Piotr Domański, Jadwiga Jarosińska, Barbara Kruczyk, Mateusz Piętak, Anna Mydlak, Tomasz Demkow, Łukasz Kuncman, Marta Darewicz, Bożena Sikora-Kupis, Paulina Dumnicka, Jakub Kucharz
{"title":"Activity of cabozantinib in further line treatment of metastatic clear cell renal cell carcinoma. Real-world experience in a single-center retrospective study.","authors":"Piotr Domański, Jadwiga Jarosińska, Barbara Kruczyk, Mateusz Piętak, Anna Mydlak, Tomasz Demkow, Łukasz Kuncman, Marta Darewicz, Bożena Sikora-Kupis, Paulina Dumnicka, Jakub Kucharz","doi":"10.5114/wo.2023.133545","DOIUrl":"10.5114/wo.2023.133545","url":null,"abstract":"<p><strong>Introduction: </strong>Cabozantinib is an oral inhibitor of MET, AXL, and vascular endothelial growth factor receptors. It has an immunomodulatory effect and may influence the tumor's microenvironment and make mutated cells more sensitive to immune-mediated killing. These properties have made cabozantinib an effective drug for first-line or subsequent-line treatment after progression of metastatic renal cell carcinoma (mRCC), even after immunotherapy.</p><p><strong>Material and methods: </strong>Seventy-one patients with mRCC were treated with second or further lines of cabozantinib at the Department of Genitourinary Oncology, Maria Sklodowska-Curie National Research Institute of Oncology. This study retrospectively evaluated the effectiveness of cabozantinib in subsequent lines of treatment. Progression-free survival (PFS) and overall survival (OS) were the primary endpoints. The best overall response (BOR) to cabozantinib was the secondary endpoint. For this purpose, Cox's proportional hazard model was used.</p><p><strong>Results: </strong>The median PFS was 11 months (5; 23) and the median OS was 16 months (10; 42) and differed significantly in the second and further lines of treatment. Progression in the second and further lines was observed in 28 (93%) and 27 (66%) patients, respectively (p = 0.006). Partial response as the BOR was observed in one patient (3%) in the second line and 13 patients (32%) in the further lines (p = 0.012).</p><p><strong>Conclusions: </strong>Cabozantinib has antitumor effects in the second and further lines of treatment. In this study we observed high efficiency of cabozantinib in further lines of treatment.</p>","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"27 3","pages":"190-197"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wawrzyniec Mantorski, Piotr Feusette, Andrzej Tukiendorf, Edyta Idalia Wolny-Rokicka
{"title":"Haemoglobin and C-reactive protein levels are efficient at identifying neoplasms as the most common early mortality of chronic diseases in emergency department patients.","authors":"Wawrzyniec Mantorski, Piotr Feusette, Andrzej Tukiendorf, Edyta Idalia Wolny-Rokicka","doi":"10.5114/wo.2023.133352","DOIUrl":"10.5114/wo.2023.133352","url":null,"abstract":"<p><strong>Introduction: </strong>Extensive research has focused on emergency department (ED) and post-admission deaths, seeking to understand their frequency and causative factors. With the rising prevalence of advanced diseases, it is crucial to identify patients in need of end-of-life care and ensure its high quality. In this epidemiological study, we analyse routine ED blood tests to identify early warning signs of deteriorating patients with common non-traumatic and non-infectious (chronic) conditions.</p><p><strong>Material and methods: </strong>We conducted a retrospective single-centre study for the years 2016-2019 using medical records and electronic data from the Multi-Specialistic Hospital in Gorzów Wielkopolski, Poland. We examined 8971 unique patients with circulatory, neoplastic, and endocrine diseases. We assessed the impact of 2 grouping variables (survivors and non-survivors) on a continuous outcome variable, including age and 37 routine blood tests.</p><p><strong>Results: </strong>Two-way analysis of variance revealed that haemoglobin (Hb), haematocrit (Hct), and C-reactive protein (CRP) are the best differentiating biomarkers for early death in ED patients with cardiovascular, oncological, and endocrine diseases (excluding Hct due to its strong correlation with Hb). The Marczewski-Steinhaus taxonomy highlighted that oncological patients had the shortest survival time, averaging just 2 days from admission among ED non-survivors.</p><p><strong>Conclusions: </strong>Among routinely tested ED biomarkers, Hb and CRP levels are efficient at identifying neoplasms as the most common early mortality of chronic diseases in ED patients.</p>","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"27 3","pages":"176-181"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariam Hamad, Radwa Ali Mehana, Mohammad M Abd-Al Haseeb, Maha Houssen
{"title":"Potential antitumour effect of all-trans retinoic acid on regorafenib-treated human colon cancer cell lines.","authors":"Mariam Hamad, Radwa Ali Mehana, Mohammad M Abd-Al Haseeb, Maha Houssen","doi":"10.5114/wo.2023.133742","DOIUrl":"10.5114/wo.2023.133742","url":null,"abstract":"<p><strong>Introduction: </strong>Colorectal cancer (CRC) is a significant contributor to cancer-related mortality worldwide, ranking as the second leading cause of such deaths. Central to the progression of this malignancy is angiogenesis - a complex process orchestrated by vascular endothelial growth factor (VEGF). Regorafenib, a potent multikinase inhibitor, acts as a critical antagonist of multiple kinases involved in angiogenesis, proliferation, and metastasis. Conversely, all-trans retinoic acid (ATRA) has demonstrated compelling antitumour effects across various cancer types. This study aims to comprehensively evaluate the combined antitumour potential of ATRA and regorafenib in human colon cancer cell lines while elucidating the intricate molecular mechanisms that underlie their action.</p><p><strong>Material and methods: </strong>Our investigative approach involved an enzyme-linked immunosorbent assay to meticulously analyse the levels of key players in the VEGF signalling pathway, including VEGF itself, activated protein kinase (AMPK), extracellular signal-regulated protein kinase 1 (ERK1), and nuclear factor kappa B (NF-κB). Additionally, we assessed caspase-3 activity as a fundamental marker of apoptosis.</p><p><strong>Results: </strong>The combined use of ATRA and regorafenib exhibited a remarkable augmentation in both AMPK and caspase-3 activities. This was accompanied by a significant reduction in VEGF, ERK1, and NF-κB levels within human colon cancer cell lines subjected to regorafenib treatment.</p><p><strong>Conclusions: </strong>Our findings underscore the remarkable antiproliferative, antiangiogenic, and proapoptotic effects resulting from the combined use of ATRA and regorafenib in the context of CRC. This modulation of tumourigenic processes is predominantly mediated through the VEGF signalling axis.</p>","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"27 3","pages":"198-210"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liang Jin, Xiaojing Zhang, Ming Fan, Weimin Li, Xuan Zhang
{"title":"NamiRNA-mediated high expression of KNSTRN correlates with poor prognosis and immune infiltration in hepatocellular carcinoma.","authors":"Liang Jin, Xiaojing Zhang, Ming Fan, Weimin Li, Xuan Zhang","doi":"10.5114/wo.2023.133507","DOIUrl":"10.5114/wo.2023.133507","url":null,"abstract":"<p><strong>Introduction: </strong>Mutations of kinetochore-localized astrin/sperm-associated antigen 5 (KNSTRN) can interfere with chromatid cohesion, increase aneuploidy in tumours, and enhance tumourigenesis. However, the role of the KNSTRN-binding protein in hepatocellular carcinoma (HCC) remains unclear.</p><p><strong>Material and methods: </strong>Using The Cancer Genome Atlas databases, we investigated the potential oncogenic functions of KNSTRN in HCC along with R and various computational tools.</p><p><strong>Results: </strong>Detailed results revealed that elevated expression of KNSTRN was considerably associated with poor overall survival (HR = 1.48, 95% CI: 1.05-2.09, <i>p</i> = 0.027) and progress-free interval (HR = 1.41, 95% CI: 1.05-1.89, <i>p</i> = 0.021) in HCC. Gene ontology/Kyoto Encyclopedia of Genes and Genomes functional enrichment analysis showed that KNSTRN is closely related to organelle fission, chromosomal region, tubulin binding, and cell cycle signalling pathway. TIMER database analysis showed the correlations between KNSTRN expression and tumour-infiltrating immune cells, biomarkers of immune cells, and immune checkpoint expression. Moreover, the KNSTRN level was significantly positively associated with immunosuppressive cells in the tumour microenvironment, including regulatory T-cells, myeloid-derived suppressor cells, and cancer-associated fibrocytes. Finally, a possible nuclear activating miRNA (NamiRNA)-enhancer network of hsa-miR-107, which activates the KNSTRN expression in liver hepatocellular carcinoma, was constructed by correlation analysis.</p><p><strong>Conclusions: </strong>NamiRNA-mediated upregulation of KNSTRN correlated with poor prognosis and tumour immune infiltration in HCC. KNSTRN could serve as an effective biomarker for the diagnosis and prognosis of HCC and support the development of novel therapeutic strategies.</p>","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"27 3","pages":"163-175"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subjective health and its predictors in leukaemia patients after bone marrow transplantation.","authors":"Helena Wrona-Polańska","doi":"10.5114/wo.2023.130021","DOIUrl":"https://doi.org/10.5114/wo.2023.130021","url":null,"abstract":"<p><strong>Introduction: </strong>The aims of the study were to assess subjective health and its psychological predictors in leukaemia patients after bone marrow transplantation (BMT). The theoretical rationale of the study was the functional model of health (FMH).</p><p><strong>Material and methods: </strong>Participants in the study comprised 141 patients after BMT (61 women, 80 men) in the age range between 20 and 40 years, most of whom had secondary education. A standardized interview and 10-point rating scales of sense of health and sense of calmness were used to assess the subjective health. Their objective health was rated likewise on a 10-point scale by a physician-haematologist. The following questionnaires were used: CISS, SES, SOC-29, and STAI.</p><p><strong>Results: </strong>The bone marrow transplantation patients' sense of health was significantly lower than their objective health status assessed using objective medical parameters (respective means: 6.69, SD = 2.52, and 7.70, SD = 2.09, <i>t</i> = -4.59, <i>df</i> = 139, <i>p</i> < 0.001). According to the FMH as the study rationale, the patients' subjective health depends on the effectiveness of their coping with illness, but also of personal resources including positive self- esteem and sense of coherence.</p><p><strong>Conclusions: </strong>The subjective health of BMT patients was predicted by their objective health status (0.413) and by experienced stress (-0.285) counterbalanced by a strong sense of meaningfulness (0.244). Contemporary medicine can save leukaemia patients' lives owing to the BMT, the recovery of their subjective health as a foundation of good functioning, which depends on psychological mechanisms, patient`s activity, and a supportive psychologist.</p>","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"27 2","pages":"90-94"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/08/WO-27-51138.PMC10546966.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maciej Michalak, Piotr Tomczak, Tomasz Milecki, Andrzej Antczak
{"title":"The role of cytoreductive nephrectomy in the treatment of patients with metastatic kidney cancer - review article.","authors":"Maciej Michalak, Piotr Tomczak, Tomasz Milecki, Andrzej Antczak","doi":"10.5114/wo.2023.133258","DOIUrl":"10.5114/wo.2023.133258","url":null,"abstract":"<p><p>The role of cytoreductive nephrectomy (CN), i.e. the removal of a kidney involved by cancer in patients with advanced kidney cancer with distant metastases, is the subject of intense debate among urologists and oncologists. For many years, CN has been considered the gold standard in the treatment of patients at this stage of the disease, especially in patients in good general health with no significant contraindications to surgical treatment. The starting point for questioning the validity of CN was the publication of the results of the cancer <i>du rein metastatique nephrectomie et antiangiogéniques</i> and SURTIME clinical trials (2018 and 2019, respectively), which questioned the validity of surgery in some patients with late-stage cancer. Given the complexity of the disease, the role of removing the involved kidney is the subject of much controversy. In recent years, several studies have been conducted to evaluate the efficacy and safety of nephrectomy in patients with metastatic kidney cancer, resulting in conflicting information regarding the eligibility criteria for patients in different risk groups. The aim of this article is to analyse the available data, provide an up-to-date review of the literature, and discuss the controversies and challenges related to CN in patients with metastatic kidney cancer. The present literature review aims to organize and systematize the current state of knowledge, which may help in making clinical decisions regarding qualification for CN in patients with advanced kidney cancer.</p>","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"27 3","pages":"132-138"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Łubińska, M. Taszner, P. Kmieć, A. Hellmann, K. Sworczak
{"title":"Case report Insufficiency of the pituitary gland resulting from the central nervous system infiltration in cours of non-Hodgkin's DLBCL lymphoma recurrence","authors":"M. Łubińska, M. Taszner, P. Kmieć, A. Hellmann, K. Sworczak","doi":"10.5114/WO.2014.40597","DOIUrl":"https://doi.org/10.5114/WO.2014.40597","url":null,"abstract":"We present a case of a 60-year-old male patient with diagnosis of non-Hodgkin’s lymphoma (NHL): dif-fuse large B cell lymphoma (non-Hod-gkin’s DLBCL), who achieved complete remission after first-line treatment. Eleven months later he was admitted to our hospital again with symptoms of the disease’s systemic relapse and central nervous system (CNS) infiltra-tion. He developed new and serious symptoms of complete pituitary gland insufficiency. Magnetic resonance im-aging findings and hormone serum levels confirmed the CNS infiltration and insufficiencies of the pituitary as well as its dependent peripheral glands. Chemotherapy and hormonal substitution significantly improved the patient’s condition for several months. That is why, in the case of deterio-rated patient condition, we have to consider possible secondary develop-ment of pathological processes in the course of the primary disease.Key words: pituitary insufficiency, di-abetes insipidus, central nervous sys-tem infiltration, lymphoma.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86570288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kostrzewska, T. Piorunek, H. Batura-Gabryel, J. Kocięcki, Danuta Nikratowicz, I. Rospond-Kubiak, Michalina Nowak-Gabryel
{"title":"Case report Coexistence of an active form of tuberculosis and non-small cell lung cancer with metastases to eyeballs","authors":"M. Kostrzewska, T. Piorunek, H. Batura-Gabryel, J. Kocięcki, Danuta Nikratowicz, I. Rospond-Kubiak, Michalina Nowak-Gabryel","doi":"10.5114/WO.2014.40600","DOIUrl":"https://doi.org/10.5114/WO.2014.40600","url":null,"abstract":"","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"25 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80952092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Kopecký, L. Slováček, P. Priester, V. Chovanec, J. Petera, O. Kopecký
{"title":"Case report Extravasation of doxorubicin – a dreaded complication of therapy","authors":"J. Kopecký, L. Slováček, P. Priester, V. Chovanec, J. Petera, O. Kopecký","doi":"10.5114/WO.2014.40593","DOIUrl":"https://doi.org/10.5114/WO.2014.40593","url":null,"abstract":"peutic regimens are based on intra venous administration. The most com mon and most frequent complication of chemotherapy is phlebitis, when giv en peripherally. The most feared com plication of chemotherapy, such as in the case of doxorubicin, is extravasa tion. The extravasation itself is not al ways immediately obvious, so doctors and nurses should be aware of it in order to begin treatment as soon as possible. Late detection of extrava sation can lead not only to immense damage of the affected area but also, in the worst case, even the inability to administer further cancer treatment. In the article we describe two clinical cases of extravasation and its therapy management. We try to show the eco nomic differences between the use of dexrazoxane and surgery alone. It is obvious that the extravasation is not only a medical problem but it also has great economic impact. Nowadays there are new approaches to the treat ment of doxorubicin extravasation, such as use of specific antidote dexra zoxane. The cost of a therapeutic dose of dexrazoxane is still the most nega tive aspect of the treatment.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"22 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84130346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Eroglu, D. Unal, Neslihan Kurtul, U. Abdulrezzak, M. K. Gumu
{"title":"Case report Positron emission tomography is moderately useful in the diagnosis of orbital metastasis","authors":"C. Eroglu, D. Unal, Neslihan Kurtul, U. Abdulrezzak, M. K. Gumu","doi":"10.5114/WO.2014.40602","DOIUrl":"https://doi.org/10.5114/WO.2014.40602","url":null,"abstract":"mon intraocular malignancy in adults. A 37-year-old male patient presented with coughing. Thorax computerized tomography (CT) scan showed bilateral multiple nodules. The bronchoscopic biopsy pathology findings were compatible with squamous cell carcinoma. The patient was diagnosed with stage IV NSCLC and received 6 cycles of chemotherapy including cisplatin and vinorelbine. Positron emission tomography (PET) imaging revealed regression of old lesions but new metastatic lesions in the musculoskeletal system, intensive involvement in the orbital muscles of the right orbita, and increased FDG uptake (SUV max : 3.6) in the posterior parts of the upper orbita. Palliative radiotherapy was performed for metastatic bone lesions. The patient complained of blurred vision two weeks after the PET imaging. Two amelanositic lesions in the upper temporal area in the right eye were detected in the examination of the eyes. Therefore, fundus fluorescein angiography and optical coherence tomography imaging were performed, and these lesions were accepted as metastasis. These lesions were in favour of metastasis.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"180 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75699838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}