Experimental and Applied Biomedical Research (EABR)最新文献_第2页

Some of the Dilemmas About Creating Arteriovenous Fistulas for Hemodialysis 血液透析造动静脉瘘的一些困境

Experimental and Applied Biomedical Research (EABR) Pub Date : 2023-09-20 DOI: 10.2478/sjecr-2021-0090

Radojica V. Stolić, Dušica V. Miljković-Jakšić, Aleksandra D. Balović, Roksanda N. Krivčević, Sanja M. Jovanović, Naja Suljković

{"title":"Some of the Dilemmas About Creating Arteriovenous Fistulas for Hemodialysis","authors":"Radojica V. Stolić, Dušica V. Miljković-Jakšić, Aleksandra D. Balović, Roksanda N. Krivčević, Sanja M. Jovanović, Naja Suljković","doi":"10.2478/sjecr-2021-0090","DOIUrl":"https://doi.org/10.2478/sjecr-2021-0090","url":null,"abstract":"Abstract The native arteriovenous fistula for haemodialysis has been described as the Achilles heel but also the Cinderella of haemodialysis. Arteriovenous fistula has been the vascular access of choice for haemodialysis, because of lower cost, morbidity and mortality. The significance of a functioning vascular access is that it takes on a major role in determining a positive outcome. Yet, they are a cause of great stress, both for patients and healthcare professionals. About 80% of patients begin dialysis with central venous catheters, 20-70% of fistulas do not reach maturity, and a fifth, of all fistulas, thrombosed before use. A quarter die from poor vascular access. Insufficient number of vascular surgeons and inadequate training to create vascular access often lead to \"congestion\" of the bed stock in nephrology. Surgeons and radiologists perform all procedures related to vascular approaches, but the dominant role of nephrologists is in the organization of planning and realization of creating a vascular access. Initiation of dialysis in the elderly and diabetics, as a risk population of patients for arteriovenous fistula, is associated with many problems, among which the creation, functioning and maturation of the vascular access dominate. Hyperdynamic conditions, due to arteriovenous communication in patients with arteriovenous fistula, are cited as a possible mechanism for increasing morbidity. However, there is still no agreement within the nephrology community regarding the height of the hemodynamic load and the indication for closing the vascular access. There are many dilemmas associated with creating, care and using an arteriovenous fistulas, and that could be the reason and justification to form a team for vascular access, which would, in addition to nephrologists, include vascular surgeons, interventional radiologists and nurses.","PeriodicalId":491601,"journal":{"name":"Experimental and Applied Biomedical Research (EABR)","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nt-Probnp in Patients with Acute Myocardial Infarction Without Heart Failure 非心衰急性心肌梗死患者的Nt-Probnp

Experimental and Applied Biomedical Research (EABR) Pub Date : 2023-09-13 DOI: 10.2478/sjecr-2023-0001

Sladjana Vlajovic, Olivera Andrejic, Miodrag Sreckovic, Goran Davidovic, Dragic Bankovic, Nada Milovanovic, Rada Vucic

{"title":"Nt-Probnp in Patients with Acute Myocardial Infarction Without Heart Failure","authors":"Sladjana Vlajovic, Olivera Andrejic, Miodrag Sreckovic, Goran Davidovic, Dragic Bankovic, Nada Milovanovic, Rada Vucic","doi":"10.2478/sjecr-2023-0001","DOIUrl":"https://doi.org/10.2478/sjecr-2023-0001","url":null,"abstract":"Abstract NT-proBNP is marker of acute heart failure. Recent investigation implicate its role in different cardiac and non-cardiac diseases and different mechanism of release in patients with STEMI and NSTEMI. Our study included 66 patients with diagnosis of acute myocardial infarction, hospitalized in Clinical Centre Kragujevac. We evaluated standard biochemical analysis including NTproBNP, electrocardiography, transthoracic echocardiography and coronary angiography. The most common cardiovascular risk factors were emotional stress (93,94%), and physical inactivity( 81,82%). NT-proBNP values were higher in patients with AMI vs health volunteers (943 vs. 162,5 pg/ml, p = 0,0001), NSTEMI vs STEMI patients (1427 pg/ml vs. 592 pg/m, p = 0,005), patients with culprit lesion on left vs right coronary artery (1421 vs. 548, p =0.02), and anterior vs inferior location AMI (1714vs. 625, p =0.022). We found positive correlation NT-proBNP values with CRP, urea, creatinine, and negative correlation with triglicerides, hemoglobin, left ventricular ejection fraction. Higher values of NT-proBNP values are recorded in patients with AMI, NSTEMI, anterior location AMI and with culprit lesion on left coronary artery.","PeriodicalId":491601,"journal":{"name":"Experimental and Applied Biomedical Research (EABR)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135733970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Injuries and Cause of Death in Fatal Accidents with Farm Tractors 农用拖拉机致命事故伤害及死亡原因分析

Experimental and Applied Biomedical Research (EABR) Pub Date : 2023-09-01 DOI: 10.2478/sjecr-2020-0052

Zivana Slovic, Katarina Vitosevic, Danijela Todorovic, Milos Todorovic

{"title":"Analysis of Injuries and Cause of Death in Fatal Accidents with Farm Tractors","authors":"Zivana Slovic, Katarina Vitosevic, Danijela Todorovic, Milos Todorovic","doi":"10.2478/sjecr-2020-0052","DOIUrl":"https://doi.org/10.2478/sjecr-2020-0052","url":null,"abstract":"Abstract Farm tractor accidents are a frequent cause of death for people in agricultural field of work. The aim of this study was to evaluate the characteristics of the fatal farm tractor accidents, as well as the most significant types of injuries and causes of death. Research is based on epidemiological criteria of subjects, traffic participation, cause of death, distribution of injury, outliving period and toxicological details. The study included 22 (4.2%) farm tractor related fatalities out of all 525 subjects who died from sustained injuries or complications of the injuries sustained in road traffic accidents. The highest number of deaths was reported in men in 95.5%. The highest percentage died of bleeding out (41%), while in 18% of cases, complications that occurred during the outliving period were the cause of death. Analyzing injuries through organ systems, it is observed that the highest number of farm tractor drivers had a chest injury (90%), and the most common chest injury was a rib fracture (82%). When determining the outliving period, the highest number of fatal farm tractor drivers died at the scene of accidents (68.2%). Of all of the subjects, 32% were under the influence of alcohol, while 23% had blood alcohol concentration level greater than 0.5 ‰. The high mortality of farm tractor drivers can be reduced by introducing a mandatory rollover protective structures system and the use of a seat belt in farm tractors with cabs, which would reduce the possibility of the driver falling out of the farm tractor seat and additional injuries due to rollover.","PeriodicalId":491601,"journal":{"name":"Experimental and Applied Biomedical Research (EABR)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serbian Translation and Validation of the SF-36 for the Assessment of Quality of Life in Patients with Diagnosed Arterial Hypertension 塞尔维亚语翻译和SF-36对诊断为动脉高血压患者生活质量评估的验证

Experimental and Applied Biomedical Research (EABR) Pub Date : 2023-09-01 DOI: 10.2478/sjecr-2020-0073

Aleksandra Nikolic, Vladimir Biocanin, Nemanja Rancic, Mirjana Duspara, Dusan Djuric

{"title":"Serbian Translation and Validation of the SF-36 for the Assessment of Quality of Life in Patients with Diagnosed Arterial Hypertension","authors":"Aleksandra Nikolic, Vladimir Biocanin, Nemanja Rancic, Mirjana Duspara, Dusan Djuric","doi":"10.2478/sjecr-2020-0073","DOIUrl":"https://doi.org/10.2478/sjecr-2020-0073","url":null,"abstract":"Abstract Precise estimation of life quality is of special importance in patients with chronic diseases, such as arterial hypertension. There are many questionnaires for that purpose. Short-form 36 (SF-36) with 8 domains has been proved as one of the most appropriate. To date, there was no translated and validated SF 36 in Serbian language for hypertensive patients. The aim of this study was to test validity and reliability of SF-36 in Serbian patients with diagnosed arterial hypertension. Cronbach’s alpha coefficient was calculated to assess the internal consistency of the Serbian version of the SF-36. After deducting the overlap between each of the 36 items and its related domain, the collective validity was considered to be good if the correlation coefficient remains > 0.4. Only 2.54% answers on the questions were missing. Values of all the 8 domains were higher in men than in women. Cronbach alpha coefficient was high for SF-36, 0.897, and it suggesting that the SF-36 had good internal reliability. All 8 domains showed high values non-rotating factorial weights (>0.300) (range from 0.742-0.856), and all measure the same thing. It means that all components in this questionnaire measure the things they are assigned to.","PeriodicalId":491601,"journal":{"name":"Experimental and Applied Biomedical Research (EABR)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking Analysis of Novel Thiourea Derivatives of Naproxen with Potential Antitumor Activity 具有潜在抗肿瘤活性的萘普生新型硫脲衍生物的分子对接分析

Experimental and Applied Biomedical Research (EABR) Pub Date : 2023-09-01 DOI: 10.2478/sjecr-2021-0037

Nikola Nedeljkovic, Vladimir Dobricic, Marina Mijajlovic, Zorica Vujic, Milos Nikolic

{"title":"Molecular Docking Analysis of Novel Thiourea Derivatives of Naproxen with Potential Antitumor Activity","authors":"Nikola Nedeljkovic, Vladimir Dobricic, Marina Mijajlovic, Zorica Vujic, Milos Nikolic","doi":"10.2478/sjecr-2021-0037","DOIUrl":"https://doi.org/10.2478/sjecr-2021-0037","url":null,"abstract":"Abstract Naproxen, as a propionic acid derivative, causes serious gastrointestinal side effects due to the presence of free carboxylic group. In that sense, masking of carboxylic group with other pharmacophores may be a promising strategy to decrease gastrointestinal toxicity. Thiourea derivatives have been intensively investigated as potential antitumor drugs, whereby their activity is based on potential inhibition of protein kinases, topoisomerases, carbonic anhydrase and sirtuins. In addition, it was shown that inhibition of certain protein kinases might reverse resistance to chemotherapeutic drugs by enhancing the cell death in the presence of low concentrations of drug. Twenty new thiourea derivatives of naproxen were designed and their binding to four selected protein kinases involved in tumor multidrug resistance (AKT2, mTOR, EGFR and VEGFR1) was estimated using two molecular docking programs (AutoDock Vina and OEDocking). According to OEDocking, the highest potential to inhibit AKT2 and mTor has derivative 1, while derivative 20 demonstrates the highest potential towards EGFR and VEGFR1. According to AutoDock Vina, the highest potential for inhibition of EGFR, AKT2 and VEGFR1 have derivatives 16 and 17. Therefore, derivatives 1, 16, 17 and 20 are potentially the most potent protein kinase inhibitors that could be further synthesized and tested for anticancer activity.","PeriodicalId":491601,"journal":{"name":"Experimental and Applied Biomedical Research (EABR)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0