Zdravniski Vestnik-Slovenian Medical Journal最新文献_第3页

Diplopija: Praktičen pristop k diagnostiki

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-06-29 DOI: 10.6016/ZdravVestn.1116

Igor Šivec, Dragica Kosec

引用次数: 1

Epilepsija in vožnja

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-05-29 DOI: 10.6016/ZDRAVVESTN.1182

Matej Mavrič, Črt Zavrnik, Marjan Bilban, Jože Grošelj

{"title":"Epilepsija in vožnja","authors":"Matej Mavrič, Črt Zavrnik, Marjan Bilban, Jože Grošelj","doi":"10.6016/ZDRAVVESTN.1182","DOIUrl":"https://doi.org/10.6016/ZDRAVVESTN.1182","url":null,"abstract":"Epilepsy poses a risk for all participants in road traffic; therefore people with epilepsy do not meet the criteria for an unlimited driving license. Their driving is affected not only by epileptic seizures causing impaired consciousness and involuntary movements, but also by antiepileptic drugs with their many unwanted affects. The experts have not yet agreed on whether people with epilepsy have an increased risk of experiencing a road traffic accident. However, recent data suggests that the overall risk is lower compared to other medical conditions. Scientific evidence forms the basis of legislation, which by limiting people with epilepsy, enables all participants in road traffic to drive in the safest possible environment. The legislation that governs epilepsy and driving in Slovenia has been recently thoroughly reformed and thus allows a less discriminatory management of people with epilepsy. Although people with epilepsy experience many issues in their daily life, including their personal relationships and employment, they often list the need for driving as a top concern in surveys. General physicians play an important role in managing the issues of people with epilepsy.","PeriodicalId":49350,"journal":{"name":"Zdravniski Vestnik-Slovenian Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87025450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ko mrtvi žive uče

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-05-29 DOI: 10.6016/ZDRAVVESTN.1375

Zvonka Zupanič Slavec

引用次数: 0

Local recurence of rectal cancer in patients with nonmetastatic disease, diagnosed in 2003 - 2005 2003 - 2005年诊断的非转移性直肠癌患者的局部复发

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-05-29 DOI: 10.6016/ZDRAVVESTN.1241

M. Rems, K. Jarm, V. Zadnik, M. Primic‐Žakelj

{"title":"Local recurence of rectal cancer in patients with nonmetastatic disease, diagnosed in 2003 - 2005","authors":"M. Rems, K. Jarm, V. Zadnik, M. Primic‐Žakelj","doi":"10.6016/ZDRAVVESTN.1241","DOIUrl":"https://doi.org/10.6016/ZDRAVVESTN.1241","url":null,"abstract":"Background : In the last decades outcomes of rectal cancer treatment are improving due to better understanding of tumor biology, neoadjuvant and adjuvant treatment and precise surgical technique, considering pathologic anatomical lines. Proportion of rectal cancer local recurrence (LR) has been substantially decreasing. Objectives of this study are, first, to find out whether two groups, with and without rectal local recurrence, are statistically important different in certain risk factors and, second, to define prognostic factors of rectal local recurrence. Methods : Total of 787 nonmetastatisc rectal cancer patients, diagnosed between 2003 and 2005, treated with surgery in all Slovenian hospitals, were enrolled retrospectively. The recurrence-free survival rates were calculated with Kaplan-Meier method. For statistical comparison of survival of two groups according to prognostic factors log-rank test was used. The adjusted hazard ratios for significant survival prognostic factors were calculated using Cox multivariate analysis. Results : Patients with LR had more tumors in the lower third of rectum (p=0,045), more abdominoperineal, Hartmann's and local excisions (p=0,000) and less radical operations (p=0,005), more of them were operated in hospitals with lesser caseload of patients (p=0,000), more often were treated only surgically (p=0,048), had more colon defects after excision of tumors (p=0,025) and had more distant disease recurrences (p=0,000). In follow up period of 5,3 years LR occurred in 13,1% and in 54% of those in 1,9 years after surgery. In the multivariate analysis, the statistically significant prognostic factors for recurrence-free survival were tumor's rectal position, regional lymph nodes status and the hospital of surgery. Conclusions : Proportion of LR is an appropriate indicator of optimal multidisciplinary rectal cancer treatment.","PeriodicalId":49350,"journal":{"name":"Zdravniski Vestnik-Slovenian Medical Journal","volume":"1 1","pages":"277-286"},"PeriodicalIF":0.0,"publicationDate":"2015-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78207391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANALGESIC EFFICACY OF TRAMADOL IN PEDIATRIC TONSILLECTOMY WITH ADENOIDECTOMY 曲马多在小儿扁桃体切除合并腺样体切除术中的镇痛效果

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-05-29 DOI: 10.6016/ZDRAVVESTN.1205

J. Benedik

{"title":"ANALGESIC EFFICACY OF TRAMADOL IN PEDIATRIC TONSILLECTOMY WITH ADENOIDECTOMY","authors":"J. Benedik","doi":"10.6016/ZDRAVVESTN.1205","DOIUrl":"https://doi.org/10.6016/ZDRAVVESTN.1205","url":null,"abstract":"Background: Tonsillectomy is one of the most commonly performed surgical prcedures in childhood. Acute pain after tonsillectomy and adenoidectomy can be treated with non-opioid and opioid analgesics. Our hypothesis stated that tramadol iv after induction of anaesthesia has superior analgesic effect compared to acetaminophen. Methods: In a prospective, randomised study we compared analgesic efficacy of tramadol (group T: 2 mg/kgBW iv) and acetaminophen (group A: elixir 15 mg/kgBW before op. procedure) in a group of 108 children (age 3-7 years). Exclusion critheria: allergy, liver or kidney failure, epilepsy, febrile convulsions. A standard anaesthetic technique was used: propofol, alfentanil, vecuronium, positive pressure ventilation with 60% nitrous oxide in oxygen. After the procedure each child received acetaminophen suppositories (10 mg/kgBW/4-6h) and combined suppositories. Monitoring: vital signs during and after op. procedure, pain intensity on the ward (facial pain score). Results: There were no significant differences between the two groups in age distribution (mean age 5,2 years), ASA physical status, body weight, operative procedure, pain scores (VAS 6h after operative procedure; group T: 4,21±1,45; group A: 4,06±1,33), oxygen saturation, pulse frequency and the consumption of acetaminophen suppositories. Significant difference was in the consumption of combined suppositories (group T: 1,85±0,79; group A: 1,43±0,69, p=0,003). Conclusion: Our study has shown, that tramadol is not a superior analgesic for the relief of posttonsillectomy pain in children compared to acetaminophen.","PeriodicalId":49350,"journal":{"name":"Zdravniski Vestnik-Slovenian Medical Journal","volume":"29 1","pages":"268-276"},"PeriodicalIF":0.0,"publicationDate":"2015-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82271827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UP-TO-DATE MANAGEMENT OF LIVER DISEASE AND COMPLICATIONS IN CYSTIC FIBROSIS AND TRANSITION OF ADOLESCENTS FROM PEDIATRIC TO ADULT CARE 肝脏疾病和囊性纤维化并发症的最新管理和青少年从儿科到成人护理的转变

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-05-05 DOI: 10.6016/ZDRAVVESTN.1228

M. Praprotnik, Nevenka Bratanič, J. Brecelj, M. Flezar, U. Krivec

引用次数: 1

Evaluation of theophylline therapeutic drug monitoring service 茶碱治疗药物监测服务评价

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-05-05 DOI: 10.6016/ZDRAVVESTN.1174

Neža Rugelj, K. Trobec, M. Pišlar, P. M. Brguljan, M. Košnik, A. Mrhar

{"title":"Evaluation of theophylline therapeutic drug monitoring service","authors":"Neža Rugelj, K. Trobec, M. Pišlar, P. M. Brguljan, M. Košnik, A. Mrhar","doi":"10.6016/ZDRAVVESTN.1174","DOIUrl":"https://doi.org/10.6016/ZDRAVVESTN.1174","url":null,"abstract":"Background Therapeutic monitoring of theophylline serum levels is required due to its narrow therapeutic range and marked interindividual pharmacokinetic variability. We evaluated therapeutic drug monitoring service for theophylline in Slovenian clinical setting, which currently includes no pharmacokinetic evaluation of measured theophylline serum concentrations. Methods We retrospectively evaluated 127 randomly selected theophylline serum level determinations performed in 2010 in a tertiary clinical setting in Slovenia. Demographic data, information on theophylline dosing and blood sampling was collected from patients’ data files. Authors evaluated the appropriateness of the following procedures: indications for theophylline serum concentration measurement, timing of blood sampling and dosage adjustments made after theophylline levels had been reported. On the basis of collected data, population pharmacokinetic model for theophylline was built and further used for the evaluation of dosage adjustments. Results Out of 127 cases, 107 (84.3%) had clinically justified indication for theophylline serum level measurement. Near half of measurements (44.9%) were performed before the steady state of theophylline concentrations was established. 65% of measured concentrations were subtherapeutic and the average measured concentration was below therapeutic range (53.1 μmol/L). Despite subtherapeutic concentrations the dose of theophylline was mainly not increased. Pharmacokinetic model enabled the calculation of average optimal daily dose which was significantly higher than the average actual daily dose used (876 mg vs. 572 mg, p < 0.001). Conclusions Theophylline TDM service should be optimized and pharmacokinetic interpretation of theophylline serum levels should be integrated into clinical practice.","PeriodicalId":49350,"journal":{"name":"Zdravniski Vestnik-Slovenian Medical Journal","volume":"36 12","pages":"191-202"},"PeriodicalIF":0.0,"publicationDate":"2015-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72494304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

6-MP based maintenance therapy of childhood ALL in Slovenia: a retrospective study from 1970 to 2004 斯洛文尼亚儿童ALL的6-MP维持治疗:1970年至2004年的回顾性研究

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-04-07 DOI: 10.6016/ZDRAVVESTN.1016

N. K. Kuželički, A. Šmid, I. M. Raščan, J. Jazbec

{"title":"6-MP based maintenance therapy of childhood ALL in Slovenia: a retrospective study from 1970 to 2004","authors":"N. K. Kuželički, A. Šmid, I. M. Raščan, J. Jazbec","doi":"10.6016/ZDRAVVESTN.1016","DOIUrl":"https://doi.org/10.6016/ZDRAVVESTN.1016","url":null,"abstract":"Background: Maintenance therapy with 6-mercaptopurine (6-MP) as its major component has been one of the main reasons for the drastic increase in overall survival of paediatric acute lymphoblastic leukaemia (ALL) patients. In our cohort, consisting of patients receiving maintenance therapy for ALL and encompassing time period of three decades, we evaluated dosage, safety and efficiency of 6-MP in the treatment of childhood ALL according to treatment protocol, age and gender. Methods: Slovenian paediatric ALL patients diagnosed and treated from 1970 to 2004 were identified through the national oncology patients` registry. Of 414 registered paediatric ALL patients, 320 received maintenance therapy for ALL and were included into the final study cohort. Information about age, gender, treatment protocol, 6-MP related toxic events and ALL relapse was extracted from patients` files. Differences in 6-MP dose reduction, 6-MP side effects and relapse according to gender, age and treatment protocol were statistically evaluated. Results: After adjustment for gender and age incidence of 6-MP dose reduction (p<0.001) and bone marrow suppression (p = 0.019) was higher in recent treatment protocols, while relapse was more common in older protocols (p < 0.001). Younger patients had greater risk for sepsis/infection (p = 0.002), while greater age was a risk factor for osteonecrosis (p = 0.001). No statistically significant associations were found according to gender. Conclusions: In the retrospective study, encompassing three decades of maintenance treatment of childhood ALL in Slovenia, recent protocols exhibited greater effectiveness and toxicity than older protocols.","PeriodicalId":49350,"journal":{"name":"Zdravniski Vestnik-Slovenian Medical Journal","volume":"124 1","pages":"99-107"},"PeriodicalIF":0.0,"publicationDate":"2015-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89273067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recommendations for physical activity for pregnant women 孕妇的运动建议

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-04-07 DOI: 10.6016/slovmedjour.v84i2.1220

M. Videmšek, Eda Bokal Vrtačnik, D. Šćepanović, L. Žgur, Naja Videmšek, M. Meško, D. Karpljuk, J. Štihec, V. Hadžić

{"title":"Recommendations for physical activity for pregnant women","authors":"M. Videmšek, Eda Bokal Vrtačnik, D. Šćepanović, L. Žgur, Naja Videmšek, M. Meško, D. Karpljuk, J. Štihec, V. Hadžić","doi":"10.6016/slovmedjour.v84i2.1220","DOIUrl":"https://doi.org/10.6016/slovmedjour.v84i2.1220","url":null,"abstract":"Properly selected and prescribed physical activity during pregnancy has a favorable effects on the health of pregnant women and the fetus, and is excellent preparation for childbirth. Absolute and relative contraindications to exercise during pregnancy are well defined, as well as the warning signs to terminate exercise while pregnant. Knowledge of these is essential for physically active pregnant women and exercise professionals that work with pregnant women. Pregnant women should be moderately physically active every day of the week for at least 30 minutes. The term moderate is thoroughly and clearly defined in the guidelines. Resistance exercises during pregnancy are safe but it is advised to use light loads and a large number of repetitions (e.g. 15-20 repetitions). Strength exercises for the pelvic floor muscles deserves a special place during pregnancy. Appropriate forms of physical activity for pregnant women are walking and jogging, swimming and aquatic exercise, cycling, Pilates and yoga, aerobics, fitness and cross-country skiing. Certain forms of physical activity need special adjustments (alpine skiing, ice skating and rollerblading, racket sports, team ball games, horseback riding and scuba diving).","PeriodicalId":49350,"journal":{"name":"Zdravniski Vestnik-Slovenian Medical Journal","volume":"1 1","pages":"87-98"},"PeriodicalIF":0.0,"publicationDate":"2015-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83001456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

UP-TO-DATE MANAGEMENT OF LUNG DISEASE IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS 囊性纤维化儿童和青少年肺部疾病的最新管理

Zdravniski Vestnik-Slovenian Medical Journal Pub Date : 2015-04-07 DOI: 10.6016/ZDRAVVESTN.1219

M. Praprotnik, A. K. Pirs, B. Salobir, M. Oštir, M. Turel, U. Krivec

{"title":"UP-TO-DATE MANAGEMENT OF LUNG DISEASE IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS","authors":"M. Praprotnik, A. K. Pirs, B. Salobir, M. Oštir, M. Turel, U. Krivec","doi":"10.6016/ZDRAVVESTN.1219","DOIUrl":"https://doi.org/10.6016/ZDRAVVESTN.1219","url":null,"abstract":"Cystic fibrosis (CF) is a multi-organ disease, affecting mostly lungs and gastrointestinal tract. Data from patient registries show that the survival of patients with CF has progressively improved over the past several decades, as a result of advances in antibiotic treatment, supplementation of pancreatic enzymes, better nutrition and a holistic approach to treatment in CF centres. The purpose of this review is to survey recent developments in the treatment of lung disease in children and adolescents with CF. We describe newborn screening for CF. When chronic respiratory insufficiency occurs, lung transplantation becomes a very important issue. Lung disease is the most common cause of morbidity and mortality in CF patients. Emerging new therapies are targeted at all points in the pathogenesis of lung disease, from drugs that treat infection and inflammation in the airways to gene transfer studies and to drugs that augment airway surface liquid height. A number of antibacterial agents formulated for inhalation are at various stages of study and there are several anti-inflammatory candidate drugs in clinical trials. The most important development in the recent years is modulation of the abnormal protein that causes CF, the cystic fibrosis transmembrane regulator (CFTR), where drugs are targeted at specific defects in the transcription, processing or functioning. When chronic respiratory insufficiency occurs, lung transplantation becomes a very important issue. The role of the CF nurse, who has responsibilities in educating and teaching clinical skills to patients and families, is described.","PeriodicalId":49350,"journal":{"name":"Zdravniski Vestnik-Slovenian Medical Journal","volume":"9 1","pages":"143-152"},"PeriodicalIF":0.0,"publicationDate":"2015-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86457163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0