Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry最新文献

{"title":"Effects of autoclave sterilization on the dimensional stability of implant surgical guides: A 3D in vitro analysis.","authors":"Lucio Lo Russo, Pierluigi Mariani, Carlo Ercoli, Giusy Caprio, Ji-Man Park, Luigi Laino, Fariba Esperouz","doi":"10.1111/jopr.14049","DOIUrl":"https://doi.org/10.1111/jopr.14049","url":null,"abstract":"<p><strong>Purpose: </strong>Surgical guides are medical devices used in static implant surgery to replicate the prosthetic and surgical implant position planned with computer-assisted software before surgery. Their use reduces invasiveness and improves safety and outcomes of implant surgery, provided that their accuracy is ensured from design to manufacturing and then to clinical usage. One of the factors that may potentially interfere with their accuracy is the sterilization procedure. The present study aimed to analyze how autoclave sterilization affects 3D-printed surgical guide stability.</p><p><strong>Materials and methods: </strong>Ten 3D-printed surgical guides were scanned before (T0) and after (T1) autoclave sterilization. T0 and T1 scans were compared with the corresponding CAD model in a surface matching software program. Trueness of the intaglio surface, linear and axial deviations of sleeves' housings at T0 and T1 were measured and statistically analyzed by generalized estimated equation (GEE) models to evaluate the effects of the sterilization procedure.</p><p><strong>Results: </strong>Surface variations, linear and axial deviations of sleeves' housings were found to be significantly (p < 0.05) affected by the sterilization only in combination with the volume or the total surface area of the surgical guides. The magnitude of the T0-T1 differences was small (0.016 mm and 0.035 mm for mean absolute deviation (MAD) at the intaglio surface in contact with teeth or mucosa; 0.009 mm for linear deviation of the central point of sleeves' housings; 0.084° and 0.180° for their axial deviation on the sagittal and frontal planes).</p><p><strong>Conclusion: </strong>The effects of autoclave sterilization on the stability of 3D-printed surgical guides remain limited and clinically insignificant.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What occlusal scheme should be used for tooth-supported fixed partial dentures?","authors":"Charles Goodacre, Gary Goldstein","doi":"10.1111/jopr.14048","DOIUrl":"https://doi.org/10.1111/jopr.14048","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The purpose of this review of occlusion for fixed partial dentures (FPD) placed on natural teeth was to determine the level of scientific evidence available regarding the occlusal scheme during eccentric mandibular movements and the scheme for occlusal contact in the maximal intercuspal position (MIP).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;A PubMed search of \"natural teeth, dental occlusion, fixed partial dentures, bridges\" using the filters: Case Reports, Clinical Trial, Randomized Controlled Trial, Systematic Review resulted in 7 citations, none of which were relevant. Two were on complete dentures, 2 on implants, and 1 on removable partial dentures. As a result of the literature search and review, it was determined there is a lack of compelling evidence to support a specific eccentric occlusal relationship, tooth form, or how opposing teeth interdigitate, necessitating a look back at First Principles.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Three natural dentition eccentric occlusal relationships have been described in the dental literature: canine protected articulation (CPA), group function (GF), and balanced occlusion. There are no clinical trials focused on the differences between occlusal schemes for occlusal rehabilitation of natural teeth using FPDs. Most clinical studies of natural dentitions determined that GF occurs more commonly than CPA but there is a lack of data supporting the superiority of either of these two eccentric occlusal relationships. There were no clinical studies on occlusal contact schemes with FPDs. Two basic intercuspal schemes have been advocated, cusp-to-fossa and cusp-to-marginal ridge. There is no evidence for how many occlusal contacts are necessary for a stable occlusion with some authors having recommended buccalized or lingualized occlusion.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;With FPD occlusion involving natural teeth, there is no clinical evidence supporting the superiority of one eccentric occlusal relationship over another. During protrusive movements, guidance by only the incisors without posterior tooth contact is the most common type of relationship and it is more common in Angle's Class Type I occlusions than in Angle Class II and III occlusions. Posterior tooth contact can occur during protrusion, and it is most common in Angle Class III occlusions and least common in Angle Class II occlusions. The canines can make occlusal contact during protrusive movements. Clinicians have used both GF and CPA in the restoration of teeth with FPDs. When restoring one arch the prostheses should harmonize with the patient's existing occlusal scheme if no other pathology exists. Nonworking side (mediotrusive) contacts should not be present on posterior teeth during lateral mandibular movements. In MIP, occlusal forces should be directed along the long axis of teeth. Some clinicians prefer that occlusal forces not be present on inclined surfaces in MIP and have cuspal contact on opposing","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between palatal coverage and accuracy of texture perception: A preliminary study using an experimental palatal plate.","authors":"Akinari Daidoji, Yasue Tanaka, Yuki Ito, Hala Al Khalili, Yoshinori Hattori","doi":"10.1111/jopr.14046","DOIUrl":"https://doi.org/10.1111/jopr.14046","url":null,"abstract":"<p><strong>Purpose: </strong>Using an experimental palatal plate, this study aimed to clarify the effect of palatal coverage on the accuracy of texture perception, including thickness discrimination (T_dis), roughness discrimination (R_dis), and roughness detection (R_det), in healthy young individuals.</p><p><strong>Materials and methods: </strong>Thirty-four healthy participants (mean age, 26.3 ± 3.5 years) were enrolled. An experimental palatal plate made from thermoplastic denture resin was used to evaluate texture perception. Thresholds for T_dis, R_dis, and R_det were determined under two conditions: with and without the plate (w/ P and w/o P), using a staircase method. These thresholds were converted into scores for T_dis, R_dis, and R_det.</p><p><strong>Results: </strong>The palatal plate significantly reduced T_dis and R_dis scores, but had no effect on R_det. T_dis scores w/o P were higher than those w/ P (median [Q1-Q3], 4 [2-5] vs. 2 [1-4]; p = 0.0051), indicating reduced T_dis accuracy with the plate. Similarly, R_dis scores w/o P were higher than those w/ P (3 [2-4] vs. 2 [1-3]; p = 0.0029), suggesting reduced roughness discrimination accuracy with the plate. The effects were more pronounced in participants with higher scores in the w/o P condition. No significant differences were observed in R_det scores.</p><p><strong>Conclusion: </strong>Wearing the experimental palatal plate significantly reduced T_dis and R_dis accuracies, particularly in participants with a higher baseline accuracy. These findings suggest that individual texture perception may affect the eating experience of denture wearers, and that texture perception testing could guide prosthodontic treatment strategies.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obtaining full-arch implant scan with smartphone video and deep learning: An in vitro investigation on trueness and precision.","authors":"Junying Li, Zhaozhao Chen, Fei Liu, Berna Saglik, Gusatvo Mendonca, Hom-Lay Wang","doi":"10.1111/jopr.14041","DOIUrl":"https://doi.org/10.1111/jopr.14041","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the accuracy of complete-arch implant scans generated by a smartphone camera and a deep learning model.</p><p><strong>Materials and methods: </strong>A deep learning model was trained to generate 3D scans from smartphone videos using a maxillary edentulous model with 6 implants and scan bodies (SBs). Three test groups were created: (1) deep learning 3D reconstruction with 1500 training epochs (DL1), (2) deep learning 3D reconstruction with 5000 training epochs (DL2), and (3) scans obtained from an intraoral scanner (IOS). Each method was repeated 10 times, with a desktop scanner scan as the reference. Test scans were aligned to the reference using two methods: (a) aligning all SBs to evaluate the overall fit, and (b) aligning just the first and second SBs to simulate passive fitting test of multiple implant-supported prostheses. Linear deviations from the reference model (trueness) and within each group (precision) were analyzed.</p><p><strong>Results: </strong>For the overall fit, the DL2 group (67.69 ± 33.29 µm) showed significantly better (p < 0.05) mean trueness than the DL1 group (127.82 ± 73.07 µm), and similar trueness to the IOS group (57.42 ± 36.09 µm). However, the DL2 group (98.12 ± 59.85 µm) showed worse (p < 0.05) precision compared to the IOS group (64.54 ± 42.53 µm). In the virtual passive-fitting test, the DL2 group showed similar trueness and accuracy compared to the IOS group.</p><p><strong>Conclusions: </strong>In the in vitro environment, combining smartphone videos with a deep learning model generated full arch implant scans with accuracy similar to an IOS. Although this accuracy is not good enough for clinical application, this approach shows promise as a potential direction for future development in economical full-arch implant scanning.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep medicine, sleep apnea, and prosthodontics","authors":"Jean C. Wu DDS","doi":"10.1111/jopr.14040","DOIUrl":"10.1111/jopr.14040","url":null,"abstract":"","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":"34 S1","pages":"3"},"PeriodicalIF":3.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jopr.14040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board","authors":"","doi":"10.1111/jopr.13709","DOIUrl":"https://doi.org/10.1111/jopr.13709","url":null,"abstract":"","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":"34 3","pages":"225-226"},"PeriodicalIF":3.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jopr.13709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting stability of surgical guides in mandibular unilateral distal extension situation: An in vitro study.","authors":"Esraa A Elnadoury, Yousria S Gaweesh, Shaimaa M Abu El Sadat, Mervat E Abd-Ellah","doi":"10.1111/jopr.14043","DOIUrl":"https://doi.org/10.1111/jopr.14043","url":null,"abstract":"<p><strong>Purpose: </strong>Unilateral tooth-supported guides reported less effective implant placement than bilateral tooth-supported guides. Therefore, this study evaluated the effect of guide design, replaced tooth location, and applied forces on implant deviation and guide stability of mandibular unilateral tooth-supported guides.</p><p><strong>Materials and methods: </strong>Ten epoxy resin models with soft tissue simulated material were used. For each model, three surgical guide designs were generated: a fully extended guide, a guide with two fixation pins, and one with one fixation pin. Two sleeves were incorporated in each guide for mandibular premolar and molar. Forces were applied from the buccal and oral directions (0.1 N, 1 N, 2.5 N, and 5 N). An intraoral scanner captured the resulting surgical guide displacement. Virtual implants were added to each scan (470 virtual implants) to measure their deviation from the original planned position.</p><p><strong>Results: </strong>Surgical guides with two fixation pins showed the least implant vertical deviation (0.38 ± 0.27 mm, p<0.001) and guide deviation (0.52 ± 0.25 mm, p<0.001). Guide design has a small to medium effect size in all the deviation measurements(p<0.001). Force direction has a significantly large effect on implant vertical deviation (η² = 0.15, p<0.001). Force magnitude greatly affects implant angular deviation (η² = 0.34, p<0.001). A larger vertical deviation was detected in the molar implant location (0.59 ± 0.48 mm p<0.001).</p><p><strong>Conclusions: </strong>Incorporating two fixation pins into unilateral tooth-supported guides significantly enhances stability and minimizes implant deviation. However, forces applied during guided surgery and implant location have a substantial impact, exceeding the influence of the guide design.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of primary healing implants with different transmucosal designs.","authors":"Mario Ceddia, Tea Romasco, Luca Comuzzi, Alessandro Cipollina, Adriano Piattelli, Natalia Di Pietro, Bartolomeo Trentadue","doi":"10.1111/jopr.14044","DOIUrl":"https://doi.org/10.1111/jopr.14044","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the response of peri-implant tissues, both hard and soft, to mechanical stress when using a primary healing implant (PHI) with two different transmucosal profiles: concave (Model A) and divergent (Model B). The investigation also sought to observe bone modeling under post-extraction conditions.</p><p><strong>Materials and methods: </strong>The methodology involved the creation of a three-dimensional bone model of the first molar region, derived from a computed tomography scan. Subsequently, two implants were inserted into the bone site and subjected to a loading force of 100 N at a 45° angle.</p><p><strong>Results: </strong>The results of stress analysis, using the von Mises criterion, indicated that Model A exhibited a more uniform stress distribution within the soft tissues, registering a maximum value of 75 MPa, in contrast to 126 MPa observed in Model B. Concerning implant stress, the peak value was recorded at the conometric connection zone between the implant and the abutment, measuring 138 MPa for Model B and 125 MPa for Model A. The study specifically analyzed cortical bone stress, which revealed levels of 72 MPa for Model B and 64 MPa for Model A. Additionally, stress distribution in immature bone ranged from 1.3 to 9 MPa for Model A and from 1.5 to 12 MPa for Model B.</p><p><strong>Conclusions: </strong>The finite element method represents a valuable tool for the design and optimization of implant shapes, taking into account occlusal loads and specific anatomical locations. This approach aims to enhance the stimulation of both soft and hard tissues, thereby mitigating the risk of implant failure.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in vitro assessment of the accuracy of guided tilted and axial implant placement in the edentulous mandible.","authors":"Brett C Freeman, Hawra Alqallaf, Chao-Chieh Yang, Wei-Shao Lin, Vinicius Dutra, Yusuke Hamada","doi":"10.1111/jopr.14037","DOIUrl":"https://doi.org/10.1111/jopr.14037","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the precision of implant placement when comparing tilted orientations to axial orientations, utilizing a fully guided surgical protocol in an edentulous mandibular model.</p><p><strong>Materials and methods: </strong>Fourteen rubber-coated mandibular models were scanned with fiducial markers using a commercial benchtop surface scanner, followed by cone beam computed tomography for implant planning through a dual-scan protocol. The models were randomly divided into control and experimental groups. In the control group, each model was planned for four axially oriented implants. Conversely, the experimental models were planned for two axially oriented implants near the lateral incisors and two posteriorly tilted implants at a 30-degree angle. A mucosal-supported, pin-retained surgical guide was designed and 3D-printed, facilitating the fully guided implant placement. All implants received scan bodies and were rescanned for evaluation of the trueness between the planned and the actual implant location using the implant planning software. Mixed model ANOVA was used to detect differences between groups with regards to angular deviation, offset at base, and offset at tip.</p><p><strong>Results: </strong>A total of 56 implants were placed across all models. Fourteen posterior implants in each group served as control and experimental conditions, while the remaining 28 anterior implants acted as secondary control. No significant differences were observed between the experimental and control groups in terms of angular deviation (p = 0.7001), offset at base (p = 0.6409), or offset at tip (p = 0.6931). Analysis comparing anterior implant deviations between groups and anterior to posterior implant deviations within the control arches also was not significant. However, secondary analysis revealed a significant difference between anterior and posterior implants within the experimental group for offset at base (p = 0.0087) and offset at tip (p = 0.0288).</p><p><strong>Conclusions: </strong>Despite the limitations inherent to a benchtop study, the findings suggest that there are no statistically significant 3D deviations at the base or apex, nor in angular deviations, when comparing tilted and axial implant placements using a digital workflow and fully guided protocols in an edentulous model.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longevity of terminal abutment teeth retaining maxillary obturator prostheses.","authors":"Tintu Chandy, Annu Singh, Akriti Mishra Meza, Elyn Riedel, Joseph M Huryn, Joseph D Randazzo","doi":"10.1111/jopr.14026","DOIUrl":"https://doi.org/10.1111/jopr.14026","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the longevity of terminal abutment teeth retaining maxillary obturator prostheses.</p><p><strong>Materials and methods: </strong>This was a retrospective study of patients who underwent maxillectomy followed by delivery of definitive obturator prostheses between 1994 and 2020. Details on patient demographics, primary tumor, and radiation therapy were collected. The tooth closest to the defect was identified as the terminal abutment, and information such as tooth type, condition of tooth at the time of maxillectomy, Aramany classification, and cause of abutment loss were noted from the dental charts. Survival time of the terminal abutment tooth was calculated from the date of maxillectomy to the last dental follow-up visit or the date of abutment loss. Univariate analyses were performed to test for the association between survival time and each of the four covariates.</p><p><strong>Results: </strong>In the 26-year study period, 148 teeth in 130 patients met the inclusion criteria. Ninety-eight (66.2%) terminal abutment teeth survived, and 50 (33.8%) were lost. Squamous cell carcinoma was the leading tumor diagnosis (51%). Aramany Class II was the most predominant arch configuration (51%). The majority of the terminal abutment teeth were maxillary incisors (43%). The chief cause of terminal abutment loss was bone loss and mobility (46%). The 10-year survival probability was 65%. Radiation therapy did not statistically contribute to terminal abutment loss. Terminal abutment teeth with dental treatment showed higher failure than those without any prior treatment or dental disease.</p><p><strong>Conclusion: </strong>Clinicians must be aware of the various factors affecting the survival of terminal abutment teeth which can ultimately affect the success of the maxillary obturator prostheses.</p>","PeriodicalId":49152,"journal":{"name":"Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}