Endocrine最新文献

{"title":"Knowledge, attitudes, and practices of healthcare professionals regarding medical nutrition therapy for type 2 diabetes: a multicenter cross-sectional study.","authors":"Xiaohong Xu, Juan Yuan, Man Zhan, Xue Li, Jie Peng, Wei Lu, Liangshu Wu, Chang Zheng, Lingfang Tian","doi":"10.1007/s12020-025-04320-w","DOIUrl":"https://doi.org/10.1007/s12020-025-04320-w","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate healthcare professionals' knowledge, attitudes, and practices (KAP) concerning medical nutrition therapy (MNT) for type 2 diabetes.</p><p><strong>Methods: </strong>A multicenter, cross-sectional study was conducted between September and October 2024 across hospitals of various levels in Guiyang City, China. Participants included healthcare professionals who voluntarily agreed to take part in the study. We included healthcare professionals from the entire hospital system to capture a broad perspective on the knowledge, attitudes, and practices towards MNT for type 2 diabetes, reflecting the multidisciplinary nature of diabetes care. Data on demographic characteristics and KAP scores were collected using a self-administered questionnaire.</p><p><strong>Results: </strong>A total of 1348 (90.77%) valid questionnaires were analyzed. Of the respondents, 1254 (93.03%) were female, 491 (36.42%) had 5-10 years of work experience, and 700 (51.93%) were actively engaged in the care and nutritional management of patients with type 2 diabetes. The mean ± SD knowledge, attitude, and practice scores were 14.18 ± 4.80 (possible range: 0-20), 36.73 ± 3.67 (possible range: 9-45), and 27.13 ± 5.27 (possible range: 7-35), respectively. Structural equation modeling show that knowledge has had specific effects on attitudes (β = 0.464, P < 0.001) and practice (β = 0.681, P < 0.001), as well as attitudes had a specific effect on practice (β = 0.491, P < 0.001).</p><p><strong>Conclusion: </strong>Healthcare professionals demonstrated suboptimal knowledge but maintained positive attitudes and proactive practices regarding MNT for type 2 diabetes. Targeted educational programs should be developed to enhance healthcare professionals' knowledge, as this could further strengthen their attitudes and practices, ultimately improving patient outcomes in MNT for type 2 diabetes.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in autoimmune thyroid diseases between females and males: the result of a complex interconnection of factors.","authors":"Fiammetta Battheu, Cristina Clausi, Simona Censi, Caterina Mian","doi":"10.1007/s12020-025-04317-5","DOIUrl":"https://doi.org/10.1007/s12020-025-04317-5","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this paper is to review the scientific evidence for the link between autoimmune thyroid diseases (AITDs) and sex, and the plausible causes of the female prevalence in AITDs.</p><p><strong>Methods: </strong>An extensive literature search of published articles was conducted using online search engines.</p><p><strong>Results: </strong>AITDs are more frequent in the female sex. Numerous studies have focused on the differences between males and females in their presentation of AITD and their response to therapy, sometimes with conflicting results. Several factors are considered to be responsible for the higher incidence of AITDs in females, crucial among which is the relationship between sex hormones and the immune system. In addition to hormones, there is also evidence that sex chromosomes, epigenetic factors, foetal microchimerism, the microbiota and endocrine-disrupting chemicals (EDCs) play an important role in the predisposition of females to AITDs.</p><p><strong>Conclusion: </strong>The prevalence of AITDs in the female sex appears to be attributable to numerous factors, the most important being the influence of sex hormones on the immune system.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal lesions in patients with abdominal multitrauma.","authors":"Anna Kistner, Lisa Kekonius, Jan Calissendorf, Seppo Koskinen, Henrik Falhammar","doi":"10.1007/s12020-025-04321-9","DOIUrl":"https://doi.org/10.1007/s12020-025-04321-9","url":null,"abstract":"<p><strong>Purpose: </strong>Most adrenal lesions are less than 2 cm and can easily be ignored during primary review of computed tomography (CT)-scans with another question. Furthermore, adrenal lesions, including adrenal hematomas, can easily be missed in patients with multitrauma. We aimed to determine the incidence of adrenal lesions in patients with multitrauma.</p><p><strong>Methods: </strong>This retrospective, single-center cohort analysis included 1373 patients with multitrauma (71.2% males) with a mean age of 42 (95%CI 41-43) years. One radiologist re-examined all multitrauma CT performed 2013-2017 using thin sliced imaging in at least two depictions. A second radiologist re-examined patients where an abnormality was found. Adrenal abnormalities were labelled adrenal lesions (size ≥10 mm) or hematomas, respectively. Clinical data were collected.</p><p><strong>Results: </strong>The adrenal lesion prevalence was 2.7% (37/1373, 78% males, 22% bilateral). Of these 27% (10/37) were mentioned in the radiological report, and in those with a size ≥15 mm (n = 13), 38% (5/13) were mentioned. Of the unilateral adrenal lesions 86% (25/29) were left-sided. In the adrenal lesion group during the mean follow-up time of 75 (61-90) months none had surgery, 6% had hormones measured (all normal), and 7% had repeated adrenal imaging. The adrenal hematoma prevalence was 5.0% (68/1373, 10% bilateral). No patient had both an adrenal hematoma and an adrenal lesion. Of the unilateral hematomas 42% (26/62) were not mentioned. Of the hematomas 77% were right-sided. No patient with adrenal abnormalities had signs of adrenal insufficiency. 30-day survival rates in the adrenal lesion and hematomas groups were similar, but the hematoma group had higher injury severity score, but no longer length of hospital stay.</p><p><strong>Conclusions: </strong>The prevalence of adrenal tumors was 2.7% and adrenal hematomas 5.0%. Most lesions were not mentioned in the image report. Few had hormonal evaluation or adrenal imaging follow-up. Survival rates were similar between the two groups.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of remission and recurrence of Cushing's disease following transsphenoidal surgery (TSS): a single center, 20-year, retrospective series.","authors":"Dana Bar Natan, Merav Serebro, Zvi Ram, Rachel Grossman, Naomi Even Zohar, Yael Sofer, Iris Yaish, Yona Greenman, Karen Tordjman","doi":"10.1007/s12020-025-04304-w","DOIUrl":"https://doi.org/10.1007/s12020-025-04304-w","url":null,"abstract":"<p><strong>Purpose: </strong>Cushing's disease (CD) is a rare condition with variable surgical outcomes. This study aimed to assess remission and recurrence rates in CD patients undergoing transsphenoidal surgery (TSS) at a major Israeli referral center, and to identify predictive factors for these outcomes. We hypothesized that microadenomas would have higher remission rates than macroadenomas.</p><p><strong>Methods: </strong>This retrospective analysis included 97 CD patients who underwent TSS at Tel Aviv Sourasky Medical Center (2002-2022). Remission was defined by biochemical criteria and clinical improvement. Suspected recurrence was confirmed by pathological dexamethasone suppression and/or elevated urinary free cortisol. Univariate and multivariate analyses identified predictors of remission, while Kaplan-Meier survival analysis and Cox proportional hazard modeling determined factors associated with recurrence.</p><p><strong>Results: </strong>The overall remission rate was 63.9%, with no significant difference between microadenomas (58.7%) and macroadenomas (73.5%), a finding confirmed in a sensitivity analysis limited to cases with pathologically confirmed adenomas. Multivariate logistic regression showed predictors of remission were adenoma presence in pathology specimens (OR = 31.25, P < 0.001) and first-time surgery status (OR = 9.42, P = 0.002), while younger age was a contributory factor (OR = 0.963, P = 0.05). The relapse rate was 22.6% over a median follow-up of 63 [IQR 35-109.5] months. Glucocorticoid withdrawal syndrome emerged as a novel protective factor against recurrence (P = 0.045).</p><p><strong>Conclusions: </strong>This largest analysis of TSS outcomes for CD in Israel challenges established notions about remission predictors, including our initial hypothesis about microadenomas. The identification of glucocorticoid withdrawal syndrome as a predictor of long-term remission provides a potential avenue for post-operative monitoring in the local healthcare context.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for postpartum prediabetes and type 2 diabetes in women with gestational diabetes: insights from the edugest study in Argentina.","authors":"J F Elgart, S Salzberg, E Mendez, P Pereyra, N I Gimenez, S Paco Leaños, L A Otiñano Merlo, M A Barrios, I Oliveros, A M Tetta Mirabal, E Sosa, S Rueda, M I Argerich, R A David, C V Farias, S Gorban de Lapertosa","doi":"10.1007/s12020-025-04313-9","DOIUrl":"https://doi.org/10.1007/s12020-025-04313-9","url":null,"abstract":"<p><strong>Aim: </strong>To describe postpartum glycemic status in a cohort of women with Gestational diabetes (GD) from the EDUGEST (Education in women with GD) study, and to determine factors associated with a diagnosis of prediabetes or T2D.</p><p><strong>Methods: </strong>This observational, analytical study analyzed records of pregnant women with GD recruited in the framework of the EDUGEST study. Data from QUALIDAB-GEST were analyzed for patients who completed postpartum glycemic assessment at six weeks. Information included concurrent cardiovascular risk factors, obstetric history in previous pregnancies, clinical and metabolic indicators, treatments, and postpartum screening results. Descriptive analyses were performed using means ± standard deviation (SD), medians with interquartile ranges [IQR], or proportions, as appropriate. Differences were tested using parametric and non-parametric tests. Regression models assessed factors associated with prediabetes or T2D development postpartum.</p><p><strong>Results: </strong>The analysis included 573 patients (median age: 31 [26-36] years; median gestational age at the first specialty visit after GD diagnosis: 28 [26-32] weeks; BMI: 31.2 [26.7-34.9]). Postpartum screening showed 76.3% normal results, 19.5% prediabetes, and 4.2% T2D. T2D was significantly associated with insulin use during pregnancy (OR: 4.20) and family history of diabetes (OR: 3.21), while prediabetes was associated with hypertension (OR: 2.39), insulin use during pregnancy (OR: 1.62), BMI al the first specialty visit (OR: 1.05), and fructosamine levels (OR: 1.01).</p><p><strong>Conclusion: </strong>This study identified locally relevant parameters associated with postpartum prediabetes and T2D in women with GD, highlighting the importance of early identification of high-risk patients and the role of postpartum glycemic assessment for timely diagnosis.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis unveils dysregulation of the tumor immune microenvironment and development of a machine learning-based multi-gene classifier for predicting lateral lymph node metastasis in papillary thyroid carcinoma.","authors":"Qingxiang Yu, Weijing Hao, Yanbin He, Xianhui Ruan, Lin Liu, Xinwei Yun, Dapeng Li, Jingzhu Zhao, Wenfeng Cao, Yu Yin, Linfei Hu, Xuan Qin, Ming Gao, Lei Zhang, Xiangqian Zheng","doi":"10.1007/s12020-025-04308-6","DOIUrl":"https://doi.org/10.1007/s12020-025-04308-6","url":null,"abstract":"<p><strong>Purpose: </strong>Lateral lymph node metastasis (LNM) critically influences surgical decision-making in papillary thyroid carcinoma (PTC). However, the sensitivity of preoperative imageological examination in detecting LNM remains suboptimal, necessitating the development of more accurate diagnostic and predictive tools. This study aims to identify multi-omics biomarkers and construct a predictive model for LNM.</p><p><strong>Methods: </strong>We performed a comprehensive multi-omics analysis of 50 PTCs presenting with (LNM group) or without lateral lymph node metastases (LNN group) using whole exome sequencing and whole transcriptome sequencing.</p><p><strong>Results: </strong>Younger age, larger tumor size, and lymphovascular invasion were associated with increased risk of LNM, while invasive follicular subtype was associated with lower risk of LNM. Genomic landscape analysis identified 23 LNM group specific driver mutations and 15 protective variants in the LNN group. Transcriptome analysis identified 444 differentially expressed genes associated with LNM. Weighted gene co-expression network analysis revealed a module that correlated negatively with LNM, with key genes significantly enriched in Notch signaling pathway and Apelin signaling pathway. Notably, elevated neutrophils in tumor immune microenvironment was strongly associated with high LNM risk, suggesting neutrophils as potential early predictors of lateral lymph node metastasis in PTC. A machine learning-based multi-gene classifier was developed to predict LNM, achieving excellent performance with an area under the curve (AUC) of 0.98 in the training set and 0.892 in the test set.</p><p><strong>Conclusions: </strong>This study provides novel insights into the molecular characteristics of PTC associated with lateral lymph node metastasis, highlighting tumor-infiltrating neutrophils as an independent LNM predictor. The multi-gene classifier developed in this study demonstrates promising clinical utility for improving the accuracy of LNM prediction and guiding personalized treatment strategies in PTC.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the annual cost burden of diabetic peripheral neuropathy in the United States.","authors":"Eric P Borrelli","doi":"10.1007/s12020-025-04318-4","DOIUrl":"https://doi.org/10.1007/s12020-025-04318-4","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic peripheral neuropathy (DPN) is one of the leading complications of diabetes. Given the significant growth in prevalence of diabetes and therefore DPN in the United States in recent years, a quantitative analysis is needed to estimate the annual cost burden of DPN.</p><p><strong>Methods: </strong>A cost-of-illness burden model was created to estimate the cost burden on DPN in the United States. A review of the literature was undertaken to identify the most appropriate epidemiologic and economic inputs. One-way sensitivity analyses were conducted for every model input parameter to show the potential variability in the estimated cost-burden.</p><p><strong>Results: </strong>There is an estimated prevalence of approximately 13,209,600 patients with DPN in the U.S., with an estimated annual cost burden from DPN of $45,930,580,972. Of the estimated cost burden, $30,859,424,749 was from DPN specific care ($2,389,038,060 for outpatient office visits, $26,830,282,752 for inpatient hospitalizations, and $1,640,103,936 from prescription medications) and $15,071,156,223 from treating incident DPN complications ($12,875,200,000 for diabetic foot ulcers and $2,195,956,223 for diabetic lower limb amputations).</p><p><strong>Conclusions: </strong>DPN is a very costly condition, and the burden is expected to continue to grow in the coming years.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levothyroxine absorption test in patients with refractory hypothyroidism: how to interpret patient's response to the test?","authors":"Ibtissem Oueslati, Ameni Terzi, Meriem Yazidi, Elyes Kamoun, Moncef Feki, Melika Chihaoui","doi":"10.1007/s12020-025-04312-w","DOIUrl":"https://doi.org/10.1007/s12020-025-04312-w","url":null,"abstract":"<p><strong>Introduction: </strong>Levothyroxine (LT4) absorption test is indicated in patients with refractory hypothyroidism to distinguish between pseudo-malabsorption and malabsorption. However, this test is not standardized and its interpretation remains controversial. The aim of the present study was to evaluate the different interpretations of the LT4 absorption test to confirm or infirm a disorder of LT4 absorption in patients with refractory hypothyroidism.</p><p><strong>Methods: </strong>This was a retrospective study including patients who were admitted for refractory hypothyroidism. LT4 absorption test was performed in all patients. Four different equations were used to interpret the test: The LT4 absorption rate, FT4 increment, FT4 increase rate, and FT4 ratio. Celiac disease serology and digestive endoscopy with biopsy were performed in all patients.</p><p><strong>Results: </strong>Seven patients were enrolled in this study. Their median age was 38 years. The median duration of hypothyroidism was 2.6 years. The median dose of LT4 was 4 µg/kg/day. Before the LT4 absorption test, the median TSH and FT4 levels were 72.59 mIU/L and 0.52 ng/dL, respectively. Using LT4 absorption rate and FT4 ratio formulas, the test was consistent with the diagnosis of malabsorption in all patients. However, when using FT4 increase rate, four patients (P1, P2, P4, and P5) had malabsorption and three patients (P3, P6, and P7) had pseudo-malabsorption. According to the FT4 increment, six patients (P1, P2, P4, P5, P6, and P7) had malabsorption and one patient (P3) had pseudo-malabsorption. Etiological investigations revealed the presence of Helicobacter pylori gastritis in four patients (P1, P2, P4, and P5). Patients 3, 6, and 7 admitted non-compliance with LT4 treatment when confronted with evidence about pseudo-malabsorption.</p><p><strong>Conclusion: </strong>The FT4 increase rate seemed more effective than LT4 absorption rate, FT4 ratio, and FT4 increment in differentiating pseudo-malabsorption from malabsorption. However, further multicenter studies involving larger sample sizes would be useful to confirm these findings.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild chronic post-natal pain induces endocrine and metabolic alterations associated to enlargement in pituitary glands size in adult CD-1 male mice.","authors":"Teresa Dipol, Andrea Fortuna, Ornella Morsilli, Valentina Zecca, Taljinder Singh, Gianmauro Palombelli, Fabrizio Mattei, Vittoria Favero, Niccolò Candelise, Zaira Maroccia, Alberto Loizzo, Roberto Rimondini, Gabriele Campana, Natalia Simona Pellegata, Stefano Loizzo, Rossella Canese, Iacopo Chiodini","doi":"10.1007/s12020-025-04297-6","DOIUrl":"https://doi.org/10.1007/s12020-025-04297-6","url":null,"abstract":"<p><strong>Background: </strong>Human adverse childhood experiences (ACEs) are associated with various types of mental and physical pathological outcomes in adulthood. Among them, they may present the enlargement of the pituitary gland and have been suggested to be a risk factor for the development of Cushing syndrome. Previously, we showed on outbred CD-1 male mice that chronic pain induced during the weaning time by pharmacological experimental design procedures caused endocrine and metabolic alterations in adulthood, suggestive of human mild hypercortisolism. Specifically, we observed an increase in pituitary glands weight and in adrenocorticotropic hormone (ACTH) expression, associated with the lack of the negative feedback mechanisms exerted by corticosterone that controls proopiomelanocortin- derived ACTH secretion.</p><p><strong>Methods: </strong>Here, to better understand the phenotype of mice subjected to early-life pain (ELP), their pituitary glands were examined. Mice tissues and plasma hormones measurements were conducted by ELISA assays. Analysis of brain and pituitary gland was performed using anatomic and diffusion-weighted magnetic resonance imaging. Hematoxylin and eosin-stained sections of pituitary glands were also examined.</p><p><strong>Results: </strong>Mice subjected to ELP showed an increase in total body weight, in pituitary ACTH expression and in plasmatic corticosterone levels. Imaging of the pituitary glands revealed a significant increment of their volume without apparent pathological alterations.</p><p><strong>Conclusion: </strong>The findings of this study may support the role of ELP as a risk factor for ACTH-dependent hypercortisolism in adulthood associated with an enlarged pituitary gland.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of oral contraceptive use on muscle mass and strength in women with PCOS.","authors":"Seren Aksun, Levend Karaçoban, Ilkay Idilman, Bulent O Yildiz","doi":"10.1007/s12020-025-04305-9","DOIUrl":"https://doi.org/10.1007/s12020-025-04305-9","url":null,"abstract":"<p><strong>Purpose: </strong>Polycystic ovary syndrome (PCOS) is characterized by androgen excess and ovulatory dysfunction and appears to be associated with alterations in muscle mass and function. The study aims to investigate whether oral contraceptive (OC) use affects muscle mass and strength in women with PCOS.</p><p><strong>Methods: </strong>Twenty women with PCOS (median age 20.5 years and BMI 26.1 kg/m²) and 20 age- and BMI-matched healthy controls were included. Clinical, hormonal, and biochemical assessments were conducted along with body composition analyses using magnetic resonance imaging (MRI) proton density fat fraction (PDFF%) and muscular strength assessment by isokinetic dynamometry. In women with PCOS, measurements were repeated after at least three cycles of OC therapy.</p><p><strong>Results: </strong>At baseline, women with PCOS exhibited significantly higher levels of total testosterone, free androgen index (FAI), and homeostasis model assessment of insulin resistance (HOMA-IR) levels compared to healthy controls (p < 0.001, p = 0.001, p = 0.004, respectively). PCOS group also showed significantly higher average power (AvP) of knee extensors at 60°/sec (p = 0.002). AvP correlated positively with total testosterone and FAI levels in the whole study group (r = 0.450, p = 0.004, r = 0.318, p = 0.045, respectively). Following OC therapy, testosterone levels and FAI decreased (p = 0.02 and p < 0.001, respectively); whereas thigh muscle mass or lower limb strength remained unchanged.</p><p><strong>Conclusions: </strong>Short-term OC use in women with PCOS led to a reduction in androgen excess without measurable effects on muscle composition or strength. These findings suggest that muscle function and composition remain stable over the short term, despite hormonal modulation. Further research is required to understand how long-term management strategies for PCOS might affect muscle mass and function.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}