{"title":"非心衰急性心肌梗死患者的Nt-Probnp","authors":"Sladjana Vlajovic, Olivera Andrejic, Miodrag Sreckovic, Goran Davidovic, Dragic Bankovic, Nada Milovanovic, Rada Vucic","doi":"10.2478/sjecr-2023-0001","DOIUrl":null,"url":null,"abstract":"Abstract NT-proBNP is marker of acute heart failure. Recent investigation implicate its role in different cardiac and non-cardiac diseases and different mechanism of release in patients with STEMI and NSTEMI. Our study included 66 patients with diagnosis of acute myocardial infarction, hospitalized in Clinical Centre Kragujevac. We evaluated standard biochemical analysis including NTproBNP, electrocardiography, transthoracic echocardiography and coronary angiography. The most common cardiovascular risk factors were emotional stress (93,94%), and physical inactivity( 81,82%). NT-proBNP values were higher in patients with AMI vs health volunteers (943 vs. 162,5 pg/ml, p = 0,0001), NSTEMI vs STEMI patients (1427 pg/ml vs. 592 pg/m, p = 0,005), patients with culprit lesion on left vs right coronary artery (1421 vs. 548, p =0.02), and anterior vs inferior location AMI (1714vs. 625, p =0.022). We found positive correlation NT-proBNP values with CRP, urea, creatinine, and negative correlation with triglicerides, hemoglobin, left ventricular ejection fraction. Higher values of NT-proBNP values are recorded in patients with AMI, NSTEMI, anterior location AMI and with culprit lesion on left coronary artery.","PeriodicalId":491601,"journal":{"name":"Experimental and Applied Biomedical Research (EABR)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nt-Probnp in Patients with Acute Myocardial Infarction Without Heart Failure\",\"authors\":\"Sladjana Vlajovic, Olivera Andrejic, Miodrag Sreckovic, Goran Davidovic, Dragic Bankovic, Nada Milovanovic, Rada Vucic\",\"doi\":\"10.2478/sjecr-2023-0001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract NT-proBNP is marker of acute heart failure. Recent investigation implicate its role in different cardiac and non-cardiac diseases and different mechanism of release in patients with STEMI and NSTEMI. Our study included 66 patients with diagnosis of acute myocardial infarction, hospitalized in Clinical Centre Kragujevac. We evaluated standard biochemical analysis including NTproBNP, electrocardiography, transthoracic echocardiography and coronary angiography. The most common cardiovascular risk factors were emotional stress (93,94%), and physical inactivity( 81,82%). NT-proBNP values were higher in patients with AMI vs health volunteers (943 vs. 162,5 pg/ml, p = 0,0001), NSTEMI vs STEMI patients (1427 pg/ml vs. 592 pg/m, p = 0,005), patients with culprit lesion on left vs right coronary artery (1421 vs. 548, p =0.02), and anterior vs inferior location AMI (1714vs. 625, p =0.022). We found positive correlation NT-proBNP values with CRP, urea, creatinine, and negative correlation with triglicerides, hemoglobin, left ventricular ejection fraction. Higher values of NT-proBNP values are recorded in patients with AMI, NSTEMI, anterior location AMI and with culprit lesion on left coronary artery.\",\"PeriodicalId\":491601,\"journal\":{\"name\":\"Experimental and Applied Biomedical Research (EABR)\",\"volume\":\"16 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental and Applied Biomedical Research (EABR)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/sjecr-2023-0001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and Applied Biomedical Research (EABR)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/sjecr-2023-0001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
NT-proBNP是急性心力衰竭的标志物。最近的研究表明其在不同心脏和非心脏疾病中的作用以及在STEMI和NSTEMI患者中不同的释放机制。我们的研究包括66例诊断为急性心肌梗死的患者，在克拉古耶瓦茨临床中心住院。我们评估了标准生化分析，包括NTproBNP、心电图、经胸超声心动图和冠状动脉造影。最常见的心血管危险因素是情绪压力(93,94%)和缺乏身体活动(81,82%)。AMI患者的NT-proBNP值高于健康志愿者(943 vs. 162,5 pg/ml, p = 0.0001)， NSTEMI患者vs. STEMI患者(1427 pg/ml vs. 592 pg/m, p = 0.005)，左冠状动脉病变患者vs.右冠状动脉病变患者(1421 vs. 548, p =0.02)，以及前位AMI vs.下位AMI患者(1714vs.下位AMI)。625, p =0.022)。我们发现NT-proBNP值与CRP、尿素、肌酐呈正相关，与甘油三酯、血红蛋白、左心室射血分数呈负相关。AMI、NSTEMI、AMI前位、左冠状动脉罪魁祸首病变患者NT-proBNP值较高。
Nt-Probnp in Patients with Acute Myocardial Infarction Without Heart Failure
Abstract NT-proBNP is marker of acute heart failure. Recent investigation implicate its role in different cardiac and non-cardiac diseases and different mechanism of release in patients with STEMI and NSTEMI. Our study included 66 patients with diagnosis of acute myocardial infarction, hospitalized in Clinical Centre Kragujevac. We evaluated standard biochemical analysis including NTproBNP, electrocardiography, transthoracic echocardiography and coronary angiography. The most common cardiovascular risk factors were emotional stress (93,94%), and physical inactivity( 81,82%). NT-proBNP values were higher in patients with AMI vs health volunteers (943 vs. 162,5 pg/ml, p = 0,0001), NSTEMI vs STEMI patients (1427 pg/ml vs. 592 pg/m, p = 0,005), patients with culprit lesion on left vs right coronary artery (1421 vs. 548, p =0.02), and anterior vs inferior location AMI (1714vs. 625, p =0.022). We found positive correlation NT-proBNP values with CRP, urea, creatinine, and negative correlation with triglicerides, hemoglobin, left ventricular ejection fraction. Higher values of NT-proBNP values are recorded in patients with AMI, NSTEMI, anterior location AMI and with culprit lesion on left coronary artery.
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