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[Renaud Mahieux (1968-2020)].
IF 0.9 4区 医学
Virologie Pub Date : 2020-12-01 DOI: 10.1684/vir.2020.0874
C. Journo, H. Dutartre
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引用次数: 0
Hervé Moreau 16/10/1958 - 05/07/2020.
IF 0.9 4区 医学
Virologie Pub Date : 2020-08-01 DOI: 10.1684/vir.2020.0855
Gwenaël Piganeau, N. Grimsley
{"title":"Hervé Moreau 16/10/1958 - 05/07/2020.","authors":"Gwenaël Piganeau, N. Grimsley","doi":"10.1684/vir.2020.0855","DOIUrl":"https://doi.org/10.1684/vir.2020.0855","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"36 1","pages":"30-31"},"PeriodicalIF":0.9,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83754916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hervé Moreau 16/10/1958 - 05/07/2020.
IF 0.9 4区 医学
Virologie Pub Date : 2020-08-01 DOI: 10.1684/vir.2020.0854
G. Piganeau, N. Grimsley
{"title":"Hervé Moreau 16/10/1958 - 05/07/2020.","authors":"G. Piganeau, N. Grimsley","doi":"10.1684/vir.2020.0854","DOIUrl":"https://doi.org/10.1684/vir.2020.0854","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"31 1","pages":"208-209"},"PeriodicalIF":0.9,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82270825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Émergence du coronavirus SARS-CoV-2 : faire face à l’épidémie de Covid-19 冠状病毒SARS-CoV-2的出现:应对Covid-19疫情
IF 0.9 4区 医学
Virologie Pub Date : 2020-03-01 DOI: 10.1684/VIR.2020.0825
S. V. D. Werf, C. Peltékian
{"title":"Émergence du coronavirus SARS-CoV-2 : faire face à l’épidémie de Covid-19","authors":"S. V. D. Werf, C. Peltékian","doi":"10.1684/VIR.2020.0825","DOIUrl":"https://doi.org/10.1684/VIR.2020.0825","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"55 1","pages":"3-6"},"PeriodicalIF":0.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86787365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cell and tissue reservoirs of HIV-1: dynamics during infection. HIV-1的细胞和组织储存库:感染期间的动态。
IF 0.9 4区 医学
Virologie Pub Date : 2019-07-01 DOI: 10.1684/vir.2019.0784
P. Trémeaux, C. Rouzioux, V. Avettand-Fenoël
{"title":"Cell and tissue reservoirs of HIV-1: dynamics during infection.","authors":"P. Trémeaux, C. Rouzioux, V. Avettand-Fenoël","doi":"10.1684/vir.2019.0784","DOIUrl":"https://doi.org/10.1684/vir.2019.0784","url":null,"abstract":"Current antiretroviral therapy allows the control of HIV replication but a relapse occurs most of the time in case of treatment interruption. The viral genome integration explains this persistence of HIV in all body tissues, at very variable levels depending on their density of CD4+ T-cells, HIV main target. Secondary lymphoid tissues are the most infected organs. Several techniques can be used to characterize the reservoir, detecting different forms of the virus. They are complementary to decipher the establishment of HIV reservoir during the primary infection and its dynamics afterwards. In peripheral blood, the earlier the initiation of treatment, the more important is the decrease in total HIV DNA. Early treatment prevents the progressive increase in stable integrated forms of HIV DNA and preserves immune cells from infection. A better understanding of HIV infection in controllers will also aid in the development of new therapeutic strategies targeting the reservoir.","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"3 5 1","pages":"211-228"},"PeriodicalIF":0.9,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83622836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Viral reservoirs, a challenging theme in HIV research. 病毒库，HIV研究中的一个具有挑战性的主题。
IF 0.9 4区 医学
Virologie Pub Date : 2019-07-01 DOI: 10.1684/vir.2019.0781
V. Avettand-Fenoël
{"title":"Viral reservoirs, a challenging theme in HIV research.","authors":"V. Avettand-Fenoël","doi":"10.1684/vir.2019.0781","DOIUrl":"https://doi.org/10.1684/vir.2019.0781","url":null,"abstract":"","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"41 1","pages":"193-194"},"PeriodicalIF":0.9,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77061177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral latency of HIV-1. HIV-1的病毒潜伏期。
IF 0.9 4区 医学
Virologie Pub Date : 2019-07-01 DOI: 10.1684/vir.2019.0782
S. Bouchat, C. Van Lint
{"title":"Viral latency of HIV-1.","authors":"S. Bouchat, C. Van Lint","doi":"10.1684/vir.2019.0782","DOIUrl":"https://doi.org/10.1684/vir.2019.0782","url":null,"abstract":"Human immunodeficiency virus (HIV-1) latency is clinically highlighting via the persistence of a residual viral load in cART-treated patients due to the reactivation of cellular reservoirs. Two forms of latency coexist but the contribution of the pre-integrationnal latency clearly plays a minor role in viral persistence. In contrast, the post-integrationnal latency significantly contributes to the evasion of the immune system by the HIV-1 cellular reservoir and consequently to HIV-1 pathogenesis. Although post-transcriptional mechanisms can contribute to the maintenance of viral latency, HIV-1 transcriptional inhibition is critical for the establishment and maintenance of post-integrational latency. This inhibition is a multifactorial phenomenon, making the development of anti-latency therapeutic strategies complex. These different notions will be described throughout this review.","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"62 1","pages":"195-210"},"PeriodicalIF":0.9,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80731419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Therapeutic approaches targeting HIV reservoirs. 针对HIV储存库的治疗方法。
IF 0.9 4区 医学
Virologie Pub Date : 2019-07-01 DOI: 10.1684/vir.2019.0786
A. Chéret
{"title":"Therapeutic approaches targeting HIV reservoirs.","authors":"A. Chéret","doi":"10.1684/vir.2019.0786","DOIUrl":"https://doi.org/10.1684/vir.2019.0786","url":null,"abstract":"The establishment of latent infection in long-lived cells is the main obstacle to HIV cure or sustained remission without antiretroviral therapy. The most developed therapeutic strategies, in current clinical trials are mainly based on the concept of \"shock and kill\". They include latency reversing agents (LRAs) to re-activate HIV transcription that can be associated with immunomodulatory treatments. The objective is to eliminate virus-producing cells or to induce the control of HIV after anti-retroviral therapy cessation. HIV reservoir or cancer cells have a number of mechanisms in common. They can escape the immune system and persist by overexpressing survival molecules. This review presents a synthesis of current therapeutic approaches as well as the therapeutic perspectives related to the field of oncology.","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"53 1","pages":"250-259"},"PeriodicalIF":0.9,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86138365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and therapeutic implications of quantifying HIV reservoirs. 定量HIV病毒库的临床和治疗意义。
IF 0.9 4区 医学
Virologie Pub Date : 2019-07-01 DOI: 10.1684/vir.2019.0785
L. Hocqueloux, J. Viard
{"title":"Clinical and therapeutic implications of quantifying HIV reservoirs.","authors":"L. Hocqueloux, J. Viard","doi":"10.1684/vir.2019.0785","DOIUrl":"https://doi.org/10.1684/vir.2019.0785","url":null,"abstract":"Archiving HIV in its long half-life target cells is responsible for building what are called its reservoirs. The quantification of total HIV DNA in blood mononuclear cells, which probably represents only an approximation of all anatomical and cellular reservoirs, has, however, been the subject of numerous studies which showed strong correlations with other methods of quantification of reservoirs, with the natural history of the infection, its virological, immunological and clinical evolution under treatment, as well as its predictive value of the success of specific strategies (i.e. therapeutic de-escalation or interruption). This technique is easily accessible routinely and, although there are still no quantitative thresholds validated for decision-making, it may be useful to use it to clarify certain clinical or virological situations or to reinforce specific therapeutic choices (especially during therapeutic de-escalation).","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"72 1","pages":"241-249"},"PeriodicalIF":0.9,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75931117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Contribution of animal models to HIV research. 动物模型对HIV研究的贡献。
IF 0.9 4区 医学
Virologie Pub Date : 2019-07-01 DOI: 10.1684/vir.2019.0783
N. Huot, P. Rascle, M. Müller-Trutwin
{"title":"Contribution of animal models to HIV research.","authors":"N. Huot, P. Rascle, M. Müller-Trutwin","doi":"10.1684/vir.2019.0783","DOIUrl":"https://doi.org/10.1684/vir.2019.0783","url":null,"abstract":"Even today, despite triple therapy, the epidemic of the human immunodeficiency virus (HIV) is a major public health problem. In this perspective, continuous research is essential for the development of curative and vaccinal approaches. Animal models contribute to the implementation of new therapeutic and preventive strategies. We present here the characteristics of major animal models of HIV, which are non-human primates (SIV or SHIV-infected macaques and natural hosts of SIV), as well as different humanized mouse models and their advances. We will also list how they have already allowed, and still allow today, to broaden our knowledge on the physiopathology of HIV infection, tissue distribution of the virus, viral reservoirs, immunological responses against the virus in the very early infection stages and at the tissue level, but also in the development of vaccine candidates (RhCMV, broad-spectrum antibodies, etc…) and clinical trials for a cure. The advantages and limitations of the different animal models will be described. While continuing research on alternative methods, refinement or reduction of the animal model, a good knowledge of the specificities of each animal model allows an adequate use in relation to the scientific questions addressed.","PeriodicalId":49377,"journal":{"name":"Virologie","volume":"41 1","pages":"229-240"},"PeriodicalIF":0.9,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88028221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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