{"title":"Case report Pilomatricoma with a bullous appearance","authors":"Liming Wu","doi":"10.5114/WO.2014.40615","DOIUrl":"https://doi.org/10.5114/WO.2014.40615","url":null,"abstract":"fying epithelioma of Malherbe, is the most common adnexal tumour in children and young adults. It typical ly occurs on the head, neck or upper limb. Here, we report a case of bul lous variant of pilomatricoma. A male adult presented a firm nodule covered by a sequent bulla on the left shoul der. Pathological examination showed the tumour was composed of irregu larly shaped epithelial islands which in cluded two cell types: basophilic cells and eosinophilic shadow cells. No cel lular atypia or abnormal mitotic fig ures were observed. These findings were consistent with a diagnosis of pi lomatricoma. The bulla was attributed to lymphatic obstruction that resulted in the dilation of lymphatic vessels. Our pilomatricoma had the unusual fea ture of a crossshaped, giant bulla measuring 10 cm × 5 cm overlying the tumour. To our knowledge, it was the largest bullous pilomatricoma in the literature. After surgical resection, there was no recurrence.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"8 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75548011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case report Long-term survival of a patient with aggressive sporadic malignant peripheral nerve sheath tumour presenting as haemothorax","authors":"R. Zaucha, Aneta Waszczuk","doi":"10.5114/WO.2014.40614","DOIUrl":"https://doi.org/10.5114/WO.2014.40614","url":null,"abstract":"mour (MPNST) belongs to the group of rare soft tissue sarcomas. High his tological grade is a common feature, explaining its poor prognosis irrespec tive of the aggressiveness of local treat ment. Standard therapy of inoperable local relapses or distant metastases has not been established, as phase II or III clinical trials are lacking and treatment strategies are based on an ecdotal reports on the effectiveness of standard chemotherapy or different novel agents. Here we present a long term survivor of the sporadic type of MPNST – a giant thoracic tumour with an uncommon presentation of haemo thorax. Despite radical excision of the tumour, followed by highdose ra diotherapy to the tumour bed, the patient was diagnosed with multiple metastases located in the postpneu monectomy thoracic cavity and the right lung. Firstline doxorubicin fol low ed by somatostatin analogue resulted in a sixmonth PFS, while secondline ifosfamidebased chemo therapy result ed in good and long lasting symptom palliation.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"225 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89180162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Eroglu, D. Unal, Neslihan Kurtul, U. Abdulrezzak, M. K. Gumu
{"title":"Case report Positron emission tomography is moderately useful in the diagnosis of orbital metastasis","authors":"C. Eroglu, D. Unal, Neslihan Kurtul, U. Abdulrezzak, M. K. Gumu","doi":"10.5114/WO.2014.40602","DOIUrl":"https://doi.org/10.5114/WO.2014.40602","url":null,"abstract":"mon intraocular malignancy in adults. A 37-year-old male patient presented with coughing. Thorax computerized tomography (CT) scan showed bilateral multiple nodules. The bronchoscopic biopsy pathology findings were compatible with squamous cell carcinoma. The patient was diagnosed with stage IV NSCLC and received 6 cycles of chemotherapy including cisplatin and vinorelbine. Positron emission tomography (PET) imaging revealed regression of old lesions but new metastatic lesions in the musculoskeletal system, intensive involvement in the orbital muscles of the right orbita, and increased FDG uptake (SUV max : 3.6) in the posterior parts of the upper orbita. Palliative radiotherapy was performed for metastatic bone lesions. The patient complained of blurred vision two weeks after the PET imaging. Two amelanositic lesions in the upper temporal area in the right eye were detected in the examination of the eyes. Therefore, fundus fluorescein angiography and optical coherence tomography imaging were performed, and these lesions were accepted as metastasis. These lesions were in favour of metastasis.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"180 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75699838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ata, T. Karabacak, T. Köşeci̇, E. Serinsöz, A. Arıcan
{"title":"Case report Gastric collision tumour of adenocarcinoma and neuroendocrine carcinoma","authors":"A. Ata, T. Karabacak, T. Köşeci̇, E. Serinsöz, A. Arıcan","doi":"10.5114/WO.2014.40603","DOIUrl":"https://doi.org/10.5114/WO.2014.40603","url":null,"abstract":"rare condition in which two histologically distinct neoplasms grow concurrently in the same locationdein a 64-year-old male patient, with sharply defined borders. Adenocarcinomas are the most common tumours of the stomach. Other types of tumours can occasionally accompany gastric adenocarcinomas. Foci of adenocarcinoma and neuroendocrine carcinoma were identified in adjacent areas in a 64-year-old male patient who had undergone total gastrectomy due to adenocarcinoma of the gastric cardia. Of the seven metastatic lymph nodes, three were affected by adenocarcinoma and four were affected by neuroendocrine carcinoma. Based on this patient case, we discussed gastric collision tumours in the light of the literature.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"44 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85461174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ł. Michalecki, D. Gabryś, G. Głowacki, H. Urbańczyk, J. Wydmański
{"title":"Case report Avascular osteonecrosis of the hip in patient after adjuvant radiotherapy for rectal cancer","authors":"Ł. Michalecki, D. Gabryś, G. Głowacki, H. Urbańczyk, J. Wydmański","doi":"10.5114/WO.2014.40604","DOIUrl":"https://doi.org/10.5114/WO.2014.40604","url":null,"abstract":"death of osteocytes and osteoblasts. AVN is encountered mostly among men in their 4 or 5 decade of life. The basic treatment for osteonecrosis is surgery, and the choice of procedure is based on preoperative staging. AVN is a very rare complication in radiotherapy (RT), but it presents an important clinical problem, still underestimated in oncological practice. Case report: This report documents an extensive symmetric avascular necrosis with acetabular protrusion and femoral head deformities in a 71-yearold woman with unresectable, poorly differentiated adenocarcinoma of the recto-sigmoid region, after therapeutic pelvic irradiation. The pelvic radiography, performed 24 months after the RT, due to bilateral hip pain, revealed advanced acetabular protrusions, with secondary deformities of both femoral heads. It is necessary to take into account the bone structures, among organs at risk (OAR), involved in irradiation fields. The detailed analysis of the dose distribution, and the use of collimators, allow a decrease in the total RT dose to OAR. Osteoradionecrosis risk awareness, early diagnosis, adequate management and prompt, appropriate treatment could probably protect patients against long-term morbidity.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"296 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76263020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Zembala-Nożyńska, D. Lange, E. Stobiecka, M. Kryj, M. Zeman, M. Wideł, Ł. Zarudzki
{"title":"Case report Peritoneal cylindromatosis – a rare teratomatous dissemination","authors":"E. Zembala-Nożyńska, D. Lange, E. Stobiecka, M. Kryj, M. Zeman, M. Wideł, Ł. Zarudzki","doi":"10.5114/WO.2014.40605","DOIUrl":"https://doi.org/10.5114/WO.2014.40605","url":null,"abstract":"neal cylindromatosis was presented. A young woman was admitted to hospital after removal of a right ovarian cystic tumour. Multiple histological reexaminations suggested the presence of a dermoid cyst, i.e. adult teratoma ad ditionally with granulosa cell tumour and endometrioid cancer. Six years after complete removal of neoplastic foci, a routine examination revealed multiple nodular lesions inside the pelvis and in the pelvic peritoneum. Multiple histological studies confirmed the presence of a cylindroma. Based on the broad histochemistry and immunohistochemistry (periodic acid Shiff, Ber-EP4, p63, CKAE1/AE3, CEA positive, as opposed to negative results with inhibin, calretinin, CK7 and only focally positive for EMA; Ki 67 mitotic index did not exceed 5% of cells), granulosa cell tumour and endometrioid cancer was excluded. A comparison of the surgical material with the specimens taken from the primary lesion operated eight years earlier showed a similarity of histological images. Our case of peritoneal dissemination of eccrine cylindroma arising from dermoid cyst suggests the introduction of the term peritoneal cylindromatosis for similar cases.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"8 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91333647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obwodowa neuropatia wywołana chemioterapią. Część II. Zapobieganie","authors":"K. Brzezinski","doi":"10.5114/WO.2012.29297","DOIUrl":"https://doi.org/10.5114/WO.2012.29297","url":null,"abstract":"ropatii wywolanej chemioterapią (chemotherapy-induced peripheral neuropathy – CIPN) w populacji pacjentow „onkologicznych” ocenia sie na 3–7% w przypadku leczenia jednym cytostatykiem, a przy politerapii moze ona siegac nawet 38%. Badając leki, ktore mialyby wplynąc na zmniejszenie uszkodzenia obwodowego ukladu nerwowego, nalezy zwrocic przede wszystkim uwage na ich dzialanie zabezpieczające pacjenta przed wystąpieniem uciązliwego i bolesnego powiklania. Drugim, byc moze nawet wazniejszym, aspektem jest zyskanie pewności, ze stosowane w profilaktyce leki nie wplyną w istotny sposob na rozwoj choroby nowotworowej ani na skutecznośc leczenia przyczynowego. Wiele lekow zostalo zbadanych pod kątem skuteczności w zapobieganiu CIPN, jednak dotąd nie wykazano niezbicie dzialania ktoregokolwiek z nich. Nie opracowano rowniez wytycznych postepowania zapobiegawczego podczas chemioterapii. Niniejszy artykul jest probą przedstawienia doniesien z dostepnego piśmiennictwa dotyczących mozliwości profilaktyki CIPN.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"11 1","pages":"262-265"},"PeriodicalIF":1.8,"publicationDate":"2012-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75462685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breast cancer screening program attitudes among women from Wielkopolska The report from Focus Group Interview (FGI) studies","authors":"Paulina Pietrzak, D. Godlewski, M. Adamczak","doi":"10.5114/WO.2011.26452","DOIUrl":"https://doi.org/10.5114/WO.2011.26452","url":null,"abstract":"screening program attitudes among women from Wielkopolska. The research was ordered by the Center of Cancer Prevention and Epidemiology in Poznan. It was conducted between 30. 01. 2009 and 11. 02. 2009. Materials: The research has been conducted in the Breast Cancer Screening Program target group (women between 50 to 69 years old). This program is financed in Poland by Ministry of Health. Participants were divided into six groups of 7-12 women by place of residence and level of education. Methods: The Focus Group Interview was used. The conversations was led by the moderator. The discussion was conducted as informal as it was possible. The main aim of moderator was to encourage women to exchange opinions spontaneously. Conclusions: 1. None of the women had a mammography in last two years. 2. Women do not attend breast cancer screening program because they do not receive invitations. 3. Mammography in mobile mammography units is the best solution for women from villages because they do not have to worry about traveling to the city. 4. Some of the women from families without the history of cancers think that they will never be diagnosed with cancer. 5. The biggest irrational reason for avoiding mammography is the fear of cancer diagnosis. 6. The recent mass media mess about the low quality of mammography is still in women’s memory. 7. Most of the respondents avoid contacts with the health service.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"8 1","pages":"421-422"},"PeriodicalIF":1.8,"publicationDate":"2011-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78656728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Adamek, M. Zazula, E. Radwańska, E. Grzywna, A. Sińczak-Kuta, M. Moskała
{"title":"Co-occurrence of MGMT gene promoter methylation and amplification of EGFR in glioblastoma","authors":"D. Adamek, M. Zazula, E. Radwańska, E. Grzywna, A. Sińczak-Kuta, M. Moskała","doi":"10.5114/WO.2011.26436","DOIUrl":"https://doi.org/10.5114/WO.2011.26436","url":null,"abstract":"ficiency of chemotherapy of malignant gliomas may be combined administration of alkylating agents and those targeted at epithelial growth factor receptor (EGFR). The patients eligible for such therapy should show hypermethylation of MGMT (O6-methylguanineDNA-methyltransferase) promoter as well as amplification of EGFR. Aim of the study: Preliminary assessment of frequency of MGMT hypermethylation and amplification of EGFR co-occurrence in malignant gliomas in patients diagnosed and operated on in the Neurosurgery Department, JUMC in Cracow. Material and methods: 21 consecutive cases of glioblastoma multiforme (W 65%, M 35%, age average 51 y). The methylation status of the MGMT promoter was determined by methylationspecific PCR (MS-PCR). Before MS-PCR, genomic DNA was treated with sodium bisulphite, purified, denatured, precipitated and eluted. EGFR amplification was investigated using the FISH method. Results: With regards to MGMT methylation status and the occurrence of EGFR amplification, four groups of tumours (patients) were established: I – hypermethylation and amplification (4/21, 19.04%); II – hypermethylation, no amplification (6/21, 28.6%); III – no hypermethylation with amplification (4/21, 19.04%); IV – no hypermethylation, no amplification (7/21, 33.3%). Conclusions: Theoretically almost one fifth (19%) of patients with glioblastoma multiforme, i.e. those featuring MGMT hypermethylation and EGFR amplification, could potentially benefit from bimodal chemotherapy with an alkylating agent and an EGFR blocker. Our results confirm other reports indicating that there are no relations between MGMT methylation and EGFR amplification. Financial support by Grant No. K/ZDS/ 001044 Jagiellonian Univ.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"5 1","pages":"362-366"},"PeriodicalIF":1.8,"publicationDate":"2011-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87834699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Stec, M. Mączewski, M. Smoter, L. Bodnar, C. Szczylik
{"title":"M-TOR inhibitors in the treatment of advanced renal cell carcinoma","authors":"R. Stec, M. Mączewski, M. Smoter, L. Bodnar, C. Szczylik","doi":"10.5114/WO.2011.26432","DOIUrl":"https://doi.org/10.5114/WO.2011.26432","url":null,"abstract":"Renal cell cancer (RCC) accounts for ap proximately 3% of all registered malig nancies in Poland. According to the most recent National Cancer Register, 2283 men and 1483 women were diag nosed with renal cancer in 2006. Up to 30% of patients with RCC present with metastatic disease. M-TOR inhibitors became a new therapeutic option for patients with metastatic RCC. Two of them, temsirolimus and everolimus, are currently approved for clinical use for pa tients with advanced renal cancer. An ticancer activity of m-TOR inhibitors is re lated to cellular cycle regulation and inhibition of uncontrolled angiogenesis. Based on clinical trials, temsirolimus is indicated as the first line of chemother apy for patients with at least three poor prognostic factors. Everolimus should be administered as the second line of treatment, for patients who re lapsed after antiangiogenic therapy.","PeriodicalId":49354,"journal":{"name":"Wspolczesna Onkologia-Contemporary Oncology","volume":"39 1","pages":"343-349"},"PeriodicalIF":1.8,"publicationDate":"2011-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87383286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}