International Journal of Lower Extremity Wounds最新文献_第9页

The Role of Negative Pressure Wound Therapy (NPWT) in the Management of Vasculitic Wounds: Case Series of Eight Patients. 负压伤口疗法（NPWT）在血管性伤口管理中的作用：八名患者的病例系列。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-12-08 DOI: 10.1177/15347346211063700

Kirsi Isoherranen, Nicolas Kluger, Katariina Hannula-Jouppi, Liisa Väkevä

引用次数: 0

Is a Left-to-Right >2.2°C Difference a Valid Measurement to Predict Diabetic Foot Ulceration in People with Diabetes and a History of Diabetic Foot Ulceration? 左右温差大于 2.2°C 是预测有糖尿病足溃疡史的糖尿病患者发生糖尿病足溃疡的有效测量值吗？

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-12-20 DOI: 10.1177/15347346211062719

Jill Featherston, Anke M Wijlens, Jaap J van Netten

{"title":"Is a Left-to-Right >2.2°C Difference a Valid Measurement to Predict Diabetic Foot Ulceration in People with Diabetes and a History of Diabetic Foot Ulceration?","authors":"Jill Featherston, Anke M Wijlens, Jaap J van Netten","doi":"10.1177/15347346211062719","DOIUrl":"10.1177/15347346211062719","url":null,"abstract":"Monitoring foot skin temperatures at home have been shown to be effective at preventing the occurrence of diabetic foot ulcers. In this study, the construct validity of using >2.2°C difference between contralateral areas on the foot as a warning sign of imminent ulceration is explored. Thirty participants with diabetes at high risk of ulceration (loss of protective sensation and previous ulceration and/or amputation) monitored their foot temperatures at six sites, four times a day for six days using a handheld infrared thermometer. Walking activity, time of day, and environmental temperature were also monitored and correlated with foot temperatures. We found that contralateral mean skin temperature difference was 0.78°C at baseline. At single sites, left-to-right temperature differences exceeding the threshold were found in 9.6% of measurements (n = 365), which reduced to 0.4% when individually corrected and confirmed the next day. No correlation was found between contralateral temperature differences and activity, time of day, and environmental temperature. We conclude that using a >2.2°C difference is invalid as a single measurement in people at high risk of ulceration, but the construct validity is appropriate if both individual corrections and next day confirmation are applied.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"428-435"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39850466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitivity of the Wound Edge Gene Signature "WD14" in Responding to Clinical Change: A Longitudinal Cohort Study. 伤口边缘基因特征 "WD14 "对临床变化的敏感性：纵向队列研究

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-11-18 DOI: 10.1177/15347346211056786

David C Bosanquet, Ryan Laloo, Andrew J Sanders, Fiona Ruge, Jane Lane, Ceri A Morris, Wen G Jiang, Keith G Harding

{"title":"Sensitivity of the Wound Edge Gene Signature \"WD14\" in Responding to Clinical Change: A Longitudinal Cohort Study.","authors":"David C Bosanquet, Ryan Laloo, Andrew J Sanders, Fiona Ruge, Jane Lane, Ceri A Morris, Wen G Jiang, Keith G Harding","doi":"10.1177/15347346211056786","DOIUrl":"10.1177/15347346211056786","url":null,"abstract":"Introduction: WounD14 (WD14) gene signature is a recently developed tool derived from genetic interrogation of wound edge biopsies of chronic venous leg ulcers to identify heard-to-heal wounds and enable clinicians to target aggressive therapies to promote wound healing. This study aimed to evaluate if changes in wound clinical healing status were detected by the WD14 gene signature over time as this is currently poorly understood. Material and methods: WD14 was developed through gene screening and subsequent validation in 3 patient cohorts involving 85 consecutive patients with chronic venous leg ulcers referred to a tertiary wound healing unit. Patients underwent a wound edge biopsy to interrogate for a \"healing\" or \"non-healing\" genotype. A smaller cohort (18%) underwent a second biopsy, which comprised this pilot cohort reported herein. Twelve weeks following biopsy, wounds were clinically assessed for healing status based on reduction in size and compared to WD14 genotype. Results: Sequential biopsies and WD14 scores were derived from 16 patients. WD14 signature predicted wound healing status among this cohort at either visit (32 wound edge biopsies) with a positive predictive value (PPV) of 85.2% (95% CI 74.1%-92.0%) and negative predictive value (NPV) of 80.0% (95% CI 34.2%-96.9%). A total of 6 wounds underwent altered clinical status between the 2 visits. In this cohort, WD14 has a PPV of 66.7% (95% CI 47.3%-81.7%) and NPV of 100%. Conclusion: Although the WD14 gene signature did change with wound healing status, larger studies are required to precisely clarify its role and ability to prognosticate wounds of differing clinical status over time.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"390-396"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39901987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Charcot Foot: An Emerging Public Health Problem for African Diabetes Patients. 夏科足：非洲糖尿病患者新出现的公共卫生问题。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-12-09 DOI: 10.1177/15347346211066684

Zulfiqarali G Abbas, J K Lutale, C Formosa, A Gatt, N Chockalingam

{"title":"The Charcot Foot: An Emerging Public Health Problem for African Diabetes Patients.","authors":"Zulfiqarali G Abbas, J K Lutale, C Formosa, A Gatt, N Chockalingam","doi":"10.1177/15347346211066684","DOIUrl":"10.1177/15347346211066684","url":null,"abstract":"Background: Although the awareness, diagnosis, management of the complications associated with diabetes have improved in African countries over the past decade, surveillance activities in Tanzania and anecdotal reports from other African countries have suggested an increased prevalence of Charcot Neuroarthropathy (CN) over the past few years. Aim: To characterize the epidemiology and the clinical burden of CN in a large diabetes population in Tanzania, and to evaluate outcomes of persons with the condition. Methods: This was a prospective analytic cohort study conducted between January 2013 through December 2015. Following informed consent, patients were followed at the outpatient clinic. Detailed clinical assessments and documented presence of diabetic peripheral neuropathy (DPN), macrovascular disease and microvascular disease were recorded. Education and counseling were part of the follow-up program. Results: 3271 ulcerations were presented at the clinic during the 3-year study period. 571 (18%) met the case definition for CN; all patients had Type 2 diabetes. The prevalence for each of the years 2013, 2014, and 2015 was 19/1192 (1.6%), 209/1044 (20%), and 343/1035 (34%), respectively; the increases in the slope of the trendline was statistically significant (P < .001). Conclusion: The prevalence of CN is increasing in the Tanzanian diabetes patient population, and is strongly associated with neuropathy. CN can lead to severe deformity, disability, and amputation. Due to the risk of limb amputation, patients with diabetes must seek immediate care if signs or symptoms appear and avoid delay in seeking medical attention. Early diagnosis of CN by caregivers is extremely important for successful outcomes.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"464-468"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39582063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Adherence to the Oral Antibiotic Treatment in Patients With Diabetic Foot Infection. 对糖尿病足感染患者坚持口服抗生素治疗的评估

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-11-15 DOI: 10.1177/15347346211057342

Irene Sanz-Corbalán, Aroa Tardáguila-García, Yolanda García-Álvarez, Mateo López-Moral, Francisco Javier Álvaro-Afonso, José Luis Lázaro-Martínez

{"title":"Evaluation of Adherence to the Oral Antibiotic Treatment in Patients With Diabetic Foot Infection.","authors":"Irene Sanz-Corbalán, Aroa Tardáguila-García, Yolanda García-Álvarez, Mateo López-Moral, Francisco Javier Álvaro-Afonso, José Luis Lázaro-Martínez","doi":"10.1177/15347346211057342","DOIUrl":"10.1177/15347346211057342","url":null,"abstract":"Introduction: The knowledge about level of adherence to oral antibiotic treatment in diabetic patients with ulcer infection could be essential as a method of evaluation/monitoring of conservative treatment. Aim: To assess the adherence to oral antibiotic treatment in outpatients with diabetic foot infection (soft tissue vs. osteomyelitis) by 8-item structured, self-reported medication adherence scale. Methods: cross-sectional study was carried out with 46 consecutive patients who had diabetic foot infection (soft tissue or bone infection) and required antibiotic oral treatment at outpatient clinical setting. Medication adherence was tested using the Spanish version of the validated eight-item self-report MMAS-8. Results: patients with diabetic ulcer infection, had well level of adherence to antibiotic medication (7 ± 1.2 vs. 7.4 ± 1.5). Patients with lower level of adherence had lower level of satisfaction with the antibiotic medication. The profile of the patients with lower level of adherence were patients with primary level of education and patient who required more help to take the medication. Conclusion: Patients with diabetic foot infection demonstrated well level of adherence to antibiotic medication, independently of type of infection (soft tissue vs. osteomyelitis) by 8-item structured, self-reported medication adherence scale.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"397-402"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39733641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise Training as an Adjunctive Therapy for Chronic Venous Insufficiency Patients: Evidence from Research to Practice. 运动训练作为慢性静脉功能不全患者的辅助疗法：从研究到实践的证据。

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-11-18 DOI: 10.1177/15347346211060126

Sothida Nantakool, Busaba Chuatrakoon, Maurits van der Veen, Amaraporn Rerkasem, Kittipan Rerkasem

引用次数: 0

The Effect of Topically Applied Boric Acid on Ephrin-Eph Pathway in Wound Treatment: An Experimental Study. 局部应用硼酸对伤口治疗中 Ephrin-Eph 通路的影响：一项实验研究

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-11-13 DOI: 10.1177/15347346211055260

Başak Büyük, Cemre Aydeğer, Yasemen Adalı, Hüseyin Avni Eroğlu

{"title":"The Effect of Topically Applied Boric Acid on Ephrin-Eph Pathway in Wound Treatment: An Experimental Study.","authors":"Başak Büyük, Cemre Aydeğer, Yasemen Adalı, Hüseyin Avni Eroğlu","doi":"10.1177/15347346211055260","DOIUrl":"10.1177/15347346211055260","url":null,"abstract":"Background: Wound healing has a vital importance for the organism and various agents are used to accelerate wound healing. Although the effect of boron on wound healing is known, its mechanisms are not completely clear yet. In this study, the effect of boron in the Ephrin /Eph pathway will be evaluated. Methods: Forty adult female rats were used in the study. A full-thickness excisional wound model was created in all groups divided as Control, Fito, Boron and Plu groups. After the applications performed twice a day and lasting 7 days, skin tissues obtained and evaluated histopathological (inflammatory cell infiltration, oedema, and fibroblast proliferation density) and immunohistochemical (TNF-α, EphrinA1, EphrinB1, EphrinB2 and EphB4). Results: Inflammatory cell infiltration score was found to be higher in the Fito group compared to Boron group (p = .018). Fibroblast proliferation density was higher in Plu group than Boron group (p = .012). While TNF-α was lower in boron group than Plu (p = .027) and Fito (p = .016) groups, EphrinA1 was higher in Boron group than Plu group (p = .005). EphrinB1 expression was higher in Boron group compared to Plu (p = .015) and Fito (p = .015) groups, and the same difference was also observed in EphrinB2 (p values .000). Similarly, EphB4 immunoreactivity was higher in the Boron group compared to Plu (p = .000) and Fito (p = .002). Conclusion: One of the mechanisms of action of boron in wound healing is to increase EphrinB1, EphrinB2 and EphB4. Low TNF-α and histopathological findings indicate that boron limits extensive wound healing.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"379-389"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39889199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Wound Healing Activity of Sea Cucumber Holothuria parva Hydroalcoholic Extract in Rat. 海参水醇提取物对大鼠伤口愈合活性的评估

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-11-18 DOI: 10.1177/15347346211059331

Elnaz Bazmakdar, Eskandar Moghimipour, Neda Sistani Karampour, Annahita Rezaie, Seyed Mohammad Bagher Nabavi

{"title":"Evaluation of Wound Healing Activity of Sea Cucumber Holothuria parva Hydroalcoholic Extract in Rat.","authors":"Elnaz Bazmakdar, Eskandar Moghimipour, Neda Sistani Karampour, Annahita Rezaie, Seyed Mohammad Bagher Nabavi","doi":"10.1177/15347346211059331","DOIUrl":"10.1177/15347346211059331","url":null,"abstract":"A significant challenge in biomedicine is the development of Biomaterials with the potential to accelerate wound healing. The aim of this study was to investigate the effect of the gel prepared from sea cucumber on wound healing in rats. Full-thickness wounds were created in male rats divided into five experimental groups, negative control (NC), positive control (PC), and treatments. The NC and PC groups received respectively gel base and phenytoin cream 1%. Treatment groups were treated topically by gels of 1%, 3%, and 5% Holothuria parva extract (HPE) in the gel base. The rats were sacrificed on days 7, 14, and 21. Pathological reports revealed the proliferation of keratinocytes in the borders of the wound in treatment groups and controls. Formation of granulation tissue was seen on day 7 in treatment groups, collagen fibers in granulation tissue were randomly organized, and the rate of fibroblast decreased. Results showed that there were statistically significant differences in wound contraction between all groups in comparison to the NC group (P < .05) on day 8. It was concluded that the 1% HPE gel has a good potential for promoting wound healing.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"412-420"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39901990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory Reconstruction of a Posterior Heel Defect Using a Proximally Based Sensate Medial Plantar Flap with Retrograde Nerve Cleavage Technique. 利用近端感觉内侧足底皮瓣和逆行神经断裂技术重建足跟后部缺损的感觉功能

IF 1.5 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-11-06 DOI: 10.1177/15347346211055261

Sung Yoon Jung, Min Bom Kim, Young Ho Lee

{"title":"Sensory Reconstruction of a Posterior Heel Defect Using a Proximally Based Sensate Medial Plantar Flap with Retrograde Nerve Cleavage Technique.","authors":"Sung Yoon Jung, Min Bom Kim, Young Ho Lee","doi":"10.1177/15347346211055261","DOIUrl":"10.1177/15347346211055261","url":null,"abstract":"Reconstruction of posterior heel defects is important because it requires thick and durable skin that can withstand pressure and shear from shoe and bed contact. Therefore, the sensate flap could be a better option for the defect. This paper reports on the safety of a medial plantar sensory flap for these defects as well as an objective measurement of the sensation of the medial plantar flap and the plantar surface distal to the donor site. Twelve patients had soft-tissue defects in the posterior heel and underwent reconstructive surgery using a proximally based sensate medial plantar sensory flap. Cases of plantar defects involving not posterior heel were excluded. For wider flap coverage, special neurovascular dissection was required. We evaluated levels of sensation quantitatively using Semmes-Weinstein (SW) monofilaments and a two-point discriminator at the final follow-up. All flaps survived without major complications. Postoperative follow-up was 12 to 64 months (mean 26 months). All 12 flaps healed without postoperative complications. There was no significant difference in minimal two-point discrimination and SW evaluator size between the transferred medial plantar flap area and the contralateral heel area or between the plantar area distal to the donor site and the contralateral side. Patients could walk normally and sleep without protective shoes or brace. A proximally based sensate medial plantar flap is a good option for the reconstruction of posterior heel defects. It can restore the characteristics of the posterior heel for shoe wearing and sleeping.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"372-378"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39599021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sticking to What Matters: A Matched Comparative Study of Fibrin Glue and Mechanical Fixation for Split-Thickness Skin Grafts in the Lower Extremity. 坚持到底：下肢裂开厚皮移植的纤维蛋白胶和机械固定的匹配比较研究。

IF 1.7 4区医学

International Journal of Lower Extremity Wounds Pub Date : 2024-06-01 Epub Date: 2021-10-04 DOI: 10.1177/15347346211047748

Sammy Othman, Charles A Messa, Omar Elfanagely, Bradford Bormann, Joseph A Mellia, Robyn B Broach, Stephen J Kovach, John P Fischer

{"title":"Sticking to What Matters: A Matched Comparative Study of Fibrin Glue and Mechanical Fixation for Split-Thickness Skin Grafts in the Lower Extremity.","authors":"Sammy Othman, Charles A Messa, Omar Elfanagely, Bradford Bormann, Joseph A Mellia, Robyn B Broach, Stephen J Kovach, John P Fischer","doi":"10.1177/15347346211047748","DOIUrl":"10.1177/15347346211047748","url":null,"abstract":"Background: Split-thickness skin grafts (STSGs) remain a valuable tool in the reconstructive surgeons' armamentarium. Staple or suture mechanical fixation (MF) serves as the gold standard of care, though fibrin glue (FG) has gained popularity as a fixation modality. We compare STSG outcomes following application of FG versus MF through a study of lower extremity wounds. Methods: A retrospective review (2016-2019) of patients who underwent a STSG was performed. Two cohorts consisting of patients undergoing a STSG with FG or MF (suture or staple) were matched according to wound size, wound location, and body mass index. Results: A total of 67 patients with 79 wounds were included (FG: n = 30, wounds = 39; MF: n = 37; wounds = 40). There was no significant difference between groups regarding time to 100% graft take (FG: 39 days, MF: 35.1 days; P < .384) or 180-day graft complications (FG: 10.3%, MF: 15%; P < .737). Adjusted operative time for FG (51.8 min) was lower than for MF cases (67.5 min) at a level that approached significance (P < .094). FG patients were significantly less likely to require a postoperative wound vacuum-assisted closure (VAC) (FG: 16.7%; MF: 76.7%; P < .001) and required a significantly lower number of 30-day postoperative visits (FG: 1.5 ± .78 visits; MF: 2.5 ± .03 visits; P < .001). The MF group had higher mean aggregate charges ($211,090) compared with the FG group (mean: $149,907), although these were not statistically significant (P > .05). Conclusion: The use of FG for STSG shows comparable clinical outcomes to MF, with a significantly decreased need for postoperative wound VAC, the number of 30-day postoperative visits, and a lower wound-adjusted operative time.","PeriodicalId":49181,"journal":{"name":"International Journal of Lower Extremity Wounds","volume":" ","pages":"231-237"},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39483039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0