Zeitschrift Fur Gerontologie Und Geriatrie最新文献

Pathophysiology and biomarkers of delirium in older adults-Narrative review. 老年人谵妄的病理生理学和生物标志物-述评。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-09-04 DOI: 10.1007/s00391-026-02638-2

Fatima Irfan, Janine Jorke, Niels Hansen, Christine A F von Arnim

{"title":"Pathophysiology and biomarkers of delirium in older adults-Narrative review.","authors":"Fatima Irfan, Janine Jorke, Niels Hansen, Christine A F von Arnim","doi":"10.1007/s00391-026-02638-2","DOIUrl":"https://doi.org/10.1007/s00391-026-02638-2","url":null,"abstract":"Background: Delirium is a frequent acute neurocognitive syndrome in older adults, associated with morbidity, mortality, and long-term cognitive decline. Its pathophysiology is multifactorial and not yet fully understood.Objective: To summarize clinically relevant concepts of delirium pathophysiology and emerging biomarkers.Methods: Narrative review of literature from 2010-2026, prioritizing human studies, reviews, meta-analyses, and clinically relevant pathophysiological literature relevant to older hospitalized or perioperative patients.Results: Delirium arises from the interaction of predisposing vulnerability and acute triggers. Relevant mechanisms include neuroinflammation, neurotransmitter imbalance, neurodegeneration, metabolic dysfunction and blood-brain barrier impairment. Biomarker research has identified promising candidates, including inflammatory, neurodegenerative, metabolic and stress-related markers but none is currently established for routine clinical use.Conclusion: Delirium prevention remains clinically driven. Multimodal biomarkers may support future risk stratification but require prospective validation.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Long lie: development of a definition using the Delphi method]. [长谎言：用德尔菲法定义的发展]。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-09-03 DOI: 10.1007/s00391-026-02637-3

Jenny Kubitza, Iris Tamara Schneider

{"title":"[Long lie: development of a definition using the Delphi method].","authors":"Jenny Kubitza, Iris Tamara Schneider","doi":"10.1007/s00391-026-02637-3","DOIUrl":"https://doi.org/10.1007/s00391-026-02637-3","url":null,"abstract":"Background: The term \"long lie\" is frequently used in German-speaking countries although no standardized national or international definition currently exists. Given the high prevalence of long lies among older adults and the significant effects for those affected, a definition is necessary. The aim of this study is to develop a standardized German language definition of the term long lie in older adults.Methods: In a three-round Delphi study 50 experts from various professions evaluated key components of the term in relation to their relevance. The consensus criteria were defined as a minimum agreement rate of 75% and an interquartile range of ≤ 1. Characteristics that met these criteria were carried over to the next round and integrated into the final definition.Results: In the final round 77.6% of the experts approved the definition. The interquartile ranges for all assessed components were consistently ≤ 1. There was consensus regarding the components of acute impaired mobility, the inability to free oneself, the resulting loss of control, the traumatic experience and the multidimensional effects. Disagreement existed regarding the significance of a temporal component as well as the prioritization of physical effects in comparison to psychological and emotional effects.Conclusion: A consensus-based definition of long lies in older adults has been developed. The results also show interprofessional differences in the assessment of key components and underscore the need for further conceptual and interprofessional coordination in research and care.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cognitive aging, dementia and need for care : Contributions of cognitive psychology to an integrative assistance for old persons]. [认知老化，痴呆和护理需求：认知心理学对老年人综合援助的贡献]。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-09-03 DOI: 10.1007/s00391-026-02641-7

Gabriele Rössler, Wolfgang Mack

{"title":"[Cognitive aging, dementia and need for care : Contributions of cognitive psychology to an integrative assistance for old persons].","authors":"Gabriele Rössler, Wolfgang Mack","doi":"10.1007/s00391-026-02641-7","DOIUrl":"https://doi.org/10.1007/s00391-026-02641-7","url":null,"abstract":"Cognitive aging, the expectable changes in cognitive abilities with age, can impair the capacity to manage everyday demands, result in the need for care or resemble dementia. Therefore, age-related mental changes should be considered as well as physical changes in preparing for aging and accompanying old people. Based on reviews in cognitive psychology, expectable age-related changes in relevant cognitive domains for everyday management, such as intelligence, memory and social cognition as well as the resulting effect on decision-making and executive functioning are summarized. The flexibility of thinking declines; actions focus on exploitation rather than necessary exploration of resources as evidenced, for example, by clinging to routines for managing everyday demands that are no longer adequate or resisting necessary changes such as the use of assistive technologies. Personal and social resources can balance these changes and promote a self-determined lifestyle. Examples such as the use of structured self-observation or of lasting power of attorney, information provision, counselling and relationship-building demonstrate how knowledge on cognitive aging can be transferred to integrative assistance for old persons.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat-associated hyponatremia and its outcomes in very old inpatients in northern Germany. 德国北部老年住院患者的热相关性低钠血症及其预后

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-09-02 DOI: 10.1007/s00391-026-02635-5

Naomi Mader, Stefan Muthers, Klaus Albrecht, Martin Scharpenberg, Andreas Kribben, Stefan Herget-Rosenthal

{"title":"Heat-associated hyponatremia and its outcomes in very old inpatients in northern Germany.","authors":"Naomi Mader, Stefan Muthers, Klaus Albrecht, Martin Scharpenberg, Andreas Kribben, Stefan Herget-Rosenthal","doi":"10.1007/s00391-026-02635-5","DOIUrl":"https://doi.org/10.1007/s00391-026-02635-5","url":null,"abstract":"Background: Hyponatremia is frequent in very old patients ≥ 80 years (VOP). Data for hyponatremia associated with moderate heat in VOP are scarce. We aimed to provide epidemiological data, to identify risk factors of hyponatremia and to present outcomes in VOP after hot and cold days in northern Germany.Methods: Of 22,085 VOP admitted unplanned to the departments of internal medicine and trauma surgery in 2011-2023, we studied those admitted 1-2 days after hot (N = 308) and cold days (N = 253) in June-August of these years (57.9% female, median age 86 years). Heat was defined as daily mean temperatures ≥ 95th (24.4 °C), cold as ≤ 5th percentile (12.3 °C) in June-August from 2011-2023. Primary outcome was hyponatremia on admission. Secondary outcomes were risk factors of hyponatremia and the frequency of major adverse hyponatremia events until day 30 (MAHE30, intensive care unit and/or long hospital stay, mortality and/or discharge to a care facility).Results: In 561 patients, hyponatremia occurred more often after hot than cold days (36.7% vs. 15.0%; P < 0.001). Hyponatremia was predominately mild, acute or acute on chronic and isotonic in patients admitted after both hot and cold days. Hyponatremia rates increased by 50% after 3 consecutive hot days. Heat was a strong risk factor of hyponatremia. In 151 hyponatremic patients, MAHE30 occurred more often after hot compared to cold days (55.6% vs. 31.6%; P = 0.008). Heat was identified as a strong risk factor also of MAHE30 in hyponatremic patients.Conclusion: Moderate heat in northern Germany is associated with an increased rate of hyponatremia and is a strong risk factor of hyponatremia in VOP. After hot days, hyponatremic VOP are at an increased risk for severe associated morbidity and mortality.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Multicomponent programs in delirium prevention and delirium management in older adults : Evidence, guideline recommendations and perspectives on delirium-sensitive care]. [老年人谵妄预防和谵妄管理的多组分方案：谵妄敏感护理的证据、指南建议和观点]。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-08-25 DOI: 10.1007/s00391-026-02643-5

Christine Thomas, Juliane Spank, Monika Sadlonova

{"title":"[Multicomponent programs in delirium prevention and delirium management in older adults : Evidence, guideline recommendations and perspectives on delirium-sensitive care].","authors":"Christine Thomas, Juliane Spank, Monika Sadlonova","doi":"10.1007/s00391-026-02643-5","DOIUrl":"https://doi.org/10.1007/s00391-026-02643-5","url":null,"abstract":"Delirium is among the most frequent neuropsychiatric complications in older people. It is associated with functional decline, increased morbidity and mortality, loss of independence, cognitive deterioration and an elevated risk of dementia. Contemporary concepts view delirium as the result of an interplay between predisposing vulnerability factors and acute physiological stressors. Current approaches to delirium prevention and management focus on nonpharmacological multicomponent interventions that combine early mobilization, cognitive reorientation, sleep hygiene, pain management, optimization of nutrition and hydration, delirium screening and family involvement. Programs such as HELP, ABCDE(F) bundle, CHOPS and AKTIVER have shaped the development of evidence-based delirium prevention. The strongest evidence to date derives from two meta-analyses published in 2026. In these studies, nonpharmacological multicomponent programs reduced delirium incidence by 44% and significantly shortened delirium duration in patients with established delirium. In contrast, pharmacological strategies demonstrated inconsistent or limited benefits. Only dexmedetomidine showed a preventive effect in selected perioperative settings. The current German S3 guidelines \"Delirium in older age\" therefore strongly recommend structured, interdisciplinary and person-centered delirium programs. Future challenges include comprehensive implementation, the development of specialized concepts for high-risk populations, improved cross-sectoral care pathways and the meaningful integration of digital technologies. A delirium-sensitive hospital culture should become a key quality indicator not only in geriatric medicine but also in inpatient care across all clinical disciplines.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Journal Club]. (杂志俱乐部)。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-08-20 DOI: 10.1007/s00391-026-02639-1

Lejla Sacic

引用次数: 0

The distinctiveness of human aging II: social processes and the regulation of aging. 人类老龄化的特殊性II：社会进程与老龄化调控。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-08-12 DOI: 10.1007/s00391-026-02609-7

Dale Dannefer, Jessica Kelley, Olugbenga Okunade

{"title":"The distinctiveness of human aging II: social processes and the regulation of aging.","authors":"Dale Dannefer, Jessica Kelley, Olugbenga Okunade","doi":"10.1007/s00391-026-02609-7","DOIUrl":"10.1007/s00391-026-02609-7","url":null,"abstract":"This paper builds upon the principles and dimensions presented in the paper, \"The distinctiveness of human aging I\", which is intended to provide a foundation for apprehending and understanding variation in individual and population patterns of human aging. Given the clearly established role of contextual factors and context-related dynamics as key explanatory factors to account for such variation, this paper sets forth key dimensions of the socioenvironmental regulation of processes of human aging and their interactions across micro, meso and macro levels of social organization. We focus on one specific domain of age-related challenges and one (albeit broad) institutional domain: rapid population aging and on the institutional level, the attendant expansion of geriatric diagnoses and elder care institutions, focusing especially on nursing homes. Through this discussion, we demonstrate that human aging entails a distinctly flexible and in key ways modifiable set of processes. It is thus continually reconstituted for individuals and for social groups and populations as existing social arrangements are continuously reproduced, regardless of the value (positive or negative) of such arrangements for human aging.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

["No shows" in dementia diagnostics: qualitative perspectives of patients and caregivers after a positive case finding by general practitioners]. [痴呆诊断中的“无表现”：全科医生发现阳性病例后患者和护理人员的定性观点]。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-08-10 DOI: 10.1007/s00391-026-02633-7

Carolin Rosendahl, Alexander Hanke, Michael Wagner, Klaus Weckbecker

{"title":"[\"No shows\" in dementia diagnostics: qualitative perspectives of patients and caregivers after a positive case finding by general practitioners].","authors":"Carolin Rosendahl, Alexander Hanke, Michael Wagner, Klaus Weckbecker","doi":"10.1007/s00391-026-02633-7","DOIUrl":"https://doi.org/10.1007/s00391-026-02633-7","url":null,"abstract":"Background: The timely diagnostics of cognitive impairments and dementia syndromes are central to geriatric care. Memory clinics typically perform differential diagnostics following positive case findings in the general practitioner's practice; however, care pathways do not function smoothly, as shown by the \"iCreate\" project. Of 95 patients with positive case findings only 68 utilized the referral to the memory clinic; 27 were no shows. While barriers before the first doctor's visit are well-researched, analysis of the transition between primary and specialist care settings is lacking. The aim was to understand why further differential diagnostics after positive case findings were not pursued and to derive recommendations for action.Method: Qualitative design with semi-structured interviews (n = 9) and telephone surveys (n = 15) of 24 of the 27 no shows or relatives from \"iCreate\". Software-assisted evaluation using qualitative content analysis according to Kuckartz and Rädiker.Results: Affected individuals experience a care gap with uncertainties and an individual interplay of barriers on three levels: a) psychosocial: fear of loss of autonomy/stigma, denial/ambivalence, desire/right not to know; b) structural and organizational: transport/appointment/coordination problems and c) care-related and process-related: unclear benefits, lack of follow-up options.Conclusion: Case finding programs require standardized communication pathways with written summaries (working diagnosis, next steps, contact persons). Stepwise shared decision-making supported by dementia care managers could reduce the perceived barriers and drop-outs while closing care gaps.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors affecting the adequacy of income among older people during periods of high inflation. 在高通货膨胀时期影响老年人收入充足性的因素。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-08-07 DOI: 10.1007/s00391-026-02630-w

Lukas Richter, Rebekka Steinlechner, Jasmin Riederer

{"title":"Factors affecting the adequacy of income among older people during periods of high inflation.","authors":"Lukas Richter, Rebekka Steinlechner, Jasmin Riederer","doi":"10.1007/s00391-026-02630-w","DOIUrl":"https://doi.org/10.1007/s00391-026-02630-w","url":null,"abstract":"Background: High inflation following the war in Ukraine has posed a major economic challenge, particularly for older adults in Austria who rely heavily on pensions and fixed social benefits. Individuals with low incomes are especially vulnerable to rising living costs.Objective: This study examines changes in subjective income adequacy among older adults during the 2022/2023 inflation period and identifies key risk factors for perceived financial deterioration.Methods: Data were obtained from a representative telephone survey of 841 adults aged 60+ years in Austria conducted between January and February 2023. Changes in income adequacy were assessed by comparing respondents' financial situation before and after the onset of high inflation. Hierarchical logistic regression models were applied to identify relevant factors.Results: Overall, 42% of respondents reported a worsening of their financial situation. Individuals with a net monthly income below € 1200 had significantly higher odds of reporting deterioration. Older adults under 65 and those experiencing psychological stress were more likely to perceive financial decline. No significant effects were found for physical health, partnership status, having children, gender, or education.Discussion: The findings highlight the heterogeneity within the older population and show that financially and psychologically vulnerable groups are particularly affected. Targeted policy interventions are needed to effectively support these groups.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Promoting self-help among family caregivers with a migration background: A qualitative study of self-help group providers]. [促进具有移民背景的家庭照顾者的自助：自助小组提供者的定性研究]。

IF 1.1 4区医学

Zeitschrift Fur Gerontologie Und Geriatrie Pub Date : 2026-08-05 DOI: 10.1007/s00391-026-02632-8

Valeria Schellenberg, Kübra Annac, Yüce Yilmaz-Aslan, Patrick Brzoska

{"title":"[Promoting self-help among family caregivers with a migration background: A qualitative study of self-help group providers].","authors":"Valeria Schellenberg, Kübra Annac, Yüce Yilmaz-Aslan, Patrick Brzoska","doi":"10.1007/s00391-026-02632-8","DOIUrl":"https://doi.org/10.1007/s00391-026-02632-8","url":null,"abstract":"Background: In Germany, most people in need of long-term care are cared for at home. Among people with a Turkish migration background, care is particularly often provided by family members. Although self-help groups offer valuable support, they are rarely utilized.Objective: Identification of strategies, barriers and support needs to enhance participation in self-help groups among family caregivers with a migration background.Methods: A total of 1029 providers of self-help groups were invited to participate in an online survey addressing structural characteristics, strategies to promote participation, perceived barriers and support needs. Closed questions were analyzed descriptively, while open-ended responses were examined using qualitative content analysis.Results: Data from 176 providers were available for the analysis and 44.9% reported actively involving family caregivers with a migration background. Frequent strategies included direct outreach through disseminators and cooperation with migrant organizations. Key barriers compromised language barriers (62.5%), lack of awareness of available services (56.8%) and cultural differences (48.9%). Important support measures included public outreach, network building and interpreting services.Conclusion: The results highlight the need for structural support and intercultural approaches to improve access to and sustained participation in self-help groups among family caregivers with a migration background.","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0