Cell Journal最新文献

{"title":"Correction: Left Ventricular Geometry and Angiogenesis Improvement in Rat Chronic Ischemic Cardiomyopathy following Injection of Encapsulated Mesenchymal Stem Cells.","authors":"Negar Karimi Hajishoreh, Nafiseh Baheiraei, Nasim Naderi, Mojdeh Salehnia, Mehdi Razavi","doi":"10.22074/cellj.2024.713824","DOIUrl":"10.22074/cellj.2024.713824","url":null,"abstract":"<p><p>In this article published in Cell J, Vol 24, No 12, 2022, on pages 741-747, the authors found that there was some mistakes in the Table 1 and we have corrected them in the following table. The authors would like to apologize for any inconvenience.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 5","pages":"334-335"},"PeriodicalIF":1.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Relationship between Salivary Alkaline Phosphatase Enzyme Activity and The Concentrations of Salivary Calcium and Phosphate Ions.","authors":"Mina Jazaeri, Hosein Malekzadeh, Hamidreza Abdolsamadi, Loghman Rezaei-Soufi, Mohammad Samami","doi":"10.22074/cellj.2024.713825","DOIUrl":"10.22074/cellj.2024.713825","url":null,"abstract":"<p><p>In this article published in Cell J, Vol 17, No 1, 2015, on pages 159-162, the authors found that the affiliation of second author in address 2 was missed during the formatting of the paper. Therefore, we corrected it. The authors would like to apologize for any inconvenience.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 5","pages":"336"},"PeriodicalIF":1.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interactive Effects of The Aerobic Exercise and Vitamin E Supplementation on Parkinson's Rat Model.","authors":"Yadollah Zibaei Yekta, Rohollah Ranjbar, Abdolhamid Habibi, Aliakbar Alizadeh","doi":"10.22074/cellj.2024.2023457.1515","DOIUrl":"10.22074/cellj.2024.2023457.1515","url":null,"abstract":"<p><strong>Objective: </strong>In Parkinson's disease (PD), mitochondrial defects and oxidative stress cause an increase in free radicals and the death of dopaminergic neurons in the substantia nigra. By preventing lipid peroxidation and protecting against peroxide radicals, vitamin E is the most important antioxidant of biological membranes that can neutralize free radicals. Also, the improvement of the functional status of mitochondria can be influenced by exercise, which can be partially the result of changes in the mitochondrial mitophagy and dynamics system. This study aimed to investigate the interactive effects of six weeks of vitamin E (VE) consumption and training on the mitochondrial function [Cytochrome C (Cyt-C), Adenosine triphosphate (Atp) synthase, optical atrophy1 mitochondrial dynamics like guanosine triphosphatase (GTPase), 8-Oxodequanosin and Pten induced kinase 1 (Pink1) is a protein coding gene] in the hippocampus tissue of PD rats.</p><p><strong>Materials and methods: </strong>In this experimental study, 4-6-month-old Sprague-Dawley rats (mean weight 250 ± 30 g) were given parkinsonism with reserpine (2 mg/kg) and were categorized into different groups, including healthy (H), PD, VE solvent+PD (Sham), aerobic exercise+PD (AE+PD), VE+PD, AE+VE+PD. The aerobic training program was carried out for six weeks and 5 sessions per week and each session lasted 15-22 minutes. VE was also taken orally at 30 mg/kg daily.</p><p><strong>Results: </strong>A six-week regimen of VE supplement along with the AE significantly reduced the Cyt-C gene expression level, also we observed a significant increase in gene expression level of the Pink1, Atp synthase and Opa1 (P<0.05). There is no significant difference was found in the level of 8-Oxog detected in hippocampal tissue samples (P>0.05).</p><p><strong>Conclusion: </strong>The consumption of VE along with AE may provide therapeutic effects on mitochondrial damage in PD rats.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 5","pages":"285-292"},"PeriodicalIF":1.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic Analysis Reveals Sex-Based Differences in The Prefrontal Cortex of Autism Spectrum Disorder Patients.","authors":"Asma Sobhani, Kolsoum InanlooRahatloo","doi":"10.22074/cellj.2024.2018050.1471","DOIUrl":"10.22074/cellj.2024.2018050.1471","url":null,"abstract":"<p><strong>Objective: </strong>The prevalence of neurological disorders often varies by sex, with conditions such as Alzheimer's disease and autism spectrum disorder (ASD) demonstrating notable differences in incidence. The aim of this study is to understand the molecular basis for these divergences in order to facilitate the creation of sex-specific therapeutic strategies.</p><p><strong>Materials and methods: </strong>This study is a bioinformatic analysis of publicly available RNA sequencing datasets involving autism patients. The study utilized RNA sequencing data from postmortem human brains' prefrontal cortex, including 38 neurotypical controls and 34 individuals with ASD. The sequencing data was obtained from previously published papers, and we downloaded the raw data from SRA. We investigated the molecular basis of sex-biased presentation in ASD through comprehensive transcriptomic analysis.</p><p><strong>Results: </strong>Comparative analysis of gene expression between male and female subjects, both autistic and unaffected, was conducted, using a significance level of ≤0.01. In autistic individuals, 136 genes demonstrated differential expression between sexes, predominantly upregulated in males, indicating a bias in male gene expression. Among these, 12 genes were identified as risk factors in the SFARI dataset. While most sex-biased genes were autosomal, expression differences on sex chromosomes were also observed in neurotypical subjects. Notable genes included TCF7L2, collagen family genes, and solute carrier family genes. In ASD males, extracellular matrix (ECM) organization emerged as a significant pathway, while immune-related processes were prominent in unaffected individuals.</p><p><strong>Conclusion: </strong>Our study highlights the impact of the ECM pathway in ASD, with notable differences between sexes, particularly in males. <i>MIR424</i> shows promise as a potential biomarker for ASD in males. Recognizing the importance of sex differences in ASD transcriptomic research is crucial, as these variances provide insights into the disorder's pathophysiology and may guide the development of more personalized treatments for both sexes.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 5","pages":"320-328"},"PeriodicalIF":1.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Significance of Circulating and Disseminated Tumor Cells in Breast Cancer Patients before and after Adjuvant Chemotherapy.","authors":"Parisa Ghaffari, Meysam Yousefi, Mozaffar Aznab, Negar Khazan, Marjan Yaghmaie, Davood Bashash, Mohammad Vaezi, Ardashir Ghavamzadeh, Seyed H Ghaffari","doi":"10.22074/cellj.2024.2017486.1466","DOIUrl":"10.22074/cellj.2024.2017486.1466","url":null,"abstract":"<p><strong>Objective: </strong>Despite the advances in treatment, breast cancer (BC) remains a major cause of death in women. This study aims to evaluate the prognostic significance of detecting circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in paired peripheral blood (PB) and bone marrow (BM) samples obtained both before and after adjuvant chemotherapy from patients with operable BC.</p><p><strong>Materials and methods: </strong>In this experimental study, from 160 patients with primary BC, we collected 160 PB and BM samples before and we could be able to collect PB and BM samples from 100 of them after adjuvant chemotherapy. The expression level of cytokeratin 19 (<i>CK19</i>), carcinoembryonic antigen (CEA), mammaglobin 1 (<i>MGB1</i>), mucin 2 (<i>MUC2</i>) and trefoil factor 1 (<i>TFF1</i>) mRNAs in the PB/BM samples were analyzed by quantitative real-time polymerase chain reaction (PCR).</p><p><strong>Results: </strong>Multivariate Cox regression analyses indicated that the detection of <i>CK19</i> mRNA-positive CTCs/DTCs either before or after adjuvant chemotherapy was an independent factor for prognosis associated with decreased diseasefree survival (DFS). Patients with tumor cells detected in both PB and BM and patients with persistent detection of tumor cells before and after chemotherapy had worse outcomes compared to those with tumor cells detected in one or neither of the compartments.</p><p><strong>Conclusion: </strong>This study suggests that the detection of <i>CK19</i> mRNA-positive CTCs/DTCs either before or after adjuvant chemotherapy could be an independent predictor of DFS in operable BC patients.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 5","pages":"293-308"},"PeriodicalIF":1.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of <i>SPOCD1</i> as A Suitable Diagnostic and Prognostic Biomarker in Various Common Cancer Types: Bioinformatics and Practical Analysis.","authors":"Samira Yavari, Maryam Naseroleslami, Maryam Peymani, Farshid Yekani, Niloufar Khayam Nekouei","doi":"10.22074/cellj.2024.2022401.1506","DOIUrl":"10.22074/cellj.2024.2022401.1506","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to assess whether Spen paralogue and orthologue C-terminal domain containing 1 (<i>SPOCD1</i>) gene expression could serve as a valuable prognostic and diagnostic biomarker in common cancers, drawing from insights in recent literature. We sought to verify this concept by utilizing data sourced from The Cancer Genome Atlas (TCGA) alongside clinical samples.</p><p><strong>Materials and methods: </strong>In this bioinformatics and experimental study, <i>SPOCD1</i> RNA-seq data from 12 common cancers were collected from TCGA Pan-Cancer Atlas using the R package \"TCGA BIOLINKS\" and normalized for analysis. Various analytical tools, including receiver operating characteristic (ROC) curves, Kaplan-Meier and Coxregression analyses, and pathway enrichment analysis via the molecular signatures database (MSigDB), were applied. Drug resistance/sensitivity correlations with <i>SPOCD1</i> expression were explored using the Gene Expression Omnibus (GEO) database. Clinical colorectal cancer (CRC) samples, including both colon and rectal malignant samples, were also evaluated.</p><p><strong>Results: </strong>The results showed elevated <i>SPOCD1</i> expression in most cancers (9/12), with notable prognostic value in COAD, HNSC, KICH, and LIHC, and a correlation with poor prognosis in COAD for disease-free survival. ROC curve analysis suggested SPOCD1 as a diagnostic biomarker in the majority of cases (7/12), although this pattern was inconsistent in clinical CRC samples. Pathway enrichment analysis revealed a strong correlation between <i>SPOCD1</i> expression and critical molecular pathways. Unlike former results, we found that SPOCD1 upregulated when interacting with PD-0325901. However, treating with Panobinostat led to downregulation. Both are as anticancer reagents.</p><p><strong>Conclusion: </strong>This study confirms the potential of <i>SPOCD1</i> as a diagnostic and prognostic biomarker in prevalent cancers. However, extensive clinical data, particularly for CRC, are required to validate its reliability. Different COAD subtypes may exhibit varying correlations with <i>SPOCD1</i> expression levels, underscoring the need for further investigation to fully understand its diagnostic and prognostic value.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 5","pages":"309-319"},"PeriodicalIF":1.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latest Developments in Early Detection and Effective Treatment of Cancer: A Meeting Report.","authors":"Morvarid Ghattan, Niloofar Bajool, Mina Pahlavanneshan, Melika Zamanian, Sharif Moradi","doi":"10.22074/cellj.2024.2026689.1553","DOIUrl":"10.22074/cellj.2024.2026689.1553","url":null,"abstract":"<p><p>Despite a lower estimated rate of cancer incidence in Iran compared to the global average, the trend is unfortunately increasing. This necessitates the implementation of early detection of cancer and targeted therapies to effectively treat various types of cancer. Therefore, the 5th \"International Royan Cancer Conference: From Bench to Bedside\" was held to focus on critical cancer-related aspects such as gene- and cell therapy, immunotherapy, oligonucleotides in cancer treatment, biosensors for detection, and drug delivery. The 2-day conference took place in February 2024 at the Royan Institute, Tehran. This collaborative effort brought together experts from both basic and clinical research fields. The primary objective of the conference was to address clinical challenges and harness the potential of basic sciences for early cancer diagnosis and treatment, with a robust emphasis on ethical considerations. The conference aimed to ensure optimal patient care while advancing scientific understanding in the field and facilitating effective research collaborations among researchers and enthusiasts dedicated to combating cancer.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 5","pages":"329-333"},"PeriodicalIF":1.7,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Streptozotocin Induced Diabetes on One-Carbon Cycle and Sperm Function.","authors":"Farnaz Pouriayevali, Marziyeh Tavalaee, Fatemeh Kazeminasab, Maurizio Dattilo, Mohammad Hossein Nasr-Esfahani","doi":"10.22074/cellj.2024.711928","DOIUrl":"https://doi.org/10.22074/cellj.2024.711928","url":null,"abstract":"<p><p>In this article published in Cell J, Vol 26, No 1, 2024, on pages 81-90, the authors found that the affiliation of authors in address 1 and also the two corresponding authors had accidentally missed during the formatting of the paper. Therefore, we corrected them. The authors would like to apologize for any inconvenience.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 4","pages":"276"},"PeriodicalIF":2.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Gene Expression of <i>LITAF, TNF-α</i> and <i>BCL6</i> in Endometrial Tissues of Women with Endometriosis: A Case-Control Study.","authors":"Ameneh Saadat Varnosfaderani, Shadi Kalantari, Fariba Ramezanali, Maryam Shahhoseini, Elham Amirchaghmaghi","doi":"10.22074/cellj.2024.2022348.1503","DOIUrl":"10.22074/cellj.2024.2022348.1503","url":null,"abstract":"<p><strong>Objective: </strong>Endometriosis, as a common inflammatory chronic disease is characterized by endometrial tissue growth outside the uterine cavity. It was reported that lipopolysaccharides (LPS) activate a transcription factor called LPSinduced tumor necrosis factor-alpha (LITAF) in macrophages, which induced transcription of cytokine genes such as tumor necrosis factor alpha (<i>TNF-α</i>). B-cell lymphoma 6 protein (BCL6) is a transcription factor which expression was increased in endometrial tissues of infertile women with endometriosis. In addition, it was shown that mRNA and protein of LITAF and BCL6 were inversely related in mature B lymphocytes and B-Cell lymphomas. Accordingly, we investigated gene expression of <i>LITAF, BCL6</i> and ,<i>TNF-α</i> in eutopic and ectopic endometrial tissues of women with endometriosis compared to the controls.</p><p><strong>Materials and methods: </strong>In this case-control study, 10 women with endometriosis (endometriosis group) and 10 women without endometriosis (control group) enrolled after diagnostic laparoscopy. Real-time polymerase chain reaction (PCR) technique was used to quantitatively analyze gene expression. One-Way ANOVA was used for data analysis.</p><p><strong>Results: </strong>This study showed that <i>LITAF</i> gene expression was significantly higher in ectopic endometrial tissues compared to the control samples. Expression level of <i>BCL6</i> gene was significantly increased in the ectopic tissues of women with endometriosis compared to the control and eutopic samples. Although <i>TNF-ɑ</i> gene expression was increased in the ectopic lesions compared to the eutopic and control endometrial samples, these differences were not significant.</p><p><strong>Conclusion: </strong>The results suggested that over-expression of these inflammatory genes in ectopic endometrial lesions can be considered as a molecular scenario in pathophysiology of endometriosis by induction of inflammatory cascades and cellular proliferation.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 4","pages":"243-249"},"PeriodicalIF":1.7,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of miR-20a as A Potential Discerning Biomarker for Non-Invasive versus Invasive Retinoblastoma.","authors":"Ahmad Bereimipour, Saeed Karimi, Mohammad Faranoush, Amir Abbas Hedayati Asl, Monireh Sadat Miri, Leila Satarian, Sara Taleahmad","doi":"10.22074/cellj.2024.2019336.1479","DOIUrl":"https://doi.org/10.22074/cellj.2024.2019336.1479","url":null,"abstract":"<p><strong>Objective: </strong>Intraocular retinoblastoma (RB) is common in kids. Although the cause of this disease is a mutation in the RB1 gene, the formed cancerous mass in different patients is seen in non-invasive states, limited to the ocular cavity or in invasive states distributed to other parts of the body. Because this tumor's aggressiveness cannot be predicted early, these patients receive systemic chemotherapy with multiple drugs. Treating non-invasive and invasive tumors separately reduces chemical drug side effects. The aim of this study was to identify diagnostic biomarkers by separating miRNAs in blood serum from invasive and non-invasive RB patients.</p><p><strong>Materials and methods: </strong>In this experimental study, selected three gene expression omnibus (GEO) datasets. Two were related to serum and tumor tissue miRNAs, and one was related to non-invasive and invasive <i>RB</i> gene expression. Examined <i>RB</i> gene-miRNA relationships. Then, we performed real-time polymerase chain reaction (PCR) on candidate miRNAs in the Y79 cell line and patient blood samples in non-invasive and invasive retinoblastoma.</p><p><strong>Results: </strong>Fourteen high-expression and 7 low-expression miRNAs resulted. <i>MiR-181, miR-135a, miR-20a, miR-373,</i> and <i>miR-191</i> were common genes with differential genes between invasive and non-invasive retinoblastoma. Only <i>MiR-181</i> was upregulated in the Y79 RB cell line. Other candidate miRNAs expressed less. Invasive retinoblastomas increased serum miR-20a and miR-191.</p><p><strong>Conclusion: </strong>Integrated and regular bioinformatics analyses found important miRNAs in patients' and <i>miR-20a, miR- 191</i>, and <i>miR-135a</i> can distinguish non-invasive and invasive retinoblastoma, suggesting further research.</p>","PeriodicalId":49224,"journal":{"name":"Cell Journal","volume":"26 4","pages":"250-258"},"PeriodicalIF":2.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}