Epigenetics & Chromatin最新文献

{"title":"A standardized nomenclature for mammalian histone genes.","authors":"Ruth L Seal, Paul Denny, Elspeth A Bruford, Anna K Gribkova, David Landsman, William F Marzluff, Monica McAndrews, Anna R Panchenko, Alexey K Shaytan, Paul B Talbert","doi":"10.1186/s13072-022-00467-2","DOIUrl":"10.1186/s13072-022-00467-2","url":null,"abstract":"<p><p>Histones have a long history of research in a wide range of species, leaving a legacy of complex nomenclature in the literature. Community-led discussions at the EMBO Workshop on Histone Variants in 2011 resulted in agreement amongst experts on a revised systematic protein nomenclature for histones, which is based on a combination of phylogenetic classification and historical symbol usage. Human and mouse histone gene symbols previously followed a genome-centric system that was not applicable across all vertebrate species and did not reflect the systematic histone protein nomenclature. This prompted a collaboration between histone experts, the Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) and Mouse Genomic Nomenclature Committee (MGNC) to revise human and mouse histone gene nomenclature aiming, where possible, to follow the new protein nomenclature whilst conforming to the guidelines for vertebrate gene naming. The updated nomenclature has also been applied to orthologous histone genes in chimpanzee, rhesus macaque, dog, cat, pig, horse and cattle, and can serve as a framework for naming other vertebrate histone genes in the future.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40386570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring.","authors":"Rose Schrott,&nbsp;Jennifer L Modliszewski,&nbsp;Andrew B Hawkey,&nbsp;Carole Grenier,&nbsp;Zade Holloway,&nbsp;Janequia Evans,&nbsp;Erica Pippen,&nbsp;David L Corcoran,&nbsp;Edward D Levin,&nbsp;Susan K Murphy","doi":"10.1186/s13072-022-00466-3","DOIUrl":"https://doi.org/10.1186/s13072-022-00466-3","url":null,"abstract":"<p><strong>Background: </strong>Cannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts sperm and whether the effects are heritable.</p><p><strong>Results: </strong>Whole genome bisulfite sequencing (WGBS) data were generated for sperm of rats exposed to: (1) cannabis extract (CE) for 28 days, then 56 days of vehicle only (~ one spermatogenic cycle); (2) vehicle for 56 days, then 28 days of CE; or (3) vehicle only. Males were then mated with drug-naïve females to produce F1 offspring from which heart, brain, and sperm tissues underwent analyses. There were 3321 nominally significant differentially methylated CpGs in F0 sperm identified via WGBS with select methylation changes validated via bisulfite pyrosequencing. Significant methylation changes validated in F0 sperm of the exposed males at the gene 2-Phosphoxylose Phosphatase 1 (Pxylp1) were also detectable in their F1 sperm but not in controls. Changes validated in exposed F0 sperm at Metastasis Suppressor 1-Like Protein (Mtss1l) were also present in F1 hippocampal and nucleus accumbens (NAc) of the exposed group compared to controls. For Mtss1l, a significant sex-specific relationship between DNA methylation and gene expression was demonstrated in the F1 NAc. Phenotypically, rats born to CSE-exposed fathers exhibited significant cardiomegaly relative to those born to control fathers.</p><p><strong>Conclusions: </strong>This is the first characterization of the effect of cannabis exposure on the entirety of the rat sperm methylome. We identified CE-associated methylation changes across the sperm methylome, some of which persisted despite a \"washout\" period. Select methylation changes validated via bisulfite pyrosequencing, and genes associated with methylation changes were involved in early developmental processes. Preconception CE exposure is associated with detectable changes in offspring DNA methylation that are functionally related to changes in gene expression and cardiomegaly. These results support that paternal preconception exposure to cannabis can influence offspring outcomes.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33460743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals.","authors":"Teruhito Ishihara,&nbsp;Oliver W Griffith,&nbsp;Shunsuke Suzuki,&nbsp;Marilyn B Renfree","doi":"10.1186/s13072-022-00465-4","DOIUrl":"https://doi.org/10.1186/s13072-022-00465-4","url":null,"abstract":"<p><strong>Background: </strong>The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a differentially methylated region (DMR) in mice. Airn silences two neighbouring genes, Solute carrier family 22 member 2 (Slc22a2) and Slc22a3, to establish the Igf2r imprinted domain in the mouse placenta. Marsupials also have an antisense non-coding RNA, ALID, expressed from a DMR, although the exact function of ALID is currently unknown. The eutherian IGF2R DMR is located in intron 2, while the marsupial IGF2R DMR is located in intron 12, but it is not yet known whether the adjacent genes SLC22A2 and/or SLC22A3 are also imprinted in the marsupial lineage. In this study, the imprinting status of marsupial SLC22A2 and SLC22A3 in the IGF2R imprinted domain in the chorio-vitelline placenta was examined in a marsupial, the tammar wallaby.</p><p><strong>Results: </strong>In the tammar placenta, SLC22A3 but not SLC22A2 was imprinted. Tammar SLC22A3 imprinting was evident in placental tissues but not in the other tissues examined in this study. A putative promoter of SLC22A3 lacked DNA methylation, suggesting that this gene is not directly silenced by a DMR on its promoter as seen in the mouse. Based on immunofluorescence, we confirmed that the tammar SLC22A3 is localised in the endodermal cell layer of the tammar placenta where nutrient trafficking occurs.</p><p><strong>Conclusions: </strong>Since SLC22A3 is imprinted in the tammar placenta, we conclude that this placental imprinting of SLC22A3 has been positively selected after the marsupial and eutherian split because of the differences in the DMR location. Since SLC22A3 is known to act as a transporter molecule for nutrient transfer in the eutherian placenta, we suggest it was strongly selected to control the balance between supply and demand of nutrients in marsupial as it does in eutherian placentas.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae.","authors":"Rachel M Reardon,&nbsp;Amanda K Walsh,&nbsp;Clairine I Larsen,&nbsp;LauraAnn H Schmidberger,&nbsp;Lillian A Morrow,&nbsp;Adriane E Thompson,&nbsp;Isabel M Wellik,&nbsp;Jeffrey S Thompson","doi":"10.1186/s13072-022-00464-5","DOIUrl":"https://doi.org/10.1186/s13072-022-00464-5","url":null,"abstract":"<p><strong>Background: </strong>Epigenetics refers to inheritable phenotypic changes that occur in the absence of genetic alteration. Such adaptations can provide phenotypic plasticity in reaction to environmental cues. While prior studies suggest that epigenetics plays a role in the response to DNA damage, no direct demonstration of epigenetically inheritable processes have been described in this context.</p><p><strong>Results: </strong>Here we report the identification of an epigenetic response to ultraviolet (UV) radiation in the baker's yeast Saccharomyces cerevisiae. Cells that have been previously exposed to a low dosage of UV exhibit dramatically increased survival following subsequent UV exposure, which we refer to as UV hyper-resistance (UVHR). This phenotypic change persists for multiple mitotic generations, without any indication of an underlying genetic basis. Pre-exposed cells experience a notable reduction in the amount of DNA damage caused by the secondary UV exposure. While the mechanism for the protection is not fully characterized, our results suggest that UV-induced cell size increases and/or cell wall changes are contributing factors. In addition, we have identified two histone modifications, H3K56 acetylation and H3K4 methylation, that are important for UVHR, potentially serving as mediators of UV protective gene expression patterns, as well as epigenetic marks to propagate the phenotype across cell generations.</p><p><strong>Conclusions: </strong>Exposure to UV radiation triggers an epigenetically inheritable protective response in baker's yeast that increases the likelihood of survival in response to subsequent UV exposures. These studies provide the first demonstration of an epigenetically inheritable dimension of the cellular response to DNA damage.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.","authors":"Nicole L Arruda, Audra F Bryan, Jill M Dowen","doi":"10.1186/s13072-022-00463-6","DOIUrl":"10.1186/s13072-022-00463-6","url":null,"abstract":"<p><strong>Background: </strong>Cohesin is an important structural regulator of the genome, regulating both three-dimensional genome organization and gene expression. The core cohesin trimer interacts with various HEAT repeat accessory subunits, yielding cohesin complexes of distinct compositions and potentially distinct functions. The roles of the two mutually exclusive HEAT repeat subunits PDS5A and PDS5B are not well understood.</p><p><strong>Results: </strong>Here, we determine that PDS5A and PDS5B have highly similar localization patterns across the mouse embryonic stem cell (mESC) genome and they show a strong overlap with other cohesin HEAT repeat accessory subunits, STAG1 and STAG2. Using CRISPR/Cas9 genome editing to generate individual stable knockout lines for PDS5A and PDS5B, we find that loss of one PDS5 subunit does not alter the distribution of the other PDS5 subunit, nor the core cohesin complex. Both PDS5A and PDS5B are required for proper gene expression, yet they display only partially overlapping effects on gene targets. Remarkably, gene expression following dual depletion of the PDS5 HEAT repeat proteins does not completely overlap the gene expression changes caused by dual depletion of the STAG HEAT repeat proteins, despite the overlapping genomic distribution of all four proteins. Furthermore, dual loss of PDS5A and PDS5B decreases cohesin association with NIPBL and WAPL, reduces SMC3 acetylation, and does not alter overall levels of cohesin on the genome.</p><p><strong>Conclusions: </strong>This work reveals the importance of PDS5A and PDS5B for proper cohesin function. Loss of either subunit has little effect on cohesin localization across the genome yet PDS5A and PDS5B are differentially required for gene expression.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity.","authors":"Koen M A Dreijerink,&nbsp;Ezgi Ozyerli-Goknar,&nbsp;Stefanie Koidl,&nbsp;Ewoud J van der Lelij,&nbsp;Priscilla van den Heuvel,&nbsp;Jeffrey J Kooijman,&nbsp;Martin L Biniossek,&nbsp;Kees W Rodenburg,&nbsp;Sheikh Nizamuddin,&nbsp;H T Marc Timmers","doi":"10.1186/s13072-022-00461-8","DOIUrl":"https://doi.org/10.1186/s13072-022-00461-8","url":null,"abstract":"<p><strong>Background: </strong>Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other types of cancers. The MEN1 gene product, menin, is involved in transcriptional and chromatin regulation, most prominently as an integral component of KMT2A/MLL1 and KMT2B/MLL2 containing COMPASS-like histone H3K4 methyltransferase complexes. In a mutually exclusive fashion, menin also interacts with the JunD subunit of the AP-1 and ATF/CREB transcription factors.</p><p><strong>Results: </strong>Here, we applied and in silico screening approach for 253 disease-related MEN1 missense mutations in order to select a set of nine menin mutations in surface-exposed residues. The protein interactomes of these mutants were assessed by quantitative mass spectrometry, which indicated that seven of the nine mutants disrupt interactions with both MLL1/MLL2 and JunD complexes. Interestingly, we identified three missense mutations, R52G, E255K and E359K, which predominantly reduce the MLL1 and MLL2 interactions when compared with JunD. This observation was supported by a pronounced loss of binding of the R52G, E255K and E359K mutant proteins at unique MLL1 genomic binding sites with less effect on unique JunD sites.</p><p><strong>Conclusions: </strong>Our results underline the effects of MEN1 gene mutations in both familial and sporadic tumors of endocrine origin on the interactions of menin with the MLL1 and MLL2 histone H3K4 methyltransferase complexes and with JunD-containing transcription factors. Menin binding pocket mutants R52G, E255K and E359K have differential effects on MLL1/MLL2 and JunD interactions, which translate into differential genomic binding patterns. Our findings encourage future studies addressing the pathophysiological relevance of the separate MLL1/MLL2- and JunD-dependent functions of menin mutants in MEN1 disease model systems.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40703987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex.","authors":"Basilia Acurzio,&nbsp;Francesco Cecere,&nbsp;Carlo Giaccari,&nbsp;Ankit Verma,&nbsp;Rosita Russo,&nbsp;Mariangela Valletta,&nbsp;Bruno Hay Mele,&nbsp;Claudia Angelini,&nbsp;Angela Chambery,&nbsp;Andrea Riccio","doi":"10.1186/s13072-022-00462-7","DOIUrl":"https://doi.org/10.1186/s13072-022-00462-7","url":null,"abstract":"<p><strong>Background: </strong>Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining it in a parental origin-specific manner in somatic cells. Despite their expected high mutation rate due to spontaneous deamination of methylated cytosines, ICRs show conservation of CpG-richness and CpG-containing transcription factor binding sites in mammalian species. However, little is known about the mechanisms contributing to the maintenance of a high density of methyl CpGs at these loci.</p><p><strong>Results: </strong>To gain functional insights into the mechanisms for maintaining CpG methylation, we sought to identify the proteins binding the methylated allele of the ICRs by determining the interactors of ZFP57 that recognizes a methylated hexanucleotide motif of these DNA regions in mouse ESCs. By using a tagged approach coupled to LC-MS/MS analysis, we identified several proteins, including factors involved in mRNA processing/splicing, chromosome organization, transcription and DNA repair processes. The presence of the post-replicative mismatch-repair (MMR) complex components MSH2 and MSH6 among the identified ZFP57 interactors prompted us to investigate their DNA binding profile by chromatin immunoprecipitation and sequencing. We demonstrated that MSH2 was enriched at gene promoters overlapping unmethylated CpG islands and at repeats. We also found that both MSH2 and MSH6 interacted with the methylated allele of the ICRs, where their binding to DNA was mediated by the ZFP57/KAP1 complex.</p><p><strong>Conclusions: </strong>Our findings show that the MMR complex is concentrated on gene promoters and repeats in mouse ESCs, suggesting that maintaining the integrity of these regions is a primary function of highly proliferating cells. Furthermore, the demonstration that MSH2/MSH6 are recruited to the methylated allele of the ICRs through interaction with ZFP57/KAP1 suggests a role of the MMR complex in the maintenance of the integrity of these regulatory regions and evolution of genomic imprinting in mammalian species.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40578434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts.","authors":"John F Dou, Lauren Y M Middleton, Yihui Zhu, Kelly S Benke, Jason I Feinberg, Lisa A Croen, Irva Hertz-Picciotto, Craig J Newschaffer, Janine M LaSalle, Daniele Fallin, Rebecca J Schmidt, Kelly M Bakulski","doi":"10.1186/s13072-022-00460-9","DOIUrl":"10.1186/s13072-022-00460-9","url":null,"abstract":"<p><strong>Background: </strong>Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3 fatty acids, zinc, and vitamins A, B6, B12, and D, and usually they contain higher concentrations of folic acid and iron than regular multivitamins in the US Nutrient levels can impact epigenetic factors such as DNA methylation, but relationships between maternal prenatal vitamin use and DNA methylation have been relatively understudied. We examined use of prenatal vitamins in the first month of pregnancy in relation to cord blood and placenta DNA methylation in two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI) and Markers of Autism Risk Learning Early Signs (MARBLES) studies.</p><p><strong>Results: </strong>In placenta, prenatal vitamin intake was marginally associated with -0.52% (95% CI -1.04, 0.01) lower mean array-wide DNA methylation in EARLI, and associated with -0.60% (-1.08, -0.13) lower mean array-wide DNA methylation in MARBLES. There was little consistency in the associations between prenatal vitamin intake and single DNA methylation site effect estimates across cohorts and tissues, with only a few overlapping sites with correlated effect estimates. However, the single DNA methylation sites with p-value < 0.01 (EARLI cord n_CpGs = 4068, EARLI placenta n_CpGs = 3647, MARBLES cord n_CpGs = 4068, MARBLES placenta n_CpGs = 9563) were consistently enriched in neuronal developmental pathways.</p><p><strong>Conclusions: </strong>Together, our findings suggest that prenatal vitamin intake in the first month of pregnancy may be related to lower placental global DNA methylation and related to DNA methylation in brain-related pathways in both placenta and cord blood.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10744212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation.","authors":"Iromi Wanigasuriya, Sarah A Kinkel, Tamara Beck, Ellise A Roper, Kelsey Breslin, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt, Quentin Gouil","doi":"10.1186/s13072-022-00458-3","DOIUrl":"10.1186/s13072-022-00458-3","url":null,"abstract":"<p><p>Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequate epigenetic patterning of the zygotic genome. We previously reported that one such factor is the epigenetic repressor SMCHD1, whose maternal supply controls autosomal imprinted expression in mouse preimplantation embryos and mid-gestation placenta. In mouse preimplantation embryos, X chromosome inactivation is also an imprinted process. Combining genomics and imaging, we show that maternal SMCHD1 is required not only for the imprinted expression of Xist in preimplantation embryos, but also for the efficient silencing of the inactive X in both the preimplantation embryo and mid-gestation placenta. These results expand the role of SMCHD1 in enforcing the silencing of Polycomb targets. The inability of zygotic SMCHD1 to fully restore imprinted X inactivation further points to maternal SMCHD1's role in setting up the appropriate chromatin environment during preimplantation development, a critical window of epigenetic remodelling.</p>","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40597411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci.","authors":"Alex Ranieri Jerônimo Lima,&nbsp;Herbert Guimarães de Sousa Silva,&nbsp;Saloe Bispo Poubel,&nbsp;Juliana Nunes Rosón,&nbsp;Loyze Paola Oliveira de Lima,&nbsp;Héllida Marina Costa-Silva,&nbsp;Camila Silva Gonçalves,&nbsp;Pedro A F Galante,&nbsp;Fabiola Holetz,&nbsp;Maria Cristina Machado Motta,&nbsp;Ariel M Silber,&nbsp;M Carolina Elias,&nbsp;Julia Pinheiro Chagas da Cunha","doi":"10.1186/s13072-022-00459-2","DOIUrl":"https://doi.org/10.1186/s13072-022-00459-2","url":null,"abstract":"","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40576327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}