Endocrine最新文献_第10页

Prediction of TNFRSF9 expression and molecular pathological features in thyroid cancer using machine learning to construct Pathomics models. 利用机器学习构建病理组学模型，预测甲状腺癌中 TNFRSF9 的表达和分子病理特征。

IF 3 3区医学

Endocrine Pub Date : 2024-10-01 Epub Date: 2024-05-16 DOI: 10.1007/s12020-024-03862-9

Ying Liu, Junping Zhang, Shanshan Li, Wen Chen, Rongqian Wu, Zejin Hao, Jixiong Xu

{"title":"Prediction of TNFRSF9 expression and molecular pathological features in thyroid cancer using machine learning to construct Pathomics models.","authors":"Ying Liu, Junping Zhang, Shanshan Li, Wen Chen, Rongqian Wu, Zejin Hao, Jixiong Xu","doi":"10.1007/s12020-024-03862-9","DOIUrl":"10.1007/s12020-024-03862-9","url":null,"abstract":"Background: The TNFRSF9 molecule is pivotal in thyroid carcinoma (THCA) development. This study utilizes Pathomics techniques to predict TNFRSF9 expression in THCA tissue and explore its molecular mechanisms.Methods: Transcriptome data, pathology images, and clinical information from the cancer genome atlas (TCGA) were analyzed. Image segmentation and feature extraction were performed using the OTSU's algorithm and pyradiomics package. The dataset was split for training and validation. Features were selected using maximum relevance minimum redundancy recursive feature elimination (mRMR_RFE) and modeling conducted with the gradient boosting machine (GBM) algorithm. Model evaluation included receiver operating characteristic curve (ROC) analysis. The Pathomics model output a probabilistic pathomics score (PS) for gene expression prediction, with its prognostic value assessed in TNFRSF9 expression groups. Subsequent analysis involved gene set variation analysis (GSVA), immune gene expression, cell abundance, immunotherapy susceptibility, and gene mutation analysis.Results: High TNFRSF9 expression correlated with worsened progression-free interval (PFI) and acted as an independent risk factor [hazard ratio (HR) = 2.178, 95% confidence interval (CI) 1.045-4.538, P = 0.038]. Nine pathohistological features were identified. The GBM Pathomics model demonstrated good prediction efficacy [area under the curve (AUC) 0.819 and 0.769] and clinical benefits. High PS was a PFI risk factor (HR = 2.156, 95% CI 1.047-4.440, P = 0.037). Patients with high PS potentially exhibited enriched pathways, increased TIGIT gene expression, Tregs infiltration (P < 0.0001), and higher rates of gene mutations (BRAF, TTN, TG).Conclusions: The GBM Pathomics model constructed based on the pathohistological features of H&E-stained sections well predicted the expression level of TNFRSF9 molecules in THCA.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of GLP-1 and glucagon receptor dual agonist for the treatment of type 2 diabetes and obesity: a systematic review and meta-analysis of randomized controlled trials. GLP-1和胰高血糖素受体双重激动剂治疗2型糖尿病和肥胖症的安全性和有效性：随机对照试验的系统回顾和荟萃分析。

IF 3 3区医学

Endocrine Pub Date : 2024-10-01 Epub Date: 2024-05-13 DOI: 10.1007/s12020-024-03857-6

Bixin Deng, Tiechao Ruan, Wenting Lu, Junjie Ying, Shiping Li, Ruixi Zhou, Dezhi Mu

{"title":"Safety and efficacy of GLP-1 and glucagon receptor dual agonist for the treatment of type 2 diabetes and obesity: a systematic review and meta-analysis of randomized controlled trials.","authors":"Bixin Deng, Tiechao Ruan, Wenting Lu, Junjie Ying, Shiping Li, Ruixi Zhou, Dezhi Mu","doi":"10.1007/s12020-024-03857-6","DOIUrl":"10.1007/s12020-024-03857-6","url":null,"abstract":"Purpose: This study aimed to investigate the effects of randomized, placebo-controlled trials involving the GLP-1 and glucagon receptor dual agonists, mazdutide, and cotadutide, on glycaemic control and body weight changes in individuals with type 2 diabetes mellitus (T2DM), obesity, or both.Methods: We conducted searches in Medline, PubMed, Scopus, the Cochrane database, and Web of Science up to March 5, 2024. The primary outcomes assessed were changes in HbA1c level and percentage changes in body weight from baseline (CFB).Results: Eleven studies and four unpublished trials were included. The pooled meta-analysis revealed a significant reduction in HbA1c (MD = -0.63%; 95% CI = [-0.82, -0.44]; P < 0.00001), fasting plasma glucose (MD = -1.71 mmol/L; 95% CI = [-2.31, -1.10]; P < 0.00001), and percentage change in body weight (MD = -4.16%; 95% CI = [-5.41, -2.92]; P < 0.00001). Safety analysis revealed no significant change in serious adverse events (OR = 1.03; 95% CI = [0.61, 1.75]; P = 0.91), but there were significantly higher odds of treatment-emergent adverse events (OR = 2.52; 95% CI = [1.92, 3.30]; P < 0.00001) and vomiting (OR = 6.05; 95% CI = [3.52, 10.40]; P < 0.00001).Conclusion: These results suggest that mazdutide and cotadutide are effective for glycaemic control and weight reduction in individuals with T2DM, obesity, or both.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140917314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time course of remnant cholesterol and the risk of heart failure. 残余胆固醇与心力衰竭风险的时间进程。

IF 3 3区医学

Endocrine Pub Date : 2024-09-21 DOI: 10.1007/s12020-024-04028-3

Xiaoxue Liu, Yijun Zhang, Xue Tian, Qin Xu, Xue Xia, Shuohua Chen, Fen Liu, Shouling Wu, Anxin Wang

{"title":"Time course of remnant cholesterol and the risk of heart failure.","authors":"Xiaoxue Liu, Yijun Zhang, Xue Tian, Qin Xu, Xue Xia, Shuohua Chen, Fen Liu, Shouling Wu, Anxin Wang","doi":"10.1007/s12020-024-04028-3","DOIUrl":"https://doi.org/10.1007/s12020-024-04028-3","url":null,"abstract":"Background and aim: Previous studies have shown that remnant cholesterol (RC) was associated with heart failure (HF). However, lack of evidence regarding the long-term trend of RC with HF risk. We aimed to investigate the association between cumulative RC exposure with incident HF and to further explore the modulating effects of the time course of RC accumulation.Methods and results: We enrolled 41,168 participants free of CVD from the Kailuan Study who completed the first three health examinations from 2006 to 2010. Cumulative RC exposure included cumulative RC and time-weighted cumulative RC. The combination of cumulative RC and RC slope over time was characterized as the time course of RC accumulation. Multivariable adjusted Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for HF risk. We also considered non-HF-related death as a competing event by performing competing risk models as a sensitivity analysis. During 8.84 years, 839 participants developed HF events. Cumulative RC exposure increased the HF risk, with HRs for cumulative RC of 1.72 (1.41-2.10) and for time-averaged cumulative RC of 1.54 (1.25-1.89). There was a nonlinear relationship between cumulative RC exposure and HF risk. Participants with higher cumulative RC and negative slope had the highest HF risk (HR, 1.46; 95% CI, 1.16-1.83).Conclusions: Both cumulative long-term exposure and the time course of RC accumulation were associated with HF risk. Early RC accumulation resulted in a greater increase in risk compared to later accumulation. This finding suggests that long-term exposure to RC may be useful in identifying individuals at high risk of developing HF and highlights the need for early initiation of appropriate RC control to prevent or reduce incident HF.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on redifferentiation strategies for radioactive iodine-refractory differentiated thyroid carcinoma. 放射性碘难治性分化型甲状腺癌再分化策略的最新进展。

IF 3 3区医学

Endocrine Pub Date : 2024-09-04 DOI: 10.1007/s12020-024-04018-5

Theodora Pappa, Lori Wirth

引用次数: 0

Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis. 通过调节 SIRT3-NLRP3 轴，服用替扎帕肽可改善高脂蛋白血症小鼠的认知障碍。

IF 3 3区医学

Endocrine Pub Date : 2024-09-02 DOI: 10.1007/s12020-024-04013-w

Jingjing Ma, Yuanyuan Liu, Junya Hu, Xingjing Liu, Yin Xia, Wenqing Xia, Ziyang Shen, Xiaocen Kong, Xia Wu, Li Mao, Qian Li

{"title":"Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis.","authors":"Jingjing Ma, Yuanyuan Liu, Junya Hu, Xingjing Liu, Yin Xia, Wenqing Xia, Ziyang Shen, Xiaocen Kong, Xia Wu, Li Mao, Qian Li","doi":"10.1007/s12020-024-04013-w","DOIUrl":"https://doi.org/10.1007/s12020-024-04013-w","url":null,"abstract":"Purpose: High-fat diet (HFD) currently is reported that in connection with cognitive impairment. Tirzepatide is a novel dual receptor agonist for glycemic control. But whether Tirzepatide exerts a protective effect in HFD-related cognitive impairment remains to be explore.Methods: During the study, the cognitive dysfunction mice model induced by HFD were established. The expressions synapse-associated protein and other target proteins were detected. The oxidative stress parameters, levels of inflammatory cytokine were also detected.Results: Our findings proved that Tirzepatide administration attenuates high fat diet-related cognitive impairment. Tirzepatide administration suppresses microglia activation, alleviates oxidative stress as well as suppressed the expression of NLRP3 in HFD mice by up-regulating SIRT3 expression. In conclusion, Tirzepatide attenuates HFD-induced cognitive impairment through reducing oxidative stress and neuroinflammation via SIRT3-NLRP3 signaling.Conclusion: This study suggest that Tirzepatide has neuroprotective effects in HFD-related cognitive dysfunction mice model, which provides a promising treatment of HFD-related cognitive impairment.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum osteoglycin is stable during various glycemic challenges in healthy men. 在健康男性面临各种血糖挑战时，血清骨甘氨酸保持稳定。

IF 3 3区医学

Endocrine Pub Date : 2024-09-01 Epub Date: 2024-03-28 DOI: 10.1007/s12020-024-03789-1

Jakob Starup-Linde, Sidse Westberg-Rasmussen, Rikke Viggers, Zheer Kejlberg Al-Mashhadi, Aase Handberg, Peter Vestergaard, Søren Gregersen

{"title":"Serum osteoglycin is stable during various glycemic challenges in healthy men.","authors":"Jakob Starup-Linde, Sidse Westberg-Rasmussen, Rikke Viggers, Zheer Kejlberg Al-Mashhadi, Aase Handberg, Peter Vestergaard, Søren Gregersen","doi":"10.1007/s12020-024-03789-1","DOIUrl":"10.1007/s12020-024-03789-1","url":null,"abstract":"Purpose: Osteoglycin is hypothesized to be metabolically active and may enhance insulin action. We hypothesized that osteoglycin levels increase during hyperglycemia as a physiological response to enhance the effects of insulin.Methods: Eight healthy males were included in a cross-over study consisting of three study days following an 8 h fast. First, we performed an oral glucose tolerance test (OGTT); second, an isoglycemic intravenous glucose infusion (IIGI); and third, a control period consisting of a three hour fast. We analyzed blood samples for circulating osteoglycin levels during the study days. Repeated measures ANOVA was performed to compare levels of s-osteoglycin between OGTT, IIGI, and the fasting control.Results: There were no differences in baseline osteoglycin levels among study days (p > 0.05). We observed no significant changes neither in absolute s-osteoglycin levels by time (p = 0.14) nor over time by study day (p = 0.99). Likewise, we observed no significant changes in percentage s-osteoglycin levels neither by time (p = 0.11) nor over time by study day (p = 0.89).Conclusion: We found that s-osteoglycin levels were stable for three hours during OGTT, IIGI, and fasting in healthy males. Based on the present study, circulating s-osteoglycin levels may be measured independently of fasting or non-fasting conditions. Furthermore, circulating physiological levels of glucose and insulin did not affect s-osteoglycin levels.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remembering Dr. Virginia A. LiVolsi (July 29, 1943-March 7, 2024): The lady of the "Butterfly Gland". 缅怀弗吉尼亚-李沃西博士（Virginia A. LiVolsi，1943 年 7 月 29 日-2024 年 3 月 7 日）：蝴蝶腺 "的女士。

IF 3 3区医学

Endocrine Pub Date : 2024-09-01 Epub Date: 2024-07-13 DOI: 10.1007/s12020-024-03894-1

Zubair Baloch, Guido Fadda

引用次数: 0

Memory in female adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 因缺乏 21-羟化酶而患有先天性肾上腺皮质增生症的女性青少年的记忆力。

IF 3 3区医学

Endocrine Pub Date : 2024-09-01 Epub Date: 2024-05-10 DOI: 10.1007/s12020-024-03806-3

Tania M Espinosa Reyes, Dainy Cordero Martín, Miguel Ángel Álvarez, Henrik Falhammar

{"title":"Memory in female adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.","authors":"Tania M Espinosa Reyes, Dainy Cordero Martín, Miguel Ángel Álvarez, Henrik Falhammar","doi":"10.1007/s12020-024-03806-3","DOIUrl":"10.1007/s12020-024-03806-3","url":null,"abstract":"Introduction: In females with congenital adrenal hyperplasia (CAH), the influence of hyperandrogenism and glucocorticoid supplementation on neurocognition is controversial.Objectives: To identify possible differences in visual working memory and verbal memory in adolescent girls with CAH due to 21-hydroxylase deficiency and matched controls. Moreover, to study if any relationship between variables associated with CAH and the scores of the selected memory tests was present.Material and methods: In total 39 individuals were studied, female adolescents with CAH and age and pubertal stage matched healthy male and female controls (13 in each group). Sociodemographic, clinical, hormonal, and neurocognitive variables were explored. In female adolescents with CAH, variables related to the disease (age at diagnosis, clinical form, time since diagnosis, and glucocorticoid doses) were correlated with the scores obtained for neurocognitive variables.Results: The mean age was 13.9 ± 3.3 years. In female adolescents with CAH the results were worse compared to controls in Free Recall (p = 0.039) and in Visual Memory Span score (p = 0.016). Age at diagnosis was negatively correlated to number of hits (p = 0.04), number recalled backward (p = 0.03), Visual Memory Span test score (p = 0.04) and Total Free Recall (p = 0.04), i.e., memory was worse with later diagnosis.Conclusions: Female adolescents with CAH had worse visual working memory compared to matched controls, but not in verbal memory. Age at diagnosis was negatively associated with the memory tests.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of dietary iron intake with diabetic kidney disease among individuals with diabetes. 糖尿病患者膳食铁摄入量与糖尿病肾病的关系。

IF 3 3区医学

Endocrine Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI: 10.1007/s12020-024-03819-y

Yichuan Wu, Manlu Xiao, Jiaqi Chen, Yuan Tao, Aomiao Chen, Huanjia Lin, Ying Xu, Linna Li, Hongxia Jia, Yaoming Xue, Yijie Jia, Zongji Zheng

{"title":"Association of dietary iron intake with diabetic kidney disease among individuals with diabetes.","authors":"Yichuan Wu, Manlu Xiao, Jiaqi Chen, Yuan Tao, Aomiao Chen, Huanjia Lin, Ying Xu, Linna Li, Hongxia Jia, Yaoming Xue, Yijie Jia, Zongji Zheng","doi":"10.1007/s12020-024-03819-y","DOIUrl":"10.1007/s12020-024-03819-y","url":null,"abstract":"Purpose: The current study investigated the correlation between dietary iron intake and diabetic kidney disease among diabetic adults.Methods: This cross-sectional study enrolled 8118 participants who suffered from diabetes from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Dietary iron intake was obtained from 24 h recall interviews, and diabetic kidney disease was defined as eGFR < 60 mL/min per 1.73 m2 or albumin creatinine ratio (ACR) ≥ 30 mg/g. Three weighted logistic regression models were utilized to investigate odd ratio (OR) and 95% CIs for diabetic kidney disease. Stratified analyses were performed by gender, age, BMI, HbA1c, hypertension status, and smoking status, and diabetes types.Results: Among 8118 participants (51.6% male, mean age 61.3 years), 40.7% of participants suffered from diabetic kidney disease. With the adjustment of potential covariates, we found that ≥ 12.59 mg of dietary iron was related to a lower risk of diabetic kidney disease (OR = 0.78, 95% CI: 0.63 to 0.96; OR = 0.79, 95% CI: 0.63 to 0.98). In stratified analyses, higher iron intake was negatively related to diabetic kidney disease, especially among those who were male, < 60 years, those with hypertension, those with HbA1c < 7.0%, and those who were ex-smokers. The result remained robust in sensitivity analyses.Conclusion: We found that ≥ 12.59 mg of dietary iron is associated with a lower risk of diabetic kidney disease, especially in those who were male, younger, heavier weight, have better blood sugar control, and those who were ex-smokers.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systolic blood pressure and risk of cardiovascular disease in normotensive diabetic adults: a prospective cohort study. 收缩压与血压正常的糖尿病成人罹患心血管疾病的风险：一项前瞻性队列研究。

IF 3 3区医学

Endocrine Pub Date : 2024-09-01 Epub Date: 2024-05-16 DOI: 10.1007/s12020-024-03803-6

Yingting Zuo, Shuohua Chen, Xue Tian, Shouling Wu, Anxin Wang

{"title":"Systolic blood pressure and risk of cardiovascular disease in normotensive diabetic adults: a prospective cohort study.","authors":"Yingting Zuo, Shuohua Chen, Xue Tian, Shouling Wu, Anxin Wang","doi":"10.1007/s12020-024-03803-6","DOIUrl":"10.1007/s12020-024-03803-6","url":null,"abstract":"Background: Currently, the special blood pressure (BP) target for normotensive diabetic patients has not been recommended. We investigated the optimal systolic blood pressure (SBP) for lower cardiovascular disease (CVD) risk in normotensive diabetic patients.Methods: In this 12-year follow-up study using the participants of the Kailuan Study, we mainly compared which SBP, 90-119 mmHg or 120-129 mmHg, had a lower risk of occurrence of CVD (stroke and myocardial infarction) in the 3072 normotensive diabetic participants and 21,532 normotensive and non-diabetic participants, respectively. The SBP was expressed as a mean time-weighted cumulative (MTWC) SBP, calculated from the multiple measurements of SBP during the follow-up. Multivariate competing risk regression analyses were used for the analysis.Results: We found that in normotensive diabetic participants, MTWC SBP of 120-129 mmHg was associated with a lower risk of CVD (HR = 0.69 [0.50-0.95]), myocardial infarction (HR = 0.48 [0.24-0.96]), and trending towards lower risk of stroke (HR = 0.80 [0.55-1.16]), compared to MTWC SBP of 90-119 mmHg. Sensitivity analyses confirmed the relationship between low SBP and increased CVD risk. Whereas, in the normotensive and non-diabetic participants, MTWC SBP of 90-119 mmHg vs 120-129 mmHg did not exhibit any difference in the risk of CVD occurrence (HR = 0.99 [0.83-1.18]).Conclusions: The higher level of SBP in normotensive diabetic patients is especially associated with a lower risk of CVD occurrence.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0