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Giornale Italiano Di Dermatologia E Venereologia最新文献

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Detection of IgE autoantibodies in mucous membrane pemphigoid and their association with disease severity. 类天疱疮粘膜IgE自身抗体的检测及其与疾病严重程度的关系。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 Epub Date: 2018-10-04 DOI: 10.23736/S0392-0488.18.06167-9
Laura Corti, Daniele Fanoni, Luigia Venegoni, Simona Muratori, Sebastiano Recalcati, Emilio Berti
{"title":"Detection of IgE autoantibodies in mucous membrane pemphigoid and their association with disease severity.","authors":"Laura Corti,&nbsp;Daniele Fanoni,&nbsp;Luigia Venegoni,&nbsp;Simona Muratori,&nbsp;Sebastiano Recalcati,&nbsp;Emilio Berti","doi":"10.23736/S0392-0488.18.06167-9","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06167-9","url":null,"abstract":"<p><strong>Background: </strong>Mucous membrane pemphigoid (MMP) is an autoimmune disease characterized by scarring lesions at mucosal sites. Although the pathogenic role of specific IgG and/or IgA has been already demonstrated and the detection of these immunoglobulins is a criterion in the diagnosis of MMP, little is known about IgE role in this disease. Therefore, the main purpose of this study was to assess the presence of circulating and tissue bound IgE in patients with MMP and their possible correlations with clinical presentation and disease course.</p><p><strong>Methods: </strong>We conducted a retrospective study on 29 patients affected by MMP, recruited from a single center. Direct and indirect immunofluorescence studies were assessed to analyze the presence of specific IgE directed against the basal membrane zone. For each patient, fluorescence data were compared to clinical features.</p><p><strong>Results: </strong>Linear deposits of C3, IgG and IgA were present in 86.2%, 62% and 37.9% of cases respectively, while IgE linear deposits were detected in 17 out of 29 patients (58.6%) including one case with isolated IgE positivity. Circulating IgE and IgA anti-BMZ were present in 7 (24.1%) and 5 (17.2%) patients, respectively. Both the presence of circulating IgA and of tissue bound IgE deposits correlated with disease activity index (P<0.014).</p><p><strong>Conclusions: </strong>Our results demonstrated the presence of IgE autoantibodies in MMP, particularly in more severe cases. Thus, IgE detection may represent an additional useful diagnostic tool in this disease.</p>","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"155 6","pages":"754-759"},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36557394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
A rare side effect: eltrombopag associated hyperpigmentation. 一种罕见的副作用:与电曲巴格相关的色素沉着。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 Epub Date: 2019-05-14 DOI: 10.23736/S0392-0488.19.06181-9
Hilmi Atay, Engin Kelkitli, Mehmet Turgut
{"title":"A rare side effect: eltrombopag associated hyperpigmentation.","authors":"Hilmi Atay,&nbsp;Engin Kelkitli,&nbsp;Mehmet Turgut","doi":"10.23736/S0392-0488.19.06181-9","DOIUrl":"https://doi.org/10.23736/S0392-0488.19.06181-9","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"155 6","pages":"803-804"},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37256896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Isochemotopic response: the first case on a scar. 同化位反应:第一例疤痕。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 Epub Date: 2018-11-12 DOI: 10.23736/S0392-0488.18.06149-7
Marta Carlesimo, Enrico Cortesi, Andrea D'Arino, Flavia Pigliacelli, Gemma Caro, Serena Zancla, Caterina M Fortuna, Federico Grifalchi, Alfredo Rossi
{"title":"Isochemotopic response: the first case on a scar.","authors":"Marta Carlesimo,&nbsp;Enrico Cortesi,&nbsp;Andrea D'Arino,&nbsp;Flavia Pigliacelli,&nbsp;Gemma Caro,&nbsp;Serena Zancla,&nbsp;Caterina M Fortuna,&nbsp;Federico Grifalchi,&nbsp;Alfredo Rossi","doi":"10.23736/S0392-0488.18.06149-7","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06149-7","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"155 6","pages":"789-791"},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36726014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Correction to: Autoinflammatory diseases: why they should matter to the dermatologist. 更正：自体炎症性疾病：为什么皮肤科医生应该重视它们。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 DOI: 10.23736/S0392-0488.21.06997-2
Dan Lipsker, Cédric Lenormand
{"title":"Correction to: Autoinflammatory diseases: why they should matter to the dermatologist.","authors":"Dan Lipsker, Cédric Lenormand","doi":"10.23736/S0392-0488.21.06997-2","DOIUrl":"10.23736/S0392-0488.21.06997-2","url":null,"abstract":"<p><p>This corrects the article DOI: 10.23736/S0392-0488.20.06778-4.</p>","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"155 6","pages":"809-810"},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25423869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What makes an inflammatory disease inflammatory? An overview of inflammatory mechanisms of allergic contact dermatitis, atopic dermatitis and psoriasis. 是什么使炎症性疾病发炎?过敏性接触性皮炎、特应性皮炎和牛皮癣的炎症机制综述。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 Epub Date: 2020-04-29 DOI: 10.23736/S0392-0488.20.06551-7
Eleonora Farinazzo, Roberta Giuffrida, Caterina Dianzani, Roberta Vezzoni, Chiara Retrosi, Iris Zalaudek, Claudio Conforti
{"title":"What makes an inflammatory disease inflammatory? An overview of inflammatory mechanisms of allergic contact dermatitis, atopic dermatitis and psoriasis.","authors":"Eleonora Farinazzo,&nbsp;Roberta Giuffrida,&nbsp;Caterina Dianzani,&nbsp;Roberta Vezzoni,&nbsp;Chiara Retrosi,&nbsp;Iris Zalaudek,&nbsp;Claudio Conforti","doi":"10.23736/S0392-0488.20.06551-7","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06551-7","url":null,"abstract":"<p><p>Inflammatory response in the skin is important for host defense against a broad spectrum of insults including microorganisms, chemicals, radiation and physical trauma. When the inflammatory process becomes prolonged and self-perpetuating, illness occurs. In this review, we discuss recent findings regarding the complex inflammatory mechanisms in allergic contact dermatitis, atopic dermatitis and psoriasis.</p>","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"155 6","pages":"719-723"},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37883175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Pityriasis versicolor with uncommon localizations. 少见部位的花斑糠疹。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 Epub Date: 2018-11-09 DOI: 10.23736/S0392-0488.18.06120-5
Vincenzo Greco, Matteo Megna, Maria A Luciano, Gabriella Fabbrocini
{"title":"Pityriasis versicolor with uncommon localizations.","authors":"Vincenzo Greco,&nbsp;Matteo Megna,&nbsp;Maria A Luciano,&nbsp;Gabriella Fabbrocini","doi":"10.23736/S0392-0488.18.06120-5","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06120-5","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"155 6","pages":"786-787"},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36665416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of nine patients with solar urticaria during summer. 夏季日光性荨麻疹9例临床分析。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 Epub Date: 2019-03-29 DOI: 10.23736/S0392-0488.19.06176-5
Nicola Milanesi, Massimo Gola, Stefano Francalanci
{"title":"Evaluation of nine patients with solar urticaria during summer.","authors":"Nicola Milanesi,&nbsp;Massimo Gola,&nbsp;Stefano Francalanci","doi":"10.23736/S0392-0488.19.06176-5","DOIUrl":"https://doi.org/10.23736/S0392-0488.19.06176-5","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"155 6","pages":"800-802"},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37101284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Meeting a rare disease: bullous ichthyosiform erythroderma. 遇到一种罕见的疾病:大疱性鱼鳞状红皮病。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 Epub Date: 2018-07-10 DOI: 10.23736/S0392-0488.18.06058-3
Giulia Tonini, Emanuele Trovato, Michele Pellegrino, Michele Fimiani
{"title":"Meeting a rare disease: bullous ichthyosiform erythroderma.","authors":"Giulia Tonini,&nbsp;Emanuele Trovato,&nbsp;Michele Pellegrino,&nbsp;Michele Fimiani","doi":"10.23736/S0392-0488.18.06058-3","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06058-3","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"155 6","pages":"783-784"},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36307036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-4497 mediates oxidative stress and inflammatory injury in keratinocytes induced by ultraviolet B radiation through regulating NF-κB expression. MiR-4497通过调节NF-κB表达介导紫外线B辐射诱导的角质形成细胞氧化应激和炎症损伤。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-12-01 DOI: 10.23736/S0392-0488.20.06825-X
Ling Yang, Zhonghua Hu, Yanxia Jin, Ning Huang, Su-Ping Xu
{"title":"MiR-4497 mediates oxidative stress and inflammatory injury in keratinocytes induced by ultraviolet B radiation through regulating NF-κB expression.","authors":"Ling Yang, Zhonghua Hu, Yanxia Jin, Ning Huang, Su-Ping Xu","doi":"10.23736/S0392-0488.20.06825-X","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06825-X","url":null,"abstract":"BACKGROUND\u0000To investigate the role and underlying mechanism of miR-4497 in oxidative stress and inflammatory injury in keratinocytes induced by ultraviolet B (UVB) radiation.\u0000\u0000\u0000METHODS\u0000An injury model of keratinocytes induced by UVB radiation was constructed. RT-qPCR, MTT assay and flow cytometry were adopted to detect miR-4497 expression in HaCaT cells, cell proliferation, and cell apoptosis, respectively. The levels of cytokines TNF-α, IL-18, IL-6 and IL-1β in cell culture supernatant were tested by ELISA. ROS levels in the cells were labeled by DCFH-DA fluorescent probe, and then quantitative fluorescence analysis was performed by flow cytometry. SOD activity in the cells was measured by Xanthine Oxidase assay kit. Western blot was used to determine NF-κB expression in cytoplasm and nucleus, and p-IκBα expression in the cells.\u0000\u0000\u0000RESULTS\u0000UVB radiation significantly increased miR-4497 expression in HaCaT cells, inhibited cell proliferation, and promoted cell apoptosis. Meanwhile, UVB radiation caused the promotion of secretion of cytokines TNF-α, IL-18, IL-6 and IL-1β. The production of reactive oxygen species (ROS) was promoted by UVB radiation, while SOD activity was inhibited. Nuclear transfer of NF-κB signal was also induced by UVB radiation. In addition, downregulation of miR-4497 expression significantly inhibited the effects of UVB radiation on cell proliferation, apoptosis, cytokine secretion, redox level and NF-κB signal in HaCaT cells, while overexpression of miR-4497 further enhanced these effects of UVB radiation on HaCaT cells.\u0000\u0000\u0000CONCLUSIONS\u0000UVB may promote the expression of inflammatory and oxidative stress signals in keratinocytes by upregulating miR-4497 expression, thus mediating cell injury.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"48 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78728153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Disseminated mucocutaneous Candida infection during anti IL-17A therapy in a psoriatic patient. 银屑病患者抗IL-17A治疗期间弥散性粘膜念珠菌感染。
IF 2
Giornale Italiano Di Dermatologia E Venereologia Pub Date : 2020-11-23 DOI: 10.23736/S0392-0488.20.06673-0
A. Raimondo, F. Salzano, S. Lembo
{"title":"Disseminated mucocutaneous Candida infection during anti IL-17A therapy in a psoriatic patient.","authors":"A. Raimondo, F. Salzano, S. Lembo","doi":"10.23736/S0392-0488.20.06673-0","DOIUrl":"https://doi.org/10.23736/S0392-0488.20.06673-0","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":"112 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82495548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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