Endocrine最新文献

{"title":"Effects of vitamin D₃ and calcium supplementation on bone of young adults after thyroidectomy of differentiated thyroid carcinoma.","authors":"Lei Sun, Xiaoyun Lin, Naishi Li, Qian Zhang, Yan Jiang, Ou Wang, Weibo Xia, Xiaoping Xing, Xiaoyi Li, Mei Li","doi":"10.1007/s12020-025-04195-x","DOIUrl":"https://doi.org/10.1007/s12020-025-04195-x","url":null,"abstract":"<p><strong>Purpose: </strong>Differentiated thyroid carcinoma (DTC) is the most frequent endocrine cancer, with a high incidence in young population. Patients with postoperative DTC are usually considered with increased risk of bone loss, possibly due to the thyroid stimulating hormone (TSH) suppression therapy. However, it remains unclear whether vitamin D and calcium supplementation is beneficial on bone metabolism of young patients with vitamin D malnutrition after thyroidectomy of DTC.</p><p><strong>Methods: </strong>In this one-year prospective study, adult men younger than 50 years or premenopausal women with DTC and vitamin D insufficiency or deficiency were enrolled after thyroidectomy, who were administered with daily supplements of 1000-2000 IU vitamin D₃ and 600 mg of elemental calcium (calcium-D₃) or not. Propensity score matching (PSM) was applied to identify baseline-matched cohorts.</p><p><strong>Results: </strong>A total of 458 patients with a median age of 37 (range 21-50) years were enrolled, with 94 (20.5%) patients supplemented with calcium-D₃. After PSM, we identified baseline-matched cohorts of 246 DTC patients, of which 82 patients were supplemented with calcium-D₃ and 164 were not. After 12 months' supplementation, lower serum levels of β-CTX (0.27 ± 0.15 vs. 0.35 ± 0.18 ng/ml, P = 0.004), PTH (36.2 ± 12.7 vs. 45.2 ± 14.6 pg/ml, P < 0.001) and higher BMD at lumbar spine (1.8% vs. 0.7%, P = 0.050) and total hip (1.1% vs. -0.4%, P < 0.001) were observed compared to the control group. Among all the 458 patients, increase of 25OHD levels was closely associated with decrease of PTH, ALP and β-CTX levels and improvement in total hip BMD throughout the one-year study period.</p><p><strong>Conclusion: </strong>Vitamin D and calcium supplements can reduce PTH levels and bone loss, possibly contributing to protecting bone of young DTC patients with vitamin D malnutrition after thyroidectomy.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus nonnegative matrix factorization reveals metastatic gene expression program and identifies E74-like ETS transcription factor 3 confers to the lymph nodes metastasis in papillary thyroid cancer.","authors":"Mei Tao, Shuping Wu, Yimeng Liu, Xianhui Ruan, Wei Zhang, Wei Luo, Jialong Yu, Yu Zeng, Junya Ning, Xiangqian Zheng, Ming Gao","doi":"10.1007/s12020-025-04205-y","DOIUrl":"https://doi.org/10.1007/s12020-025-04205-y","url":null,"abstract":"<p><strong>Background: </strong>Advanced papillary thyroid carcinoma (PTC) exhibits significant heterogeneity. Understanding the gene expression programs underlying tumor heterogeneity is crucial for improving diagnostic and therapeutic strategies.</p><p><strong>Methods: </strong>We integrated single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data to explore transcriptional heterogeneity in PTC. Using consensus nonnegative matrix factorization (cNMF), we identified gene expression programs (GEPs) within malignant cells. A machine learning framework was applied to establish a lymph node metastasis (LNM) signature. Functional validation of key genes was performed through in vitro experiments, and drug screening was conducted to identify potential therapeutic candidates.</p><p><strong>Results: </strong>We identified an epithelial-mesenchymal transition (EMT)-related gene expression program, GEP3, which was strongly associated with LNM and poor clinical outcomes in PTC. Within the GEP3^high subcluster, we pinpointed ELF3 as a hub gene driving tumor invasiveness and angiogenesis. Notably, BRAF V600E mutations were associated with higher GEP3 expression levels, indicating that ELF3 may be a pivotal marker for aggressive disease progression, especially in BRAF-mutant PTC. Functional assays confirmed that ELF3 knockdown suppressed EMT and angiogenesis, reducing PTC cell migration and invasion. Regardless of whether they are positive or negative for BRAF V600E mutations, showed increased sensitivity to vemurafenib in higher ELF3 expression group.</p><p><strong>Conclusions: </strong>This study highlights the critical role of GEP and ELF3 in driving PTC progression and metastasis. Drug screening revealed that tanespimycin and vemurafenib were effective in targeting GEP3^high cells, offering therapeutic potential for aggressive PTC. These insights advance precision strategies for managing metastatic and heterogeneous PTC by targeting ELF3-driven pathways.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of oral nutrition on diabetic ketoacidosis resolution time: Retrospective Cohort study.","authors":"Başak Can, Zeynep Karaali","doi":"10.1007/s12020-025-04204-z","DOIUrl":"https://doi.org/10.1007/s12020-025-04204-z","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic ketoacidosis (DKA) is a serious disease that requires urgent and aggressive intervention. Although the medical treatments and protocols are well established, the role of oral nutrition during DKA treatment remains unclear. We aimed to evaluate the effect of oral nutritional status on the resolution rate of DKA.</p><p><strong>Material and methods: </strong>This retrospective cohort study is a single-centre study consisting of patients who were admitted with a diagnosis of DKA and were followed up in the ward. Patients were divided into two groups based on their oral nutrition status. The first group consisted of patients who received open oral nutrition during DKA treatment. The second group consisted of patients whose oral feeding was stopped until DKA resolved. Factors such as diabetes-related characteristics, DKA resolution time, and length of hospital stay were compared between the groups. The Chi-square test and Mann-Whitney U test were used for comparisons between groups.</p><p><strong>Results: </strong>Of the 51 DKA patients evaluated, 29 were in the open oral feeding group, while there were 22 patients in the oral feeding stopped group. The recovery time for DKA was 9.9 ± 9.1 h in the oral nutrition group and 20.2 ± 13.7 h in the oral nutrition stopped group (p < 0.001). The mean length of hospital stay was 5.9 ± 3.3 days in the oral nutrition group and 7.4 ± 5.9 days in the oral nutrition stopped group (p = 0.346). The mean anion gap normalization time was 12.5 ± 8.6 h in the open oral feeding group and, 22.6 ± 14 h in the oral feeding stopped group (p < 0.001).</p><p><strong>Conclusion: </strong>Oral nutrition until DKA resolves allows the patient to recover more quickly and have a shorter hospital stay. These findings suggest a relationship between oral nutrition and faster DKA recovery.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired renal function in patients with permanent hypoparathyroidism after thyroidectomy: analysis of a nationwide cohort in Spain.","authors":"Juan J Díez, Emma Anda, Begoña Pérez-Corral, Miguel Paja, Victoria Alcázar, Cecilia Sánchez-Ragnarsson, Aida Orois, Ana R Romero-Lluch, Marcel Sambo, Amelia Oleaga, Águeda Caballero, María R Alhambra, Virginia Urquijo, Ana M Delgado-Lucio, José C Fernández-García, Viyey K Doulatram-Gamgaram, Suset Dueñas-Disotuar, Tomás Martín, Mercedes Peinado, Julia Sastre","doi":"10.1007/s12020-025-04187-x","DOIUrl":"https://doi.org/10.1007/s12020-025-04187-x","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to assess the decline in renal function in patients with chronic postoperative hypoparathyroidism.</p><p><strong>Methods: </strong>We performed a multicenter, retrospective cohort study including patients with chronic hypoparathyroidism lasting ≥ 3 years. We evaluated the changes in serum creatinine and estimated glomerular filtration rate (eGFR) before surgery and at the last visit. Changes were evaluated in absolute value (ΔeGFR = eGFR at last visit - eGFR before thyroidectomy) and corrected for time (ΔeGFR/yr = ΔeGFR / time in years).</p><p><strong>Results: </strong>We included 236 patients with hypoparathyroidism (85.6% women, median age 47 [37-58] years, median time of follow-up 7.3 [5.0-11.0] years), and 458 control subjects with similar age, gender, and time of follow-up. Before thyroidectomy we found no significant differences in serum creatinine levels or eGFR between patients and controls. At the end of follow-up, ΔeGFR and ΔeGFR/yr in the patients with hypoparathyroidism were -4.87 (-17.0-0.00) ml/min/1.73 m² and -0.68 (-2.31-0.00) ml/min/1.73 m² per year, respectively, whereas in the control subjects these changes were 0.00 (-10.10-4.00) ml/min/1.73 m² (P < 0.001), and 0.00 (-1.34-0.54) ml/min/1.73 m² per year (P < 0.001). In multivariable regression analysis the annual eGFR decline in patients with hypoparathyroidism was related to age (P < 0.001), eGFR before thyroidectomy (P < 0.001), and incident nephrolithiasis (P = 0.028).</p><p><strong>Conclusion: </strong>The decline in renal function over time is significantly higher in patients with chronic hypoparathyroidism after thyroidectomy compared to thyroidectomized patients without hypoparathyroidism. Age, preoperative eGFR and nephrolithiasis are the main determinants of renal function loss in these patients.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indocyanine green angiography to evaluate immediate hypoparathyroidism after thyroid cancer surgery.","authors":"Carlos Eduardo Santa Ritta Barreira, Andre Povoa Miranda, Thaísa Fabiana Peixoto, Rodrigo Nascimento Pinheiro","doi":"10.1007/s12020-025-04210-1","DOIUrl":"https://doi.org/10.1007/s12020-025-04210-1","url":null,"abstract":"<p><strong>Introduction: </strong>Indocyanine green (ICG) fluorescence angiography has been introduced to assess parathyroid perfusion intraoperatively. This study aimed to evaluate whether the number of well-vascularized parathyroid glands identified using ICG fluorescence could predict the maintenance of adequate parathyroid hormone (PTH) levels in the immediate postoperative period.</p><p><strong>Materials and methods: </strong>A retrospective study was conducted on 150 consecutive patients who underwent total thyroidectomy for papillary thyroid cancer between March 2021 and December 2023. Parathyroid perfusion was assessed using ICG fluorescence angiography, and glands were classified on a scale from 0 (no vascularization) to 2 (good vascularization). PTH levels were measured 1 h postoperatively, and biochemical hypoparathyroidism was defined as PTH < 15 pg/dL. Statistical analyses were performed using Fisher's exact test and Chi-square test, with p < 0.05 considered significant.</p><p><strong>Results: </strong>Transient biochemical hypoparathyroidism occurred in 34.7% of patients. Among patients with two or more well-vascularized parathyroid glands (score 2), 70.2% did not experience a decrease in parathyroid hormone levels below 15 pg/mL (NPV 70.2%, 95% CI: 62.4-78.1%). However, 29.8% of patients with two or more well-vascularized glands still developed hypoparathyroidism, highlighting the limitations of using this metric alone to predict postoperative outcomes. The overall accuracy for predicting hypoparathyroidism was 70% (95% CI: 62.7-77.3%). No patient developed permanent hypoparathyroidism.</p><p><strong>Conclusion: </strong>ICG fluorescence angiography is a reliable tool for assessing parathyroid gland perfusion during thyroidectomy. However, the identification of two or more well-vascularized parathyroid glands does not completely exclude the risk of transient hypoparathyroidism, indicating that additional factors must be considered in predicting postoperative outcomes.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of corticoresistance in patients with thyroid eye disease and use of rituximab as a second-line treatment.","authors":"Klara Pekarova, Jan Schovanek, Roman Dohnal, Martin Radvansky, David Karasek, Marta Karhanova","doi":"10.1007/s12020-024-04108-4","DOIUrl":"10.1007/s12020-024-04108-4","url":null,"abstract":"<p><strong>Purpose: </strong>High-dose intravenous glucocorticoids are the standard first-line treatment in active, moderate to severe and severe thyroid eye disease (TED). We evaluate the usefulness of clinical activity score (CAS) and thyroid-stimulating immunoglobulin (TSI) as predictors and/or post-treatment markers of corticoresistance in patients with TED and the effect of rituximab in second-line treatment.</p><p><strong>Methods: </strong>We enrolled 236 patients with an active TED into this retrospective single-tertiary-center cohort study. All patients were initially treated with high-dose systemic glucocorticoids. Rituximab was later administered to 29 of 42 corticoresistant patients.</p><p><strong>Results: </strong>The CAS of the corticoresistant patients was significantly higher both before (p = 0.0001) and after (p = <0.0001) first-line treatment compared to the corticosensitive group. ROC analysis established the cut-point value as CAS ≥ 2.5 with a sensitivity of 96.3%, specificity of 57.5% and area under the curve of 82.8%. In 22 patients treated with rituximab, CAS gradually decreased to zero values without reactivation during extended follow-up. There was no difference in the TSI of corticosensitive and corticoresistant patients before or after first-line therapy.</p><p><strong>Conclusion: </strong>CAS ≥ 2, after first-line treatment, could be used as a corticoresistance marker. Corticoresistant patients should be subject to long-term follow-up for early detection of reactivation to reduce the delay to second-line treatment. Rituximab is a well-tolerated choice of second-line treatment and has a long-lasting effect on disease activity. Although TSI is a valuable biomarker of Graves' disease and TED activity, according to our results, TSI cannot be used as a marker of corticoresistance.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1112-1119"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is peptide receptor radionuclide therapy still a promising option for medullary thyroid carcinoma?","authors":"Fernanda Accioly de Andrade, Daniel Bulzico, Rossana Corbo, Fernanda Vaisman","doi":"10.1007/s12020-024-04114-6","DOIUrl":"10.1007/s12020-024-04114-6","url":null,"abstract":"<p><p>Medullary thyroid carcinoma (MTC) is a rare cancer that originates from germline RET proto-oncogene mutations in all hereditary forms and from somatic RET mutations in most sporadic cases. Currently, highly selective RET inhibitors have been approved for clinical use in patients with RET mutations with persistent, recurrent or metastatic disease. This therapy has proven efficacy, low toxicity, and a limited impact on patients' quality of life. However, for recurrent or metastatic RET-negative disease, few systemic therapies are available. Multikinase inhibitors are used; however, tumour cells frequently develop resistance mechanisms, or treatment must be discontinued due to the high incidence of side effects. In this context, peptide receptor radionuclide therapy (PRRT) may be a treatment option, but its clinical utility remains under investigation. The aim of this review is to evaluate the evidence of PRRT in MTC and discuss its limitations in the RET inhibitor era.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"943-950"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there still a place for etomidate in the management of Cushing's syndrome? The experience of a single center of low-dose etomidate and combined etomidate-osilodrostat treatment in severe hypercortisolemia.","authors":"Lukasz Dzialach, Joanna Sobolewska, Wioleta Respondek, Agnieszka Wojciechowska-Luzniak, Pawel Kuca, Przemysław Witek","doi":"10.1007/s12020-024-04135-1","DOIUrl":"10.1007/s12020-024-04135-1","url":null,"abstract":"<p><strong>Purpose: </strong>Severe Cushing's syndrome (SCS) is a life-threatening endocrine condition that requires prompt medical intervention. Intravenous etomidate infusion is considered to be the most effective in rapid cortisol overproduction inhibition. This single-center retrospective study aimed to present the safety and effectiveness of intravenous, low-dose, lipid-formulated etomidate infusion in patients with SCS.</p><p><strong>Methods: </strong>Seven patients with complicated SCS related to ectopic ACTH syndrome (n = 6) or Cushing's disease (n = 1) who received low-dose etomidate infusion as a part of their cortisol-lowering treatment between April 2019 and April 2024 in the Department of Internal Medicine, Endocrinology and Diabetes of Medical University of Warsaw were included in the study. A continuous etomidate infusion was initiated at 0.01-0.02 mg/kg/h.</p><p><strong>Results: </strong>In all patients, rapid control of hypercortisolemia was achieved with a median time of 30 h (range: 12-48 h). Median serum cortisol concentration reduced from 101.9 μg/dL (range: 78.2-119.6 μg/dL) before etomidate to 19.5 μg/dL (range: 18.3-22.5) after 72 h of etomidate treatment. Etomidate infusion was followed by etomidate and osilodrostat combined treatment and then osilodrostat monotherapy in four patients; one patient underwent adrenalectomy, and two patients died during etomidate infusion due to complications of advanced malignancy.</p><p><strong>Conclusions: </strong>This study shows that low-dose and short-term lipid formulation etomidate therapy is highly effective in severe hypercortisolemia management. Combined therapy with etomidate and osilodrostat is well tolerated and could serve as a bridge in long-term SCS treatment.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1305-1313"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the impact Of ChatGPT support on acromegaly management and patient education.","authors":"Ekin Yiğit Köroğlu, Reyhan Ersoy, Muhammed Saçıkara, Fatma Dilek Dellal Kahramanca, Şefika Burçak Polat, Oya Topaloğlu, Bekir Çakır","doi":"10.1007/s12020-024-04086-7","DOIUrl":"10.1007/s12020-024-04086-7","url":null,"abstract":"<p><strong>Purpose: </strong>ChatGPT is a widely used artificial intelligence modeling tool. Healthcare is one potential area of use of ChatGPT. This study aimed to test the usability and reliability of ChatGPT in acromegaly, which is less known in society and should be evaluated by a group of specialized physicians.</p><p><strong>Methods: </strong>The study is designed in two parts. For the first part, 35 questions regarding acromegaly that patients frequently ask were identified, and these questions were asked to ChatGPT. In the second part, four patient examples were presented to ChatGPT using medical terminology. Three experts evaluated ChatGPT's answers to the questions and approaches in case management using 7-point scales in terms of safety, reliability, correctness, and usability.</p><p><strong>Results: </strong>When the ChatGPT answers to the patient's questions were evaluated, a mean score of 6.78 ± 0.55 was given for correctness and 6.69 ± 0.60 for reliability. The mean scores given by the raters for correctness, safety and usability in the evaluation of the cases were as follows: 6.33 ± 0.88, 6.16 ± 0. 71 and 6.08 ± 0.79 points for case 1; 5.35 ± 1.88, 5.29 ± 1.80 and 5.20 ± 1.86 points for case 2; 6.08 ± 0.97, 6.00 ± 0.93 and 5.91 ± 0.82 points for case 3; 6.10 ± 1.29, 6.13 ± 1.30 and 6.16 ± 1.14 points for case 4.</p><p><strong>Conclusion: </strong>ChatGPT can actively answer the questions of acromegaly patients. Although it is not a reliable source alone in managing patients with acromegaly, it can be a supportive tool for physicians.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1141-1149"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical expression of ephrin receptors in neuroendocrine neoplasms: a case-series of gastroenteropancreatic neuroendocrine neoplasms and a systematic review of the literature.","authors":"Krystallenia I Alexandraki, Eirini Papadimitriou, Ariadni Spyroglou, Angeliki Karapanagioti, Ioanna Antonopoulou, Irini Theohari, Odysseas Violetis, Georgios C Sotiropoulos, Stamatios Theocharis, Gregory A Kaltsas","doi":"10.1007/s12020-024-04079-6","DOIUrl":"10.1007/s12020-024-04079-6","url":null,"abstract":"<p><strong>Purpose: </strong>Erythropoietin-producing hepatocellular (EPH) receptors are the largest known family of tyrosine kinases receptors (TKR) in humans, implicated in cell proliferation, adhesion, migration, tumor angiogenesis, invasion and metastasis. The aim of the present study is to assess the expression of EPHs in neuroendocrine neoplasms (NENs).</p><p><strong>Methods: </strong>Immunohistochemical staining of specimens of 30 patients with gastroenteropancreatic and lung NENs was performed for EPH-A1, EPH-A2, EPH-A4, EPH-A5 protein expression, in addition to ki-67 multiplication index and programmed death-ligand 1. Additionally, we performed a systematic review of the available literature in three different databases reporting on the expression of EPH in all neuroendocrine neoplasms.</p><p><strong>Results: </strong>Positive expression was seen in 16/19 (84%) specimens for EPH-A1, 15/23 (65%) for EPH-A2, 21/24 (88%) for EPH-A4, 24/26 (92%) for EPH-A5. EPH-A1 was expressed in 9/9 pancreatic, 3/4 small intestine, but not in one lung NEN, EPH-A2 in 5/10 pancreatic, 3/4 small intestine and lung, and in one of each of gastric, appendix, colorectal, and cervical NENs, respectively. EPH-A4 showed positive expression in 9/11 pancreatic, 4/4 small intestine, 3/3 lung specimens and EPH-A5 in 10/11, 4/4 and 4/4, respectively. Data retrieved from the systematic review of the literature in combination with the data from the present study are suggestive of a frequent EPH expression in pituitary, thyroid, lung and gastroenteropancreatic NENs, yet, with varying expressions of the single receptor subtypes.</p><p><strong>Conclusion: </strong>EPHs may have a role in NEN tumorigenesis, prognosis as well as a role in the evolving molecular-targeted therapies.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1323-1332"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}