Wspolczesna Onkologia-Contemporary Oncology最新文献

{"title":"Prognostic value of expression of intracellular and extracellular domains of HER2 in patients with HER2-possitive breast cancer","authors":"S. Dębska, R. Kusińska, U. Czernek, Katarzyna Szydłowska-Pazera, M. Błasińska-Morawiec, I. Dowgier-Witczak, E. Olas, A. Kulig, M. Jakubiak-wielganowicz, P. Potemski","doi":"10.5114/WO.2011.25654","DOIUrl":"https://doi.org/10.5114/WO.2011.25654","url":null,"abstract":"Background: HER2 consists of an extra cellular domain (the target for trastuzum ab), a transmembrane domain, and an in tracellular domain, which is recognized by an antibody used in the immunohisto chemical assessment of HER2 overex pression. The study consisted of 31 pa tients with metastatic breast cancer treated with trastuzumab. The aim of the studywas to evaluate ret rospectively expression of extracellular and intracellular HER2 domains in primary breast cancers treated with surgery and to assess their correlation with biological features of tumours, disease-free survival, overall survival, as well as pro gression-free survival and survival since the start of trastuzumab treatment. Material and methods: All these patients relapsed and were treated with tras tuzumab because of metastatic disease ‐ none of them received trastuzumab in an adjuvant setting. Two kinds of anti bodies were used in immunohisto chemical evaluation: against extracellu lar and intracellular domains of the HER2. Results: A significant correlation be tween different patterns of HER2 domain overexpression and disease-free sur vival was found. Disease-free survival (the time from the primary operation to re lapse ‐ prior to the start of any palliative treatment) was the shortest in patients with overexpression of both domains compared to patients without overex pression of both domains and the group with intracellular domain overexpression combined with absence of extracellular domain overexpression (median 13.2 vs. 24.3 vs. 52.4 months, p= 0.01). There was no significant difference between these 3 groups of patients in aspects of bio logical features of tumours, overall sur vival, progression-free survival and survival since the start of trastuzumab treatment. Conclusion: Concurrent assessment of ex tracellular and intracellular domains of HER2 may have prognostic value for HER2-positive patients.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"16 1","pages":"267-273"},"PeriodicalIF":1.8,"publicationDate":"2011-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85961992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical guidance on implementation of the Personal Data Security Management System in an oncology centre","authors":"M. Mocydlarz-Adamcewicz","doi":"10.5114/WO.2011.25656","DOIUrl":"https://doi.org/10.5114/WO.2011.25656","url":null,"abstract":"Aim of the study: To analyse practical as pects of implementing the Personal Data Security Management System (PDSMS) in an oncology centre based on applicable legal requirements and pro fessional standards. Material and methods: The research method is based on the analysis of le gal documents, quality standards, analy sis of progress in the achievement of ob jectives of the PDSMS based on interviews with heads of units and on re view of data protection documenta tion. Results: The implementation of the PDSMS has caused the processed data to be adequately protected, minimised the risk of such data being used in a manner incompatible with their pur pose, while ensuring the hospital’s com pliance with applicable legal regula tions. Conclusions: The implementation of the PDSMS has required technical and orceoisational measures to be taken in the centre’s organisational units, in particular appointing data protection of ficers, engaging staff in the data pro tection process by awarding them with authorisations to process data and fa miliarising them with securities that have been put in place.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"110 1","pages":"279-285"},"PeriodicalIF":1.8,"publicationDate":"2011-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82439061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate cancer radiotherapy [Polish version: Radioterapia raka gruczołu krokowego p... 323]","authors":"A. Kulik, Mateusz Dąbkowski","doi":"10.5114/WO.2011.25661","DOIUrl":"https://doi.org/10.5114/WO.2011.25661","url":null,"abstract":"","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"6 1","pages":"317-329"},"PeriodicalIF":1.8,"publicationDate":"2011-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73247283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies and difficulties of CT and MR imaging evaluation – on the basis of a case study of liposarcoma in the retroperitoneal space","authors":"M. Fundowicz, Mariusz Uściniak","doi":"10.5114/WO.2011.25662","DOIUrl":"https://doi.org/10.5114/WO.2011.25662","url":null,"abstract":"all tumours. About 10 to 20% of these tumours are localized in the retroperitoneal space. The basis of diagnostics is radiological examinations. The treatment of retroperitoneal sarcomas is based on surgery combined with radiotherapy and chemotherapy. The patient, aged 45, with a histopathological diagnosis of liposarcoma, was operated on with brachytherapy and radiotherapy. After 18 months the recurrence of the disease was diagnosed in CT examination. Before chemotherapy, CT andMR examinations and biopsy had been done with no recurrence result. The above-mentioned changes were found to be the post-treatment changes. The current condition of the patient is good; there is no recurrence and no remote metastasis.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"71 1","pages":"330-332"},"PeriodicalIF":1.8,"publicationDate":"2011-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83341992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of aerobic training on body composition in premenopausal women undergoing endocrine therapy for breast cancer","authors":"K. Hojan, P. Milecki","doi":"10.5114/WO.2011.25653","DOIUrl":"https://doi.org/10.5114/WO.2011.25653","url":null,"abstract":"study was to determine the body composition (BC) changes in women with breast cancer after endocrine therapy, and the influence of aerobic training on the parameters under discussion. Material and methods: 41 women aged 32-48 (mean ± SD 44.1 ±4.4) with breast cancer during endocrine therapy (ET). This was a nonrandomized, prospective trial. The following examinations were conducted in patients according to the schedule: I before the beginning of ET; II after 6 months of the ET; III after 12 months of ET and after 6-month aerobic training. Body composition was evaluated using dual X-ray absorptiometry (DEXA) with respect to free fatty mass, lean, fat and the percentage location of android and gynoid fat. The body build was evaluated with respect to body height, body weight and selected anthropometric parameters BMI and WHR. Results: During the first six months of ET without regular physical activity the following was reported: a significant increase of body weight, BMI, the amount of fatty tissue, including android fat distribution (p 0.05). At that time muscle (p 0.05) reductions were reported. After the sixmonth aerobic workout no significant body weight or BMI increase was observed. However, there was a significant reduction in WHR (p < 0.05), which correlated with the decrease of android fatty tissue (p < 0.05). The other elements evaluated in the DEXA underwent statistically insignificant changes. Conclusions: The outcome analysis allows us to conclude that during breast cancer ET the patients are reported to have negative changes in BC and phy sique. Therefore, this patient group is advised to receive regular rehabilitation with the aim of reducing the side effects of the treatment. However, aerobic training seems to be insufficient in order to fully reduce the side effects of this form of cancer therapy.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"38 1","pages":"261-266"},"PeriodicalIF":1.8,"publicationDate":"2011-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75304651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and neck squamous cell cancer – the role of computed tomography enhanced with perfusion imaging in tumour staging","authors":"A. Trojanowska, P. Trojanowski, A. Drop, J. Klatka","doi":"10.5114/WO.2011.25657","DOIUrl":"https://doi.org/10.5114/WO.2011.25657","url":null,"abstract":"ded value of computed tomography perfusion (CTP) images combined with contrast-enhanced computed tomography (CECT) images in staging of head and neck squamous cell cancer (SCC). Material and methods: Forty-seven consecutive patients with histologically proven squamous cell cancer of the head and neck and qualified for surgical treatment were prospectively evaluated in 2 groups: based on CECT multiplanar reformations (axial, coronal and sagittal), and separately, based on CTP images combined with CECT data. Tumour stage was assessed in each group separately, with special emphasis on T4 stage, and results were compared with histological findings. Five patients underwent endoscopic laser tumour resection, 11 underwent other tumour resection (glossectomy, pharyngectomy) and 31 patients underwent en-bloc resection of the hypopharynx and larynx, allowing detailed pathological evaluation of possible tumour infiltration into surrounding structures. Two experienced head and neck radiologists evaluated the images. Inter-observer agreement was tested with the modified κ test. The χ2 test was applied to compare the number of correctly staged tumours for the two methods and readers. Results: Inter-observer agreement was high (k = 0.88-0.90). Significant differences between the two groups were observed; with added CTP assessment more anatomical structures were rated positive for tumour infiltration and diagnostic accuracy of this method was significantly higher when compared to CECT images. Sole evaluation of CECT images in less advanced cases led to overestimation of the disease, since inflammation and slight oedema could not be differentiated from tumour. Conclusions: Contrast-enhanced computed tomography multi-planar images enhanced with CTP images were proven to improve accuracy in head and neck cancer staging. The added value of CTP may help to avoid overestimation of the malignant process and at the same time may facilitate depiction all infiltrated structures.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"3 1","pages":"286-293"},"PeriodicalIF":1.8,"publicationDate":"2011-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75339126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of complementary alternative medicine use with anxiety, depression and quality of life in Turkish cancer patients","authors":"O. Tarhan, A. Alacacıoğlu, I. Somalı, H. Sipahi, M. Zencir, Ç. Erten, M. Dirioz, I. Oztop, Mehmet Ozgur Niflioglu, U. Yilmaz","doi":"10.5114/WO.2011.25655","DOIUrl":"https://doi.org/10.5114/WO.2011.25655","url":null,"abstract":"Aim of the study: The purpose of this study is to investigate the complemen tary/alternative medicine (CAM) usage and the factors affecting this among can cer patients in the western region of Turkey. 220 adult cancer patients par ticipated in the study and 93 patients (42.3%) were found to use at least one CAM method. Material and methods: Our study was done by face-to-face communication in auniversity hospital, in Turkey. Oncolo gy patients’ primary diseases, sociode mographic characteristics, complemen tary alternative medicine usage, psychological conditions and quality of life were evaluated with proper psy chological scales. Patients using and not using CAM were compared with re spect to Beck Depression, State Trait Anx iety and Beck Hopelessness scores. No statistically significant difference was de tected between/among the groups in BDI (12.0 ±8.4, 11.9 ±8.7, p = 0.96), BHS (5.5 ±4.9, 4.8 ±4.4, p = 0.27) or STAI (43.7 ±8.0, 44.3 ±8.2, p= 0.64) scores. Pa tients using and not using CAM were compared with respect to WHOQOLBREF quality of life scores. There was no statistically significant difference be tween/among the groups in WHOQOLBREF sub-group scores (physical, psy chological, social relations, environment, standardized by culture (environment), general health). Results: Nearly half of the patients (42.3%) in this region were found to be using at least one of the CAM methods. The patients mostly preferred herbal methods, with the leading product be ing stinging nettle ( Urtica dioica ). The severity of disease (recurrence and dis semination) and patients’ knowledge of the diagnoses were the most important factors affecting the CAM usage. Conclusions: The usage of CAM by on cology patients and the effects of CAM on the present medication prescribed by oncology practitioners must be remem bered when they are admitted to poly clinics. Also it must be known that pa tients with advanced stage and patients with recurrence are more likely to use complementary alternative medications than early stage patients. Therefore on cology patients must be informed about CAM besides their clinical situations. At least physicians should give answers about the CAM to their patients.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"22 1","pages":"274-278"},"PeriodicalIF":1.8,"publicationDate":"2011-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72702062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioidy w leczeniu polineuropatii wywołanej chemioterapią","authors":"K. Brzezinski, Roman Chwedorowicz","doi":"10.5114/WO.2011.24435","DOIUrl":"https://doi.org/10.5114/WO.2011.24435","url":null,"abstract":"","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"51 1","pages":"251-255"},"PeriodicalIF":1.8,"publicationDate":"2011-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81813473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate tumour originating from interstitial cells of Cajal: a case presentation and review of the literature","authors":"G. Grotthuss, S. Poletajew, T. Dzik, A. Borówka","doi":"10.5114/WO.2011.24318","DOIUrl":"https://doi.org/10.5114/WO.2011.24318","url":null,"abstract":"We present a case of an extremely rare, atypical prostate tumour, diagnosed in a 57-year-old man, who reported pain in the pelvic area, problems with defe cation and lower urinary tract symp toms (LUTS). A giant prostate tumour was diagnosed in computed tomogra phy. The histopathological examination findings from core needle biopsy of mul tiple sites were not unequivocal. The patient underwent pelvic exenterative surgery. Also Bricker ileal conduit uri nary diversion and sigmoidostomy were performed. Histopathological examina tion of the surgical specimen revealed a gastrointestinal stromal tumour orig inating from the prostate and infiltrat ing the urinary bladder and the rectum. The patient was qualified for systemic adjuvant chemotherapy, but he did not give his consent to that treatment. Clin ical evaluation at 6 months following the surgery revealed major improve ment in the patient’s health status, but the patient still rejects adjuvant treat ment. The paper also presents an overview of the literature on gastrointestinal stro mal tumour (GIST) of the prostate.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"43 1","pages":"224-228"},"PeriodicalIF":1.8,"publicationDate":"2011-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88300966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8-year follow-up after partial ex vivo resection of tumour in a single kidney followed by autotransplantation","authors":"M. Karczewski, W. Turkiewicz, J. Skowronek, J. Karczewski","doi":"10.5114/WO.2011.24317","DOIUrl":"https://doi.org/10.5114/WO.2011.24317","url":null,"abstract":"Radical nephrectomy (RN) in the treat ment of renal cell carcinoma remains the “gold standard”, but sparing tech niques (nephron sparing surgery, NSS), consisting of enucleation, partial nephrectomy or ex vivo resection, are increasingly gaining in importance. The techniques allow the achievement of better results, with a low rate of com plications and mortality. Ex vivo resec tion is a technique which is becoming equivalent to radical nephrectomy. The risk of multifocal cancer ranges from 6.5 to 28%, whereas when the tumour has a diameter not exceeding 4 cm, the risk of multiplicity drops to 5%. The main risk involved in NSS is the possibility of recurrence in the ipsilateral kidney. The incidence of recurrence ranges between 0 and 10% and it is the lowest when the tumour has a low malignant potential and does not exceed 4 cm in diameter. Sometimes, due to the lack of the oth er kidney, this is the only opportunity that allows preservation of function of the remaining kidney. The paper describes a patient with a single kidney, affected by a tumour with a diameter of more than 5 cm, reaching the pyelocalyceal structure. Due to infiltration of the renal calyx, the ex vivo technique was adopted, allow ing appropriate resection with an onco logically adequate margin and accurate supply of the urinary tract. The tech nique of surgery and the outcome of treatment in the very few cases described so far are discussed.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"46 1","pages":"220-223"},"PeriodicalIF":1.8,"publicationDate":"2011-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90892616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}