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Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova最新文献

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[Tectal Evoked Potentials during Retinal Baclofen Application in the Carp]. [巴氯芬在鲤鱼视网膜应用时的顶侧诱发电位]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-09-01
N S Garina
{"title":"[Tectal Evoked Potentials during Retinal Baclofen Application in the Carp].","authors":"N S Garina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Changes of primary visual center evoked potentials in response to white light and optic nerve electric stimulation were investigated during retinal GABAb-receptors activation with baclofen in dark-adapted carp. It was found, that baclofen - induced b-wave ERG decreasing, was accompanied by a significant amplitude growing as in the evoked potential to light as in the evoked potential to electric nerve stimulation: It is proposed, that light evoked potential changes reflect the increasing of the third retinal neuron responses to light and/or tectal neuron responsiveness enhancement.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 5","pages":"626-631"},"PeriodicalIF":0.3,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36954616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy]. [抑制神经变性的治疗靶点:自噬]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-09-01
A B Pupyshev, T A Korolenko, M A Tikhonova
{"title":"[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy].","authors":"A B Pupyshev,&nbsp;T A Korolenko,&nbsp;M A Tikhonova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role of autophagy in cell survival and suppression of neurodegeneration was considered. We discussed its involvement in Alzheimer's, Parkinson's, and Huntington's diseases connected with accumulation of amy- loid-β, α-synuclein, and huntingtin, respectively. Autophagy is reduced in these diseases and in aging as well to various extent. Elimination of accumulated toxic proteins and structures is performed by autophagy mech- anisms (chaperon-mediated autophagy, macroautophagy, selected autophagy) in an interaction with ubiqui- tin-proteasome system. In many cases activation of mTOR-dependent autophagy and mTOR-independent regulatory pathways lead to the therapeutic effect of inhibition of neurodegeneration in cell cultures and an- imal models. Some autophagy enhancers such as resveratrol, metformin, rilmenidine, lithium, and curcumin are tested now in clinical trials.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 5","pages":"515-540"},"PeriodicalIF":0.3,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36897859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Association of Brain-Derived Neurotrophic Factor and Serotonin Transporter Genes with the Parameters of Early Event-Related Potentials During the Passive Perception of Words]. [脑源性神经营养因子和血清素转运蛋白基因与被动词语感知早期事件相关电位参数的关系]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-09-01
V E Golimbet, Zh V Garakh, G I Korovaitseva, T V Lezheiko, Yu S Zaytsevac, I Ya Gurovich, A B Shmukler, G I Rodionov, V B Strelets
{"title":"[The Association of Brain-Derived Neurotrophic Factor and Serotonin Transporter Genes with the Parameters of Early Event-Related Potentials During the Passive Perception of Words].","authors":"V E Golimbet,&nbsp;Zh V Garakh,&nbsp;G I Korovaitseva,&nbsp;T V Lezheiko,&nbsp;Yu S Zaytsevac,&nbsp;I Ya Gurovich,&nbsp;A B Shmukler,&nbsp;G I Rodionov,&nbsp;V B Strelets","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We explored the association of brain-derived neurotrophic factor (BDNF) and serotonin transporter genes with neurophysiological characteristics of the early stages of verbal information processing in the brain in the groups of patients with schizophrenia and schizophrenia spectrum disorders and healthy people. It has been shown that Val66Met and 5-HTTLPR polymorphisms are associated with P100 and N170 during the passive reading of single words written in Russian presented with different occurrence frequency. The healthy carriers of the ValVal genotype (BDN F Val66Met) allele or the SS (5-HTTLPR) genotype performed the task better compared to those with an Met or an L allele. The differences were significant in healthy people and observed as a trend in thepatients.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 5","pages":"556-564"},"PeriodicalIF":0.3,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36897861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of a Single Injection of Brain Derived Neurotrophic Factor into Midline Ventral Tegmental Area on Morphine Reinforcing Properties]. [中线腹侧被盖区单次注射脑源性神经营养因子对吗啡增强特性的影响]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-09-01
D I Peregud, M Yu Stepanichev, N A Lazareva, L F Panchenko, N V Gulyaeva
{"title":"[Effect of a Single Injection of Brain Derived Neurotrophic Factor into Midline Ventral Tegmental Area on Morphine Reinforcing Properties].","authors":"D I Peregud,&nbsp;M Yu Stepanichev,&nbsp;N A Lazareva,&nbsp;L F Panchenko,&nbsp;N V Gulyaeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Opiate reinforcement is considered as a stimulus inducing addiction, however underlying neurobiological mechanisms remain obscure. According to the literature, BDNF (brain-derived neurotrophic factor) in the lateral ventral tegmental area (VTA) could modulate morphine reinforcement, but the role of BDNF in the midline VTA has not been studied yet. The aim of the study was to investigate the effect of a single intra-mid- line VTA injection on the acquisition and expression of morphine conditioned place preference (CPP). CPP procedure was composed of eight conditioning sessions (one session per day): morphine (i.p., 10 mg/kg) and saline injections were paired to the compartments and counterbalanced.Recombinant human BDNF (0.75 ug) or phosphate-buffered saline (PBS) as a vehicle were injected once into the midline VTA one day before or after conditioning. According to the CPP test rats spent more time in the morphine-paired compartments a scompared to the saline-paired compartments (p < 0.05). After a single BDNF injection into the midline VTA be- fore conditioning, but not after conditioning, differences in time spent in morphine and saline-paired compartments did not reach significance (p > 0.05). Thus, taking into account limitations of the results, we sug- gest that BDNF in the midline VTA may block morphine reinforcement.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 5","pages":"632-640"},"PeriodicalIF":0.3,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36954617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Correlation of Resting State Functional Connectivity with Behavioral and Psychological Indices]. [静息状态功能连通性与行为和心理指标的相关性]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-09-01
O Martynova, V Balaev, A Sushiskaia-Tetereva, A Ivanitsky
{"title":"[Correlation of Resting State Functional Connectivity with Behavioral and Psychological Indices].","authors":"O Martynova,&nbsp;V Balaev,&nbsp;A Sushiskaia-Tetereva,&nbsp;A Ivanitsky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In recent years, a large amount of data was published about resting state networks (RSN), namely, continu- ously recorded brain activity in a state of quiet wakefulness. In particular, such states are reflected in the spa- tial maps of active regions of the brain, obtained by means of functional magnetic resonance imaging (fMRI). RSNs have stable and reproducible spatial structure over time in healthy subjects, but may differ substantially in clinical pathology. One of the important parameters of the brain activity is functional connectivity (FC) of individual elements within a network or between resting state networks. This review considers results of the studies focused at correlation of behavioral indicators and FC of brain areas activated during resting state. In addition, we describe data on reproducibility of RSN over time in healthy subjects, as well as data on changes in FC-of networks, depending on the individual experience.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 5","pages":"541-555"},"PeriodicalIF":0.3,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36897860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Effects of Chronic Combined Stress: Changes in Behavior of Rats with Various Responses to Novelty]. [慢性联合应激的影响:对新奇事物有不同反应的大鼠的行为变化]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-09-01
M Yu Stepanichev, A O Tishkina, M R Novikova, I P Levshina, A K Piskunov, N A Lazareva, N V Gulyaeva
{"title":"[The Effects of Chronic Combined Stress: Changes in Behavior of Rats with Various Responses to Novelty].","authors":"M Yu Stepanichev,&nbsp;A O Tishkina,&nbsp;M R Novikova,&nbsp;I P Levshina,&nbsp;A K Piskunov,&nbsp;N A Lazareva,&nbsp;N V Gulyaeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We studied the effect of chronic combined stress (model of experimental neurosis) on behavior of rats with different basal strategies of behavior in novelty conditions. Chronic stress resulted in decreases in the body weight and testosterone contents in the blood and neocortex in all animals. Animals with initially low orient- ing-exploratory response in the \"open field\" test did not exhibit substantial alterations of behavior during repeated testing in this test of the \"dark-light chamber\" test; however, the depression-like behavior was more expressed in the second forced swim test. Chronic combined stress did not significantly affect the behavior of this group of rats. Animals with initially high orienting-exploratory response in the \"open field\" test exhibited decreased locomotor and exploratory activity in the repeated \"open field\" tests. The decreases in the locomotor and exploratory activity were substantially less expressed in the repeated tests in these rats after chronic combined stress. The indices of depression-like behavior increased one month after the end of exposure to chronic combined stress. Our data demonstrate that different responses to novelty in the \"open field\" test do not allow predict with reasonable certainty the development of depression-like behavior after exposure to chronic combined stress.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 5","pages":"611-625"},"PeriodicalIF":0.3,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36954615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Visual Fear Conditioning in Mice: Comparison with Auditory Fear Conditioning]. [小鼠的视觉恐惧条件反射:与听觉恐惧条件反射的比较]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-07-01
O I Ivashkina, K A Toropova, M A Roshchina, K V Anokhin
{"title":"[Visual Fear Conditioning in Mice: Comparison with Auditory Fear Conditioning].","authors":"O I Ivashkina,&nbsp;K A Toropova,&nbsp;M A Roshchina,&nbsp;K V Anokhin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Up to date, rodent fear conditioning is the most commonly used model of mammalian associative memory in neurobiology. Since the mechanisms of associative memory in this model are mainly studied using audi tory fear conditioning, the question about the generality of this mechanisms in respect to other conditioned stimuli remains open. The aim of this work-was to compare dynamics of visual-and auditory fear memory for- mation and retrieval. We showed that acquisition of freezing in response to visual conditioned stimulus is significantly slower in comparison with the. auditory conditioned stimulus. Moieover, the dynamics of memory retrieval was different in animals, trained to these stimuli, being slower in response to visual conditioned stim- ulus. This may reflect distinct mechanisms of visual and auditory associative memory consolidation or re- trieval in this Model. Our results impose constraints on the generality of conclusiois about the dynamics as- sociative memory formation obtained solely from classical auditory fear conditioning model in mice.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 4","pages":"493-498"},"PeriodicalIF":0.3,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36907983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
["Unpredictable stress": Ambiguous Stress-Reactivity of Long-Term Plasticity]. [“不可预测的应力”:长期可塑性的模糊应力反应性]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-07-01
I Y Kudryashova, N V Gulyaeva
{"title":"[\"Unpredictable stress\": Ambiguous Stress-Reactivity of Long-Term Plasticity].","authors":"I Y Kudryashova,&nbsp;N V Gulyaeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The review considers possible mechanisms underlying large unpredictability of stress induced modulation of long-term synaptic plasticity. In studies of LTP, both increase and decrease can be observed dependently on stress paradigms, severity, duration, and period of recording, brain structure etc. Stress-induced glucocrti- coids release does not directly correlate with LTP changes, and corticosterone application in vivo andin vitro can either enhance or suppress LTP. The nature of stress induced modifications is usually explained by the balance between mineralocorticoid and glucocorticoid receptors, the later seems to provoke synaptic meta- plasticity rather than LTP disturbance, increasing the threshold of LTP induction. In addition, metaplasticity can be also modulated be many other neurotransmitters,'enhancing uncertainty and unpredictability of stress response, in particular because their action is highly regulated-by emotional experience.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 4","pages":"414-428"},"PeriodicalIF":0.3,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36954633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evoked Potentials on Faces Presented in Emotional Context]. [情绪情境下面孔的诱发电位]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-07-01
I E Kanunikov, V I Pavlova
{"title":"[Evoked Potentials on Faces Presented in Emotional Context].","authors":"I E Kanunikov,&nbsp;V I Pavlova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ability for face recognition is a key skill for our social behavior. A lot of attention is devoted to investigation of emotional faces and expressions perception, but issue of context influence on face recognition process is not so explored. In the current study subjects had watched emotional film fragment before their EEG were recorded during the task with photos of neutral faces: actors from the film and fillers (actors who didn't appear in the film). Method of event-related potentials were used (ERP). The difference between amplitude of P200 component on faces of culprit and victim was found that may be connect with different subjective rele- vance of stimuli for person, who watched the film. Correlations between personal traits of subjects (anxiety, aggression, animosity) and enhanced amplitude of P200 on face of victim in comparison with filler face also were found. Further investigation of emotional context influence on face perception process is necessary.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 4","pages":"437-447"},"PeriodicalIF":0.3,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36954635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Relationship of Executive Functions and Processing Speed with Cortical Gray Matter Morphometry in Healthy Adults and at The Early Stages of Schizophrenia]. [健康成人和早期精神分裂症患者脑皮层灰质形态与执行功能和处理速度的关系]。
IF 0.3 4区 医学
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2016-07-01
M V Alfimoval, A S Tomyshev, I S Lebedeva, T A Akhadov, N A Semenoval, V G Kaleda
{"title":"[Relationship of Executive Functions and Processing Speed with Cortical Gray Matter Morphometry in Healthy Adults and at The Early Stages of Schizophrenia].","authors":"M V Alfimoval,&nbsp;A S Tomyshev,&nbsp;I S Lebedeva,&nbsp;T A Akhadov,&nbsp;N A Semenoval,&nbsp;V G Kaleda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>13 male patients with schizophrenia and 18 age-matched healthy men underwent structural magnetic reso- nance imaging and completed the Stroop task which included the switching condition. As compared to con- trols, the patients showed slowing of color naming in the neutral condition and a reduction ofgray matter vol- ume and thickness in the frontal and temporal areas. In healthy subjects, the time of color naming was neg- atively correlated with gray matter volume in the left cuneus. In the schizophrenia group, there was a positive correlation between the time of color naming and cortical thickness in the middle and inferior frontal gyri of the right hemisphere. These results indicate a change in structural-functional relationships at the early stages of schizophrenia.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 4","pages":"448-457"},"PeriodicalIF":0.3,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36907979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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