabdominal ultrasound for the diagnostic workup of parenchymal pancreatic diseases. 经腹超声诊断胰腺实质疾病。
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-06-20 DOI: 10.1055/a-2336-1700
Robert Henker, Valentin Blank, Thomas Karlas
{"title":"Transabdominal ultrasound for the diagnostic workup of parenchymal pancreatic diseases.","authors":"Robert Henker, Valentin Blank, Thomas Karlas","doi":"10.1055/a-2336-1700","DOIUrl":"https://doi.org/10.1055/a-2336-1700","url":null,"abstract":"<p><p>This continuing medical education article highlights the central role of transcutaneous sonography in diagnosing parenchymal pancreatic diseases. It emphasizes the importance of in-depth knowledge of sonographic imaging of organ anatomy and a structured examination methodology, particularly for identifying acute and chronic pancreatitis and related complications. The article provides detailed guidance for optimized examination techniques and equipment settings, even under challenging conditions, and discusses the application of ultrasound in various scenarios of pancreatic diseases. Moreover, the relevance of advanced sonographic techniques such as high-frequency sonography, elastography, and contrast-enhanced sonography is illuminated in the context of expanded diagnostic workup.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound Diagnosis of Malformations of the Fetal Kidneys and Urinary System. 胎儿肾脏和泌尿系统畸形的超声诊断。
IF 3.4 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-06-01 Epub Date: 2023-09-28 DOI: 10.1055/a-2132-6573
Kai-Sven Heling, Rabih Chaoui
{"title":"Ultrasound Diagnosis of Malformations of the Fetal Kidneys and Urinary System.","authors":"Kai-Sven Heling, Rabih Chaoui","doi":"10.1055/a-2132-6573","DOIUrl":"10.1055/a-2132-6573","url":null,"abstract":"<p><p>Malformations of the fetal kidneys and urinary system are common and easily visualized and diagnosed on ultrasound. This article presents the typical sonographic findings of these abnormalities during the various stages of pregnancy. Because malformations of the urogenital tract often have an association with genetic diseases/ciliopathies, these are also discussed. To complete the article, we provide a brief overview of the normal anatomy of the kidneys and urinary system. The normal anatomy and malformations of the genitalia will not be discussed in this article due to their complexity.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":"232-268"},"PeriodicalIF":3.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic relevance of ARFI elastography in comparison to liver histology and the FIB-4 score. ARFI 弹性成像与肝组织学和 FIB-4 评分的预后相关性比较。
IF 3.1 3区 医学
Ultraschall in Der Medizin Pub Date : 2024-06-01 Epub Date: 2024-01-03 DOI: 10.1055/a-2178-4808
Moritz Klüppel, Werner Adler, Barbara Schellhaas, Daniel Jesper, Markus F Neurath, Lukas Pfeifer
{"title":"Prognostic relevance of ARFI elastography in comparison to liver histology and the FIB-4 score.","authors":"Moritz Klüppel, Werner Adler, Barbara Schellhaas, Daniel Jesper, Markus F Neurath, Lukas Pfeifer","doi":"10.1055/a-2178-4808","DOIUrl":"10.1055/a-2178-4808","url":null,"abstract":"<p><strong>Purpose: </strong>Liver histology has prognostic relevance and is used in surveillance and therapeutic strategies. This longitudinal study was designed to evaluate the prognostic relevance of ARFI elastography in comparison to liver histology and to the FIB-4 score in a 5-year observation interval.</p><p><strong>Materials and methods: </strong>Based on the hospital database, patients with an elastography examination of the liver between 2010-2012, a liver biopsy, and a follow-up of 5 years were included in the study. The AUROCs of the events liver-related death, HCC, and liver decompensation/variceal bleeding were calculated for ARFI elastography, liver histology, and FIB-4 and compared using the DeLong test.</p><p><strong>Results: </strong>In the final analysis 113 patients were included with 30 (26.5 %) patients having high-grade fibrosis and 19 (16.8 %) having liver cirrhosis in histology. The AUROC for liver-related death in the 5-year interval (9.7 %, n=11) was 0.80 [0.68-0.92] for ARFI elastography, 0.79 [0.66-0.92] for liver histology, and 0.66 [0.53-0.79] for FIB-4 with a p-value of 0.83 comparing ARFI to histology and a p-value of 0.02 comparing ARFI to FIB-4. The AUROC for liver decompensation/variceal bleeding (13.3 %, n=15) was 0.86 [0.76-0.94] for ARFI, which is significantly higher than the AUROC of liver histology with 0.71 [0.56-0.86] (p=0.02) and FIB-4 with 0.67 [0.54-0.80] (p=0.003). There was no significant difference for the event HCC when comparing ARFI to histology (p=0.33) or FIB-4 (p=0.14).</p><p><strong>Conclusion: </strong>The prognostic value of ARFI elastography seems to not be inferior to liver histology regarding liver-related survival and might even outperform histology and the FIB-4 score for predicting some liver-related complications.</p>","PeriodicalId":49400,"journal":{"name":"Ultraschall in Der Medizin","volume":" ","pages":"316-322"},"PeriodicalIF":3.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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