Tiffany J. Wendt-Aquino DDS, MS, FACP, Ryan R. Sheridan DDS, MS, FACP
{"title":"Changes in facial soft tissue support with and without a maxillary labial flange","authors":"Tiffany J. Wendt-Aquino DDS, MS, FACP, Ryan R. Sheridan DDS, MS, FACP","doi":"10.1111/jopr.13973","DOIUrl":"10.1111/jopr.13973","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To quantify facial esthetic outcomes of prosthetic upper lip support in both full animation and repose for patients with an existing implant-supported fixed complete dental prosthesis (ISFCDP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Twenty patients had a removable prosthetic labial flange fabricated for their existing maxillary prosthesis. The 3dMDface system was used to capture video sets of each patient going from repose to high smile with and without the labial flange. A single frame representing high smile and repose was selected from each video. Five facial anatomic markers and 21 individual points on the upper lip were evaluated for both image sets using quantitative photometric analysis. To provide a qualitative assessment, the same images were shown to dentists, laypeople, and the research subjects (patients) to determine which they found to be more esthetically pleasing, or if there was no difference. Quantitative data was evaluated using paired <i>t</i>-tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The two-dimensional analysis showed a difference with and without a labial flange for lip projection and lip thickness. Additionally, 13 out of 21 landmarks in the three-dimensional analysis showed differences when comparing the superimposed labial flange and no flange linear difference values between high smile and repose. Survey results showed that research subjects (54.41%), dentists (51.50%), and laypeople (44.50%), all preferred labial flange versus no flange photos or were not able to tell a difference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Qualitative and quantitative results suggest that a prosthetic labial flange has an impact on upper lip support. Clinicians should consider lip support both in full animation and repose when treatment planning for the maxillary ISFCDP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":"34 4","pages":"357-364"},"PeriodicalIF":3.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of the color of 3D-printed scan aids on the trueness of complete arch digital scans.","authors":"Özay Önöral, Selin Çakır","doi":"10.1111/jopr.13969","DOIUrl":"https://doi.org/10.1111/jopr.13969","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the influence of using 3D-printed scan aids in varying colors on the trueness of digital scans.</p><p><strong>Materials and methods: </strong>A master cast with five multi-unit analogues was scanned. The acquired dataset was exported to standard tessellation language (STL) file format to serve as the reference STL. 3D printing of the prototype in five distinct colors (beige [SA<sup>BEIGE</sup>], grey [SA<sup>GREY</sup>], white [SA<sup>WHITE</sup>], red [SA<sup>RED</sup>], and blue [SA<sup>BLUE</sup>]) of polylactic acid filament was executed. The experimental STLs of each color group were aligned to the reference STL. RMS values were solely computed for the scan bodies. Based on the centers of the created best-fit and offset planes, scan bodies were converted into virtual cylinders. Cartesian coordinates of each cylinder were acquired. Subsequently, angular (AD) and linear deviation (LD) values were calculated. LD was further examined separately along the x, y, and z axes. Data were statistically analyzed.</p><p><strong>Results: </strong>According to the results of one-way ANOVAs, significant differences were detected among color groups on AD, LD, RMS estimate error, ∆x, ∆y, and ∆z data. The lowest AD and LD values were exhibited by the SA<sup>GREY</sup> group in all implant sites. The SA<sup>GREY</sup> group was followed by the SA<sup>BEIGE</sup>, SA<sup>WHITE</sup>, SA<sup>RED</sup>, and SA<sup>BLUE</sup> groups.</p><p><strong>Conclusions: </strong>The SA<sup>GREY</sup> outperformed the other groups in terms of trueness. Although the LD values of all color groups were below the threshold value (<100 µm), only the AD values of the SA<sup>GREY</sup>, SA<sup>BEIGE</sup>, and SA<sup>WHITE</sup> groups were clinically acceptable (<0.5°).</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Silicone cure inhibition with material jetting additive manufacturing utilized for facial prosthesis fabrication - A clinical report.","authors":"Chen Chen, Denny Chao, Jay Jayanetti","doi":"10.1111/jopr.13968","DOIUrl":"https://doi.org/10.1111/jopr.13968","url":null,"abstract":"<p><p>This clinical report outlines the prosthetic restoration of a 92-year-old Caucasian patient who underwent a partial rhinectomy. Utilizing CAD-CAM technology, scanning and design were accomplished digitally, and material jetting additive manufacturing was used to create a two-piece mold for a partial nasal silicone prosthesis. An unprecedented challenge was observed involving cure inhibition when the silicone came into contact with the additively manufactured (AM) material, and multiple attempted strategies to remedy this situation were discussed. The report emphasizes the critical need for further research to optimize digital workflows in prosthetic facial rehabilitation.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justinas Pletkus, Liudas Auškalnis, Ieva Gendvilienė, Rolandas Pletkus, Tan Fırat Eyüboğlu, Mutlu Özcan, Mykolas Akulauskas, Vygandas Rutkūnas
{"title":"Accuracy of different maxillomandibular relationship recording techniques in the edentulous maxillary arch.","authors":"Justinas Pletkus, Liudas Auškalnis, Ieva Gendvilienė, Rolandas Pletkus, Tan Fırat Eyüboğlu, Mutlu Özcan, Mykolas Akulauskas, Vygandas Rutkūnas","doi":"10.1111/jopr.13976","DOIUrl":"10.1111/jopr.13976","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the effect of three digital bite registration techniques on the accuracy of intraoral scanning in maxillary edentulous and mandibular dentate arches.</p><p><strong>Materials and methods: </strong>Maxillary edentulous and mandible fully dentate models were created. Four dental implants were placed in the maxilla, fitted with scan bodies, and reference scans were obtained using a Nikon Altera 10.7.6 scanner. Digital impressions were acquired 10 times for each model using a Trios 4 intraoral scanner. Three different digital bite records were collected for each pair of mandible and maxilla scans. The first one was a bite record without additional material (WSB), the second utilized a silicone index between the models (WSB silicone), and the third followed a pre-preparation scanning protocol (Pre-PREP). The data was exported in standard tessellation language (STL) format, which was assessed for trueness and precision using statistical analysis.</p><p><strong>Results: </strong>According to mean trueness values, WSB exhibited the lowest value, 173 µm, followed by WSB silicone 242 µm and Pre-PREP 620 µm. The differences were significant only when comparing Pre-PREP to WSB and Pre-PREP to WSB silicone (p < 0.05). Regarding precision, WSB demonstrated a mean value of 171.5 µm, followed by WSB silicone with 213.8 µm, and Pre-PREP with 222.2 µm with no significant difference between the groups.</p><p><strong>Conclusion: </strong>The presence of interarch bite registration material adversely affected interocclusal record accuracy, while WSB silicone presented a suitable substitute for WSB.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haoxin Lv MDS, Hongzhao Wu BDS, Liqun Hu BDS, Wenjuan Song BDS, Yutong Gao BDS, Mingyu Zhao BDS, Yuwei Mao BDS, Shici Xia BDS, Yue Sa DDS, PhD
{"title":"Pterygoid implant-based maxillary full-arch rehabilitation using an autonomous robot system: A case report","authors":"Haoxin Lv MDS, Hongzhao Wu BDS, Liqun Hu BDS, Wenjuan Song BDS, Yutong Gao BDS, Mingyu Zhao BDS, Yuwei Mao BDS, Shici Xia BDS, Yue Sa DDS, PhD","doi":"10.1111/jopr.13979","DOIUrl":"10.1111/jopr.13979","url":null,"abstract":"<p>Pterygoid implant placement has been proven to be a viable option in full-arch implant rehabilitation for extremely atrophic maxillae. Nevertheless, the utilization of pterygoid implants remains a challenge for the dentist due to the difficulties of accessing the surgical site and poor visibility. To address these difficulties, digital techniques have been used to enhance the accuracy of pterygoid implant placement. This clinical case describes the application of an autonomous robot system to enhance the precision and efficacy of pterygoid implant placement. The results demonstrated that the integration of automation and real-time imaging provided by the robot system significantly improved the safety and accuracy of the surgical procedure.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":"34 3","pages":"232-239"},"PeriodicalIF":3.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majed S Altoman, Lamia Yahya M Alshowail, Mohammed A Alfaifi, Hatem Alqarni, Thuraya S Gadah, Mathew T Kattadiyil
{"title":"Utilization of digitally milled verification jigs for recording jaw relations in complete-arch implant rehabilitation: A digital clinical report.","authors":"Majed S Altoman, Lamia Yahya M Alshowail, Mohammed A Alfaifi, Hatem Alqarni, Thuraya S Gadah, Mathew T Kattadiyil","doi":"10.1111/jopr.13985","DOIUrl":"10.1111/jopr.13985","url":null,"abstract":"<p><p>This clinical report introduces a digital approach that utilizes milled verification jigs to acquire the jaw relations for the fabrication of monolithic zirconia implant-supported fixed complete dental prosthesis (IFCDP), in patients without a conversion implant prosthesis. The procedures employ photogrammetry for precise data acquisition, combined with image-based capture in 4 dimensions (ICAM4D), to design and mill verification jigs that accurately record the occlusal vertical dimension (OVD) and centric relation (CR). This approach streamlines the clinical workflow by reducing the number of patient visits and associated costs while enhancing precision and predictability. It eliminates the need for conventional steps and analog definitive casts in the fabrication of IFCDP without a conversion implant prosthesis.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hian Parize, Norbert Meier, Johannes Kleinheinz, Dalva Cruz Laganá, Newton Sesma, Lauren Bohner
{"title":"Effect of magnetic resonance imaging protocol on decision-making for positioning of dental implants in edentulous cases.","authors":"Hian Parize, Norbert Meier, Johannes Kleinheinz, Dalva Cruz Laganá, Newton Sesma, Lauren Bohner","doi":"10.1111/jopr.13975","DOIUrl":"10.1111/jopr.13975","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the influence of magnetic resonance imaging (MRI) protocol on the decision-making for the positioning of dental implants in edentulous arches in comparison to planning based on cone beam computed tomography (CBCT).</p><p><strong>Materials and methods: </strong>One phantom was scanned with CBCT and two MRI protocols (T1- and T2-weighted). Two calibrated examiners performed digital implant planning (coDiagnostiX, Dental Wings), considering a digital prosthetic planning and alveolar ridge surface scan. Four implants were planned for each patient dataset, and the angular deviation between the long axis of the implants and the prosthetic planning occlusal plane was measured.</p><p><strong>Results: </strong>Each examiner planned 40 implants, 12 implants with CBCT and 28 implants with MRI (16 with T1 and 12 with T2 images). Significant differences in angle deviation were observed between CBCT, T1, and T2 in the anterior region for both examiners (p = 0.009 for examiner 1 and p = 0.042 for examiner 2). Implants planned with CBCT showed significantly lower angular deviation than those based on the T1 and T2 scans for both examiners (p = 0.028 and p = 0.046 for examiner 1 and p = 0.028 and p = 0.027 for examiner 2). No significant difference in angular deviation was found between T1 and T2 for both examiners (examiner 1: p = 0.600, examiner 2: p = 0.916).</p><p><strong>Conclusion: </strong>Compared to CBCT planning, the MRI protocol influenced decision-making for anterior dental implants, with angular deviations within acceptable clinical thresholds, but further studies are needed to validate these findings.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sergio López-García, Miguel Ramón Pecci-Lloret, María Pilar Pecci-Lloret, David García-Bernal, Ricardo Elías Oñate-Sánchez
{"title":"Influence of the post-processing protocol on a biocompatible 3D-printed resin.","authors":"Sergio López-García, Miguel Ramón Pecci-Lloret, María Pilar Pecci-Lloret, David García-Bernal, Ricardo Elías Oñate-Sánchez","doi":"10.1111/jopr.13980","DOIUrl":"10.1111/jopr.13980","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the cytotoxicity of a biocompatible 3D-printed resin material for occlusal devices after post-processing with two different high-intensity UV-polymerization devices and two rinsing solvents, in the presence of human gingival fibroblasts (HGFs).</p><p><strong>Material and methods: </strong>Sample discs from the 3D-printed resin material were printed (2 mm in height and 6 mm in diameter [N = 40]) and divided into 4 groups (n = 10) based on post-processing methods: a high-intensity UV polymerization device with isopropyl alcohol, a high-intensity UV polymerization device with a modified glycol solvent, a UV cleaning and curing unit with isopropyl alcohol, a UV cleaning and curing unit with a modified glycol solvent, and a control group cultured in DMEM medium. Different tests were performed to evaluate their cytocompatibility on HGFs: MTT assay, cell migration assay, cell cytoskeleton staining, scanning electron microscopy (SEM), and cell apoptosis and generation of intracellular reactive oxygen species (ROS). Statistical analyses were performed using one-way ANOVA and the Tukey post hoc test (α = 0.05).</p><p><strong>Results: </strong>Cytocompatibility, MTT assay, cell migration assay, cell cytoskeleton staining, and SEM images were similar, regardless of the post-processing protocol, compared with the control group.</p><p><strong>Conclusions: </strong>No differences were found in the cytotoxicity of the 3D-printed resin material for occlusal devices after the following post-processing methods: two different UV-polymerization devices and two rinsing solvents (isopropyl alcohol and a modified glycol solvent).</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Toshiki Nagai, Weiqing Liu, Chao-Chieh Yang, Waldemar D Polido, Dean Morton, Wei-Shao Lin
{"title":"Intraoral scanning for implant-supported complete-arch fixed dental prostheses (ISCFDPs): Four clinical reports.","authors":"Toshiki Nagai, Weiqing Liu, Chao-Chieh Yang, Waldemar D Polido, Dean Morton, Wei-Shao Lin","doi":"10.1111/jopr.13971","DOIUrl":"https://doi.org/10.1111/jopr.13971","url":null,"abstract":"<p><p>Although there are difficulties with using intraoral scans for implant-supported complete-arch fixed dental prostheses (ISCFDPs), several commercially available systems have become helpful in simplifying the treatment process in the prosthetic phase. These systems help patients move from interim ISCFDPs to receiving definitive prostheses in just three clinical visits. This clinical report summarizes the indications, benefits, and limitations of the four systems. The information provided in this report about the digital prosthetic workflow of ISCFDPs aims to help clinicians make well-informed choices and improve treatment results. With digital technologies advancing, refining these tools and protocols, and validating research is crucial for continued evolution in the field.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cibele Dal Fabbro DDS, PhD, Thomas Bornhardt-Suazo DDS, MSc, Anaïs Landry Schönbeck DMD, MSc, Micheline de Meyer DDS, PhD, Gilles J. Lavigne DMD, PhD
{"title":"Understanding the clinical management of co-occurring sleep-related bruxism and obstructive sleep apnea in adults: A narrative and critical review","authors":"Cibele Dal Fabbro DDS, PhD, Thomas Bornhardt-Suazo DDS, MSc, Anaïs Landry Schönbeck DMD, MSc, Micheline de Meyer DDS, PhD, Gilles J. Lavigne DMD, PhD","doi":"10.1111/jopr.13966","DOIUrl":"10.1111/jopr.13966","url":null,"abstract":"<p>Sleep-related bruxism (SRB) is a motor oral behavior characterized by tooth grinding and jaw clenching activity, reported by 8%–12% of the adult general population and 3% of older individuals. The frequency of one of its biomarkers, rhythmic masticatory muscle activity (RMMA), remains elevated across ages. Obstructive sleep apnea (OSA) is associated with the brief and repetitive pause of breathing (apnea) and with transient reduction in oxygen (hypoxia). OSA is observed at all ages and in about 50% of older individuals with a male preponderance. SRB clinical assessment is based on self-reporting of tooth grinding sound, awareness of clenching, jaw pain or headache, and clinical observation of tooth damage. OSA clinical assessment is based on sleepiness and fatigue, snoring, sleep quality, and awareness of breathing cessation, plus clinical examination of anatomical factors (e.g., obesity, retrognathia, large tonsil, macroglossia), age, gender, and body mass. Although the literature does not support association or causality between these two conditions, the co-occurrence is reported in about 30%–50% of adults. To confirm a diagnosis of co-occurring SRB and OSA, home sleep testing (HST) may be indicated. A sleep test is performed using electromyography (EMG) of jaw muscle (masseter or temporalis) and cardio-respiratory variables (e.g., air flow, respiratory effort, oxygen level, heart rate). The management of co-occurring SRB and OSA for individuals with prosthodontic needs is challenging to prevent compromising the oro-pharyngeal space and breathing efficiency. OSA treatment in the presence of SRB includes continuous positive airway pressure (CPAP) use alone or with an occlusal splint or mandibular advancement device (MAD). In addition, the following may be considered: supine sleep correction device, myofuncional therapy, medications, and surgeries. All have limitations and risks. Individual variability suggests that phenotyping is mandatory to select the most efficient and personalized treatment.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":"34 S1","pages":"46-61"},"PeriodicalIF":3.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jopr.13966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}