Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny最新文献

{"title":"Health implications forecast for electronic cigarette users","authors":"I. L. Vysochyna, T. O. Yashkina","doi":"10.31640/ls-2023-3-01","DOIUrl":"https://doi.org/10.31640/ls-2023-3-01","url":null,"abstract":"Electronic cigarettes have rapidly gained popularity in the tobacco market, primarily among young adults. Marketers exploit the lack of evidence regarding their health effects and label them as a safe alternative to traditional cigarettes. Our study aims to expand the existing body of evidence on their impact on the human body. Objective: To identify the most significant characteristics of individuals using electronic cigarettes based on statistical analysis of clinical and laboratory examination data. Materials and Methods. The study included 102 participants (main group – 66 individuals using electronic cigarettes as an alternative form of smoking; control group – 36 individuals who did not use electronic or industrial cigarettes) aged 20 to 35 years. Each participant provided written informed consent to participate. Patient examinations included the following parameters: height, weight, body mass index (BMI) calculation; measurement of blood pressure, heart rate, pulse, and respiratory rate; throat swab collection. Results. According to our data, individuals in the main group had higher height, weight, and BMI values. A higher BMI may be associated with excessive stimulation of salivary glands and, consequently, increased gastric secretion and appetite stimulation. Electronic cigarette users had significantly higher blood pressure levels compared to the control group. Users of nicotine delivery systems in throat swabs had significantly higher levels of mucus, coccal flora, and neutrophil percentage, indicating the presence of bacterial agents in the oral cavity mucosa. This may be related to bacterial agents’ dissemination through nicotine delivery devices. We conducted multiple logistic regression analysis with potential patient characteristics. Conclusions. Electronic cigarette users are characterized by higher height, weight, BMI, blood pressure levels compared to non-smoking peers, as well as reduced adaptation potential and a prevalence of parasympathetic nervous system regulation. It was found that a typical electronic cigarette user is a male (OR = 15.9364) with reduced IFZ – adaptive potential of functional abilities (OR = 7.8128) and an abnormal amount of oral cavity flora (OR = 1.7748).","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psycho-emotional portrait of primary school-age children with recurrent respiratory infections","authors":"V. V. Kramarchuk, I. L. Vysochyna","doi":"10.31640/ls-2023-3-02","DOIUrl":"https://doi.org/10.31640/ls-2023-3-02","url":null,"abstract":"Respiratory infections occupy a leading place in the structure of the population’s morbidity, especially among children. At the same time, recurrent respiratory infections (RRIs) impose the main burden on society and families. Most of the factors contributing to the manifestation of the RRI phenomenon have already been well-studied. However, the influence of psychological and emotional aspects on a child’s health has remained largely overlooked. Aim. to study the psychological characteristics of children aged 5–7 years in comparison to episodically ill peers and their correlation with local immunity indicators. Materials and Methods. The study involved 80 children, with 60 in the main group (children with recurrent respiratory infections) and 20 in the control group (episodically ill children). For psychological testing (psychometrics), the following methods were used: Blob Tree test (P. Wilson) to determine motivation and adaptation of children in a group setting. The projective „Family Sociogram‟ test (E.G. Aidemiller) to determine the place of the subject in the system of interpersonal relationships and to assess the nature of communication within the family. A modified version of A. Etkind’s Color Relations Test was used to determine individual typological personality characteristics and attitudes towards significant people and the surrounding environment on both a conscious and partially unconscious level. Clinical laboratory examination included measuring levels of secretory IgA and lysozyme in unstimulated saliva. Results. When analyzing the data obtained, a statistically significant difference was found between the results of children in the main and control groups. Conclusions. During color selection, children with RRIs more often associated themselves with the color red (40.7 %), their mothers with purple (40.7 %), and kindergarten or school with yellow (29.7 %) compared to episodically ill peers (p < 0.05). Children with RRIs in the „Family Sociogram‟ test more often than episodically ill peers demonstrated reduced self-esteem (73 % vs. 30 %, p = 0.038). In the Blob Tree test, children with RRIs differ in their first choice (current position in the group) from episodically ill peers (p < 0.0001). The level of sIgA and lysozyme in saliva in the group of children with RRIs correlates with the sensory choice of color for the mother (p < 0.0001).","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135083984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Водні техніки колоноскопії та їх еволюція. Тотальна підводна колоноскопія","authors":"V. S. Korpiak, V. O. Yakovenko, K. O. Naumenko, A. Yu. Palkin, A. I. Boychenko, O. S. Kochubei, S. M. Kunytsja, O. S. Gubar, V. E. Glagovsjkyj","doi":"10.31640/ls-2023-2-03","DOIUrl":"https://doi.org/10.31640/ls-2023-2-03","url":null,"abstract":"Тотальна підводна колоноскопія є однією і найновіших методик виконання скринінгу колоректального раку. На сьогоднішній час активно вивчаються способи її виконання та вдосконалення шляхом доповнення різноманітними додатковими режимами огляду та використання додаткових пристосувань. У статті аналізуються водні техніки колоноскопії з часу їх першого застосування до технік виконання у наш час.","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Оцінка споживання стимуляторiв фізичної та розумової працездатності для лікування астенiчного синдрому методом анкетування фармацевтичних працiвникiв","authors":"S. M. Drohovoz, M. M. Babenko, A. L. Shtroblia, К. H. Shchokina, H. V. Bielik, O. V. Tkachova, T. O. Kutsenko, L. V. Derymedvid","doi":"10.31640/ls-2023-2-02","DOIUrl":"https://doi.org/10.31640/ls-2023-2-02","url":null,"abstract":"Asthenia or asthenic syndrome (AS) is a condition in which a person is characterized by excessive fatigue, marked weakness, mood swings and mainly negative mood. Asthenia is a symptom of many organic and mental diseases. A person usually cannot engage in both physical and mental work for a long time due to prolonged or chronic fatigue. AS can be considered as a universal protective mechanism that accompanies various psychophysiological processes and somatic diseases, which are based on mechanisms of energy deficiency. Being in its essence a protective mechanism that signals the exhaustion of energy resources, AS can become a pathological, extremely disabling condition and even transform into its own nosology - chronic fatigue syndrome, an immune-mediated disease. Therefore, AS is a medical and social problem and requires adequate pharmacological correction. Today, drugs such as: adaptogens of plant and animal origin are used for the treatment of AS and stimulation of physical and mental performance; actoprotectors, antihypoxants; drugs with metabolic and neurotropic effects, B vitamins. The purpose of the work. Assessment of consumption and availability in the pharmaceutical market of Ukraine and analysis of the range of drugs for stimulation of physical and mental performance in the treatment of AS when dispensing over-the-counter drugs for the symptomatic treatment of asthenia. Research methods. Sociological, system-analytical, analytical. Results. A study was conducted to assess consumption and availability on the pharmaceutical market of Ukraine and to analyze the assortment of pharmaceutical products for the dispensing of over-the-counter drugs for the symptomatic treatment of asthenia.","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"239 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Комбінація метилпреднізолону та інтравенозного імуноглобуліну у лікуванні звичного завмирання вагітності у пацієнток із підвищенною NK-цитотоксичністю на тлі гіперандрогенії","authors":"B. V. Dons’koi, V. P. Chernyshov, T. O. Popova","doi":"10.31640/ls-2023-2-05","DOIUrl":"https://doi.org/10.31640/ls-2023-2-05","url":null,"abstract":"Висока цитотоксичність натуральних кіллерів є несприятливим фактором репродуктивного процесу. Вона як знижує імовірність імплантації, так і збільшує частоту завмирань вагітності першого триместру. Підходи до терапії високої NK-цитотоксичності (NKц), як і в цілому до терапії репродуктивних втрат, дискутуються вже більше 20 років і основною проблемою у цій дискусії є висока контраверсійність результатів, що отримується у різних клінічних групах. На нашу думку причиною таких розбіжностей є неврахування особливостей імунофентипу та гормонального статусу у поєднанні із клініко-анамнестичною рандомізацією. У цій роботі ми продемонструємоефективністьтакого підходу. Ретроспективно проаналізовані результати лікування комбінацією метилпреднізолон + інтравенозний імуноглобулін (ІВІГ) у 46 пацієнток із високою NK-цитотоксичністю та гіперандрогенним статусом, що мали у анамнезі звичайне невиношування вагітності.45 із 46 пацієнток народили здорову дитину, а показники NK-цитотоксичності у переважної більшості демонстрували високу чутливість до лікування.","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The history of the activity of the “Pavlovian Council” and its negative impact on the development of scienсe in 50s of the 20th century","authors":"L. O. Klymenko, I. G. Strokina","doi":"10.31640/ls-2023-2-07","DOIUrl":"https://doi.org/10.31640/ls-2023-2-07","url":null,"abstract":"Further development of the history of science including history of physiology requires the analysis of a number of methodological problems which related to the history of the development of science in Ukraine during the dramatic times of the rule of the communists in Soviet Union. The article considers the ideological distortion of achievements and teachings of I. Pavlov by party structures. It is talking about the events that took place in the early 50’s XX sentures. The scientific community of the world should remember the negative events that resulted from the decisions of the joint meeting of the Academy of Sciences of the USSR and the Academy of Sciences of the USSR in June-July 1950 (“Pavlovian session”). It is shown that the Moscow authorities forced scientific community of many union republics, including Ukraine, to carry out similar meetings. The results of this conference had a long-term negative impact on physiology, psychology, and medicine. In fact, at the meeting, the work of world-famous scientists and the scientific directions of some institutions were criticized, although the organizers of the meeting declared the main problem of the discussion the physiological teaching of academician I. Pavlov. They aimed to establish the methodology of conditioned reflexes and the doctrine of the leading role of the cerebral cortex in considering all physiological and psychologycal processes. Some of Pavlov’s students, who had their own concept were labeled as “anti-Pavlov”. “Anti Pavlov” scientists were forced to admit their mistakes. Organizers of session recommended them to work within the framework of the Pavlov’s theory of higher nervous activity and to avoid Western influences. To control the implementation of Pavlov’s teachings, the “Pavlovian Council” was created. The article presents the results of the activity of this committee. On the basis of archival documents, the author describes how, at these meetings, council members put pressure on physiologists and persist new topics on research institutes. It has been proven that the task of the council was to destroy physiology under the guise of developing the teachings of I. Pavlov. According to the author of the article, the resolutions of the Pavlovian Committee provided only the methodology of the experiment on the physiology of higher nervous activity. The positive effect for some scientists was usually related to the official doctrine. However, the decisions of the Pavlovian Committee inhibited the development of those studies that did not relate to the official doctrine. These scientific investigations were branded as “hostile”. The aim of the article is to show the negative impact of the “Pavlovian Session” and the activities of the “Pavlovian Council” on the development of physiology, medicine, and psychology. The author proved that physiologists of Ukraine, having experienced the consequences of the joint session, were able to defend their science thanks to the organization of t","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"364 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theory of immune accentuations: formation of accentuated immunophenotype","authors":"B. V. Dons’koi","doi":"10.31640/ls-2023-2-01","DOIUrl":"https://doi.org/10.31640/ls-2023-2-01","url":null,"abstract":"In numerous previous studies, we have formulated the idea of immune accentuation, demonstrated associations between immune accentuations and the unfavorable course of physiological processes, and shown that the association of several accentuations has a reliable negative effect on the further course of the reproductive process. In the article, we demonstrated the correlative and associative nature of certain immune accentuations, which explains the causes of the formation of an unfavorable immuno-accentuated phenotype. Thus, we found highly reliable correlative and associative relationships between the parameters of natural resistance (NK quantity, NK cytotoxicity, expression of CD158a and CD8 on NK cells), all these parameters were mutually correlated with each other and their accentuations were associated with accentuations of partner parameters. Another immuno-accented cluster had pro-inflammatory features, so the expression of HLA-DR on NK and T-cytotoxic cells, as well as NKT-like populations (CD3+CD56+ and CD3+CD158a+) also had highly reliable correlations and associations. This pro-inflammatory phenotype was negatively correlated and inversely associated with T-helper levels. Presumably, this is a consequence of uncontrolled chronic activation with the appearance of alternative ways of differentiation of T cells that bypass regulatory control by T-helpers. We showed a fundamental difference in the association and correlative relations between immune parameters depending on their level. Thus, HLA-DR levels on NK cells within (NK < 24 %) had a negative correlation with % NK cells, while, within (NK > 24 %) they begin to correlate positively and reliably with the number of NK. So, accentuation is the place in the distribution of the parameter, where the parameter begins to put pressure on other parameters and determine their level of direction. These are the same zones where the parameter becomes unfavorable, because it loses the possibility of regulation. Accentuation of the immune parameter is associated with specific accentuations of other parameters. Whether it causes changes in other links or whether it and other changes are the result of extra-immune or environmental factors are unknown. But it is clear that this leads to the formation of an immuno-accented phenotype. Accentuation creates prerequisites for the formation of other immune accentuations due to the imbalance of systemic immune regulation.","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Можливості хондропротекторів при остеоартриті","authors":"V. V. Shtroblіa, S. S. Philip, R. V. Lutsenko","doi":"10.31640/ls-2023-2-04","DOIUrl":"https://doi.org/10.31640/ls-2023-2-04","url":null,"abstract":"Остеоартрит (ОА) є найбільш поширеним захворюванням суглобів та основною причиною порушення їх функції і інвалідності. Незважаючи на досягнення у вивченні патогенезу цього захворювання, лікування його досі залишається складним завданням. В наш час, як варіанти фармакологічного лікування ОА, для контролю болю та запалення застосовують нестероїдні протизапальні засоби (НПЗЗ), анальгетики, глюкокортикостероїди. Однак вони діють як симптоматичне лікування та мають високий ризик побічних ефектів Симптоматичні препарати повільної дії (SYSADOA) для лікування ОА не є швидкодіючими, такими як НПЗЗ і їхня клінічна ефективність щодо зменшення симптомів ОА може бути продемонстрована лише через кілька тижнів регулярного їх прийому. Проте при ОА вони не тільки зменшують біль у суглобах, а й уповільнюють прогресування захворювання. Одним із таких препаратів є хондроїтинсульфат – складний гетерогенний полісахарид, який має відмінний профіль безпеки. Саме хондроїтинсульфат і глюкозамін сульфатостаннім часом набули широкого використання як варіанти SYSADOA для лікування ОА. Вони діють як хондропротектори та/або як «ліки, що модифікують захворювання при ОА»,які полегшують біль та частково відновлюють функцію суглобів у пацієнтів з ОА, і таким чиномпроявляючи не лише симптоматичне лікування, а і вплив на патогенетичні ланки ОА. Хондроїтинсульфат знижує активність прозапальних цитокінів та фактору транскрипції, що беруть участь у запаленні. Глюкозамін сульфатпосилює специфічні компоненти матриксу хряща і запобігає дегенерації колагену в хондроцитах шляхом інгібування гідролітичних ферментів. Клінічні дослідження хондроїтинсульфату при лікуванні ОА показали, що він ефективний, безпечний та добре переноситься. Отже, використання препаратів SYSADOA знижує застосування кількості НПЗЗ при терапії ОА і, зменшує ризик розвитку побічної дії їх. Мета. Провести збір і аналіз літератури щодо терапевтичної ефективності симптоматичних препаратів повільної дії (SYSADOA) при лікуванні ОА. Методи. Пошук наукової інформації проведений в електронних базах PubMed, Google Scholar. Результати. Проведено огляд і аналіз літературищодотерапевтичної ефективності SYSADOA при лікуванні ОА. Висновки. Симптоматичні препарати повільної діїзменшують біль, скутість, функціональні обмеження при ОА та мають гарний профіль безпеки.","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Властивості яблучного пектину та його застосування в медицині та фармації","authors":"M. B. Hainiuk, O. V. Gerush, N. S. Bogdan, M. V. Savokhina, O. L. Khalieieva","doi":"10.31640/ls-2023-2-06","DOIUrl":"https://doi.org/10.31640/ls-2023-2-06","url":null,"abstract":"Пектини – це природні гетерополісахариди, що входять до складу клітинної стінки вищих рослин. В промислових умовах пектини отримують з відходів виробництва фруктових соків, іноді з відходів виробництва бурякового цукру або рослинних олій. В раціоні середньостатистичного українця присутня достатня кількість овочів та фруктів що містить яблучний пектин. Метою даного огляду було узагальнити дані про структуру, фізико-хімічні властивості пектинів та проаналізувати інформацію щодо застосування яблучного пектину в медицині та фармації.","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD8αα expression on NK cells is associated with different K562 and MOLT4 killing capabilities of PBMC and different involvement CD8pos and CD8neg subsets in anti-viral response","authors":"B. V. Dons’koi, E. I. Dubrovskyi","doi":"10.31640/ls-2023-1-04","DOIUrl":"https://doi.org/10.31640/ls-2023-1-04","url":null,"abstract":"Introduction. The CD8αα are present in a subset of T cells and NK cells, but its function is mostly unknown, as well as the role of CD8+ and CD8- NK cell subsets in physiological and pathological environments. Methods. We investigated 130 healthy individuals’ blood samples for the NK cell cytotoxicity against K562 and MOLT4 cell lines. We also analyzed patients after SarsCov2 infection and compared to healthy control. The NK cell phenotype and cytotoxicity were studied by the FACScan flow cytometer using BD monoclonal antibodies. Results. We confirmed that MOLT4 is significantly more resistant to the NK cell cytotoxicity compared to the “classical” K562. CD8+ NK cells are more effective at K562 killing compared to CD8- subsets. The correlation of lymphocyte levels with the specific K562 lysis was weaker for CD8- NK cell subsets (r = 0.37) than CD8+ NK cells (r = 0.45) or whole NK cells population (r = 0.46). However, we found that CD8+ NK cells mostly did not participate in the MOLT-4 killing. CD8- NK cells frequency correlates with MOLT4 lysis more significantly (r = 0.49) than CD8+ NK cells lymphocytes levels (r = 0.27) or whole NK cells population (r = 0.44). Also, we showed that HLA-DR and CD158a positive NK cell levels did not correlate with the MOLT4 and K562 killing, while HLA-DR and CD158a negative subsets levels did with the same significance as the whole NK cells population. Decreased of NK lymphocytes after SarsCov2 infection results to decrease NK population owing to CD8+NK decreased but not CD8neg. Conclusion. NK cell numbers determine NK cell cytotoxicity indirectly through the surface phenotype. CD8 expression on the NK cells is associated with the effective cytotoxicity against K562 but at the same time obstructs a response to MOLT4. CD8αα on NK cells might participate in HLA recognition or enhance response to HLA class-I negative target cells.","PeriodicalId":493511,"journal":{"name":"Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136266447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}