Zeitschrift Fur Gerontologie Und Geriatrie最新文献

{"title":"The role of oxygen in the formation of fluorescent advanced glycation end products from α-dicarbonyl compounds.","authors":"Parisa Ghaffari Makhmalbaf, Andreas Simm","doi":"10.1007/s00391-026-02662-2","DOIUrl":"https://doi.org/10.1007/s00391-026-02662-2","url":null,"abstract":"<p><strong>Background: </strong>Advanced glycation end products (AGEs) are heterogeneous compounds that can be endogenously generated and can also be exogenously consumed through heated food. The AGEs accumulate in cells and tissues over time, increasing oxidative stress and thereby contributing to the aging process via inflammation. The physiological oxygen concentration in tissues is significantly lower than atmospheric oxygen (~21%); however, most experimental studies have been conducted under atmospheric conditions rather than physiologically relevant oxygen levels.</p><p><strong>Objective: </strong>This study aims to assess the oxygen-dependent formation of AGEs induced by glyoxal (GO) and methylglyoxal (MGO) in vitro.</p><p><strong>Material and methods: </strong>In this study, the AGE-associated fluorescence intensity was measured in human serum albumin (HSA) incubated with GO or MGO under different oxygen concentrations using a CLARIOstar plate reader. Fluorescent AGEs were quantified using excitation wavelengths of 330/360 nm and emission wavelengths of 405/440 nm. Non-fluorescent AGEs, such as carboxymethyl lysine (CML) and methylglyoxal-derived hydroimidazolone1 (MG-H1), were detected via immunoblotting.</p><p><strong>Results: </strong>The formation of AGEs increased following incubation of HSA with GO or MGO, showing clear concentration-dependent and time-dependent patterns. No statistically significant differences were observed among the tested oxygen conditions.</p><p><strong>Conclusion: </strong>These findings suggest that under the experimental conditions used in this in vitro study, glycation did not significantly differ across the tested oxygen conditions. Further investigation is warranted to explore the impact of oxygen on glycation in vivo, where additional regulatory mechanisms could play a role.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The eye as a mirror of the heart-retinal findings in heart failure and cardiovascular diseases].","authors":"Alaa Din Abdin, Amr Abdin, Giuseppe Merone, Michael Böhm, Berthold Seitz","doi":"10.1007/s00391-026-02667-x","DOIUrl":"https://doi.org/10.1007/s00391-026-02667-x","url":null,"abstract":"<p><strong>Background: </strong>Due to its unique anatomical and functional characteristics, the retina represents a promising organ for the evaluation of systemic vascular diseases. Modern imaging techniques, particularly optical coherence tomography angiography (OCT-A), enable noninvasive and quantitative assessment of retinal microcirculation. The aim of this review is to present current findings on the significance of retinal biomarkers in cardiovascular diseases, with a focus on heart failure.</p><p><strong>Results: </strong>Numerous studies show associations between retinal vascular changes and arterial hypertension, coronary heart disease, left ventricular hypertrophy, and heart failure. Changes in retinal vascular parameters such as vascular density and perfusion density correlate with structural and functional cardiac changes. Patients with retinal vascular occlusions have an increased risk of stroke, myocardial infarction, and higher cardiovascular mortality. Initial studies in patients with acute decompensated heart failure have demonstrated changes in retinal vascular and perfusion density that can be reversed by recompensation. These observations led to the introduction of the term \"cardio-ocular syndrome,\" which describes the interactions between cardiac function, systemic congestion, and retinal microcirculation.</p><p><strong>Conclusion: </strong>Retinal imaging opens up new possibilities for the noninvasive assessment of systemic microcirculatory disorders in cardiovascular diseases. OCT‑A could contribute in the future to risk stratification, assessment of disease progression, and monitoring of therapy in heart failure.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[From clinical practice to interventional study : Adaptation of a local approach to therapeutic and rehabilitative care to a complex intervention in the \"SGB Reha\" project].","authors":"Anke K Desch, Andreas Häusler, Bernd R Förstner, Friederike Deeken, Jörg Artmann, Sibel Altin, Oskar Dierbach, Charlotte Boutmans, Olaf Beckmann, Laura Schleich, Nikola Nitzschke, Sarah Siegert, Aileen Hommel, Jennifer Schroth, Manuel Du, Nora Mierzwa, Björn Gradel, Michael Hauptmann, Michael Rapp, Christine Holmberg","doi":"10.1007/s00391-026-02647-1","DOIUrl":"https://doi.org/10.1007/s00391-026-02647-1","url":null,"abstract":"<p><strong>Background: </strong>Therapeutic-rehabilitative care aims to promote the independence, quality of life and social participation of people in need of care through multiprofessional collaboration and therapeutic interventions. Transforming practice-based concepts into interventions that can be scientifically evaluated requires an understanding of their mechanisms of action and the necessary adaptations to new care contexts.</p><p><strong>Objective: </strong>This paper reconstructs the transformation process of a therapeutic-rehabilitative care concept into the intervention of the project \"SGB Reha\". The goal is to provide a clear account of the adaptations made during this process.</p><p><strong>Methods: </strong>The basis for the intervention concept was a theory of change model which was further refined in collaboration with stakeholders through a participatory and iterative process. Requirements regarding implementability, evaluability and contextual conditions, were taken into account.</p><p><strong>Results: </strong>Additional resources, frequency and design of measures were adjusted, while central mechanisms of action were retained and made explicit in the action model. The development process illustrates the necessary balance between standardization and context-sensitive adaptation.</p><p><strong>Discussion: </strong>The transition of a care concept to an evaluable intervention was an iterative transformation process. The action model supported the systematic adaptation and made assumptions, mechanisms of action, and adjustments transparent.</p><p><strong>Conclusion: </strong>The development of complex interventions requires a balance between preserving core principles of effectiveness and adapting them to new contexts. The experiences from SGB Reha demonstrate how a practice-based concept can be transformed in a theory-guided manner into a scientifically evaluable intervention.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ophthalmogeriatric assessment : Algorithm for structuring of communication in the ophthalmological care of older visually impaired patients, the \"5 questions\"].","authors":"Udo Hennighausen","doi":"10.1007/s00391-026-02664-0","DOIUrl":"https://doi.org/10.1007/s00391-026-02664-0","url":null,"abstract":"<p><strong>Background: </strong>The ophthalmogeriatric assessment originated from the practiced synopsis of the two fields, ophthalmology and geriatrics.</p><p><strong>Objective: </strong>In a retrospective study the process of the evolution of the ophthalmogeriatric assessment is evaluated.</p><p><strong>Material and methods: </strong>Based on the accessible literature, mainly on the history of both disciplines and the comprehensive geriatric assessment (CGA), the ophthalmogeriatric assessment is presented and explained exemplified by age-related macular degeneration (AMD).</p><p><strong>Results: </strong>The \"5 questions\" of the ophthalmogeriatric assessment are defined and explained. 1. Which visual complaints are named by the patient? 2. Which diagnosis is made and how does a patient perceive her/his surroundings, concerning this diagnosis? 3. How much can the patient see (the visual function, e.g. the visual acuity and also concerning the visual field)? 4. What is the patient able to perceive visually, particularly in everyday life? 5. How can the patient be given help?</p><p><strong>Conclusion: </strong>The concept of the ophthalmogeriatric assessment is a supporting tool with the aim of a structured and participative consideration of the often complex visual disabilities of visually impaired older patients, not only with respect to vision but also in synopsis with other impairments of affected patients.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying fall-related injuries in older adults using ICD-10 injury codes : Validation study of emergency department patients with and without subsequent hospitalization.","authors":"Michaela Gross, Daniel Schoene, Clemens Becker, Christoph Wasser, Gisela Büchele, Jochen Klenk, Kilian Rapp","doi":"10.1007/s00391-026-02663-1","DOIUrl":"https://doi.org/10.1007/s00391-026-02663-1","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the burden of fall-related injuries at the population level, diagnosis-based electronic healthcare records could represent a valuable instrument. The German ICD system (ICD-10-GM) does not include the coding of falls. The aim of the study was to assess to what extent specific ICD-10 injury diagnoses, alone or in combination, are attributable to falls.</p><p><strong>Methods: </strong>This retrospective single-center validation study analyzed routinely collected electronic healthcare records of 2256 patients aged ≥ 65 years who were treated either exclusively in the emergency department (ED sample) or in the emergency department with subsequent hospitalization (HO sample) and had an injury diagnosis (ICD-10: S00-S99, T00-T14). To determine whether the injury was caused by a fall, electronic patient records were reviewed. Positive predictive values (PPVs) of ICD codes and combinations of ICD codes for fall-related injuries were calculated (derivation phase) and the potential for statistical overfitting was assessed (validation phase).</p><p><strong>Results: </strong>The study included 1378 patients in the ED sample (mean age 79.8 years, 59.2% female) and 878 patients in the HO sample (mean age 82.6 years, 66.5% female). All models yielded PPVs of at least 0.9 in the HO sample and 0.8 in the ED sample. The PPVs in the validation set were closely comparable to those in the derivation set.</p><p><strong>Conclusion: </strong>The ICD-10 diagnoses from routine administrative data can be used to identify fall-related injuries with a high PPV in older adults treated in the ED with or without subsequent hospitalization. Thus, ICD-10 diagnoses can be a valuable resource for monitoring secular trends and evaluating the impact of population-based fall prevention programs.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Rehabilitation in residential long-term care : Longitudinal study of functional independence, quality of life and return home].","authors":"Franziska Gierke, Uwe Bettig","doi":"10.1007/s00391-026-02661-3","DOIUrl":"https://doi.org/10.1007/s00391-026-02661-3","url":null,"abstract":"<p><strong>Background: </strong>The rehabilitation-oriented approach is gaining relevance in residential long-term care; however, the empirical evidence remains fragmented.</p><p><strong>Objective: </strong>This study examined patient-related outcomes of a structured rehabilitation-oriented nursing approach in long-term care, focusing on functional independence, perceived health, health-related quality of life and return to private home.</p><p><strong>Method: </strong>A prospective single-arm study was conducted in three long-term care facilities with assessments at three time points (T0, T1 and T2). From the 90 recruited patients, 67 were included. The outcomes included the SINGER score (Scores of Independence for Neurologic and Geriatric Rehabilitation), the Barthel index, the SF-36 score (Short Form Health Survey) and HPEAS_KD (German short version of Hertz perceived enactment of autonomy scale [HP_KD]). Longitudinal changes were analyzed using repeated measures general linear models.</p><p><strong>Results: </strong>The functional independence increased descriptively from T0 to T2, without a significant T0-T2 time effect (p = 0.306). The perception of general health showed a significant time effect (p = 0.023). Significant time effects were also observed in the SF-36 domains of physical functioning, physical role functioning, social functioning, mental health and the mental component summary scale. Within 6 months 32.8% of the patients (n = 22) returned to their private homes.</p><p><strong>Conclusion: </strong>Under real-world conditions, no uniform pattern of change was observed across all outcomes. The findings are consistent with the international discourse on functional ability, reablement and geriatric rehabilitation; however, interpretation of the observed trajectories and return home events is limited by the nonrandomized design, selective allocation to the lighthouse group and selective attrition over time; causal conclusions regarding effectiveness cannot be drawn.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Vascular medicine in old age: a call for structured collaboration for better care : Position paper of the German Society for Vascular Surgery and Vascular Medicine, the German Society for Geriatrics and the German Society for Angiology].","authors":"Gerald Kolb, Farzin Adili, Michael Denkinger, Gesine Dörr, Ursula Müller-Werdan, Oliver Müller, Christoph Ploenes, Alexander Oberhuber, Barbara Rantner, Markus Steinbauer, Norbert Weiss, Rainer Wirth, Hartmut Görtz","doi":"10.1007/s00391-026-02636-4","DOIUrl":"10.1007/s00391-026-02636-4","url":null,"abstract":"","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":"505-507"},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multicomponent programs in delirium prevention and delirium management in older adults : Evidence, guideline recommendations and perspectives on delirium-sensitive care].","authors":"Christine Thomas, Juliane Spank, Monika Sadlonova","doi":"10.1007/s00391-026-02643-5","DOIUrl":"10.1007/s00391-026-02643-5","url":null,"abstract":"<p><p>Delirium is among the most frequent neuropsychiatric complications in older people. It is associated with functional decline, increased morbidity and mortality, loss of independence, cognitive deterioration and an elevated risk of dementia. Contemporary concepts view delirium as the result of an interplay between predisposing vulnerability factors and acute physiological stressors. Current approaches to delirium prevention and management focus on nonpharmacological multicomponent interventions that combine early mobilization, cognitive reorientation, sleep hygiene, pain management, optimization of nutrition and hydration, delirium screening and family involvement. Programs such as HELP, ABCDE(F) bundle, CHOPS and AKTIVER have shaped the development of evidence-based delirium prevention. The strongest evidence to date derives from two meta-analyses published in 2026. In these studies, nonpharmacological multicomponent programs reduced delirium incidence by 44% and significantly shortened delirium duration in patients with established delirium. In contrast, pharmacological strategies demonstrated inconsistent or limited benefits. Only dexmedetomidine showed a preventive effect in selected perioperative settings. The current German S3 guidelines \"Delirium in older age\" therefore strongly recommend structured, interdisciplinary and person-centered delirium programs. Future challenges include comprehensive implementation, the development of specialized concepts for high-risk populations, improved cross-sectoral care pathways and the meaningful integration of digital technologies. A delirium-sensitive hospital culture should become a key quality indicator not only in geriatric medicine but also in inpatient care across all clinical disciplines.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":"473-481"},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment of delirium with psychotropic drugs-update 2026].","authors":"Walter Hewer, Daniel Kopf","doi":"10.1007/s00391-026-02655-1","DOIUrl":"10.1007/s00391-026-02655-1","url":null,"abstract":"<p><p>Causal and general therapeutic measures, as well as non-pharmacological interventions are key elements in the prevention and treatment of non-substance-induced delirium. However, if certain target symptoms persist, such as delusions, hallucinations or marked agitation, there is an indication for psychopharmacotherapy, usually with antipsychotics. This narrative review provides an overview of the current state of knowledge on this topic, with particular reference to the recently published Association of the Scientific Medical Societies in Germany (AWMF) guideline, \"Delirium in Older Adults\". The guidline focuses on how to achieve the best possible balance between benefits and risks when using high-risk medication in vulnerable patients.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":"482-487"},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Antibody therapy in Alzheimer's disease].","authors":"Marlena Schnieder","doi":"10.1007/s00391-026-02640-8","DOIUrl":"10.1007/s00391-026-02640-8","url":null,"abstract":"<p><p>Alzheimer's disease, the leading cause of dementia, is defined by extracellular amyloid‑β (Aβ) plaques, intracellular tau aggregates and neurodegeneration. Lecanemab and donanemab, are the first disease-modifying antibodies available for early Alzheimer's disease. Both reduce Aβ plaques and slow cognitive decline. Lecanemab targets soluble protofibrils and donanemab targets fibrillar Aβ. The primary side effect is amyloid-related imaging abnormalities (ARIA), which can occur as edema (ARIA-E) or hemorrhages (ARIA-H). The risk is higher in APOE4 homozygotes, anticoagulation or cerebrovascular diseases. Therefore, during treatment a regular monitoring with magnetic resonance imaging (MRI) is mandatory.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":"522-530"},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}