Journal of Developmental Origins of Health and Disease最新文献

{"title":"Sexual behavior and sexual identity in female offspring of women exposed <i>in utero</i> to diethylstilbestrol (DES).","authors":"Rebecca Troisi, Elizabeth E Hatch, Kimberly Bertrand, William C Strohsnitter, Dezheng Huo, Michael Curry, Marianne Hyer, Julie A Palmer, Gretchen Gierach, Linda Titus","doi":"10.1017/S2040174424000175","DOIUrl":"10.1017/S2040174424000175","url":null,"abstract":"<p><p>Hormone exposure <i>in utero</i> affects male- and female-typical behavior in animals, and these effects may persist in the next generation. Prenatal exposure to diethylstilbestrol (DES), a potent estrogen and endocrine disruptor, has been associated with a tendency toward greater heterosexual behavior in women, but the association in the next generation has not been studied. We evaluated the associations of maternal prenatal DES exposure with sexual behavior, sexual identity, and gender identity in 982 female offspring participating in the National Cancer Institute's DES Third Generation Study, a cohort born to mothers who were prenatally exposed and unexposed to DES. Odds ratio (OR) and 95% confidence intervals (CIs) were estimated from logistic regression models that included birth year. The ORs were 0.71 (CI 0.46-1.1) for DES in relation to non-heterosexual compared with heterosexual behavior, and 0.99 (CI 0.55-1.8) for non-heterosexual identity, compared with heterosexual identity. Results were similar after additional adjustment for education. Only three individuals reported a gender identity distinct from what was reported by the mother at cohort inception, preventing meaningful quantitative analysis of DES and gender identity. These data do not provide evidence of differences in sexual behavior and sexual identity in female offspring of mothers with and without prenatal exposure to DES.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e41"},"PeriodicalIF":1.5,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental programming of the neonatal period in ruminant livestock: a review.","authors":"Allison M Meyer","doi":"10.1017/S2040174425100226","DOIUrl":"https://doi.org/10.1017/S2040174425100226","url":null,"abstract":"<p><p>Early life, or the neonatal period, is perhaps the most challenging time for ruminant livestock, as they adapt to the extra-uterine environment, undergo important physiological maturation, and navigate harsh ambient conditions. Maternal influences during gestation, especially energy and protein nutrition in late pregnancy, can alter many processes that affect the neonatal period. These processes include fetal growth and development, gestation length, difficulty of parturition, and maternal behavior, which interact to affect offspring vigor at birth. Moreover, colostrum and early milk production and composition are affected by gestational nutrition, and these along with the previous factors affect the neonate's ability to obtain transfer of passive immunity, thermoregulate, perform basal metabolism, and ultimately survive to weaning. Often, the long-term effects of maternal nutrition during gestation on offspring are attributed solely to the prenatal environment, but it is critical to also consider influences of early life on later productivity and health. More research is needed to integrate these neonatal outcomes with prenatal and postnatal mechanisms as well as later ruminant livestock performance. Better understanding of the maternal environment's effects on the neonatal period provides opportunity for improved management of ruminant livestock dams and offspring.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e40"},"PeriodicalIF":1.5,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early prenatal undernutrition leads to metabolic dysfunction-associated steatotic liver disease in a rat model of menopause.","authors":"Tomoko Kimura, Kodai Hino, Minoru Kuroida, Jun Udagawa","doi":"10.1017/S204017442510024X","DOIUrl":"https://doi.org/10.1017/S204017442510024X","url":null,"abstract":"<p><p>The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has increased. MASLD notably increases after menopause in women owing to the drastic reduction in estrogen, which regulates lipid metabolism. While prenatal undernutrition leads to hepatic steatosis after birth, whether prenatal undernutrition affects the onset of postmenopausal MASLD remains unknown. Therefore, we examined the impact of early prenatal undernutrition on the predisposition to postmenopausal MASLD in a rat model of menopause. Pregnant female rats were assigned to the control (CNTL) group, while the undernourished (UN) group was fed 40% of the diet of the control group. Furthermore, both groups were assigned to the ovariectomized (CNTL-OVX/UN-OVX) and sham-operated (CNTL-Sham/UN-Sham) groups at 12 weeks of age. Two-way analysis of variance revealed significant main effects of ovariectomy and prenatal undernutrition on body weight and hepatic triglyceride content. Triglycerides accumulated in the liver at 12 and 24 weeks after ovariectomy, while hepatic steatosis was histologically observed at 24 weeks after ovariectomy in UN-OVX rats. Hepatic gene expression analyses showed an interaction effect between prenatal undernutrition × ovariectomy in <i>ESR1</i> expression; however, <i>PPARα</i>, <i>RXRα</i>, <i>RARα</i>, <i>Raldh1</i>, and <i>Raldh3</i> expression was not affected by prenatal undernutrition and ovariectomy. These results suggest that early prenatal undernutrition predisposes postmenopausal women to MASLD by uncovering aberrant estrogen signaling, which may be influenced by estrogen reduction.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e39"},"PeriodicalIF":1.5,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-conception maternal nutrition and its association with offspring sex: a prospective cohort study using the Japan Environment and Children's Study data.","authors":"Rie Matsushita, Sachiko Tanaka-Mizuno, Misaki Nakahata, Satomi Yoshida, Masato Takeuchi, Chihiro Kawakami, Koji Kawakami, Shuichi Ito","doi":"10.1017/S2040174425100251","DOIUrl":"https://doi.org/10.1017/S2040174425100251","url":null,"abstract":"<p><p>The impact of maternal nutrition during the peri-conception period on offspring sex remains unclear. Therefore, this study aimed to explore the association between maternal nutritional intake around conception and offspring sex. Data were collected from the Japan Environment and Children's Study, which enrolled 97,510 mother-child pairs. The effect of maternal intake of fats, proteins, and fatty acids on offspring sex was analyzed, adjusting for maternal demographics and lifestyle factors. Overall, maternal intake of total fatty acids, saturated fatty acids (SFAs), polyunsaturated fatty acids (PUFAs), <i>n-</i>3 PUFA, <i>n</i>-6 PUFA, and protein and the ratios of <i>n</i>-6/<i>n</i>-3 and SFA/energy showed no consistent associations with offspring sex.However, further analyses revealed notable patterns related to maternal age and energy intake. Among mothers with high energy intake (≥4,000 kcal/day), higher residual protein intake was associated with increased odds of having a male child (aOR, 1.87; 95% CI, 1.17-2.98). In mothers aged under 20 years, increased n-3 PUFA intake was linked to higher odds of male births, while a higher <i>n</i>-6/<i>n</i>-3 ratio was associated with lower odds of male births. Additionally, among mothers aged 20-35 years, higher n-3 PUFA intake was associated with decreased odds of having a male child (aOR, 0.89; 95% CI, 0.82-0.98).These findings indicate that while no consistent overall relationship was observed, certain maternal nutritional patterns may influence offspring sex, highlighting the need for further research on maternal diet and reproductive outcomes.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e38"},"PeriodicalIF":1.5,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal iron deficiency alters the expression of glucose transporters in offspring.","authors":"Misaki Furuta, Shunsuke Fujii, Madoka Kumai","doi":"10.1017/S2040174425100238","DOIUrl":"https://doi.org/10.1017/S2040174425100238","url":null,"abstract":"<p><p>Iron deficiency anemia is a major health problem worldwide. Iron is an essential micronutrient in the human body; its demand increases with fetal growth and gestation. Although it has been reported that glucose metabolism is also affected by iron deficiency, only few studies have investigated the influence of iron deficiency during gestation and in offspring. In this study, glucose metabolism in newborns was investigated in terms of maternal iron deficiency prior to pregnancy in a rat model. Briefly, rats were divided into control (CL) and iron deficiency (ID) groups. The levels of serum glucose and insulin and the protein expression of liver GLUT2 in neonates born to dams in the ID group increased. In contrast, the mRNA and protein expression levels of GLUT2 and GLUT4 in the skeletal muscle tended to decrease. In addition, the expression of p-Akt (Thr308), which is involved in GLUT4 membrane translocation, decreased, suggesting that GLUT4 translocation to the plasma membrane may not have been sufficiently promoted. These results suggest that maternal iron deficiency may influence glucose metabolism in neonates and potentially increase the risk of developing metabolic abnormalities and lifestyle-related diseases later in life.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e37"},"PeriodicalIF":1.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrauterine growth restriction promotes hypothalamic circadian dysregulation in adult mouse offspring.","authors":"Alexandra E O'Brien, Peter J Mark, Jeremy T Smith, Kimberley C W Wang","doi":"10.1017/S2040174425100214","DOIUrl":"https://doi.org/10.1017/S2040174425100214","url":null,"abstract":"<p><p>Adverse prenatal conditions can induce intrauterine growth restriction (IUGR) and increase the risk of adulthood metabolic disease. Mechanisms underlying developmentally programmed metabolic disease remain unclear but may involve disrupted postnatal circadian rhythms and kisspeptin signalling. We investigated the impact of maternal hypoxia-induced IUGR on hypothalamic and hepatic expression of clock genes (<i>Bmal1</i>, <i>Per2</i> and <i>Reverbα</i>), metabolic genes (<i>Pparα</i>, <i>Pparγ</i> and <i>Pgc1α</i>) and kisspeptin genes (<i>Kiss1</i> and <i>Kiss1r</i>) in adult offspring. Pregnant BALB/c mice were housed in hypoxic conditions (10.5% oxygen) from gestational day 11 to 17.5 and then returned to normoxic conditions until term (gestational day ∼ 21). Control animals were housed in normoxic conditions throughout pregnancy. Offspring were weighed at birth. At 8 weeks of age, body, liver and brain tissues were collected and weighed. Relative clock gene, metabolic gene and kisspeptin signalling gene expression were measured using qPCR. The IUGR offspring were lighter at birth and remained lighter at 8 weeks but with higher brain relative to body weight. The IUGR offspring had decreased hypothalamic <i>Bmal1</i> and <i>Reverbα</i> expression, but unchanged hepatic clock gene expression and no change in hypothalamic or hepatic <i>Per2</i> expression, compared with Control offspring. This tissue-specific change in clock gene expression suggests circadian dysregulation. There were no IUGR-related changes to metabolic gene expression in the hypothalamus or liver, but IUGR offspring had increased hypothalamic <i>Kiss1r</i> expression. These results demonstrate IUGR offspring from hypoxia pregnancies show central circadian misalignment and potentially disrupted hypothalamic <i>Kiss1/Kiss1r</i> signalling, which may contribute to developmentally programmed metabolic disease.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e36"},"PeriodicalIF":1.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the bifidogenic effect of various infant formula supplementations: a systematic review and network meta-analysis of randomized controlled trials.","authors":"Fatemeh Mansouri, Mahnaz Mardani, Maryam Rezapour, Laura Bordoni, Rosita Gabbianelli","doi":"10.1017/S2040174425100196","DOIUrl":"10.1017/S2040174425100196","url":null,"abstract":"<p><p>This study aimed to investigate the effects of infant formula supplements on <i>Bifidobacterium</i> level in the infant gut through a systematic review and network meta-analysis (NMA) of randomized controlled trials (RCTs).Systematic review included PubMed, EMBASE, MEDLINE, Scopus, Web of Science, and Cochrane CENTRAL to identify RCTs evaluating the effects of formulas supplemented with prebiotics, probiotics, synbiotics, β-palmitic acid, or combinations of β-palmitic acid with prebiotics on infant gut <i>Bifidobacterium</i> levels. A meta-analysis compared bifidogenic effects to standard formula. The main outcome was the relative abundance (RA) of <i>Bifidobacterium</i> in fecal samples measured by various microbiota assessment techniques, with effect sizes as mean differences and standard deviations. An overall effect estimate was derived using a random-effects model. NMA assessed formula effects using breastfeeding as the reference.Nineteen studies were included. Compared to standard formula, supplementation with prebiotics (<i>p</i> < 0.0001), synbiotics (<i>p</i> < 0.0001), β-palmitic acid (<i>p</i> = 0.0005), or β-palmitic acid combined with prebiotics (<i>p</i> < 0.0001) significantly increased <i>Bifidobacterium</i> levels in the infant gut. Probiotic supplementation showed no significant effect (<i>p</i> = 0.9755). NMA and p-score ranking, comparing formulas to breastmilk, indicated that prebiotic-supplemented formulas with the lowest ranking <i>p</i>-score (0.2764), most closely resembled breastfeeding's bifidogenic effect. However, prebiotics and probiotics were analyzed as broad categories, and group variability may affect outcomes. In conclusion, formula supplementation with prebiotics, synbiotics, β-palmitic acid, or combinations of β-palmitic acid with prebiotics increased the RA of <i>Bifidobacterium</i> in infant's gut, with prebiotic formula most closely mimicking the bifidogenic effects of breastfeeding.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e35"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between low birth weight, childhood adversity, and natural disaster with delay discounting among children.","authors":"Shuhei Terada, Yuto Maeda, Pamela J Surkan, Takeo Fujiwara","doi":"10.1017/S2040174425100160","DOIUrl":"https://doi.org/10.1017/S2040174425100160","url":null,"abstract":"<p><p>According to the Developmental Origins of Health and Disease (DOHaD) hypothesis, low-birthweight (LBW) infants are programmed to seek additional resources as compensation for early deprivation. However, no study has yet explored this in the context of delay discounting (DD), which refers to the tendency to prefer smaller, immediate rewards over larger, delayed ones. Both prenatal factors, such as LBW, and postnatal factors, including adverse childhood experiences (ACEs) and exposure to natural disasters, may influence DD. To investigate whether LBW children seek larger future rewards, we analyzed LBW's effect on DD, accounting for ACEs and natural disaster exposure. This prospective cohort study involved 167 children from areas affected by the Great East Japan Earthquake (GEJE), with a mean age of 8.3 years at the time of the DD experiment. LBW was assessed in the 2012 baseline questionnaire using the Mother-Child Handbook, along with ACEs prior to the GEJE and traumatic earthquake experiences. In 2014, DD was assessed through a token-based experiment where children allocated tokens for either immediate rewards (one candy per token for \"now\") or delayed rewards (two candies per token for \"one month later\"). Our results showed that children with LBW and three or more ACEs exhibited lower DD, while traumatic earthquake experiences were not associated with DD. These findings suggest that children with LBW and multiple ACEs may develop adaptive strategies to seek more resources, indicating a responsive reward system to childhood adversity, even after exposure to a severe natural disaster.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e32"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically predicted maternal prepregnancy BMI increased risk of childhood intestinal malformation: evidence from a Mendelian randomization study.","authors":"Siqi Xie, Xiaojin Zhuang, Lan Liu, Yifan Fang, Bing Zhang","doi":"10.1017/S2040174425100184","DOIUrl":"https://doi.org/10.1017/S2040174425100184","url":null,"abstract":"<p><p>The study aimed to explore the causal effect of maternal prepregnancy body mass index (BMI) on congenital malformations of intestine (CMI). The genome-wide association data of BMI and CMI were obtained via the Mendelian randomization (MR) base platform. Single nucleotide polymorphisms (SNPs) significantly associated with BMI in females were identified and used as instrumental variables, and the causal relationship between BMI in females and CMI was examined using the bidirectional two-sample MR analyses research method. Three statistical methods including inverse-variance weighted (IVW) method, weighted median estimator, and MR-Egger regression were employed. A total of 36 SNPs significantly associated with BMI in females were identified in the study (<i>P</i> < 5 × 10⁻⁸; linkage disequilibrium r² < 0.001). Consistent association between BMI in females and CMI was observed when evaluated by different methods (IVW: odds ratio (OR) 0.364, 95% confidence interval (CI) 0.144–0.922; weighted median estimator: OR 0.395, 95% CI 0.096–1.619; MR-Egger Method: OR 0.244, 95% CI 0.020–2.974), which suggests that BMI in females is negatively associated with increased risk of CMI. The MR analysis provided the strong evidence to indicate that decreasing BMI in females might be causally associated with the risk of CMI.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e34"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of perinatal exposure to an endocrine disruptor mixture on the renal microenvironment of aged male rat offspring: histopathological aspects.","authors":"Pedro Meira Dolfini, Karianne Delalibera Hinokuma, Gisele Alborghetti Nai, Anthony César de Souza Castilho, Leonardo de Oliveira Mendes","doi":"10.1017/S2040174425100172","DOIUrl":"https://doi.org/10.1017/S2040174425100172","url":null,"abstract":"<p><p>The developmental origins of health and disease hypothesis suggests that environmental exposures during critical developmental windows increase the risk of disease later in life. Among these, endocrine disruptors (EDs) are particularly concerning due to their ubiquitous presence. The kidneys are highly susceptible to EDs toxicity during the perinatal period; however, long-term effects of ED mixtures on renal structure in aging remain unclear. This study aimed to characterize the renal histoarchitecture of aged rats after perinatal exposure to an ED mixture. Pregnant Sprague-Dawley rats were assigned to two groups: Control (corn oil, 2 ml/kg) and ED Mix (32.11 mg/kg/day of 12 EDs, including phthalates, pesticides, UV filters, bisphenol A, and butylparaben, in corn oil). Exposure occurred from gestational day 7 to postnatal day 21. Offspring were euthanized at postnatal day 440. ED mixture exposure did not affect the organosomatic index. However, ED Mix offspring presented renal lesions, including necrosis and tubular fusion, with a trend toward increased pathological changes. Morphometric analysis revealed enlarged nuclei and increased nuclear perimeters in the cortex and medulla, along with altered cellular organization in glomerular and medullary regions. Collagen organization was disrupted, with increased fibrosis in cortical and medullary compartments and reduced collagen type I and III in glomeruli. These findings indicate that perinatal exposure to an ED mixture alters nuclear phenotype and promotes extracellular matrix remodeling in distinct renal compartments. Such changes suggest long-term impacts on renal structure and function, emphasizing the health risks associated with early-life exposure to complex ED mixtures.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e33"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}