Giornale Italiano Di Dermatologia E Venereologia最新文献_第7页

Vitamin B12 induced extragenital lichen sclerosus et atrophicus: an unconventional association. 维生素B12诱导外阴硬化性地衣和萎缩性地衣:一种非常规的关联。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-23 DOI: 10.23736/S0392-0488.20.06700-0

V. Piccolo, P. Corneli, G. Ferrara, P. Goglia, T. Russo

引用次数: 1

Immune serological diagnosis of pemphigus. 天疱疮免疫血清学诊断。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-23 DOI: 10.23736/S0392-0488.20.06788-7

F. Solimani, K. Meier, C. Zimmer, T. Hashimoto

{"title":"Immune serological diagnosis of pemphigus.","authors":"F. Solimani, K. Meier, C. Zimmer, T. Hashimoto","doi":"10.23736/S0392-0488.20.06788-7","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06788-7","url":null,"abstract":"Pemphigus is a rare autoimmune blistering disease which manifests with painful erosions and blisters of the skin and mucosa. This disorder is caused by autoantibodies attacking desmosomal proteins, necessary for cell-cell contact stability and epidermal integrity. Desmoglein (Dsg) 1 and Dsg3 are the two major target antigens in pemphigus. Yet, many other target proteins, which have been described over the years, seem to be involved in the loss of epidermal integrity. Clinical examination, combined to serological advances and detection of targeted antigens, permitted to differentiate among several pemphigus subtypes, in which pemphigus vulgaris and pemphigus foliaceus are the most common. Nowadays, serological analysis in pemphigus is a fundamental step of the diagnostic algorithm. This is based on analysis of clinical symptoms, histopathological examination of lesional skin, detection of tissue bound and circulating antibodies by direct and indirect immunofluorescence and determination of target antigens either by enzyme-linked immunosorbent essay (ELISA) or by western blot analysis. A correct and exhaustive diagnostic algorithm is fundamental to characterize pemphigus subtypes, which lastly permits to adopt a correct treatment approach. Moreover, quality and quantity of circulating antibodies in patient's sera deliver important information regarding clinical course, disease severity and treatment response, thus relevantly affecting physician's decision. To facilitate this process, \"easy-to-perform\" diagnostic kits with high sensitivity and specificity are being commercialized. In this review, we focus on available methods and established assays to correctly detect circulating autoantibodies in pemphigus. Further, we discuss subtype specific serological peculiarities in the five most relevant subtypes (pemphigus vulgaris, pemphigus foliaceus, pemphigus vegetans, paraneoplastic pemphigus and intercellular IgA dermatosis (also called as IgA pemphigus).","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"51 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85753149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Successful ustekinumab treatment of severe refractory psoriasis vulgaris in a haemodialysis patient: a case report. ustekinumab成功治疗血液透析患者严重难治性寻常型银屑病:1例报告。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-23 DOI: 10.23736/S0392-0488.20.06789-9

A. Michelerio, Christian Ciolfi, Giuseppe Rotatore, F. Grosjean, V. Brazzelli

引用次数: 0

Brodalumab treatment in psoriasis patients with severe renal failure. 博达鲁单抗治疗银屑病合并严重肾功能衰竭。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-23 DOI: 10.23736/S0392-0488.20.06719-X

S. Ribero, V. Conti, A. Gambardella, A. De Rosa, Paolo Da Pavo, G. Argenziano

引用次数: 1

Bartholin's gland cysts: dermoscopic clues and differential diagnosis. 巴托林腺囊肿:皮肤镜线索和鉴别诊断。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-23 DOI: 10.23736/S0392-0488.20.06763-2

Valeria Evangelista, A. Barisani, G. Tosti, C. Baraldi, A. Patrizi, S. Vaccari

引用次数: 0

Dermoscopic features of a primary scalp melanoma and its cutaneous metastases. 原发性头皮黑色素瘤及其皮肤转移的皮肤镜特征。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-23 DOI: 10.23736/S0392-0488.20.06742-5

M. Pizzichetta, V. Canzonieri, L. Militello, E. Borsatti, G. Lo Re, S. Bolzonello, M. Olivieri, C. Pinzani, G. Magaton-Rizzi, F. Puglisi, I. Zalaudek

引用次数: 0

Nevus Depigmentosus: a series with analysis of 37 cases. 色素痣37例临床分析。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-23 DOI: 10.23736/S0392-0488.20.06681-X

K. Sharquie, Fatema A. Al-Jaralla, R. Schwartz, Reem M. Alhyali

引用次数: 0

Trauma-induced bullous pemphigoid mimicking fracture blisters. 外伤性大疱性类天疱疮模拟骨折水泡。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-12 DOI: 10.23736/S0392-0488.20.06740-1

D. Abbenante, B. Raone, C. Baraldi, C. Loi, A. Patrizi, F. Bardazzi

引用次数: 1

Autoreactive T cells in pemphigus. Perpetrator and target. 自体反应性T细胞在天疱疮中的作用。肇事者和目标。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-12 DOI: 10.23736/S0392-0488.20.06706-1

L. Scarsella, R. Pollmann, K. Amber

{"title":"Autoreactive T cells in pemphigus. Perpetrator and target.","authors":"L. Scarsella, R. Pollmann, K. Amber","doi":"10.23736/S0392-0488.20.06706-1","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06706-1","url":null,"abstract":"Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against epidermal cadherins, such as desmoglein (Dsg)1 and Dsg3, lead to the development of blisters and erosions on the skin and the mucous membranes. Autoreactive CD4+ T cells are essential for the induction and perpetuation of the disease by interaction with B cells producing autoantibodies. PV has a strong genetic association with certain human leucocyte antigen (HLA) alleles with being HLA-DRB1*04:02 and DQB1*05:03 the most prevalent in patients. Recently, genome-wide association studies have provided a new approach to identify single nucleotide polymorphisms, alongside the known association with HLA alleles. Loss of tolerance against Dsgs and other autoantigens is a critical event in the pathogenesis of PV. Epitope spreading contributes to the progression of PV, leading to an extension of the Dsg-specific autoimmune response to other molecular epitopes of autoantigens, such as desmocollins or muscarinic receptors. Alterations in CD4+CD25+ FoxP3+ regulatory T-cells are thought to contribute to the development of PV representing a suitable target for therapeutic interventions. Several CD4+ T-cell subsets and cytokines are involved in the pathogenesis of PV, while Th2 cells are the extensively studied population. Recently, other T cell subsets like T follicular helper cells and Th17 have gained attention as new potential players in PV pathogenesis. The involvement of local autoantibody production in the lesional skin of PV patients in tertiary lymphoid organs is currently discussed but not yet clarified. Here, we will review the current knowledge about the development, characteristics and function of autoreactive T cells in pemphigus and present current new T cell-targeted therapeutic approaches.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"1981 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88187006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Italian guidelines for the diagnosis and treatment of classic and iatrogenic Kaposi's sarcoma. 意大利经典医源性卡波西肉瘤的诊断和治疗指南。

IF 2

Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-12 DOI: 10.23736/S0392-0488.20.06703-6

L. Brambilla, G. Genovese, E. Berti, K. Peris, F. Rongioletti, G. Micali, F. Ayala, S. Della Bella, R. Mancuso, P. Calzavara Pinton, A. Tourlaki

{"title":"Italian guidelines for the diagnosis and treatment of classic and iatrogenic Kaposi's sarcoma.","authors":"L. Brambilla, G. Genovese, E. Berti, K. Peris, F. Rongioletti, G. Micali, F. Ayala, S. Della Bella, R. Mancuso, P. Calzavara Pinton, A. Tourlaki","doi":"10.23736/S0392-0488.20.06703-6","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06703-6","url":null,"abstract":"Kaposi's sarcoma (KS) is a lymphangioproliferative disorder associated with human herpesvirus 8 (HHV8) infection. Four clinical subtypes are recognized: classic, endemic, epidemic (HIV-related) and iatrogenic. KS diagnosis is based on clinical features, histopathological assessment, and HHV8 serology. Classic KS is usually skin-limited and has a chronic course, while the iatrogenic variant may show mucosal, nodal or visceral involvement. Clinical staging is fundamental to guide the management. Localized disease may be treated with different local therapies, even if there are no randomized trials comparing these different modalities. Aggressive, disseminated KS and cases with visceral involvement usually require systemic chemotherapy, most commonly vinblastine, bleomycin or paclitaxel. Iatrogenic KS needs immunosuppression tapering/withdrawal and, if possible, switch to m-TOR inhibitors in post-transplant KS. The present work by a panel of Italian experts provides guidelines on KS diagnosis and management based on a critical review of the literature and a long and extensive personal experience.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"34 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72942950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2