the Quarterly Journal of Nuclear Medicine and Molecular Imaging最新文献_第4页

Angio-immunoblastic lymphadenopathy: report of ten cases and review of the literature. 血管免疫母细胞性淋巴结病:附十例报告并文献复习。

IF 1.5 4区医学

the Quarterly Journal of Nuclear Medicine and Molecular Imaging Pub Date : 1979-01-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A067563

M. Cullen, A. Stansfeld, R. Oliver, T. Lister, J. Malpas

{"title":"Angio-immunoblastic lymphadenopathy: report of ten cases and review of the literature.","authors":"M. Cullen, A. Stansfeld, R. Oliver, T. Lister, J. Malpas","doi":"10.1093/OXFORDJOURNALS.QJMED.A067563","DOIUrl":"https://doi.org/10.1093/OXFORDJOURNALS.QJMED.A067563","url":null,"abstract":"Angio-immunoblastic lymphadenopathy (AIL) is a disease of unknown aetiology and pathogenesis. It has features of hyperimmunity, immune deficiency and can behave like a malignant lymphoma. An underlying abnormality of T-cell regulatory function has been proposed. We report ten patients with AIL followed prospectively and review 200 cases from the literature. As well as showing the typical features described in previous retrospective series namely: constitutional symptoms, generalized lymphadenopathy, hepatosplenomegaly, skin eruptions, hypergammaglobulinaemia and characteristic lymph node histology; four patients had oedema with ascites or pleural effusions associated with hyponatraemia and hypoalbuminaemia. We have also observed low free thyroxine indices in three patients with elevated TSH levels in two, but without clinical features of hypothyroidism. Seven of the patients in this study were treated with prednisone and cyclophosphamide. Three achieved complete remission but only one patient has survived longer than two years. Failure to achieve complete remission has been associated with a 90 per cent mortality within one year of the onset of disease in the reports reviewed. Corticosteroids alone have produced only a 40 per cent rate of remission. The management of poor responders, non-responders and many relapse cases in unsatisfactory. More instensive chemotherapy is very hazardous, increasing the already high risk of severe infections, and is often unsuccessful. Histological features recently reported to represent co-existent immunoblastic lymphoma at diagnosis were recognized in three of our patients, two of which went on to develop definite lymphoma.","PeriodicalId":49135,"journal":{"name":"the Quarterly Journal of Nuclear Medicine and Molecular Imaging","volume":"111 1","pages":"151-77"},"PeriodicalIF":1.5,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76716924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 70

Dissecting aortic aneurysms: a clinicopathological study. I. Clinical and gross pathological findings. 夹层主动脉瘤:临床病理研究。1 .临床及大体病理表现。

IF 1.5 4区医学

the Quarterly Journal of Nuclear Medicine and Molecular Imaging Pub Date : 1979-01-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A067566

J. C. Leonard, P. Hasleton

{"title":"Dissecting aortic aneurysms: a clinicopathological study. I. Clinical and gross pathological findings.","authors":"J. C. Leonard, P. Hasleton","doi":"10.1093/OXFORDJOURNALS.QJMED.A067566","DOIUrl":"https://doi.org/10.1093/OXFORDJOURNALS.QJMED.A067566","url":null,"abstract":"One hundred and seventy-one patients with dissecting aneurysm seen between 1951 and 1976 at three hospitals in Manchester were studied. There were 60 proximal dissections, 80 distal dissections, 10 abdominal dissections and in 21 the site of origin was uncertain. Pain was the major symptom in 88 per cent of patients; radiation of pain to the interscapular region was much more common in distal dissections. Systemic hypertension was present in 77 per cent, being commoner in distal dissections (83 per cent) than in proximal dissections (70 per cent). Aortic incompetence, hemiplegia and shock were all more common in proximal dissections. Post-mortem examination was performed in 125 patients. Eighty-four per cent of proximal dissections had ruptured, 74 per cent into the pericardium and five per cent into the left pleural cavity. Seventy per cent of distal dissections had ruptured, 11 per cent into the pericardium and 41 per cent into the left pleural cavity. The extent of the dissection was analysed, and it was shown that 25 per cent of distal dissections had extended proximally into the ascending aorta and arch. This implies that diagnosis of the site of origin of dissection from clinical signs and the plain chest-radiograph is inaccurate. Aortography is required for precise assessment. Since treatment often varies with the site of dissection, aortography should be performed in most patients surviving the first few hours. Attention is drawn to the frequency (10.4 per cent) of multiple aortic lesions, and to the occasional aetiological significance of giant-cell arteritis, and, possibly, hypothyroidism.","PeriodicalId":49135,"journal":{"name":"the Quarterly Journal of Nuclear Medicine and Molecular Imaging","volume":"20 1","pages":"55-63"},"PeriodicalIF":1.5,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74267518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 79

Neurological complications of carbon monoxide poisoning. 一氧化碳中毒的神经系统并发症。

IF 1.5 4区医学

the Quarterly Journal of Nuclear Medicine and Molecular Imaging Pub Date : 1967-10-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A067122

H. Garland, J. Pearce

引用次数: 163

Renal venous thrombosis in children. 儿童肾静脉血栓形成。

IF 1.5 4区医学

the Quarterly Journal of Nuclear Medicine and Molecular Imaging Pub Date : 1965-07-01 DOI: 10.1093/OXFORDJOURNALS.QJMED.A067049

McFarland Jb

引用次数: 36