[The Association of Brain-Derived Neurotrophic Factor and Serotonin Transporter Genes with the Parameters of Early Event-Related Potentials During the Passive Perception of Words].
V E Golimbet, Zh V Garakh, G I Korovaitseva, T V Lezheiko, Yu S Zaytsevac, I Ya Gurovich, A B Shmukler, G I Rodionov, V B Strelets
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引用次数: 0
Abstract
We explored the association of brain-derived neurotrophic factor (BDNF) and serotonin transporter genes with neurophysiological characteristics of the early stages of verbal information processing in the brain in the groups of patients with schizophrenia and schizophrenia spectrum disorders and healthy people. It has been shown that Val66Met and 5-HTTLPR polymorphisms are associated with P100 and N170 during the passive reading of single words written in Russian presented with different occurrence frequency. The healthy carriers of the ValVal genotype (BDN F Val66Met) allele or the SS (5-HTTLPR) genotype performed the task better compared to those with an Met or an L allele. The differences were significant in healthy people and observed as a trend in thepatients.
目的探讨脑源性神经营养因子(BDNF)和血清素转运蛋白基因与精神分裂症及精神分裂症谱系障碍患者和正常人早期大脑言语信息加工神经生理特征的关系。研究表明，在被动阅读不同出现频率的俄语单字时，Val66Met和5-HTTLPR多态性与P100和N170相关。携带ValVal基因型(BDN F Val66Met)或SS (5-HTTLPR)基因型的健康人比携带Met或L基因型的人表现更好。这种差异在健康人群中是显著的，并在患者中观察到一种趋势。
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