Konstantinos A Manousopoulos, Panagiotis Varelas, Petros Dardas, Nikolaos Mezilis, Ioannis Tsiafoutis
{"title":"Percutaneous closure of a giant coronary artery aneurysm: a case summary.","authors":"Konstantinos A Manousopoulos, Panagiotis Varelas, Petros Dardas, Nikolaos Mezilis, Ioannis Tsiafoutis","doi":"10.25270/jic/25.00172","DOIUrl":"10.25270/jic/25.00172","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Attilio Lauretti, Iginio Colaiori, Simone Calcagno, Enrico Romagnoli, Fabrizio D'Ascenzo, Antonio Di Matteo, Francesco Gemelli, Gaetano Pero, Marco Bernardi, Luigi Spadafora, Antonio Esposito, Marco Borgi, Giuseppe Biondi-Zoccai, Francesco Versaci
{"title":"Performance of large language models in interventional cardiology: the ILLUMINATE blinded model-comparison study.","authors":"Attilio Lauretti, Iginio Colaiori, Simone Calcagno, Enrico Romagnoli, Fabrizio D'Ascenzo, Antonio Di Matteo, Francesco Gemelli, Gaetano Pero, Marco Bernardi, Luigi Spadafora, Antonio Esposito, Marco Borgi, Giuseppe Biondi-Zoccai, Francesco Versaci","doi":"10.25270/jic/25.00104","DOIUrl":"10.25270/jic/25.00104","url":null,"abstract":"<p><strong>Objectives: </strong>Large language models (LLMs) have the potential to assist in complex decision making for interventional cardiology (IC). However, their comparative performance in providing clinical recommendations remains uncertain. In this blinded model‑comparison study, the authors evaluated and compared the quality of recommendations produced by 6 LLMs for complex IC cases.</p><p><strong>Methods: </strong>Twenty detailed and complex clinical cases focusing on coronary artery disease (n=10) and structural heart disease (n=10) were developed. Six LLMs were tested: default ChatGPT (ChatGPTd), ChatGPT with European Society of Cardiology guidelines (ChatGPT-gl), ChatGPT with internet search enabled (ChatGPTi), Gemini (Google), Mistral 7B (Mistral AI), and Perplexity AI (Perplexity AI, Inc.). Only the ordering of anonymized outputs was randomized to ensure blinding. Five expert ICs independently assessed the anonymized and randomized responses using a 0 to 10 scale for appropriateness, accuracy, relevance, clarity, and clinical utility, generating a composite score. Statistical analysis was performed using a mixed linear model.</p><p><strong>Results: </strong>Six hundred blinded evaluations (20 cases x 6 models x 5 raters) were analyzed, yielding an overall composite score of 7.1 (95% CI, 7.0-7.2). Performance significantly varied across LLMs (P less than .001), with ChatGPTi (7.8 [7.5-8.0]) and ChatGPT-gl (7.7 [7.4-7.9]) outperforming others. ChatGPTd (6.9 [6.6-7.3]), Mistral 7B (7.0 [6.7-7.3]), and Perplexity AI (7.0 [6.7-7.3]) performed moderately, while Gemini had the lowest score (6.3 [6.0-6.7]). These differences were consistent across all scoring dimensions (P less than .001). Case type did not affect LLM performance (P = .900).</p><p><strong>Conclusions: </strong>LLMs show promise in IC decision making, but their performance remains suboptimal. Maximizing their potential requires systematic integration of web search capabilities and guideline-based knowledge retrieval.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blocked: a curious case of recurrent syncope following coronary intervention.","authors":"Shivam Goel, Nayani Makkar, Satyavir Yadav","doi":"10.25270/jic/25.00281","DOIUrl":"10.25270/jic/25.00281","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pooja Mishra, Jonathan Rosenberg, Verghese Mathew, Justin Levisay, Mark J Ricciardi, Arman Qamar
{"title":"Coronary intravascular lithotripsy for acute stent underexpansion: a case series.","authors":"Pooja Mishra, Jonathan Rosenberg, Verghese Mathew, Justin Levisay, Mark J Ricciardi, Arman Qamar","doi":"10.25270/jic/25.00293","DOIUrl":"10.25270/jic/25.00293","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olufemi Olorunda, Jason Wollmuth, Hsin-Fang Li, Jacob Abraham
{"title":"Outcomes of Impella 5.5-supported percutaneous coronary intervention in patients with cardiogenic shock.","authors":"Olufemi Olorunda, Jason Wollmuth, Hsin-Fang Li, Jacob Abraham","doi":"10.25270/jic/25.00250","DOIUrl":"10.25270/jic/25.00250","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145858721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thebesian veins causing severe myocardial ischemia due to coronary steal.","authors":"Gurpreet Singh, Vien Le, Vishnu Patlolla","doi":"10.25270/jic/25.00323","DOIUrl":"10.25270/jic/25.00323","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leila Alizadeh, Maria Eleni Drosou, Takayuki Onishi, Roya Anahita Mousavi, Amit Hooda, Sahil Khera, Lucy M Safi, George D Dangas, Gilbert H L Tang, Samin K Sharma, Annapoorna S Kini, Stamatios Lerakis
{"title":"Late degeneration of a transcatheter aortic valve replacement presenting with flail leaflet.","authors":"Leila Alizadeh, Maria Eleni Drosou, Takayuki Onishi, Roya Anahita Mousavi, Amit Hooda, Sahil Khera, Lucy M Safi, George D Dangas, Gilbert H L Tang, Samin K Sharma, Annapoorna S Kini, Stamatios Lerakis","doi":"10.25270/jic/26.00064","DOIUrl":"https://doi.org/10.25270/jic/26.00064","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hospital outcomes of patients with acute myocardial infarction-related cardiogenic shock with and without revascularization.","authors":"Tobias Heer, Matthias Hochadel, Sebastian Kerber, Bernward Lauer, Ralf Zahn, Uwe Zeymer","doi":"10.25270/jic/25.00204","DOIUrl":"10.25270/jic/25.00204","url":null,"abstract":"<p><strong>Objectives: </strong>An early invasive strategy is recommended for patients with acute myocardial infarction-related cardiogenic shock (AMICS). However, data on outcomes of patients undergoing early coronary angiography (CA) without subsequent percutaneous coronary intervention (PCI) are limited. The authors examined the characteristics and outcomes of patients with AMICS who underwent early CA and were treated with or without acute PCI.</p><p><strong>Methods: </strong>The authors analyzed data from the prospective Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK) CA registry. Patient characteristics, indications for CA, treatments, and in-hospital outcomes were collected and analyzed. All patients who underwent CA for AMICS were included.</p><p><strong>Results: </strong>Between January 2009 and December 2020, 4290 patients with AMICS underwent CA within 24 hours after symptom onset. Patients referred to urgent coronary artery bypass grafting (CABG) were excluded. Among the remaining 4075 patients, 3249 (79.7%) underwent acute PCI, 428 (10.5%) had significant coronary artery disease (CAD) but were not treated with PCI, and 398 (9.8%) had no significant CAD. Patients who did not undergo PCI were older and more likely to have a history of prior PCI or CABG. The in-hospital mortality rate was 47.2% among patients without PCI, 41.9% among those treated with PCI, and 36.5% among those without significant CAD.</p><p><strong>Conclusions: </strong>In this large, contemporary CA registry, approximately 10% of AMICS patients had significant CAD but did not undergo acute PCI; this subgroup exhibited high in-hospital mortality. Another 10% of patients had no significant CAD, with one-third dying during hospitalization. Further studies are needed to identify strategies to improve outcomes in these populations.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Hinton, William Carr, Natasha Khullar, Trisha Singh, Vivek Kodoth, Jehangir Din, Peter O'Kane
{"title":"Comparison of excimer laser coronary atherectomy as a sole device or as part of a multimodality technique.","authors":"Jonathan Hinton, William Carr, Natasha Khullar, Trisha Singh, Vivek Kodoth, Jehangir Din, Peter O'Kane","doi":"10.25270/jic/25.00225","DOIUrl":"10.25270/jic/25.00225","url":null,"abstract":"<p><strong>Objectives: </strong>There are limited data on the use of excimer laser coronary atherectomy (ELCA) in conjunction with other calcium modification devices (intravascular lithotripsy [IVL], rotational/orbital atherectomy [RA/OA]). The aim of this analysis was to compare the use of ELCA as a sole device for coronary intervention with ELCA in combination with additional calcium modification devices.</p><p><strong>Methods: </strong>This was a retrospective analysis of all patients treated with ELCA (either as a sole modification device or in conjunction with another calcium modification device) at a single high-volume center. Data and comparisons between ELCA alone and each of the combination therapies (with IVL, with RA/OA, with both IVL and RA/OA) were presented and compared using statistical methods appropriate to the data type.</p><p><strong>Results: </strong>This analysis included 98 interventions using ELCA (67 as a sole device, 22 with IVL, 6 with RA/OA, 3 with IVL and RA/OA). ELCA alone or in conjunction with IVL were most utilized for in stent restenosis/underexpansion compared with ELCA in conjunction with RA/OA +/-IVL, which were used more frequently for uncrossable/calcified lesions. The frequency of coronary artery perforation across the entire cohort was 4.1%. Target vessel revascularization frequency was 9.2%, and target vessel myocardial infarction was 3.1% at a median of 1051 days, with no statistically significant differences between the device groups.</p><p><strong>Conclusions: </strong>ELCA combination therapies have a potential role in certain complex cases and though these are associated with higher risk, they can be safely performed in selected centers using radial access with good medium-term outcomes.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}