Contact Lens & Anterior Eye最新文献

{"title":"Combination effect of levofloxacin and cefmenoxime against ocular isolates of Pseudomonas aeruginosa","authors":"Motohiro Itoi ,&nbsp;Mark D.P. Willcox","doi":"10.1016/j.clae.2024.102311","DOIUrl":"10.1016/j.clae.2024.102311","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to investigate the effects of the combination of levofloxacin (LVFX) and cefmenoxime (CMX) on ocular isolates of <em>Pseudomonas aeruginosa.</em></div></div><div><h3>Methods</h3><div>Twenty-three strains of <em>P. aeruginosa</em> isolated from microbial keratitis cases in Australia were utilized in this study. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of each antibiotic alone were determined and the combined susceptibility of antibiotics was assessed through fractional inhibitory concentration index (FICI). Additionally, tolerance of a ciprofloxacin tolerant <em>P. aeruginosa</em> isolate to each antibiotic alone and combination were analyzed.</div></div><div><h3>Results</h3><div>The median MIC and MBC values of CMX against <em>P. aeruginosa</em> were 16 µg/mL and 32 µg/mL, respectively. The median MIC and MBC values of LVFX were 0.5 µg/mL and 1 µg/mL, respectively, and all isolates were susceptible. In dual combination, the median of FICI of all strains was 0.63; seven strains showed synergistic effects (FICI≤0.5), and fifteen strains showed additive activities, while no strains exhibited antagonism. The isolate of <em>P. aeruginosa</em> that had previously exhibited tolerance to ciprofloxacin showed high tolerance to CMX alone and low tolerance to LVFX alone. This strain showed low tolerance to the combination of CMX and LVFX.</div></div><div><h3>Conclusion</h3><div>The combination of LVFX with CMX may have beneficial interactions which increase antibacterial activity against <em>P. aeruginosa</em> isolates and may be a feasible option for addressing the issue of bacteria resistant to each antibiotic.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102311"},"PeriodicalIF":4.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Turkish version of the 5-item Dry Eye Questionnaire (T-DEQ-5): Translation, validity, and reliability","authors":"Semra Akkaya Turhan ,&nbsp;Elif Bagatur Vurgun ,&nbsp;Ece Yalçındağ ,&nbsp;Samet Gülkaş ,&nbsp;Canan Şanal Toprak ,&nbsp;Ayşe Ebru Toker","doi":"10.1016/j.clae.2024.102309","DOIUrl":"10.1016/j.clae.2024.102309","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the reliability and validity of Turkish translation of the 5-item Dry Eye Questionnaire (T-DEQ-5) and to compare it with the Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), corneal staining, and Schirmer test results.</div></div><div><h3>Methods</h3><div>The linguistic validation procedures adopted internationally, including forward translations, backward translation into English, examination of the translation quality, and a pilot test on 10 subjects, were employed. The translated and validated questionnaire was applied to 25 subjects two-time points (second time within three days) to evaluate the intra-test reliability. One hundred subjects were recruited for the study. They underwent an ophthalmic examination, including Schirmer tests, TBUT, and ocular surface staining (OSS) after completing OSDI questionnaire. Receiver operating characteristics (ROC) were assessed to determine sensitivity and specificity of the T-DEQ-5.</div></div><div><h3>Results</h3><div>The mean age of subjects was 45.7 ± 16.2 years, with 65 % being female. Overall, the test–retest reliability was excellent with an intra-class correlation coefficient value of 0.95 (95 % CI 0.90–0.98, p &lt; 0.001). The Cronbach’s alpha reliability coefficient was 0.90, which demonstrated a strong level of internal consistency of the T-DEQ-5. Using ROC analysis to compare the results of the T-DEQ-5 with those of the OSDI, the area under the curve was found 0.95, with an optimal cut-off threshold of 6, resulting in 81 % sensitivity and 91 % specificity. Establishing the diagnosis based on a positive OSDI (≥13) and at least one positive sign (TBUT and/or OSS) yielded a sensitivity of 95 % and a specificity of 87 % at the cut-off threshold of 6.</div></div><div><h3>Conclusion</h3><div>The Turkish version of the DEQ-5 is a valid and reliable questionnaire and capable of differentiating patients with dry eye.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102309"},"PeriodicalIF":4.1,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of upper eyelid pressure and ocular surface parameters in dry eye disease and benign essential Blepharospasm: A cross-sectional study","authors":"Guohong Zhao ,&nbsp;Jingyi Wang ,&nbsp;Qian Ma ,&nbsp;Yiran Hao ,&nbsp;Lei Tian ,&nbsp;Ying Jie","doi":"10.1016/j.clae.2024.102298","DOIUrl":"10.1016/j.clae.2024.102298","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the upper eyelid pressure (UEP) and ocular surface parameters between dry eye disease (DED) and DED coexisting with benign essential blepharospasm (BEB), exploring which parameters could assist in distinguishing between DED and BEB, as potential risk factors for DED with BEB.</div></div><div><h3>Methods</h3><div>All enrolled participants diagnosed with DED or DED coexisting with BEB were initially subjected to ocular surface disease index (OSDI) determination. Subsequently, the upper eyelid pressure was recorded using an innovative eyelid pressure measurement device, followed by a series of ocular surface examinations. The two groups were compared using the independent <em>t</em>-test and Mann-Whitney <em>U</em> test. A logistic regression analysis was performed to identify which parameters can predict the onset of blepharospasm.</div></div><div><h3>Results</h3><div>The BEB group achieved a higher upper eyelid pressure (101.9 ± 23.5mN vs 88.4 ± 18.1mN, P = 0.009), lower number of total blink (6.2 ± 4.2 vs 7.1 ± 4.1, P = 0.016), higher corneal fluorescein staining score (4.0 ± 1.9 vs 3.0 ± 1.7, P = 0.046), higher partial blink rate (0.9 ± 0.2 vs 0.5 ± 0.4, P = 0.000) and the lower grade of meibum expressibility (1 (1, 2) vs 2 (1, 3), P = 0.000) and meibum quality (1 (1, 1) vs 1 (1, 1), P = 0.033) compared with the DED group. The upper eyelid pressure (OR = 1.123), partial blink rate (OR = 0.014) and the grade of meibum expressibility (OR = 10.804) showed significant associations with BEB (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Despite similar OSDI scores, DED coexisting with BEB exhibited higher upper eyelid pressure, lower corneal fluorescein staining score, lower partial blink rate, more total blinks, lower grades of meibum expressibility, and lower meibum quality compared to DED alone. Among these, higher upper eyelid pressure, lower partial blink rate, and worse grade of meibum expressibility were identified as risk factors for BEB in DED.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102298"},"PeriodicalIF":4.1,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International trends in prescribing silicone hydrogel contact lenses for daily wear (2000–2023): An update","authors":"Nathan Efron ,&nbsp;Philip B. Morgan ,&nbsp;Craig A. Woods ,&nbsp;Deborah Jones ,&nbsp;Lyndon Jones ,&nbsp;Jason J. Nichols","doi":"10.1016/j.clae.2024.102310","DOIUrl":"10.1016/j.clae.2024.102310","url":null,"abstract":"<div><h3>Purpose</h3><div>Introduced around the turn of the 21st century, silicone hydrogel contact lenses alleviated hypoxic anterior eye complications due to their high oxygen transmissibility. The purpose of this work is to update earlier surveys by describing international trends in silicone hydrogel daily wear contact lens fitting between 2000 and 2023.</div></div><div><h3>Method</h3><div>An annual contact lens prescribing survey was sent to eye care practitioners in up to 71 countries between 2000 and 2023. Data relating to 260,144 daily wear soft contact lens fits undertaken in 20 countries returning reliable longitudinal data were analysed in respect of silicone hydrogel daily wear contact lens fitting.</div></div><div><h3>Results</h3><div>There has been a dramatic increase in silicone hydrogel daily wear lens fits (p &lt; 0.0001), increasing from 2.8 % of all daily wear soft lens fits in 2000 to 73.7 % in 2023. Of all daily wear soft contact lenses prescribed to males, 44.6 % were silicone hydrogel lenses, compared with 43.5 % for females (p = 0.0146). The mean age of those wearing silicone hydrogel daily wear lenses was 32.0 ± 14.5 years, compared to 30.4 ± 13.6 years for those wearing daily wear hydrogel lenses (p &lt; 0.0001). Between 2019–2023, the average percentage of fits was – (a) material type: silicone hydrogel – 73 %; mid-water content hydrogels – 13 %; high water content hydrogels – 9 %; and low water content hydrogels – 5 %, and (b) lens design: spherical – 44 %, toric – 32 %, multifocal – 17 %, monovision – 4 %, and ‘other’ – 3 %.</div></div><div><h3>Conclusion</h3><div>The dramatic increase in silicone hydrogel contact lens prescribing for daily wear has been commensurate with the introduction of multiple lens brands and an ongoing expansion of lens designs, parameters and replacement frequency options. The balance between silicone hydrogel and hydrogel lens prescribing is perhaps starting to approach an equilibrium.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102310"},"PeriodicalIF":4.1,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The effects of eyelash extensions on the ocular surface” [Cont. Lens Anterior Eye. 47(2) (2024) 102109]","authors":"Jiaxin Han ,&nbsp;Zihong Xie ,&nbsp;Xingwei Zhu ,&nbsp;Wanting Ruan ,&nbsp;Meng Lin ,&nbsp;Zhiqiang Xu ,&nbsp;Lijie Miao ,&nbsp;Junyang Zhong ,&nbsp;Fan Lu ,&nbsp;Liang Hu","doi":"10.1016/j.clae.2024.102286","DOIUrl":"10.1016/j.clae.2024.102286","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102286"},"PeriodicalIF":4.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLOW: Global Ophthalmic Women","authors":"Lakshmi Shinde","doi":"10.1016/j.clae.2024.102302","DOIUrl":"10.1016/j.clae.2024.102302","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 5","pages":"Article 102302"},"PeriodicalIF":4.1,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear levels of Transforming Growth Factor-β1 and Interleukin 1-β, and clinical correlations in new contact lens users","authors":"Eduardo Insua Pereira ,&nbsp;Ana Paula Sampaio ,&nbsp;Madalena Lira","doi":"10.1016/j.clae.2024.102299","DOIUrl":"10.1016/j.clae.2024.102299","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess alterations in the tear Transforming Growth Factor (TGF)-β1 and Interleukin (IL1)-β concentration in new contact lens wearers; and explore correlations with tear film stability, and ocular physiological response.</div></div><div><h3>Methods</h3><div>In this clinical setting, 12 neophytes (5 males), with an average age of 24.0 ± 5.0 years were fitted with delefilcon A contact lenses. Physiological responses (bulbar and limbal hyperemia), Pre-corneal (NIBUT), Pre-lens (PL-NIBUT) non-Invasive Break-Up Times, and tear samples were collected in the morning (before lens insertion; 9 – 10 a.m.) and afternoon (before lens removal; 7 – 8p.m.) of the same day. NIBUT and PL-NIBUT were measured using a tearscope. Tear samples were assayed for TGF-β1 and IL1-β concentrations using Enzyme-Linked Immunosorbent Assay kits. An 11-members control group (6 males) aged 25.0 ± 5.0, served to assess biomarker levels in non-contact lens wearers’ tears.</div></div><div><h3>Results</h3><div>Subjects wore lenses for an average of 7 h and 20 min (range: 6 to 9 h). Bulbar and limbal hyperemia increased significantly throughout the day (p &lt; 0.001). PL-NIBUT were lower than NIBUT (4.7 ± 2.0 Vs. 12.2 ± 8.8 s; p &lt; 0.001). The IL1-β levels were higher in neophytes than controls (3.2 ± 4.7 Vs. 0.1 ± 0.1 pg/ml; p = 0.05), correlating significantly with bulbar (r = 0.405, p = 0.008) and limbal hyperemia (r = 0.499, p = 0.027). No substantial changes were reported for TGF-β1.</div></div><div><h3>Conclusion</h3><div>The presence of TGF-β1 in tears does not appear significantly affected by lens wear. The association between physiological parameters and IL1-β levels suggests that lenses may disrupt ocular surface homeostasis by altering cytokine regulatory mechanisms. However, due to its low concentration, IL1-β’s role in the subclinical inflammatory response to lens wear is limited.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102299"},"PeriodicalIF":4.1,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective registry-based external validation cohort analysis of dry eye disease subtype classification criteria","authors":"Michael T.M. Wang ,&nbsp;Jennifer P. Craig ,&nbsp;Barry Power ,&nbsp;James S. Wolffsohn","doi":"10.1016/j.clae.2024.102290","DOIUrl":"10.1016/j.clae.2024.102290","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 5","pages":"Article 102290"},"PeriodicalIF":4.1,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in corneal diseases: A narrative review","authors":"Tuan Nguyen ,&nbsp;Joshua Ong ,&nbsp;Mouayad Masalkhi ,&nbsp;Ethan Waisberg ,&nbsp;Nasif Zaman ,&nbsp;Prithul Sarker ,&nbsp;Sarah Aman ,&nbsp;Haotian Lin ,&nbsp;Mingjie Luo ,&nbsp;Renato Ambrosio ,&nbsp;Aydano P. Machado ,&nbsp;Darren S.J. Ting ,&nbsp;Jodhbir S. Mehta ,&nbsp;Alireza Tavakkoli ,&nbsp;Andrew G. Lee","doi":"10.1016/j.clae.2024.102284","DOIUrl":"10.1016/j.clae.2024.102284","url":null,"abstract":"<div><div>Corneal diseases represent a growing public health burden, especially in resource-limited settings lacking access to specialized eye care. Artificial intelligence (AI) offers promising solutions for automating the diagnosis and management of corneal conditions. This narrative review examines the application of AI in corneal diseases, focusing on keratoconus, infectious keratitis, pterygium, dry eye disease, Fuchs endothelial corneal dystrophy, and corneal transplantation. AI models integrating diverse imaging modalities (e.g., corneal topography, slit-lamp, and anterior segment OCT images) and clinical data have demonstrated high diagnostic accuracy, often outperforming human experts. Emerging trends include the incorporation of biomechanical data to enhance keratoconus detection, leveraging in vivo confocal microscopy for diagnosing infectious keratitis, and employing multimodal approaches for comprehensive disease analysis. Additionally, AI has shown potential in predicting disease progression, treatment outcomes, and postoperative complications in corneal transplantation. While challenges remain such as population heterogeneity, limited external validation, and the “black box” nature of some models, ongoing advancement in explainable AI, data augmentation, and improved regulatory frameworks can serve to address these limitations.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102284"},"PeriodicalIF":4.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between vision-related quality of life and mental health status in myopia children using various optical correction aids","authors":"Wen Zhang ,&nbsp;Shuai Chang ,&nbsp;Jinyun Jiang,&nbsp;Mengting Yu,&nbsp;Shuoshuo Chen,&nbsp;Yin Hu,&nbsp;Zhouyue Li,&nbsp;Xiao Yang","doi":"10.1016/j.clae.2024.102287","DOIUrl":"10.1016/j.clae.2024.102287","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the relationship between vision-related quality of life and mental health in myopia children with various optical aids.</p></div><div><h3>Methods</h3><p>This cross-sectional study enrolled children aged 8–13 years, exhibiting myopia ranging from −4.50 to −0.75 D, and utilizing various optical aids for correction. Full ocular examinations and completion of two questionnaires were performed. Vision-related quality of life was evaluated using the Paediatric Refractive Error Profile (PREP), and mental health status was assessed utilising the Screen for Child Anxiety Related Emotional Disorders (SCARED). Univariate and multivariate analyses were conducted to evaluate the association between vision-related quality of life and mental health status.</p></div><div><h3>Results</h3><p>The study sample comprised 209 children with corrected myopia using single vision spectacles (100 [47.8 %]), soft contact lenses (66 [31.6 %]), and orthokeratology lenses (43 [20.6 %]). The mean age was 10.31 ± 1.65 y, and males accounted for 50.7 % of the sample. The distribution of demographic characteristics showed no significant difference among all correction types, except that the myopia duration was longer for orthokeratology lens wearers than those using spectacles (<em>P</em>=0.03). Contact lens showed clear benefits in almost all dimensions of vision-related quality of life, especially in appearance, satisfaction, activity and peer perceptions dimensions. The prevalence of anxiety disorders among spectacle wearers was 25.0 %, the highest among all groups. For myopia children with optical corrections, not being in the top 30 percent of their class rank, reporting lower PREP scores on symptoms, handling and peer perceptions dimensions were related with a higher prevalence of anxiety disorders.</p></div><div><h3>Conclusions</h3><p>Lower vision-related quality of life was associated with worse mental health status of myopia children with optical corrections. Identifying this association is crucial for protecting the mental health of myopia children and enhancing corrective measures.</p></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 5","pages":"Article 102287"},"PeriodicalIF":4.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}